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Aloe Vera Gel Effect on Skin and Pharmacological Properties
Abstract
Aloe Vera, a cactus-like plant belongs to Asphodelaceae (Liliaceae) family has been used for traditional medical purposes for thousands of years. Aloe Vera derives its name from the Arabic word “Alloeh” which means “shining bitter substance” because of the bitter liquid found in the leaves and Vera which means “true” in Latin. There are over 300 species of aloe, most of which are native to South Africa, Madagascar and Arabia. Aloe leaves can be separated into two basic products: the latex, a bitter yellow liquid beneath the epidermis of the leaf and the gel, a colorless and tasteless substance in the inner part of the leaf. Both of them have many biologically active components, mainly anthraquinones and polysaccharides (the most active is acemannan), which may act alone or in synergy. Application of Aloe vera gel is cosmetic-moisturizers, toothpastes and flavoring compounds or preservative of fresh products and in medicine of humans or animals. Aloe vera gel is an active ingredient in hundreds of skin lotions, sun blocks and cosmetics. Aloe vera seems to treat of wounds, burns, insect stings, and skin inflammation, anti-inflammatory, antiseptic and antimicrobial, anti-tumor, anti- skin protection, anti-diabetic, anti-bacterial, anti-viral, and which are very important for wound healing. Aloe Vera gel helps in activating new hair growth as it increases blood circulation to the scalp. It also provides essential minerals and vitamins.
... Antibiotics, growth hormones, and anti-inflammatory medicines are just a few of the therapeutic medications that can be put inside them to give targeted delivery to the wound site and continuous release. This may aid in tissue regeneration, lessen discomfort and inflammation, and guard against infection [33]. ...
... In these cases, an incision is made on the posterior vaginal wall, perineal muscles, and skin to increase the vagina's diameter, which helps the fetus exit the birth canal more easily, particularly in primiparous women [49]. Aloe vera gel was used in research Nazari (2019) to relieve perineal pain and aid in the healing of wounds following episiotomy in Iranian primiparous women [33]. ...
... Aloe vera can shorten the time it takes for wounds to heal because its organic components, which include amino acids and polysaccharides, work as antibacterial inhibitors, keep the wound area moist, and reduce discomfort. Aloe vera can be applied topically as an ointment, lotion, or gel for wounds [33]. The first step in applying aloe vera to wounds is to clean the area with saline solution or running water, then allow it to dry. ...
Objective: The purpose of this study is to review a number of research papers about postpartum perineal wound care technologies. Methods: The systematic review for this investigation was carried out using PRISMA, or Preferred Reporting Items for Systematic Reviews and Meta-analyses. Electronic databases are used in this study to find pertinent papers. An electronic database search (PubMed and Connected Papers). The papers that are sought after were published between 2019 and 2023, or the last five years. Results: It has been demonstrated that Negative Pressure Wound Dressing (NPWT) works to speed up wound healing, lower complications, and improve the outcome of skin grafts. Foam dressings with rims efficiently reduce discomfort from wounds and enhance their ability to recover. NPWT can hold the skin securely, minimizing shear pressures and limiting the development of subcutaneous hematomas. It can also be used to prepare the wound bed for flap closure grafting. Perineal skin graft wounds can also be managed using NPWT, but this is more difficult because of the possibility of infection and the requirement for a tight seal. Conclusion: By taking into account the evidence level of the study methodology, the intervention strategies for lowering pain, healing perineal lesions, and boosting comfort.
... Aloe barbadense is Mill is fleshy (succulent xeropytes) cactus plant which used to be placed in family Liliaceae (Saleem et al., 2022) but recently it was classified as a member of Aloaceae (Maan et al., 2018). It has 400 species and cultivated in dry and warm countries like Asian countries including Indian, China and Japan (Baruah et al., 2016;Lee et al., 2021). ...
... Aloe vera gel is commonly used as an important constituent in several cosmetics and skin care products. It is recognized for its various biological properties such as antifungal (Sarker and Grift, 2021), antibacterial (Riaz et al., 2021;Ahmad et al., 2018), antiviral (Subasree et al., 2016), antioxidant (Mondal et al., 2021), anti-diabetic (Arora et al., 2019) ant-inflammatory activity (Heng, 2018), anti-ulcer (Sánchez-Machado et al., 2017Shakib et al., 2019), anticancer (Hussain et al., 2015), wound healing (Komatsu, 2017;Saleem, 2022) and skin diseases (Svitina et al., 2019;Lee et al., 2021;Mikołajczak, 2018). Several anti-biotic and anti-fungal substances (polysaccharides, anthraquinone) are present in Aloe vera gel, which can stop the growth of microorganisms. ...
... Itsgel speeds up the healing process and also reduces pain. It also has anti-inflammatory properties that could be useful in the treatment of H. Pylori infection (Saleem et al., 2022). Sterols are useful inflammatory components which are found in Aloe vera gel. ...
Aloe vera, a succulent perennial and drought resisting plant, is well known for its therapeutic potential. Different beneficial effects of Aloe vera have been reported such as anticancer, wound and burn healing, hypoglycemic, gastro-protective, antifungal, and anti-inflammatory properties. These beneficial therapeutic properties of Aloe vera have been employed for a number of commercial applications. Its gel has been used in variety of commercial products including skin care, cosmetics and medicinal. Aloe vera is being used as an edible coating for fruits or vegetables, which could be a good and safe option to postharvest chemical treatments. The current review focus on the therapeutics properties and various application of Aloe vera. Chemical characterization of Aloe vera is in progress through scientific developments in the area of analytical chemistry. It is expected that further information will be available at a faster rate in the near future, resulting in enhanced applications.
... The flowers are produced on a spike up to 90 cm tall, each flower pendulous, with a yellow tubular corolla 2-3 cm long ( Figure 1). The tissue in the center of the aloe leaf contains a gel that yields aloe gel or Aloe vera gel [13,14]. Aloe vera is classified: as Kingdom: Plantae, Order: Asparagales, Family: Liliaceae, Genus: Genus: Aloe Species: Aloe barbadensis [15]. ...
... Aloe vera is classified: as Kingdom: Plantae, Order: Asparagales, Family: Liliaceae, Genus: Genus: Aloe Species: Aloe barbadensis [15]. [14]. ...
... The peptidase bradykinase was isolated from aloe and shown to break down the bradykinin, an inflammatory substance that induces pain. A novel antiinflammatory compound, C-glucosyl chromone, was isolated from gel extracts [14,16]. ...
