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Correction to: Increased 30-day mortality in very old ICU patients with COVID-19 compared to patients with respiratory failure without COVID-19

Authors:
  • French Institute of Health and Medical Research U1136
Intensive Care Med
https://doi.org/10.1007/s00134-022-06674-5
CORRECTION
Correction to: Increased 30-day mortality
invery old ICU patients withCOVID-19
compared topatients withrespiratory failure
withoutCOVID-19
Bertrand Guidet1,2* , Christian Jung3, Hans Flaatten4,5, Jesper Fjølner6, Antonio Artigas7,
Bernardo Bollen Pinto8, Joerg C. Schefold9, Michael Beil10, Sviri Sigal10, Peter Vernon van Heerden11,
Wojciech Szczeklik12, Michael Joannidis13, Sandra Oeyen14, Eumorfia Kondili15, Brian Marsh16,
Finn H. Andersen17,18, Rui Moreno19, Maurizio Cecconi20, Susannah Leaver21, Dylan W. De Lange22
and Ariane Boumendil1,2 on behalf of the VIP2 and COVIP study groups
© 2022 Springer-Verlag GmbH Germany, part of Springer Nature
Correction to: Intensive Care Med
https:// doi. org/ 10. 1007/ s00134- 022-
06642-z
ere is a mistake in the list of participating countries
and ICUs listed in the Acknowledgement section. e
Publisher apologizes for this mistake.
Additionally, the correct full name of Alex Cornet is
Alexander Daniel Cornet. e authors apologize for the
mistake.
Author details
1 UPMC Univ Paris 06, INSERM, UMR_S 1136, Institut Pierre Louis
d’Epidémiologie et de Santé Publique, Equipe: épidémiologie hospitalière
qualité et organisation des soins, Medical Intensive Care, Sorbonne Universités,
184 rue du Faubourg Saint Antoine, 75012 Paris, France. 2 Assistance Publique-
Hôpitaux de Paris, Hôpital Saint-Antoine, service de réanimation médicale,
75012 Paris, France. 3 Department of Cardiology, Pulmonology and Vascular
Medicine, Medical Faculty, Heinrich-Heine-University Duesseldorf, Duesseldorf,
Germany. 4 Department of Clinical Medicine, University of Bergen, Bergen,
Norway. 5 Department of Anaestesia and Intensive Care, Haukeland University
Hospital, Bergen, Norway. 6 Department of Intensive Care, Aarhus University
Hospital, Aarhus, Denmark. 7 Department of Intensive Care Medicine, CIBER
Enfermedades Respiratorias, Corporacion Sanitaria Universitaria Parc Tauli,
Autonomous University of Barcelona, Sabadell, Spain. 8 Department of Acute
Medicine, Geneva University Hospitals, Geneva, Switzerland. 9 Department
of Intensive Care Medicine, Inselspital, Universitätsspital, University of Bern,
Bern, Switzerland. 10 Medical Intensive Care, Hadassah Medical Center, Faculty
of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel. 11 General
Intensive Care, Hadassah Medical Center, Faculty of Medicine, Hebrew Uni-
versity of Jerusalem, Jerusalem, Israel. 12 Center for Intensive Care and Perio-
perative Medicine, Jagiellonian University Medical College, Krakow, Poland.
13 Division of Intensive Care and Emergency Medicine, Department of Internal
Medicine, Medical University Innsbruck, Innsbruck, Austria. 14 Department
of Intensive Care 1K12IC, Ghent University Hospital, Ghent, Belgium. 15 Inten-
sive Care Unit, University Hospital of Heraklion, Medical School University
of Crete, Giofirakia, Greece. 16 Mater Misericordiae University Hospital, Dublin,
Ireland. 17 Department of Anaesthesia and Intensive Care, Ålesund Hospital,
Alesund, Norway. 18 Department of Circulation and Medical Imaging, Nor-
wegian University of Science and Technology, Trondheim, Norway. 19 Centro
Hospitalar Universitário de Lisboa Central, Faculdade de Ciências Médicas de
Lisboa, Nova Médical School, Unidade de Cuidados Intensivos Neurocríticos e
Trauma. Hospital de São José, Lisbon, Portugal. 20 Department of Anaesthesia
IRCCS, Instituto Clínico Humanitas, Humanitas University, Milan, Italy. 21 Gen-
eral Intensive Care, St George’s University Hospitals NHS Foundation Trust,
London, UK. 22 Department of Intensive Care Medicine, University Medical
Center, University Utrecht, Utrecht, The Netherlands.
