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Intrinsic Severity of SARS-CoV-2 Omicron BA.2 in Uninfected, Unvaccinated Children: A Population-Based, Case-Control Study on Hospital Complications

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... 8 In addition, during the last COVID-19 wave, the rate of COVID-19-associated hospitalisations in children in the United States, South Africa and Hong Kong is notably higher in comparison to hospitalisations occurring in the Delta period. [9][10][11][12] Following publication of phase 2 and 3 studies demonstrating the safety and efficacy of the different vaccines, the Emergency Use Authorization (EUA) for the 3-17 age groups was approved by different international health organisations. [13][14][15][16][17] Argentina started vaccination rollout in the adolescent subpopulation in August 2021 with mRNA-1273 (Spikevax) from Moderna and BNT162b2 (Comirnaty) from Pfizer-BioNTech. ...
... 28 However, more severe clinical presentations in the paediatric population have been reported due to Omicron BA.1 and BA.2 sub-lineages. [10][11][12] Two recent studies from South Africa and Hong Kong performed during the Omicron wave recorded more severe disease in children, including laryngeal obstruction and neurological symptoms, with increased requirement of ICU admission. 10,11 Further research is needed to assess the need for a booster dose in 3-11- ...
... [10][11][12] Two recent studies from South Africa and Hong Kong performed during the Omicron wave recorded more severe disease in children, including laryngeal obstruction and neurological symptoms, with increased requirement of ICU admission. 10,11 Further research is needed to assess the need for a booster dose in 3-11- ...
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