Aloe vera is a well-known medicinal plant belonging to the Liliaceae family. The plant has been used for medicinal purposes by different countries and in several cultures. There is a broad list of the therapeutic claims of different parts of Aloe vera due to its pharmacological activities which are employed in traditional management of diverse veterinary and human diseases. The plant leaves contain numerous minerals, enzymes, amino acids, natural sugars, and other bioactive compounds with emollient, purgative, antimicrobial, anti-inflammatory, antioxidant, aphrodisiac, anti-helminthic, antifungal, antiseptic, and cosmetic values for health care. Aloe vera may also be used in food supplements, is a flavoring agent in food products, and helps to balance metabolism.
... Bioactive compounds in aloe vera gel include carbohydrates (monosaccharides like mannose-6-phosphate, polysaccharides like glucomannans, and glycoproteins like alprogen), fatty acids (lupeol and campesterol), minerals (zinc, copper, selenium, and calcium), various vitamins (A, C, E, B 12 ), enzymes (amylase, catalase, and peroxidase), plant hormones (auxins and gibberellins), anthraquinones (aloin and emodin), and miscellaneous compounds like salicylic acid, lignin, and saponins. [21,22] The dermatological uses of aloe vera gel along with the proposed mechanism are summarized in Table 2. [22][23][24][25][26][27] ...
... Bioactive compounds in aloe vera gel include carbohydrates (monosaccharides like mannose-6-phosphate, polysaccharides like glucomannans, and glycoproteins like alprogen), fatty acids (lupeol and campesterol), minerals (zinc, copper, selenium, and calcium), various vitamins (A, C, E, B 12 ), enzymes (amylase, catalase, and peroxidase), plant hormones (auxins and gibberellins), anthraquinones (aloin and emodin), and miscellaneous compounds like salicylic acid, lignin, and saponins. [21,22] The dermatological uses of aloe vera gel along with the proposed mechanism are summarized in Table 2. [22][23][24][25][26][27] ...
... Photoaging [24] The antioxidant protein, metallothionein, scavenges hydroxyl radicals, making superoxide dismutase and glutathione peroxidase available, reducing the production of keratinocyte-derived anti-inflammatory cytokines and leading to UV-induced suppression of delayed-type hypersensitivity. Antimicrobial (antibacterial, antifungal, and antiviral) effects [22,24] Anthraquinones in it are bacteriostatic against S. aureus and Streptococcus pyogenes. It also inhibits the growth of Candida albicans and is virucidal against the herpes virus. ...
This article describes evidence-based usage of common household items to treat dermatological diseases. We have compiled the rationale of their usage from various studies and practical ways to use items like household vinegar, bleach, and common salt, in diseases such as pseudomonas nail infections, other bacterial and fungal infections, pyogenic granuloma, etc.
... The flowers are produced on a spike up to 90 cm tall, each flower pendulous, with a yellow tubular corolla 2-3 cm long ( Figure 1). The tissue in the center of the aloe leaf contains a gel that yields aloe gel or Aloe vera gel [13,14]. Aloe vera is classified: as Kingdom: Plantae, Order: Asparagales, Family: Liliaceae, Genus: Genus: Aloe Species: Aloe barbadensis [15]. ...
... Aloe vera is classified: as Kingdom: Plantae, Order: Asparagales, Family: Liliaceae, Genus: Genus: Aloe Species: Aloe barbadensis [15]. [14]. ...
... The peptidase bradykinase was isolated from aloe and shown to break down the bradykinin, an inflammatory substance that induces pain. A novel antiinflammatory compound, C-glucosyl chromone, was isolated from gel extracts [14,16]. ...
Aloe vera is a well-known medicinal plant belonging to the Liliaceae family. The plant has been used for medicinal purposes
by different countries and in several cultures. There is a broad list of the therapeutic claims of different parts of Aloe vera due
to its pharmacological activities which are employed in traditional management of diverse veterinary and human diseases.
The plant leaves contain numerous minerals, enzymes, amino acids, natural sugars, and other bioactive compounds with
emollient, purgative, antimicrobial, anti-inflammatory, antioxidant, aphrodisiac, anti-helminthic, antifungal, antiseptic, and
cosmetic values for health care. Aloe vera may also be used in food supplements, is a flavoring agent in food products, and
helps to balance metabolism.
Keywords: Aloe vera; Aloe vera juice; Aloe vera gel; Medicinal values; Chemical Constituents
... Aloe barbadense is Mill is fleshy (succulent xeropytes) cactus plant which used to be placed in family Liliaceae (Saleem et al., 2022) but recently it was classified as a member of Aloaceae (Maan et al., 2018). It has 400 species and cultivated in dry and warm countries like Asian countries including Indian, China and Japan (Baruah et al., 2016;Lee et al., 2021). ...
... Aloe vera gel is commonly used as an important constituent in several cosmetics and skin care products. It is recognized for its various biological properties such as antifungal (Sarker and Grift, 2021), antibacterial (Riaz et al., 2021;Ahmad et al., 2018), antiviral (Subasree et al., 2016), antioxidant (Mondal et al., 2021), anti-diabetic (Arora et al., 2019) ant-inflammatory activity (Heng, 2018), anti-ulcer (Sánchez-Machado et al., 2017Shakib et al., 2019), anticancer (Hussain et al., 2015), wound healing (Komatsu, 2017;Saleem, 2022) and skin diseases (Svitina et al., 2019;Lee et al., 2021;Mikołajczak, 2018). Several anti-biotic and anti-fungal substances (polysaccharides, anthraquinone) are present in Aloe vera gel, which can stop the growth of microorganisms. ...
... Itsgel speeds up the healing process and also reduces pain. It also has anti-inflammatory properties that could be useful in the treatment of H. Pylori infection (Saleem et al., 2022). Sterols are useful inflammatory components which are found in Aloe vera gel. ...
... Aloe barbadense is Mill is fleshy (succulent xeropytes) cactus plant which used to be placed in family Liliaceae (Saleem et al., 2022) but recently it was classified as a member of Aloaceae (Maan et al., 2018). It has 400 species and cultivated in dry and warm countries like Asian countries including Indian, China and Japan (Baruah et al., 2016;Lee et al., 2021). ...