Acknowledgements
List of collaborators COVIP: Philipp Eller, Allgemeine Medizin Intensivstation,
Medical University Graz, Graz, Austria. Michael Joannidis, Division of Intensive
Care and Emergency Medicine, Department of Internal Medicine, Medical
University Innsbruck, Innsbruck, Austria. Dieter Mesotten, Department of
Intensive Care, Ziekenhuis Oost-Limburg, Genk, Belgium. Pascal Reper,
Department of Intensive Care, CHR Haute Senne, Soignies, Belgium. Sandra
Oeyen, Department of Intensive Care, Ghent University Hospital, Ghent,
Belgium. Walter Swinnen, Department of Intensive Care, AZ Sint-Blasius,
Dendermonde, Belgium. Helene Brix, Intensiv Behandling, Herlev og Gentofte
Hospital, Herlev, Denmark. Jens Brushoej, Intensiv, Slagelse, Slagelse, Denmark.
*Correspondence: bertrand.guidet@aphp.fr
1 UPMC Univ Paris 06, INSERM, UMR_S 1136, Institut Pierre Louis
d’Epidémiologie et de Santé Publique, Equipe: épidémiologie hospitalière
qualité et organisation des soins, Medical Intensive Care, Sorbonne
Universités, 184 rue du Faubourg Saint Antoine, 75012 Paris, France
Full author information is available at the end of the article
The original article can be found online at https:// doi. org/ 10. 1007/
s00134- 022- 06642-z.
Maja Villefrance, Intensiv, Regionshospitalet Horsens, Horsens, Denmark.
Helene Korvenius Nedergaard, Intensive Care Unit, Odense University Hospital,
Odense, Denmark. Anders Thais Bjerregaard, Intensive, Sygehus Lillebælt,
Kolding, Denmark. Ida Riise Balleby, Intensiv, Regionshospitalet Viborg, Viborg,
Denmark. Kasper Andersen, Department of Anaesthesia and Intensive Care,
Sygehus Sønderjylland, Aabenraa, Denmark. Maria Aagaard Hansen, Intensiv
Afdeling, Regionshospitalet Herning, Herning, Denmark. Stine Uhrenholt,
Department of Anaesthesia and Intensive Care, Nordsjællands Hospital,
Hillerød, Denmark. Helle Bundgaard, Intensiv, Regionshospitalet Randers,
Randers, Denmark. Jesper Fjølner, Department of Intensive Care, Aarhus
University Hospital, Aarhus, Denmark. Aliae AR Mohamed Hussein, Medical
ICU and Isolation Centers, Assiut University Hospital, Assiut, Egypt. Rehab
Salah, Cardiology ICU, One day surgery hospital, Nasr city, Egypt. Yasmin Khairy
NasrEldin Mohamed Ali, MICU, Minia University Hospitals, Minia, Egypt. Kyrillos
Wassim, MICU, Quweisna central hospital, Quweisna, Egypt. Yumna A. Elgazzar,
MICU, Mayo Isolation Hospital, Cairo Governorate, Egypt. Samar Tharwat,
Mansoura university Hospital, Temi El amdid, Mansoura, Egypt. Ahmed Y.
Azzam, Alazhar University Hospitals, Cairo, Egypt. Ayman abdelmawgoad
habib, intermediate ccu, one day surgery, nasr city, Egypt. Hazem Maarouf
Abosheaishaa, MICU, Mostafa Mahmoud Specialized Hospital, Giza, Egypt.
Mohammed A Azab, Sherif Mokhtar Cairo University ICU, Kar Al-Ainy Cairo
University Hospital, Cairo, Egypt. Susannah Leaver, General Intensive care, St
George’s University Hospitals NHS Foundation trust, London, England. Arnaud
Galbois, Medico-surgical ICU, Hôpital Privé Claude Galien, Quincy sous Sénart,
France. Tomas Urbina, Medical intensive care unit, Saint Antoine, Paris, France.
