The present study is a detailed structural analysis of 3D seismic data in the Selis Ridge in the western part of the Loppa High in the Norwegian Barents Sea, to which new seismic attributes and spectral decomposition were applied. The analysis reveals that pre-Devonian basement rocks in the Barents Sea are crosscut by a 40–50 kilometers wide, several kilometers thick, E–W- to WNW–ESE-striking fold-and-thrust belt, including a steep, major, kilometer-thick, top-south shear zone. The folds display dome- and trough-shaped geometries, the thrusts appear to have been reactivated dominantly as top-west structures, and the main shear zone warps over the top of the Selis Ridge. The fold-and-thrust belt is interpreted as remnants of the latest Neoproterozoic (ca. 650–550 Ma) Timanian Orogeny, which potentially reworked preexisting Neoproterozoic rift basins and highs and was reworked during E–W-oriented Caledonian contraction in the Ordovician–Silurian. The present results are analogous to recent findings in the northern Norwegian Barents Sea and Svalbard. The presented interpretation provides the basis for discussing Neoproterozoic–Paleozoic plate tectonics reconstructions, the influence of Precambrian–early Paleozoic structures on post-Caledonian fault complexes, the location of the Timanian and Caledonian suture zones, Neoproterozoic rifting, and the origin of the Seiland Igneous Province.