... Aloe vera gel is commonly used as an important constituent in several cosmetics and skin care products. It is recognized for its various biological properties such as antifungal (Sarker and Grift, 2021), antibacterial (Riaz et al., 2021;Ahmad et al., 2018), antiviral (Subasree et al., 2016), antioxidant (Mondal et al., 2021), anti-diabetic (Arora et al., 2019) ant-inflammatory activity (Heng, 2018), anti-ulcer (Sánchez-Machado et al., 2017Shakib et al., 2019), anticancer (Hussain et al., 2015), wound healing (Komatsu, 2017;Saleem, 2022) and skin diseases (Svitina et al., 2019;Lee et al., 2021;Mikołajczak, 2018). Several anti-biotic and anti-fungal substances (polysaccharides, anthraquinone) are present in Aloe vera gel, which can stop the growth of microorganisms. ...
... Itsgel speeds up the healing process and also reduces pain. It also has anti-inflammatory properties that could be useful in the treatment of H. Pylori infection (Saleem et al., 2022). Sterols are useful inflammatory components which are found in Aloe vera gel. ...
Aloe vera, a succulent perennial and drought resisting plant, is well known for its therapeutic potential. Different beneficial effects of Aloe vera have been reported such as anticancer, wound and burn healing, hypoglycemic, gastro-protective, antifungal, and anti-inflammatory properties. These beneficial therapeutic properties of Aloe vera have been employed for a number of commercial applications. Its gel has been used in variety of commercial products including skin care, cosmetics and medicinal. Aloe vera is being used as an edible coating for fruits or vegetables, which could be a good and safe option to postharvest chemical treatments. The current review focus on the therapeutics properties and various application of Aloe vera. Chemical characterization of Aloe vera is in progress through scientific developments in the area of analytical chemistry. It is expected that further information will be available at a faster rate in the near future, resulting in enhanced applications.
... The absorbance was detected using a Synergy HT microplate reader (BioTek, USA) to determine the antipsoriatic potential at 550 nm after the addition of 200 μL of 10 mM Tris buffer. Every sample was analyzed in triplicate, and the results were expressed as a percentage against fluorouracil [15]. ...
... HaCaT cells treated with 10 µg/mL and 5 µg/mL showed the lowest inhibition values (64.15% and 62.79%, respectively). The current study concluded that Aloe vera gel extracts have antipsoriatic and therapeutic uses [15]. ...
Aloe vera gel is popular as a beauty product, laxative, and herbal medicine, including antipsoriatic and therapeutic properties with antimicrobial activities. Aloe vera gel has been detected for the antipsoriatic potentials, some physical parameters, phytochemical, and biological activities against multiple microbial pathogens. HaCaT cells treated with 100 µg/ml demonstrated the most inhibition 71.55 % followed by 50 µg/ml treatment which reported 69.05 % against the psoriatic cells. Color index was recorded (33.52, 7.88, and 35.78) for L*, a*, and b*, respectively. The results indicated that only mannose and glucose were the main sugar components (85.98 % and 13.55 %). Results showed that the most abundant flavonoid was kaempefrol (6770 mg/kg) followed by myricetin (12.10 mg/kg) and quercetin (4.22 mg/kg). Aloe vera gel extract at a concentration of 500 µg/mL showed the maximum scavenging ability 90.83 %, followed by 84.19 % and 84.01 % for the other concentrations 20 µg/mL and 1000 µg/mL, respectively, Using Aleo vera gel detected higher values than the commercial inulin oligofructan which recorded (2.44, 2.58, and 2.99 fold increase) and (0.88, 0.78, and 0.77 fold increase) for L. plantarum, L. fermentum, and L. casei, respectively. The Aloe vera gel at the concentration of 100 μg/ml reported a 20.25 mm diameter zone of inhibition against Escherichia coli, followed by 22.47 and 23.58 mm zone of inhibition against Salmonella typhi and Staphylococcus aureus. More researches are needed to fully understand the adaptability of Aloe vera extracts, which hold promise for pharmacological and nutrition-related applications.
... Recent studies in cicatricial alopecia have focused on understanding the specific inflammatory pathways involved and developing anti-inflammatory and regenerative therapies. This includes the exploration of JAK inhibitors and stem cell-based treatments (Saleem et al. 2022;Rahbardar and Hosseinzadeh 2020). ...
... Anti-inflammatory agents like aloe vera and rosemary oil have also demonstrated potential. Aloe vera's soothing properties can help reduce scalp inflammation, while rosemary oil has been shown to improve blood circulation to the scalp and reduce inflammation, with efficacy comparable to minoxidil (Saleem et al. 2022;Rahbardar and Hosseinzadeh 2020). Saw palmetto, known for its DHT-inhibiting effects, and ginseng, with its potential to modulate hormonal pathways, are additional natural agents that have shown promise in managing hair loss (Natarelli et al. 2023;Chougule et al. 2017). ...
Alopecia, a common dermatological condition, poses significant psychological and social challenges. Despite the availability of various treatments, their efficacy is often limited by poor bioavailability and delivery challenges. Nanostructured lipid carriers have emerged as promising advanced drug delivery systems for alopecia treatment due to their ability to encapsulate both hydrophilic and lipophilic compounds, enhancing their stability, solubility, and controlled release. This manuscript explores the potential of Nanostructured lipid carriers as innovative delivery platforms for alopecia therapeutics, focusing on their formulation, characterization, and application in topical treatments. The unique properties of Nanostructured lipid carriers, including their small size, biocompatibility, and ability to target specific skin layers, are discussed in relation to improving the penetration and therapeutic efficacy of active ingredients such as minoxidil, finasteride, and plant-derived compounds. Additionally, we highlight the role of Nanostructured lipid carriers in improving scalp penetration, reducing side effects, and offering a more efficient alternative to conventional treatments. The manuscript concludes with insights into future trends, challenges, and the clinical potential of Nanostructured lipid carriers-based formulations in revolutionizing alopecia treatment.
... The bioactive chemicals present in Aloe vera, such as polysaccharides and vitamins, have a substantial impact on enhancing wound healing and encouraging better skin. This may potentially result in diminished scarring and blemishes caused by acne (Saleem et al., 2022). Although there is promising scientific evidence about the efficacy of Aloe vera in treating acne, it is crucial to acknowledge that the response to Aloe vera-based treatments can differ among individuals. ...
... Additional comprehensive investigations are required to clarify the exact processes by which Aloe vera exerts its antibacterial and anti-inflammatory effects against acne-causing microorganisms. Comprehending these mechanisms on a molecular scale can assist in optimizing Aloe vera-based formulations to improve effectiveness (Saleem et al., 2022). ...