Cyril Charron, Medical intensive care unit, Hôpital Ambroise Paré, Boulogne
Billancourt, France. Emmanuel Guerot, Medical intensive care unit, Hopital
Européen Georges Pompidou, Paris, France. Guillaume Besch, Medico-surgical
ICU, CHU de Besançon, Besançon, France. Jean-Philippe Rigaud, Medical
intensive care unit, Dieppe General Hospital, Dieppe, France. Julien Maizel,
Medical intensive care unit, CHU Amiens, Amiens, France. Michel Djibré,
Medico-surgical ICU, Tenon, Paris, France. Philippe Burtin, Surgical ICU, Clinique
Du Millenaire, Montpellier, France. Pierre Garcon, Medico-surgical ICU, Marne
La Vallee, Jossigny, France. Saad Nseir, Medical intensive care unit, CHU Lille,
Lille, France. Xavier Valette, Medical intensive care unit, CHU de Caen, Caen,
France. Nica Alexandru, Medico-surgical ICU, Compiegne Noyon Hospital,
Compiegne, France. Nathalie Marin, Medical intensive care unit, Cochin, Paris,
France. Marie Vaissiere, Medico-surgical ICU, CH Pau, Pau, France. Gaëtan
Plantefeve, Medico-surgical ICU, Victor Dupouy, Argenteuil, France. Thierry
Vanderlinden, Medical intensive care unit, CH Saint Philibert, Lomme lez Lille,
France. Igor Jurcisin, Medico-surgical ICU, Beaujon, Clichy, France. Bruno
Megarbane, Medical intensive care unit, Lariboisière, Paris, France. Anais
Caillard, Surgical ICU, Lariboisière, Paris, France. Arnaud Valent, Surgical ICU,
Saint-Louis, Paris, France. Marc Garnier, Surgical ICU, Saint Antoine, Paris,
France. Sebastien Besset, Medico-surgical ICU, Louis Mourier, Colombes,
France. Johanna Oziel, Medico-surgical ICU, Avicenne, Bobigny, France.
Jean-Herlé Raphalen, Medico-surgical ICU, Centre hospitalier de Versailles, Le
Chesnay, France. Stéphane Dauger, Pediatric Intensive and Intermediate Care
Unit, Robert Debré, Paris, France. Guillaume Dumas, Medical intensive care
unit, Saint-Louis, Paris, France. Bruno Goncalves, Medico-surgical ICU,
Sainte-Anne, Paris, France. Gaël Piton, Medical ICU, CHU de Besancon,
Besançon, France. Eberhard Barth, Anesthesiologic Intensive Care Department,
University Hospital Ulm, Ulm, Germany and IOI-Interdisziplinäre Operative
Intensivmedizin, University Hospital Ulm, Ulm, Germany. Ulrich Goebel, Klinik
für Anästhesie und operative Intensivmedizin, St. Franziskus-Hospital Münster,
Münster, Germany. Anselm Kunstein, MX01, Uniklinik Düsseldorf, Düsseldorf,
Germany. Michael Schuster, Anästhesie-Intensivstation, Universitätsmedizin
der Johannes Gutenberg-Universität Mainz, Mainz, Germany. Martin Welte,
Interdiszipinaere Operative Intensivstation, Klinik fuer Anaesthesiologie und
operative Intensivmedizin, Klinikum Darmstadt GmbH, Darmstadt, Germany.
Matthias Lutz, Internistische Intensivstation, Uniklinik Schleswig Holstein
Campus Kiel, Kiel, Germany. Patrick Meybohm, Klinik für Anästhesie und
operative Intensivmedizin, University Hospital Würzburg, Würzburg, Germany.
Stephan Steiner, ICU, St Vincenz, Limburg, Germany. Tudor Poerner, ITS,
Marienhospital Aachen, Aachen, Germany. Hendrik Haake, Internistische
Intensivstation I und II, Kliniken Maria Hilf, Mönchengladbach, Germany. Stefan
J. Schaller, Klinik für Anaesthesiologie, Klinikum rechts der Isar, Technische
Universität München, Munich, Germany. Detlef Kindgen-Milles, CIA1,
University Hospital Duesseldorf, Duesseldorf, Germany. Christian Meyer,
Intensivstation, Evangelisches Krankenhaus Düsseldorf, Düsseldorf, Germany.
