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"Curcumin" for Body's Immunity



Curcumin" is a traditional Chinese medicine used in China for a long time ago. It possesses a series of biological properties including antioxidant, anti-inflammatory, antiviral, antimicrobial, and antitumor functions to enhance the body's immunity. This article describes the background, research progress of curcumin and its usages such as health supplements or tea daily life.
International Journal on Infectious Disease and Epidemiology
Volume 3 Issue 2- 2022
Author Details
Siukan Law1*, Dawn Chingtung Au1, Albert Wingnang Leung2, Chuanshan Xu3
1Faculty of Science and Technology, The Technological and Higher Education Institute of Hong Kong, Tsing Yi, New Territories, Hong
2School of Nursing, Tung Wah College, 31 Wylie Road, Ho Man Tin, Kowloon, Hong Kong
3Key Laboratory of Molecular Target and Clinical Pharmacology, State Key Laboratory of Respiratory Disease, School of Pharmaceutical
Sciences & Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou 511436, China
*Corresponding author
Siukan Law, Faculty of Science and Technology, e Technological and Higher Education Institute of Hong Kong, Tsing Yi, New
Territories, Hong Kong
Article History
Received: February 25, 2022 Accepted: February 25, 2022 Published: March 03, 2022
“Curcumin” for Body’s Immunity
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“Curcumin” is a traditional Chinese medicine used in China for a long time ago. It possesses a series of biological properties including
Turmeric is a natural herbal and used as a spice in a wide variety
of food. e active ingredient is called “Curcumin”, derived from
a Curcuma longa plant belonging to the Zingiberaceae family. It is
a short-stemmed perennial and grows about 100 cm in height with
curved leaves, oblong, ovate, and cylindrical rhizomes [1]. According
to traditional Chinese medicine (TCM) theory, the nature of curcumin
is warm; bitter, and pungent in taste. is classies as an “invigorating
the blood” category [2], which stimulates blood ow, circulation, and
relieves pain [3].
Research Progress
Growing evidence has shown that curcumin possesses a wide range of
biological activities, such as antioxidant, anti-inammatory, antiviral,
antimicrobial, and antitumor properties (Table 1).
Health Supplement
Apart from the treatment or ight against some diseases of curcumin,
it is also used as a health supplement in daily life to enhance the body’s
immunity. Peterson CT et al. reported the eects of turmeric and
curcumin dietary supplementation on human gut microbiota. e
results have shown that 1000 mg turmeric-treated subjects displayed
the modest 7% which increased as following species: Clostridium spp.,
Bacteroides spp., Citrobacter spp., Cronobacter spp., Enterobacter
spp., Enterococcus spp., Klebsiella spp., Parabacteroides spp., and
Pseudomonas spp., while 1000 mg curcumin displayed an average
increase of 69% to combat these species [9].
Turmeric tea is one of the popular drinks nowadays since curcumin
has low bioavailability, which is brewed using grated turmeric root or
pure powder to have higher concentrations of biologically available
and promote its absorptivity within the body. ere are some simple
steps for the preparation of turmeric tea:
(i) Take around 400 mL (4 cups) of water and boil it;
(ii) Add 1 g (1 to 2 teaspoons) of turmeric to the boiling water;
(iii) Stir the mixture for 5 to 10 mins continuously until the turmeric
completely dissolve;
(iv) Transfer to tea container and allow it to cool at room temperature.
Based on the JECFA (e Joint United Nations and World Health
Organization Expert Committee on Food Additives) and EFSA
(European Food Safety Authority) reports, the Allowable Daily Intake
(ADI) value of curcumin is 0-3 mg/kg body weight. It is around 1 to 3
grams daily intake for adults [10].
51“Curcumin” for Body’s Immunity
Citation: Int. Jr. Infect Dis & Epidemlgy
Table 1: Biological activities of curcumin for some diseases.