Aloe barbadensis, often known as Aloe vera, has garnered extensive acclaim for its multifaceted therapeutic capabilities, generating significant interest in both traditional and scientific spheres. This review attempts to thoroughly examine the botany, photochemistry, and therapeutic uses of Aloe vera. We conduct a meticulous analysis of its taxonomic categorization, physical characteristics, and worldwide distribution, establishing the basis for comprehending its widespread utilization. We explore the importance of the phytochemical elements of Aloe vera, such as polysaccharides, anthraquinones, vitamins, minerals, and other bioactive substances, in influencing its many biological activities. A thorough examination of the therapeutic uses of Aloe vera encompasses various fields, such as dermatology, wound healing, gastrointestinal problems, immunological modulation, and its growing use as an ingredient in cosmeceuticals and nutraceuticals. In addition, we thoroughly examine the clinical evidence that supports the usefulness of Aloe vera in various health issues, clarifying areas that require additional research. This study is a valuable resource for researchers, healthcare practitioners, and industry stakeholders since it consolidates existing knowledge and identifies areas where future research is needed. It highlights the significant potential of Aloe vera in enhancing human health and well-being, encouraging further investigation in this field.
... Aloe vera is a plant known for its therapeutic properties, including antiinflammatory, healing and moisturizing effects, which makes it suitable for topical application (JADHAV et al., 2020). In addition to its medicinal properties, Aloe vera gel is biodegradable, low cost and can be a viable option to replace synthetic gels used in ultrasound examinations (SALEEM et al., 2022). ...
... For example, the liver and spleen are organs with homogeneous echotexture. Echotexture changes can be observed in several diseases, such as liver cirrhosis (ROSSELLI et al., 2023). ...
Ultrasound is an imaging diagnostic method that uses mechanical waves and requires acoustic coupling gel for the efficient transmission of ultrasonic waves. This study investigated Aloe vera gel as an alternative to the commercial gel used in ultrasound exams. The chemical, biological, electrical, and physical aspects of both gels were analyzed using Fourier Transform Infrared Spectroscopy (FTIR), Energy Dispersive X-ray Spectroscopy (EDS), cytotoxicity assays, and conductivity tests. The Aloe vera gel contained carbon, oxygen, magnesium, calcium, and phosphorus, while the commercial gel contained only carbon and oxygen. Aloe vera was found to be safe for biological tissues, with performance equivalent to or superior to the commercial gel in ultrasound exams. This can be attributed to its lower electrical resistance and higher quantity of free ions, which reduced impedance between the transducer and the skin, facilitating the propagation of ultrasonic waves. Thus, Aloe vera gel emerges as a promising and viable alternative for ultrasound, offering biocompatibility, technical performance, and safety.
... Additionally, it plays a significant role in the pharmaceutical sector, contributing to the production of topical ointments, gel formulations, tablets, and capsules. Furthermore, the cosmetic industries utilize Aloe vera gel as a basic ingredient for making creams, lotions, soaps, shampoos, and facial cleansers (Saleem et al., 2022) [10] . Because of its high water content, Aloe vera gel has a tendency to be unstable and making it prone to both discoloration and microbial contamination (Suriati, 2018) [12] . ...
... Additionally, it plays a significant role in the pharmaceutical sector, contributing to the production of topical ointments, gel formulations, tablets, and capsules. Furthermore, the cosmetic industries utilize Aloe vera gel as a basic ingredient for making creams, lotions, soaps, shampoos, and facial cleansers (Saleem et al., 2022) [10] . Because of its high water content, Aloe vera gel has a tendency to be unstable and making it prone to both discoloration and microbial contamination (Suriati, 2018) [12] . ...
... Aloe Vera is widely known for its soothing and moisturizing properties, but research has also demonstrated its anti-aging potential. The plant's gel contains compounds like glucomannan and polysaccharides that stimulate collagen production and skin hydration [30] . ...
... Its moisturizing and antiinflammatory properties can help alleviate symptoms such as itching, redness, and inflammation. Aloe vera gel may be applied topically to affected areas or incorporated into skincare products for daily use [28]. ...
Diabetes mellitus (DM) is a chronic condition characterized by elevated blood glucose levels, leading to nerve and blood vessel damage, organ failure, and impaired wound healing. Wound healing in diabetic patients is further complicated by reduced cytokine responses and delayed healing processes, which can lead to severe complications such as sepsis and gangrene if left untreated. In this study, we explored the potential of acemannan, an herbal extract from aloe gel incorporated into niosomes, for wound healing. Acemannan exhibits antihyperglycemic, antiseptic, and anti-inflammatory properties with discrete delivery mechanisms and minimal side effects. The aim of this study was to develop herbal-loaded niosomes for wound healing. Niosomes, self-assemblies of nonionic surfactants with or without cholesterol, offer versatile delivery systems for both hydrophilic and hydrophobic substances. The formulation consisted of Span 60, cholesterol, chloroform, methanol, buffer, and spray-dried aloe vera powder, prepared using the Thin Hydration method The resulting herbal niosomes were evaluated for entrapment efficiency, particle size, and zeta potential. A batch with a 2:2 ratio of Span 60 and cholesterol exhibited favorable characteristics with a particle size of 144.1 nm and a zeta potential of -17.1 mV. In conclusion, the developed herbal-loaded niosome formulation shows promise for wound healing, offering a potentially safer and more effective alternative to traditional antibiotic treatments for diabetic wounds.
... Aloe barbadensis Mill., commonly known as Aloe vera, is a fleshy, succulent xerophyte historically classified under the Liliaceae family [1]. However, recent classifications place it in the Aloaceae family [2]. ...
Aloe vera, a drought-resistant succulent, is renowned for its wide-ranging medicinal properties. It has significant health benefits, including anticancer, wound and burn healing, hypoglycemic, gastroprotective, antifungal, and antiinflammatory properties. These properties have led to its use in various commercial applications, particularly in skincare, cosmetics, and medicinal products. Additionally, Aloe vera is increasingly employed as an edible coating for fruits and vegetables, providing a natural alternative to postharvest chemical treatments. This review highlights Aloe vera's diagnostic properties and diverse applications, focusing on its rich polysaccharides, enzymes, vitamins, and minerals composition. Advances in analytical chemistry are enhancing the chemical characterization of Aloe vera, promising more information and broader applications shortly. The study also explores the plant's processing into juice, concentrate, and powder forms, underscoring its extensive use in pharmaceuticals, cosmetics, and functional foods, particularly for its antioxidant and anti-inflammatory benefits.
... Challenges and considerations in formulating with Aloe Vera with a focus on stability issues of Aloe vera extracts. 16 ...