Muhammed Kurt, 32, Florence-Nightingale Krankenhaus, Duesseldorf,
Germany. Karl Friedrich Kuhn, 144i, Charité—Universitätsmedizin Berlin, Berlin,
Germany. Winfried Randerath, Intensivpflege Bethanien, Krankenhaus
Bethanien GmbH, Solingen, Solingen, Germany. Jakob Wollborn, Anaesthesi-
ologiesche Intensivtherapiestation, Medical Center—University of Freiburg,
Freiburg, Germany. Zouhir Dindane, Interdisziplinäre Intensivstation,
Städtische Kliniken Mönchengladbach, Mönchengladbach, Germany.
Hans-Joachim Kabitz, I01, Klinikum Konstanz, Konstanz, Germany. Ingo Voigt,
Kardiologisch-internistische Intensivstation, Elisabeth-Krankenhaus Essen,
Essen, Germany. Gonxhe Shala, Station 2, Johanna Etienne Krankenhaus,
Neuss, Germany. Andreas Faltlhauser, Interdisziplinäre Intensivmedizin,
Kliniken Nordoberpfalz AG, Klinikum Weiden, Weiden, Germany. Nikoletta
Rovina, ICU 1st Department of Pulmonary Medicine Athens Medical School,
National and Kapodistrian University of Athens, Sotiria Hospital, Athens,
Greece. Zoi Aidoni, ICU, University General Hospital Ahepa, Thessaloniki,
Greece. Evangelia Chrisanthopoulou, 2nd Department of Critical Care,
University Hospital (ATTIKON), Haidari, Greece. Antonios Papadogoulas, ICU,
General Hospital of Larissa, Larissa, Greece. Mohan Gurjar, Critical Care
Medicine, Sanjay Gandhi Postgraduate Institute of Medical Sciences
(SGPGIMS), Lucknow, India. Ata Mahmoodpoor, General, Imam Reza, Tabriz,
Iran. Abdullah khudhur Ahmed, Baghdad teaching hospital, Baghdad, Iraq.
Brian Marsh, Department of Critical Care Medicine, Mater Misericordiae
University Hospital, Dublin, Ireland. Ahmed Elsaka, Covid ICU, Cork University
Hospital, Cork, Ireland. Sigal Sviri, Corona ICU, Hadassah University Medical
Center, Jerusalem, Israel. Vittoria Comellini, Terapia Intensiva Respiratoria,
Policlinico S. Orsola-Malpighi, Bologna, Italy. Ahmed Rabha, MICU, Askar, Suq
Elkamis, Libya. Hazem Ahmed, MICU, Tripoli University Hospital, Tripoli, Libya.
Silvio A. Namendys-Silva, Department of Critical Care Medicine, Instituto
Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City,
Mexico. Abdelilah Ghannam, Service de Réanimation—Institut National
d´Oncologie, CHU Ibn Sina de Rabat, Rabat, Morocco. Martijn Groenendijk, ICU
Department, Alrijne Zorggroep, Leiderdorp, Netherland. Marieke Zegers,
Intensive Care department Radboudumc, Radboudumc, Nijmegen,
Netherland. Dylan de Lange, ICU departement, UMC Utrecht, Utrecht,
Netherland. Alexander Daniel Cornet, Intensive Care Center, Medisch
Spectrum Twente, Enschede, Netherland. Mirjam Evers, ICU Department,
Canisius Wilhelmlina Ziekenhuis, Nijmegen, Netherland. Lenneke Haas,
Intensive care, Diakonessenhuis Utrecht, Utrecht, Netherland. Tom Dormans,
Zuyderland Heerlen, Zuyderland Medical Center, Heerlen, Netherland. Willem
Dieperink, Department of Critical Care, University Medical Center Groningen,
Groningen, Netherland. Luis Romundstad, Department of Critical Care and
Emergencies, Oslo University Hospital, Rikshospitalet Medical, Oslo, Norway.