Jakubczyk K et al. [4] Peng Y et al. [5] Jennings MR et al. [6] Adamczak A et al. [7] Walker BC et al. [8]
Objective Antioxidant Potential of
Eects of Curcumin in the
Inammatory Diseases
Curcumin as an
Antiviral Agent
Curcumin, a Natural
Antimicrobial Agent with
Strain-Specic Activity
Antitumor Activity
of Curcumin in
function Antioxidant Anti-inammatory Antiviral Antimicrobial Antitumor
Curcumin signicantly
increase total antioxidant
capacity (TAC) and
tendency to decrease
malondialdehyde (MDA)
Curcumin regulates NF-
κB, MAPK, AP-1, JAK/
STAT, and other signaling
pathways, and inhibits the
production of inammatory
Curcumin inhibits
the replication of a
diverse group of viruses
through numerous
mechanisms such as
NF-κB signaling
Curcumin is eective
against some species with
the minimum inhibitory
concentration (MIC) such
asStreptococcus pyogenes,
lwoi, and individual
strains ofEnterococcus
Curcumin induces
multiple cytotoxic
eects in tumor cells
including cell cycle
arrest, apoptosis,
autophagy, changes
in gene expression,
and disruption of
molecular signaling
Curcumin reduces
MDA concentration
and increases total
antioxidant capacity
Curcumin reduces the
inammatory response,
improve symptoms, and
treatment of diseases
e consumption of
curcumin in high doses
in humans appears to
be safe, in v itro CC50
concentrations are tens
of micromolar
Curcumin is considered
acting an antibacterial agent
with high selectivity.
potentiates the
eect of radiation
on cancer cells and
exhibits a protective
eect on normal
Alzheimer’s and
Parkinson's disease,
atherosclerosis, obesity,
or simply aging
Inammatory bowel
disease, arthritis,
psoriasis, depression, and
virus, zika virus, dengue
virus, chikungunya
virus, vesicular
stomatitis virus,
inuenza A virus, etc
Staphylococcus aureus, S.
haemolyticus, Escherichia
coli, and Proteus mirabilis
malignant gliomas
e above information demonstrates that curcumin can enhance the
body’s immunity through its antioxidant, anti-inammatory, antiviral,
antimicrobial, and antitumor properties with the usage as a health
supplement or tea. However, much more works need to be done for
the future development of curcumin.
1. Prasad S, Aggarwal BB (2011) Turmeric, the Golden Spice: From
Traditional Medicine to Modern Medicine.
2. Law S, Lo C, Han J, Leung AW, Xu C (2020) A perspective of traditional
Chinese medicine, curcumin, for the treatment of COVID-19. Aust J
Herb Naturop 32(4): 165-166.
3. Yang J, Miao X, Yang F, Cao J, Liu X, et al. (2021) erapeutic potential
of curcumin indiabetic retinopathy (Review). Int J Mol Med 47(5): 75.
4. Jakubczyk K, Drużga A, Katarzyna J, Skonieczna-Żydecka K (2020)
Antioxidant Potential of Curcumin-A Meta-Analysis of Randomized
Clinical Trials. Antioxidants (Basel) 9(11): 1092.
5. Peng Y, Ao M, Dong B, Jiang Y, Yu L, et al. (2021) Anti-Inammatory
Eects of Curcumin in the Inammatory Diseases: Status, Limitations
and Countermeasures. Drug Des Devel er 15: 4503-4525.
6. Jennings MR, Parks RJ (2020) Curcumin as an Antiviral Agent. Viruses
12(11): 1242.
7. Adamczak A, Ożarowski M, Karpiński TM (2020) Curcumin, a Natural
Antimicrobial Agent with Strain-Specic Activity. Pharmaceuticals
(Basel) 13(7): 153.
8. Walker BC, Mittal S (2020) Antitumor Activity of Curcumin in
Glioblastoma. Int J Mol Sci 21(24): 9435.
9. Peterson CT, Vaughn AR, Sharma V, Chopra D, Mills PJ, et al. (2018)
Eects of Turmeric and Curcumin Dietary Supplementation on Human
Gut Microbiota: A Double-Blind, Randomized, Placebo-Controlled
Pilot Study. J Evid Based Integr Med 23: 2515690X18790725.
10. Kocaadam B, Sanlier N (2017) Curcumin, an active component of
turmeric (Curcuma longa), and its eects on health.Crit Rev Food Sci
Nutr 57: 2889-2895.
... Curcumin, an essential active ingredient in traditional Chinese turmeric (Curcuma longa), possessed multiple pharmacological effects including antioxidant, antiinflammatory, antiviral, antimicrobial, and antitumor functions (Koboziev et al., 2020;Law et al., 2022;Nurcahyanti et al., 2022). The physiological and pharmacological properties depend on the curcumin metabolites, e.g., Dihydrocurcumin (DHC), Tetrahydrocurcumin (THC), Hexahydrocurcumin (HDC), and Octahydrocurcumin (OHC). ...