One of the most ancient species of the Asphodelaceae family, Aloe barbadensis, known for its medicinal, cosmetic, and therapeutic properties, has been used for thousands of years. The Egyptians called it the "plant of immortality," and the use of this plant in skin care dates back thousands of years to ancient Greece and China, where it had a high esteem for its healing and soothing properties. In the modern world, Aloe vera has become an indispensable ingredient in topical dermatological preparations because of its great variety of bioactive compounds, including vitamins, enzymes, polysaccharides, and amino acids, which help confer to it hydrating, anti-inflammatory, and antimicrobial properties. This study focuses on investigating the role played by Aloe vera in skincare by considering its biochemical composition, action mechanisms, clinical uses, and safety evaluations. The bioactive compounds of Aloe vera, including polysaccharides and vitamins, synergistically hydrate, reduce inflammation, and facilitate wound healing. These characteristics contribute to the importance of the application of its use in products against many conditions: acne, eczema, psoriasis, and aging skin. Carrying out a critical evaluation of its therapeutic activity, this work deals with the multi-purpose uses of Aloe vera in commercial cosmetics such as sunscreens, after-sun care products, and sensitive skin preparations. This study juxtaposes unadulterated Aloe vera extracts with commercially formulated products, emphasizing their respective efficacies and constraints. Furthermore, the investigation assesses clinical research that substantiates the therapeutic benefits of Aloe vera in managing burn injuries, hydrating the skin, and soothing irritation. The research also tackles the obstacles encountered in the formulation of Aloe vera-infused products, including concerns regarding stability and interactions with other cosmetic components. The project emphasizes the need for quality control and standardization as well as regulatory consideration that ensures safety and efficacy in long-term usage of Aloe vera. Additionally, the prevailing consumer trends that prioritize natural, vegan, and cruelty-free products are examined, highlighting the increasing prominence of Aloe vera within the skincare sector. The project culminates in a discussion of prospective developments, accentuating advancements such as nanotechnology, genetic engineering, and sustainable farming practices that may significantly augment Aloe vera's application in dermatology, especially in relation to anti-aging and skin barrier repair therapies.
... Aloe vera generally has no stem or has a very short stem; its leaves are arranged in a rosette pattern, and during the summer, orange-yellow flowers can be observed [3]. The leaves are the most used part of the plant, and from them, two main commercial products are obtained: latex, a yellow liquid located below the epidermis, and gel, located in the internal part [5]. ...
Aloe vera gel is widely used in cosmetics due to its biological activities, but its extraction leads to high waste generation. Therefore, developing alternatives that can convert Aloe vera residues into value-added products is attractive. The present study proposes obtaining bioactive phenolic compounds and ethanol from the fractionation of the residue, including solid–liquid extraction, alkaline pretreatment, and extraction in aqueous two-phase systems (ATPSs). The solid–liquid extraction with ethanol was effective, recovering 26.99 mg of phenolic compounds per gram of material. In the ATPS extraction, the composition of the ethanol/ammonium sulfate system and the pH showed sensitive effects on the yield of phenolic compounds in the top phase, which presented a level of 90%. To improve productivity, the 20% ethanol/22% ammonium sulfate/40% extract condition without pH adjustment was selected, and it was able to achieve 93.5% yield and a partition coefficient of 14.2. In addition to ensuring the isolation of phenolics, the top phase of ATPS showed high DPPH (4710.53 mmol TE/mL) and ABTS (2217.50 mmolTE/mL) radical scavenging capacity, similar to the results of the initial extract. The post-extraction residue was used as raw material for alkaline pretreatment, and the pretreated residue showed higher enzymatic digestibility than the untreated residue. Under 10% solids loading and 20 FPU/g cellulases, 30.31 g/L glucose and 75.45% cellulosic conversion were obtained from the hydrolysis of the alkaline-pretreated residue. Ethanol production via simultaneous saccharification and fermentation increased as a function of the solid loading and reached its maximum value of 21.74 g/L at 15% solids (yield of 70.93%). Therefore, this study acts on the circular economy of Aloe vera and can contribute to efforts to increase the value of the plant.
... Aloe vera, an adaptable herbal plant, has been widely employed for traditional and medicinal purposes in several cultures [30], [31], [32], [33]. The healing of aloe vera initiates tissue granulation, acts as an anti-inflammatory and antiseptic agent, and is a rich source of bioactive compounds such as flavonoids, anthraquinones, and phytosterols [34]. It plays a central role in immune system modulation, wound healing, and inflammation reduction. ...
... Aloe vera, an adaptable herbal plant, has been widely employed for traditional and medicinal purposes in several cultures [30], [31], [32], [33]. The healing of aloe vera initiates tissue granulation, acts as an anti-inflammatory and antiseptic agent, and is a rich source of bioactive compounds such as flavonoids, anthraquinones, and phytosterols [34]. It plays a central role in immune system modulation, wound healing, and inflammation reduction. ...
Aloe vera, one of the most versatile medicinal plants, has been widely popularized in the field of green synthesis due to its phenomenal characteristics. This can be further discussed in the present review paper concerning the comprehensive analysis of Ag and Cu codoped ZnO nanoparticles and their potential benefits. The use of aloe vera extract as a source for green synthesis is a viable and environmentally friendly choice for traditional chemical reconstruction approaches. In this review, the primary properties of codoped nanoparticles are reviewed based on their structure, optics, and morphology, which promote their physicochemical properties in comparison to those of doping-free nanoparticles. This article investigates how the synergistic effect of codoped ZnO manifests improved catalysis, disinfection, and photocatalysis. Moreover, the review also covers the potential applications of these promising nanostructures in many fields, such as environmental remediation, biomedical applications, and energy storage devices. The outcome of this review paper will add value to the increasing literature based on the potential of aloe vera-mediated green synthesis for the development of composite materials for various advanced functional materials as a sustainable and eco-friendly solution.
... Preservation of semen using alternative additives such as plant extracts have been used in different farm animal species to improve semen quality, which thereby increases sperm fertility. Aloe vera is a medicinal plant that contains specific bioactive ingredients, including proteins, lipids, amino acids, alkaloids, saponins, flavonoids, enzymes, organic and inorganic compounds (Hamman, 2008;Akaberi et al., 2016, Lopez-Cervantes et al., 2018, vitamins C, B (1, 2, and 6), A, and E (Daniel, 2024), and mineral salts like sodium, calcium, iron, potassium, chloride, manganese, copper, and zinc (Sánchez et al., 2020;Ebrahim et al., 2020;Darzi et al., 2021;Saleem et al., 2022;Kamble et al., 2022). The physical parameters of a fresh Aloe vera leaf, including length, width, and gel weight, were conducted by Talukdar et al., (2023). ...