Britt Sjøbø, General ICU, Haukeland University Hospital, Bergen, Norway. Finn
H. Andersen, Dept. Anesthesia and Intensive Care, Surgical ICU, Ålesund
Hospital, Ålesund, Norway. Hans Frank Strietzel, ICU, Kristiansund Hospital
Helse Møre og Romsdal HF, Kristiansund N, Norway. Theresa Olasveengen,
Surgical ICU, Oslo University Hospital, Oslo, Norway. Michael Hahn, ICU,
Haugesund Hospital, Haugesund, Norway. Miroslaw Czuczwar, II Department
of Anesthesiology and Intensive Care, First Independent Teaching Hospital No.
1, Lublin, Poland. Ryszard Gawda, Department of Anesthesiology and Intensive
Care, Opole University Hospital, Opole, Poland. Jakub Klimkiewicz, COVID-19
ICU, Military Institute of Medicine, Warsaw, Poland. Maria de Lurdes Campos
Santos, Infectious Diseases ICU, Centro Hospitalar e Universitário São João,
Porto, Portugal. André Gordinho, Serviço de Medicina Intensiva, Hospital de
Beatriz Ângelo, Loures, Portugal. Henrique Santos, D, Centro Hospitalar Tráz os
Montes e Alto Dour, Vila Real, Portugal. Rui Assis, Serviço de Medicina
Intensiva, Centro Hospitalar do Médio Tejo, Abrantes, Portugal. Ana Isabel
Pinho Oliveira, Unidade de Cuidados Intensivos Polivalente, Centro Hospitalar
de Tondela-Viseu, EPE, Viseu, Portugal. Mohamed Raafat Badawy, MICU,
Fundeni Clinical Institute, Jeddah, Saudi Arabia. David Perez-Torres, UVI
Polivalente y Coronaria, Hospital Universitario Río Hortega, Valladolid, Spain.
Gemma Gomà, Intensive Care Department, Corporacion Sanitaria Universitaria
Parc Tauli, Sabadell, Spain. Mercedes Ibarz Villamayor, Intensive Care Unit,
Hospital Universitario Sagrado Corazon, Barcelona, Spain. Angela Prado Mira,
Intensive Care Unit, Hospital General Universitario de Albacete, Albacete,
Spain. Patricia Jimeno Cubero, ICU Segovia, Complejo Hospitalario de Segovia,
Segovia, Spain. Susana Arias Rivera, Intensive Care and Burn Unit, Universitario
de Getafe, Getafe, Spain. Teresa Tomasa, General ICU, Germans Trias i Pujol
Hospital, Badalona, Spain. David Iglesias, UCI Burgos, Hospital Universitario de
Burgos, Burgos, Spain. Eric Mayor Vázquez, Unidad de Cuidados Intensivos,
Hospital de Tortosa Verge de la Cinta, Tortosa, Spain. Cesar Aldecoa,
Reanimación Quirurgica, Hospital Universitario Rio Hortega, Valladolid, Spain.
Aida Fernández Ferreira, Servicio de Medicina Intensiva CHUVI, Hospital Alvaro
Cunqueiro, Vigo, Spain. Begoña Zalba-Etayo, Unidad de Cuidados Intensivos,
Clínico Universitario Lozano-Blesa, Zaragoza, Spain. Isabel Canas-Perez,
Servicio de Medicina Intensiva - Unidad 2, Hospital Universitario Río Hortega,
Valladolid, Spain. Luis Tamayo-Lomas, Servicio de Medicina Intensiva - Unidad
3, Hospital Universitario Río Hortega, Valladolid, Spain. Cristina Diaz-Rodriguez,
Servicio de Medicina Intensiva - Unidad 4, Hospital Universitario Río Hortega,
Valladolid, Spain. Susana Sancho, General, H. Universitari i Politècnic La Fe,
Valencia, Spain. Jesús Priego, UCI CHUO, Complexo Hospitalario Universitario
Ourense, Ourense, Spain. Enas M. Y. Abualqumboz, Khartoum Bahri Hospital,
Khartoum, Sudan. Momin Majed Yousuf Hilles, Medical Military Hospital,
Khartoum, Sudan. Mahmoud Saleh, Wad Medani teaching Hospital, Wad
Medani, Sudan. Nawfel Ben-HAmouda, Service de Médecine Intensive Adulte
(SMIA), Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland. Andrea
Roberti, Clinica Luganese Moncucco, Lugano, Switzerland. Alexander
Dullenkopf, IPS KSF, Spital Thurgau Frauenfeld, Frauenfeld, Switzerland. Yvan
Fleury, Intensive Care Unit, Fribourg Hospital, Fribourg, Switzerland. Bernardo
Bollen Pinto, Intensive Care Unit (Service des Soins Intensifs), Geneva
University Hospitals, Geneva, Switzerland. Joerg C. Schefold, Dept of Intensive
Care Medicine, Inselspital Bern, Bern, Switzerland. Mohammed Al-Sadawi, ICU,
SUNY Downstate, Brooklyn, USA.
