Anticancer Study of Innovative Macrocyclic Formazan Compounds from Trimethoprim Drug
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![Fig(1):FT.IR-Trimethoprim Derivative[1]](https://www.researchgate.net/profile/Nagham-Aljamali/publication/360173292/figure/fig1/AS:11431281152702467@1682099350607/Fig1FTIR-Trimethoprim-Derivative1_Q320.jpg)
![Fig(11):H.NMR-Spectrum of Trimethoprim Derivative[1]](https://www.researchgate.net/profile/Nagham-Aljamali/publication/360173292/figure/fig2/AS:11431281152663063@1682099351417/Fig11HNMR-Spectrum-of-Trimethoprim-Derivative1_Q320.jpg)
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... (2021). Magnitudes and Future Direction', Journal Pipelines, 4,[95][96][97][98][99][100][101][102] 1984., Available at : http://www.accessdata.fda.gov/scripts/cdrh/cf docs/cfres/res.cfm ...
The world today depends mainly on coal, nuclear power, natural gas, hydropower, wind turbines, and petroleum, with a small amount of energy being generated [1-3]. Almost all of the electrical energy generated on a commercial scale uses electromagnetic induction, in which mechanical energy forces an electrical generator to rotate. There are many different ways to acquire this mechanical energy, including heat engines, hydro, wind and tidal Transportation emissions are close to this percentage, and contribute to about a third of the United States' CO2 production Wind turbines usually generate electrical energy in conjunction with other energy production methods. Many other technologies for power generation have been studied and developed. The Solid-state generation (without moving parts) is of particular interest in portable applications. This field is largely dominated by thermoelectric devices, although thermionic and thermoelectric systems have evolved as well. Typically, thermoelectric devices are used at lower temperatures than thermionic and thermoelectric systems, piezoelectric devices are used to generate energy from mechanical stress, particularly in the "Energy Harvesting" process. Beta-voltaic generators are another type of solid state power generator that produces electricity from radioactive decay.
... (2021). Magnitudes and Future Direction', Journal Pipelines, 4,[95][96][97][98][99][100][101][102] 1984., Available at : http://www.accessdata.fda.gov/scripts/cdrh/cf docs/cfres/res.cfm ...
The world today depends mainly on coal, nuclear power, natural gas, hydropower, wind turbines, and petroleum, with a small amount of energy being generated [1-3]. Almost all of the electrical energy generated on a commercial scale uses electromagnetic induction, in which mechanical energy forces an electrical generator to rotate. There are many different ways to acquire this mechanical energy, including heat engines, hydro, wind and tidal Transportation emissions are close to this percentage, and contribute to about a third of the United States' CO2 production Wind turbines usually generate electrical energy in conjunction with other energy production methods. Many other technologies for power generation have been studied and developed. The Solid-state generation (without moving parts) is of particular interest in portable applications. This field is largely dominated by thermoelectric devices, although thermionic and thermoelectric systems have evolved as well. Typically, thermoelectric devices are used at lower temperatures than thermionic and thermoelectric systems, piezoelectric devices are used to generate energy from mechanical stress, particularly in the "Energy Harvesting" process. Beta-voltaic generators are another type of solid state power generator that produces electricity from radioactive decay.
issions, which is greater than $ 1 any other source. Transportation emissions are close to this percentage, and contribute to about a third of the United States' CO2 production Wind turbines usually generate electrical energy in conjunction with other energy production methods. Many other technologies for power generation have been studied and developed. The Solid-state generation (without moving parts) is of particular interest in portable applications. This field is largely dominated by thermoelectric devices, although thermionic and thermoelectric systems have evolved as well. Typically, thermoelectric devices are used at lower temperatures than thermionic and thermoelectric systems, piezoelectric devices are used to generate energy from mechanical stress, particularly in the "Energy Harvesting" process. Beta-voltaic generators are another type of solid state power generator that produces electricity from radioactive decay.
"Energy Harvesting" process. Beta-voltaic generators are another type of solid state power generator that produces electricity from radioactive decay.
The prepared bio-ligand derived from chalcone-azo (E)-1-(4-(E)-4-methyl-derivative of di-nitrogen atoms-cycle. In view of the effect of the compensating groups on the effectiveness and uses of the five-cyclic heterogeneous compounds, in this research new substitutes for the aromatic azo and chalcon compounds were prepared from different raw materials and compounds that could have different biological effects and effects on the cell of the organism were prepared and their physical and spectral properties were studied. The importance of studying the spectral characterization of a number of prepared compounds containing different groups of compensators, which may have an impact in the inorganic chemistry field or the industrial field., In addition to anti-cancer study against cancer cell.