... Preservation of semen using alternative additives such as plant extracts have been used in different farm animal species to improve semen quality, which thereby increases sperm fertility. Aloe vera is a medicinal plant that contains specific bioactive ingredients, including proteins, lipids, amino acids, alkaloids, saponins, flavonoids, enzymes, organic and inorganic compounds (Hamman, 2008;Akaberi et al., 2016, Lopez-Cervantes et al., 2018, vitamins C, B (1, 2, and 6), A, and E (Daniel, 2024), and mineral salts like sodium, calcium, iron, potassium, chloride, manganese, copper, and zinc (Sánchez et al., 2020;Ebrahim et al., 2020;Darzi et al., 2021;Saleem et al., 2022;Kamble et al., 2022). The physical parameters of a fresh Aloe vera leaf, including length, width, and gel weight, were conducted by Talukdar et al., (2023). ...
This study was done in the Animal Field, Department of Animal Production Techniques, Technical Institute of Kufa, Al-Furat Al-Awsat Technical University, to evaluate the effect of adding vitamins (thiamine, pyridoxine, and cobalamin) to improve some goat semen diluent characteristics post-cooling. Five young male goats were used in this study, the experiment was divided into four groups, T1 (control), T2: thiamine (150 microgram (µg)/ 1 ml, T3: Pyridoxine 150 µg/1 ml and T4: Cobalamin (150 µg/1 ml). As the semen was collected and divided into four experimental treatments. The semen was stored for 24, 72 and 120 hours (hr.) at 5 ºC. The study recorded a highly significant rise in sperm motility percentage at 24 hr. by adding 150 µg thiamine, pyridoxine, and cobalamin compared with the T1 (control group) which noticed a high significant reduce during different times of cooling storage. The highest motility recorded after 120 hr. was noticed in group T2 (71.333±1.740) and T3 (70.499±2.027) followed by group T4 (67.833±2.185) than group T1 (control) (62.499±2.185). Non-significant effect of sperm abnormalities after 24 hr. between thiamine, pyridoxine, and cobalamin compared to the control group (T1), however, highly significant differences were shown after 72 hr. of cooling, the group T2 (thiamine) noticed highly significant abnormalities decrease at 72 hr. by 11.200+1.588 and non-significant variations were shown between T1, T3 (Pyridoxine) and T4 (Cobalamin). The results showed a significant decrease in the dead sperm percentage by adding thiamine, pyridoxine, and cobalamin to diluted goat semen after 24 and 72 hr. at cooling compared with the control group which were 18.833 ± 1.201 (T2), 22.167 ± 1.453 (T3), 22.000 ± 1.607 (T4) and 26.500 ± 1.527 (T1 control) for 24 hr. and 21.833 ± 1.443 (T2), 24.833 ± 1.166 (T3), 25.333 ± 2.309 (T4) and 29.500 ± 0.881 (T1 control) for 72 hr. respectively, while no significant differences observed among thiamine, pyridoxine, and cobalamin groups for first and second periods of cooling. After 24 hr., adding thiamine (T2) and cobalamin (T4) observed significantly increasing a high in host % by 76.333±1.453 and 76.167±1.453 respectively against the control group (72.000±0.763). Non-significant variations were noticed among thiamine (T2), and cobalamin (T4) for all periods of cooling. It could be concluded that adding the vitamins Thiamine, Pyridoxine, and Cobalamin at cooling periods have a positive role in enhancing the characteristics of cooled goat semen.
... Aloe vera has been identified as having a multitude of biological properties, including the ability to combat fungal infections [20], bacteria, viruses, and antioxidants [21], wound healing [22], and skin diseases [23]. Both Tulsi and Aloe vera gel have gained widespread use in coating food due to its antimicrobial characteristics and its ability to reduce moisture and moisture loss [24]. ...
Background: In western Uttar Pradesh, jaggery is a widespread cottage enterprise based on agriculture, and farmers are forced to sell their product at a lesser price when it is still fresh. Therefore, it was thought to be desirable to create better storage techniques in order to extend its shelf life. Aloe vera, and Ocimum sanctum, often known as "Tulsi," are frequently utilised as antimicrobial food additives because they offer a host of other health advantages in addition to their well-known antibacterial qualities. Because the edible coatings made of these herbs provide a semi-permeable barrier to gases and water vapours, they may prolong the shelf life of jaggery by preventing degradation. Objective: The goal of the current study was to assess the ability of edible coatings of common Indian herbs, such as tulsi and Aloe vera,, to extend the shelf life of jaggery while maintaining attributes that are equal to those of fresh jaggery, in accordance with the guidelines set forth by the Food Safety and Standards Authority of India (FSSAI). Methodology: The physicochemical characteristics, antioxidant activity, total viable count, and antibacterial activity of tulsi-Aloe vera, coated (TAC), Ocimum sanctum, and Aloe vera, (AC) jaggery were assessed and compared with non-coated control. The physicochemical properties were ascertained using standard methodology for measurement of reducing sugars, proteins, phenols, saponins, tannin, alkaloids, and flavonoids. The antimicrobial activity was ascertained by means of the agar double diffusion method. According to established protocol, antioxidant activity was assessed using the DPPH radical scavenging assay and the reducing power assay. Results: According to the research, there is no discernible microbiological deterioration and the edible coatings containing tulsi and Aloe vera, extend the shelf life of jaggery during storage. When compared to uncoated jaggery, coatings were efficient at preventing the growth of both Gramme positive and Gramme negative microorganisms. Over the course of six months, the herb-infused coatings also retained their phenolic, flavonoid, and tannin contents, which improved their anti-oxidant efficacy when compared to the untreated control group.
... Aloe vera gel is known to exert anti-inflammatory, antibacterial, antioxidant, immune-stimulating and hypoglycemic characteristics, along with a range of other pharmacological effects [20,21]. Fani and Kohanteb [22] (2012), reported that aloe vera gel can exhibit a significant bactericidal effect against cariogenic bacteria. ...