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... Therefore, it can be speculated that the limited use of mechanical ventilation in this patient group was primarily in response to patient wishes rather than based on a physician triage system. In fact, a recent study of elderly (≥80 years) ICU patients reported more frequent withholding or withdrawal of life-sustaining measures in COVID-19 patients compared to non-COVID-19 patients [18]. The same study also found an increased 30-day mortality in COVID-19 patients compared to non-COVID-19 patients. ...
... The same study also found an increased 30-day mortality in COVID-19 patients compared to non-COVID-19 patients. However, it remains unclear whether this finding reflects a more active policy of withholding treatment or an inherent increased mortality risk due to COVID-19 [18]. Overall, these findings highlight the need for comprehensive research on LLST. ...
Article
Full-text available
During the COVID-19 pandemic, large numbers of elderly, multimorbid people required treatment in intensive care units. This study investigated how the inherent patient factors age and comorbidity burden affected the treatment strategy and the outcome achieved. Retrospective analysis of data from intensive care patients enrolled in the Lean European Open Survey on SARS-CoV2-Infected Patients (LEOSS) cohort found that a patient's age and comorbidity burden in fact influenced their mortality rate and the use of ventilation therapy. Evidence showed that advanced age and multimorbidity were associated with the restrictive use of invasive ventilation therapies, particularly ECMO. Geriatric patients with a high comorbidity burden were clustered in the sub-cohort of non-ventilated ICU patients characterized by a high mortality rate. The risk of death generally increased with older age and accumulating comorbidity burden. Here, the more aggressive an applied procedure, the younger the age in which a majority of patients died. Clearly, geriatric, multimorbid COVID-19 patients benefit less from invasive ventilation therapies. This implies the need for a holistic approach to therapy decisions, taking into account the patient's wishes.
... Therefore, it can be speculated that the limited use of mechanical ventilation in this patient group was primarily in response to patient wishes rather than based on a physician triage system. In fact, a recent study of elderly (≥80 years) ICU patients reported more frequent withholding or withdrawal of life-sustaining measures in COVID-19 patients compared to non-COVID-19 patients [18]. The same study also found an increased 30-day mortality in COVID-19 patients compared to non-COVID-19 patients. ...
... The same study also found an increased 30-day mortality in COVID-19 patients compared to non-COVID-19 patients. However, it remains unclear whether this finding reflects a more active policy of withholding treatment or an inherent increased mortality risk due to COVID-19 [18]. Overall, these findings highlight the need for comprehensive research on LLST. ...
Article
Full-text available
During the COVID-19 pandemic, large numbers of elderly, multimorbid people required treatment in intensive care units. This study investigated how the inherent patient factors age and comorbidity burden affected the treatment strategy and the outcome achieved. Retrospective analysis of data from intensive care patients enrolled in the Lean European Open Survey on SARS-CoV2-Infected Patients (LEOSS) cohort found that a patient’s age and comorbidity burden in fact influenced their mortality rate and the use of ventilation therapy. Evidence showed that advanced age and multimorbidity were associated with the restrictive use of invasive ventilation therapies, particularly ECMO. Geriatric patients with a high comorbidity burden were clustered in the sub-cohort of non-ventilated ICU patients characterized by a high mortality rate. The risk of death generally increased with older age and accumulating comorbidity burden. Here, the more aggressive an applied procedure, the younger the age in which a majority of patients died. Clearly, geriatric, multimorbid COVID-19 patients benefit less from invasive ventilation therapies. This implies the need for a holistic approach to therapy decisions, taking into account the patient’s wishes.
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