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... Describe the usage and biological effect because of curcumin with many pharmacological actions including antibacterial, antiviral, anti-oxidation, and anti-inflammatory properties [2] . This laboratory section is suitable either for secondary or tertiary students as curcumin is easily extracted by soxhlet extraction, microwave-assisted extraction, and supercritical fluid [3] , but it is preferable to do a soxhlet extraction since the steps are not complicated and use water or ethanol as distillation solvents. ...
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Background: Curcuma longa (common name: turmeric) and one of its biologically active constituents, curcumin, have received increased clinical attention. Insufficient data exist on the effects of curcumin and turmeric on the gut microbiota and such studies in humans are lacking. Methods: Turmeric tablets with extract of piperine (Bioperine) (n = 6), curcumin with Bioperine tablets (n = 5), or placebo tablets (n = 3) were provided to healthy human subjects and subsequent changes in the gut microbiota were determined by 16S rDNA sequencing. Results: The number of taxa detected ranged from 172 to 325 bacterial species. The placebo group displayed an overall reduction in species by 15%, whereas turmeric-treated subjects displayed a modest 7% increase in observed species posttreatment. Subjects taking curcumin displayed an average increase of 69% in detected species. The gut microbiota response to treatment was highly personalized, thus leading to responders and nonresponders displaying response concordance. These "responsive" subjects defined a signature involving uniform increases in most Clostridium spp., Bacteroides spp., Citrobacter spp., Cronobacter spp., Enterobacter spp., Enterococcus spp., Klebsiella spp., Parabacteroides spp., and Pseudomonas spp. Common to these subjects was the reduced relative abundance of several Blautia spp. and most Ruminococcus spp. Conclusions: All participants' microbiota displayed significant variation over time and individualized response to treatment. Among the responsive participants, both turmeric and curcumin altered the gut microbiota in a highly similar manner, suggesting that curcumin may drive the majority of observed changes observed in turmeric-treated subjects.
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Turmeric (Curcuma Longa) is a type of herb belonging to ginger family, which is widely grown in southern and south western tropical Asia region. Turmeric, which has an importance place in the cuisines of Iran, Malesia, India, China, Polynesia and Thailand, is often used as spice and has an effect on the nature, color and taste of foods. Turmeric is also known to have been used for centuries in India and China for the medical treatments of such illnesses as dermatologic diseases, infection, stress and depression. Turmeric's effects on health generally are centered upon an orange-yellow colored, lipophilic polyphenol substance called 'curcumin', which is acquired from the rhizomes of the herb. Curcumin is known recently to have antioxidant, anti-inflammatory, anti-cancer effects and, thanks to these effects, to have an important role in prevention and treatment of various illnesses ranging notably from cancer to autoimmune, neurological, cardiovascular diseases and diabetic. Furthermore, it is aimed to increase the biological activity and physiological effects of the curcumin on the body by synthesizing curcumin analogues. This paper reviews the history, chemical and physical features, analogues, metabolites, mechanisms of its physiological activities and effects on health of curcumin.
Curcuma longa (curcumin) is a traditional Chinese herbal medicine that has been used in many traditional medicine systems for a long time because of its wide range of pharmacological properties and applications. Based on the traditional Chinese medicine theory, curcumin belongs to the 'invigorate blood' category and COVID-19 belongs to the 'epidemic' category. Curcumin is one of the possible candidates that could be used in the treatment of COVID-19 as it possesses anti-inflammatory and antiviral properties according to previous studies. The Chinese medicine formulation that includes curcumin, 'Qingfei Touxie Fuzheng decoction', was developed with this in mind. In this article, the mechanisms of C. longa L for COVID-19 will be discussed.
Turmeric is a plant that has a very long history of medicinal use, dating back nearly 4000 years. In Southeast Asia, turmeric is used not only as a principal spice but also as a component in religious ceremonies. Because of its brilliant yellow color, turmeric is also known as “Indian saffron.” Modern medicine has begun to recognize its importance, as indicated by the over 3000 publications dealing with turmeric that came out within the last 25 years. This review first discusses in vitro studies with turmeric, followed by animal studies, and finally studies carried out on humans; the safety and efficacy of turmeric are further addressed.
  • A Adamczak
  • M Ożarowski
  • T M Karpiński
Adamczak A, Ożarowski M, Karpiński TM (2020) Curcumin, a Natural Antimicrobial Agent with Strain-Specific Activity. Pharmaceuticals (Basel) 13(7): 153.