Fluoridated dentifrices have antibacterial effects on children's teeth. On the other hand, the side effects encountered with the use of them have led researchers to look for safe alternatives. This study aimed to determine the antibacterial effect of different commercially available fluoride-free dentifrices on Streptococcus mutans (S. mutans) in comparison with different concentrations of fluoridated dentifrices. Study groups comprised of fluoride-free dentifrices, which contain Probiotic (Activated Charcoal Probiotic Dentifrice-Group P), Aloe Vera-Group AV and Salivary Proteins-Group SP. Fluoridated dentifrices containing 1450 ppm fluoride-Control Group 1 and 500 ppm fluoride-Control Group 2 served as control groups. Antibacterial activity was assessed by Minimum Inhibitory Concentrations and agar well diffusion assays on S. mutans. Biofilm inhibition assay was performed with dentifrices, which had antibacterial activities, and a negative control phosphate-buffered saline (Group PBS) on sterile hydroxyapatite discs against S. mutans. Statistical evaluation was performed. Only group AV showed an antibacterial effect on S. mutans, while control groups showed a similar antibacterial effect. The mean number of viable bacteria present in S. mutans biofilm in Control Group 1 and 2 and Group AV were statistically significantly lower than that in Group PBS, but there were no statistically significant differences between Control Groups and Group AV. Antibacterial activity of commercial dentifrices against S. mutans may be exerted by antibacterial components other than fluoride. Aloe vera-containing toothpaste showed an antibacterial effect on S. mutans, although not as much as the fluoride-containing toothpastes in the control groups. However, further in vivo and long-term studies are required.
... Additionally, it adheres the surface flaky epidermal cells together, having cohesive actions that soften the skin. A study reported that gloves containing A. vera gel enhanced skin integrity, reduced appearance of fine wrinkles, and reduced erythema caused by occupational exposure (Saleem, et al., 2022). ...
... Improved blood circulation ensures that hair follicles receive an adequate supply of nutrients and oxygen, which are essential for healthy hair growth. When blood flow to the scalp is optimized, it can enhance hair follicle function and promote hair growth (Abelan et al., 2022;Saleem et al., 2022). ...
Hair loss in adult men albeit common, can cause emotional distress. Many people with hair fall issues try chemical-based treatments that may lead to health complications and allergic reactions. Cosmetics using natural ingredients derived from plants have fewer side effects compared to synthetic alternatives. The study aimed to formulate herbal hair oil using various ingredients like castor oil, sunflower oil, jojoba oil, olive oil, pumpkin oil, etc. and evaluate its effectiveness in promoting hair growth and prevention of hair fall (HG-HF). Besides, the oil was supposed to provide a range of benefits for hair health, including preventing dandruff, improving scalp health, providing antioxidant properties, and thereby protecting against oxidative damage. The DPPH radical scavenging test was done to evaluate the antioxidant activity of the oils. Varying IC50 values were found such as olive oil and sunflower oil showed IC50 values of 3.79 μg/ml and 4.44 μg/ml respectively. Hence, these oils have significant antioxidant activity with a strong ability to scavenge or neutralize free radicals. A study was conducted on sixteen volunteers with hair loss, dandruff, and other hair problems to check the performance of the oil. 56.25% of the participants experienced increased hair growth and 50% reported a decrease in hair fall after using the oil for 3 months, with no remarkable side effects. Data demonstrated effectiveness and overall acceptable perception of the HG-HF oil by the participants. Bangladesh Pharmaceutical Journal 27(1): 9-18, 2024 (January)
... It also showed anti-inflammatory potential for the treatment of H. Pylori infection (Sánchez et al., 2020). The most prevalent skin condition that bothers adolescents and adult is acne and aloe vera has an excellent anti-acne properties and works against any type of skin irritation (Saleem et al., 2022). Plant-based therapies have a distinct place in medicine because of their powerful advantages and lack of adverse effects. ...
Lumpy skin disease is a rising bovine viral illness that is widespread in most African and Middle Eastern nations, with a high probability of disease transmission throughout the Asia and Europe. The causative agent is capripoxivirus endangering hundreds of dairy cattle across the country in recent years. The LSD virus infects cattle and buffaloes and results in nodular skin sores all over their bodies. This results in chronic debility, decreased milk supply, poor development, infertility, abortion, and other issues in cattle and buffaloes infrequently leading to death of animals. The only infected animal species are cattle and water buffalo, both of which have high morbidity and low mortality rates. However, mortality rates are greater in calf populations. LSD causes sterility in males and abortions in female cattle. This mini review highlights existing information on epidemiology, pathogenesis, clinical manifestations, and potential role of phytochemicals particularly turmeric and aloe vera in treating lumpy skin disease.
... These factors all play a role in shaping the unique composition of this remarkable plant [29][30][31] . [49,50] Adaptogen Adaptive & Defence mechanisms of the body [51,52] Digestion Improves digestive tract [53,54] Immune System Build Immunity [55,56] Antibacterial and antiviral Fight against Bacteria and Viruses [57][58][59] Weight loss Helps to lose weight [60,61] Inflammation Reduce inflammation [62] Table 1 provides a summary of some of the most important advantages of consuming Aloe vera, which may be traced back to the plant's high nutrient content [63] . ...
The main aim is to identify the effectiveness of Aloe vera in patients with diabetes mellitus and its effects on skin health and Its effectiveness on other diseases. Its gel, composed of various compounds like saccharides, vitamins, phenolics, enzymes, and more, has therapeutic properties, acting as an antioxidant, anti-inflammatory, and antimicrobial agent. Aloe vera's gel is sought after for its wound healing, skin moisturizing, and anti-inflammatory properties. Additionally, Aloe vera juice is known to aid digestion and alleviate upset stomachs, benefiting those with digestive issues like constipation and irritable bowel syndrome. The chemical properties of Aloe vera reveal a diverse range of compounds, with polysaccharides, anthraquinones, phenolic compounds, vitamins, minerals, amino acids, and enzymes being among the most significant. These compounds contribute to the antioxidant, moisturizing, and laxative effects of the plant. Aloe vera's wide array of health benefits, including detoxification, immune support, antibacterial properties, and potential for aiding weight loss, are attributed to its nutrient-rich content. The Aloe vera leaf consists of three layers, each playing a specific role in the plant's function and composition. The amount and type of chemical compounds found in Aloe vera can vary depending on various factors such as growth conditions, harvest time, climate, and the specific Aloe vera species being examined. Aloe vera's versatile applications extend beyond personal health benefits. It shows potential for environmental processes such as biodegradation, bioremediation, detoxification, and more, making it a valuable natural resource with various practical applications. In the context of diabetes, Aloe vera has drawn significant interest in traditional medicine due to its potential anti-diabetic effects. Studies have indicated that Aloe vera gel and isolated compounds like anthraquinones may positively impact glucose tolerance and insulin sensitivity. Furthermore, Aloe vera's use in combination with other herbs has shown promise in altering gut microbiota and providing relief from type 2 diabetes symptoms. Overall, Aloe vera's rich chemical composition, extensive medicinal uses, and positive impact on health make it a remarkable natural resource with broad applications in various fields. Moreover, innovative drying techniques, such as microwave-assisted drying, offer efficient alternatives for obtaining Aloe vera powder without compromising its bioactivity. The multifaceted benefits and adaptability of Aloe vera make it a valuable addition to traditional and modern approaches to health and well-being.