Cyclic Formazan was invented and prepared for the first time by researcher Dr. Nagham Aljamali was established in April 2021. Therefore, it is considered one of the developed and modern compounds, which is described by a lack of references and researches. Therefore, the researcher, Dr. Nagham prepared and created a series of these compounds and studied several applications, including biological, pharmaceutical studies , also as antifungal, antibacterial, and anticancer agents, and here in this research, cyclic formazan was studied as medical nanomaterials. A number of technical spectroscopic studies have been used to demonstrate their chemical structures which provided clear evidences of their chemical structures via many technical instruments like (FT IR-Spectra , 1H.NMR-Spectra, Mass-Spectra)., Melting points, other studies represented by evolution them as Nano-compounds by {Scanning Electron Microscopy (FESEM) , and their Chromatographic behavior}.
The research included the invention of cyclic formazan compounds for the first time in this research that carried out in April 2021, where the usual formazan compounds were previously attended, but in the current research we attended the cyclic formazan compounds as innovative compounds and after that they were diagnosed by reliable chemical means of measurement, that provided vibrant indication of their chemical constructions via numerous technical apparatuses similar (FT IR-Bands, 1H.NMR-Peeaks, Mass-Identification). Melting points, other studies represented by antimicrobial Evaluation., These Compounds have been distinguished by their bright colors and their using as fixed dyes for many tissues and as anti-corrosion materials , and as a ligands with transitional elements as coordination complexes., The results appeared good evidence for efficiency of Innovative Cyclic formazan derivatives that compounds gave high inhibition in bacteria more than other compounds via creation of band of formazan (-N=C-N=N-) in innovated derivative more than initial materials beginning Aldamine compounds that produced inhibition action of bacteria.
Macrocyclic Sulfazan and Macrocyclic Formazan were created and developed globally for the first time by researcher Dr. Nagham Aljamali in April 2021, while same researcher created and innovated Sulfazan compounds as the first time in 2019., Therefore, these compounds considered one of the developed and modern compounds which have a lack of references or scarcity of books and researches. Therefore, the researcher, Dr. Nagham prepared and created a chain of these innovated compounds and studied by numerous applications, containing biological, pharmaceutical studies, also as antifungal, antibacterial, anticancer agents, and here in this research, also cyclic sulfazan and cyclic formazan were studied a several applications. A numeral of practical spectroscopic studies has been used to exhibit their chemical structures which provided strong evidence of their chemical structures through various technical devices like (FT IR-Spectra, 1H.NMR-Spectra, Mass-Spectra)., Melting points, other studies represented by evolution them as bio-compounds by scanning them as anticancer compounds.
Sulfazan and Triazan Compounds were created for the first time as a class of organic chemistry in 2019 globally for the first time, then developed by researcher Dr. Nagham Aljamali in April 2021, while same researcher created and invented Sulfazan compounds as a nano-compounds, anti-bio compounds .,and since the references are few on Sulfazan, so we have prepared a many of them and studied their applications in various fields to enrich this topic with references. A numeral of practical spectroscopic studies have been used to exhibit their chemical structures which provided strong evidences of their chemical structures through various technical devices like (FT IR-Spectra, 1H.NMR-Spectra, Mass-Spectra)., Melting points, other studies exemplified by evolution them as a Nano-compounds by Scanning Electron Microscopy (FESEM).
Sulfazan compounds were invented for the first time globally by researcher Dr.
Nagham Aljamali in 2019 was named as sulfazan compounds, then it was developed
into cyclic sulfazan and cyclic formazan, which was also first prepared in April 2021
in this current study., which prepared by using various conditions and different basic
medium like (Pyridine, Pipridine, 5 % Sodium hydroxide, Triethyl amine,…) .,Several
technical spectroscopic studies have been used to prove their chemical structures
which gave clear evidence of its chemical structures via many technical instruments
like (FT IR-Spectra , 1H.NMR-Spectra, Mass-Spectra)., Melting points, other studies
represented by evolution them as antifungal compounds.
Keywords: Sulfazan; Cyclic Sulfazan; Cyclic Formazan; Formazan; Imine; Schiff Base;
Azo; Antifungal; Aldamine; Anil; Triazole; Oxadiazole
Cancerous tumors are considered a serious and fatal diseases for both sexes and for all ages, even fetuses before their birth. Therefore, it has become necessary to find an alternative treatment for radiation to be safer and less dangerous than chemical treatments. Therefore, derivatives of one of the amino acids, such as tyrosine, were prepared. Tyrosine or tyrosine is one of the well-known and important amino acids for humans, and it is present in most proteins; The human body uses it to produce several types of hormones such as noradrenaline and adrenaline. In this paper, we prepared new derivatives of tyrosine represented by (four, five, six)-membered ring, then all these new tyrosine derivatives investigated by several techniques (FT.IR, H.NMR)-spectrophotometric, other physical and chemical properties, with assaying for some new created derivatives as anti-cancer.
This Book concerned with Effect of Conditions and Catalysts on Type of Products), types of heterocyclic compounds, preparation methods of cyclic compounds and other Organic synthetic reactions, this book involved Five chapters: {Chapter One : Effect of Conditions and Catalysts on Type of Products, Effect of Catalysis on Rate of Reactions, Effect of Conditions and Catalysts on Type of Products, Effected Factors on Chalcone Reaction, Effect of Catalyst in any Reaction, Mechanism of Catalysis in reactions, Reduction and Oxidation Catalysts, Types of Catalysts., Chapter Two : Selective Site (Selective Reaction), Selective Site (Selective Reaction), Michael reaction, Chalcone, Selected Reaction for Chalcone Formation, Mechanism of Chalcone Preparation in Basic Medium, Mechanism of Chalcone Preparation in Acidic Medium, Some Preparation Methods for Chalcone via Selective Site, Reactions Of Chalcone, Bio-Applications of Chalcone., Chapter Three : Conditions of Cyclization Processes for Heterocycles ( Three to Six)-Membered Ring, Types of Common heterocycles, Mono-Cyclic Compounds, Bi and Multi-Cyclic Compounds, Preparation Methods of Preparations, Conditions of Cyclization Processes, Cyclization Methods via Various Catalysts, Catalysis and Synthesis Methods of Bi-cyclic systems, Catalysis and Synthesis Methods of Six Membered Ring, Catalysis and Synthesis Methods of Pyrimidine, Catalysis and Synthesis Methods of Five Membered Ring, Catalysis and Synthesis Methods of Four Membered Ring, Catalysis and Synthesis Methods of Oxadiazole, Catalysis and Synthesis Methods of Thiadiazole, Catalysis and Synthesis Methods of Tetrazole, Catalysis and Synthesis Methods of Triazole, Catalysis and Synthesis Methods of Pyrazole, Catalysis and Synthesis Methods of Imidazole, Catalysis and Synthesis Methods of Thiazole., Chapter Four: Reactions of 1,3-Dipoles Compounds, Characteristic of Dipoles Compounds, 1,3-Dipoles Compounds, Conditions of 1,3-Dipoles Reactions, Reactions of Dipoles Compounds., Chapter Five: Preparation of Thio and Semicarbazide , reaction of Semi and thiosemicarbazide , Applications ., Chapter Six : Mechanism of Tautomerism., Which is More Stable, Keto or Enol, Tautomerism–forms of Amino acids, There are many types of Tautomerism –forms, Examples for Types of Tautomerisms, Phenol: (Keto- Enol) form, Imine-Enamine Form, Aldehyde and ketone – Tautomerism, Mechanism of Tautomerism Reaction.
This Book in the field :Identification of Functional Groups In Compounds (Spectral Identification and Laboratory methods) , involved Six chapters: {Chapter One: Infrared Spectroscopy (IR), Finger print region, Sampling Techniques, Types of Beam in IR- Spectra , Calculation of the Number of Vibrational Degrees , Hydrogen bonding., Some Examples of I.R of Organic Compounds., Types of (OH) in I.R., Chapter Two: H.NMR –Spectra ,Nuclear Magnetic Resonance Spectroscopy (H. NMR) ,The solvent should be, H.NMR is used to study a wide variety of nuclei , The Contents of NMR –Chart, Chemical Shift , Coupling constant (J) , Calculation of Integration: examples, EXPRESSION OF CHEMICAL SHIFTS, Examples of Compounds, Effect of Tautomerism in Shift of Signals, Properties of Solvents., Chapter Three: C.NMR–Spectra , Nuclear Magnetic Resonance Spectroscopy (13C. NMR), Factors that affect chemical shifts, Data of 13C. NMR Chemical Shift ranges, Examples of Compounds., Chapter Four: Dimensional Nuclear Magnetic Resonance Spectroscopy,1D and 2D NMR-Interpretation, Dimensional NMR spectroscopy (COSY), ¹H-¹³C HSQC , ¹H-¹³C HMBC , Cosy- Spectrum , 1H-1H COSY (Correlation Spectroscopy) , 1H-13C COSY (HETCOR) .,Chapter Five: Mass Spectra ,Mass Spectrum ,Measurement of Mass for The sample, Types of Samples, Ionization Methods in Mass Spectrum, Determination of Formula, Fragments of Compounds, Principles in Calculation of Mass, Examples of Compounds., Chapter Six: TLC-Technique and Paper Chromatography, TLC- Technique, How to prepare a TLC–plate , Paper Chromatography, How to calculate Rf , Distillation, Recrystallization., Chapter Seven : Organic Solvents ,Contents of Chapter Seven, Solvents., Classifications of Solvents., Types of Solvents, Index of Solvents properties.
Cited this book : Nagham Mahmood Aljamali, "Spectral and Laboratory Diagnostics of Compounds" ., 1th –Edition, 2022 , Eliva Press SRL., ISBN: 9781636482118
This study involvedsynthesisof (thiadiazole,triazole, thiadiazine, andheterocyclic-azo) andbio-studying of compounds that containing effective groups linked with mefenamicacid drug via cyclizationreaction ofthiosemicarbazide with mefenamicdrug toyieldnew drug-derivatives.All reactions are followedby (TLC) chromatographicand all the synthesized compounds have been identifiedbyusingvariouschemical techniques, like (1 H.NMR-spectra, 13 C.NMR-spectra, FT.IR-spectra), melting points,physical propertiesand studying ofits effectonbreast cancer cells.