... Improved blood circulation ensures that hair follicles receive an adequate supply of nutrients and oxygen, which are essential for healthy hair growth. When blood flow to the scalp is optimized, it can enhance hair follicle function and promote hair growth (Abelan et al., 2022;Saleem et al., 2022). ...
The main objective of the current study was to examine the anti-influenza effects of Aloe vera gel on the Madin–Darby Canine Kidney (MDCK) cell line, as well as its protective efficacy against ultraviolet-C exposure, by studying its biochemical characterization and microbial activities. The lowest IC50 value (4.23 mg/mL) was reported for the treated cells, with a concentration of 8 mg/ML of Aloe vera extract after contamination with the AP/R/8 virus. After 2 h of ultraviolet-C exposure, all cells in the control group and those with single-sided gel application died, while the cells treated with the gel on both sides showed 29.000 viable cells. The lowest inhibition activity was detected against Bacillus subtilis (2.20 mm) at a concentration of 20 μL. In comparison, the highest inhibition activity was observed against Pseudomonas aeruginosa (21.29 mm) at a concentration of 100 μL. The highest values were detected in the Aloe vera gel samples in the following sequence: magnesium (28.43 mg/100 g), phosphorus (2.98 mg/100 g), zinc (143.01 μg/100 g), selenium (137.18 μg/100 g), iron (19.78 μg/100 g), chromium (15.40 μg/100 g), aluminum (12.35 μg/100 g), and vanadium (8.70 μg/100 g). On the other hand, trace elements such as cadmium, cobalt, and nickel showed the lowest concentrations (0.05, 0.12, and 0.23 μg/100 g, respectively). The plant contained high quantities of phenols, flavonoids, tannins, saponins, and anthraquinones, along with high antioxidant activity (1,1-diphenyl-2picrylhydrazyl, DPPH) and ascorbic acid content. Based on these observations, it can be concluded that Aloe vera plants contain variable compounds that may be responsible for their therapeutic and pharmacological uses.
Abstract---Background: The anti-inflammatory, antioxidant, antiviral,
antibacterial, antitumor, antiarthritic, and anti-diabetic properties of
aloe vera has been well documented in the literature. Considering its
antibacterial properties evaluating its benefits as mouth rinse in the
oral diseases may facilitate the patients in getting cheaper and safer
herbal remedy to clean their oral cavities. Objective: To evaluate the
Antibacterial efficacy of aloevera peel extract against Streptococcus
mutans and P. gingivalis.
The burgeoning interest in natural components in personal care products has led to significant research and development of ingredients such as plant extracts, antioxidants, peptides, and probiotics. These components have been recognized for their potential to enhance skin health through various mechanisms, addressing consumer demand for products that are both effective and benign. Plant extracts, known for their rich composition of bioactive compounds, offer a myriad of benefits including antioxidant, anti-inflammatory, and antimicrobial properties, making them invaluable in skin care formulations. Antioxidants, derived from both plants and other natural sources, play a pivotal role in protecting the skin from oxidative damage, thereby preventing premature aging and promoting skin vitality. Bioactive peptides have garnered attention owing to their multifunctional activities that include promoting collagen synthesis, inhibiting enzymes responsible for skin degradation, and reducing inflammation, thereby contributing to skin regeneration and anti-aging. Probiotics have expanded their utility beyond gut health to skin care, where they help in maintaining skin microbiome balance, thus enhancing skin barrier function and potentially mitigating various skin disorders. The purpose of this review is to explore the individual roles of plant extracts, antioxidants, peptides, and probiotics in personal care products, while emphasizing their synergistic effects when combined. By integrating these natural components, this paper aims to highlight the potential for developing innovative skincare formulations that not only address specific skin concerns but also contribute to overall skin health, aligning with the increasing consumer preference for natural and holistic skincare solutions.
This study aims to formulate and characterize zinc-loaded hydrogel infused with Aloe barbadensis mucilage for wound dressing. Five formulations containing varying proportions of carbopol, zinc, aloe and water (as vehicle) were developed via physical crosslinking using triethanolamine. All formulations had a translucent off-white colour while the control gave a transparent gel. The viscosity was highest in the control, 30000.00 ± 2.07 PaS. The pH of the formulations was between 5.7 and 5.8. Formulation 2 which is composed of 30 mg of Zinc and 1.4 mg of Aloe barbadensis incorporated into 1% w/v Carbopol Ultrez hydrogel polymer had the lowest swelling index of 79.2 ± 1.95% implying that it had the fastest drug release rate. The wounds treated with Formulation 2 had the most rapid wound healing with no sign of scars in the wound area. Histomorphometric evaluation reflected a high re-epithelisation rate of 70%, a significant percentage occupied by collagen in granulation tissue of 85%. The thickness of the tissue's central region was 10 mm. The inflammatory cells /mm2 tissue was 200 cells/mm2 while the number of microvessels in granulation tissue was 1.0 microvessels/mm2. Zinc-loaded hydrogel infused with Aloe barbadensis mucilage shows great potential as a modern wound dressing.
Background
Antimicrobial resistance exhibited by bacteria against the major-ity of antibiotics has resulted in research on alternative methods of treatment. Aloe vera has a strong tradition as a medical plant with a wide range of therapeutic uses.
Objective
The objective of this study is to determine the antibacterial activity of gel and crude ethanol leaf extract of Aloe vera against Staphylococcus aureus and Enterobacter-ales isolated from wound infections.
Methods
It is a cross-sectional study conducted over a period of 7 months. Antibacterial effect of the ethanol leaf extract and gel was determined by the punch well method. Min-imum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of the ethanol leaf extract were determined by macro broth dilution technique.
Results
Aloe vera ethanol leaf extract induced a mean zone size of 13.0 ± 6.0 mm and 16.7 ± 8.4 mm, respectively, for S. aureus and Enterobacterales by Punch Well method (p≤0.002). Whereas Aloe vera gel failed to induce any zone of inhibition for all the isolates p<0.001. Mean MIC of Aloe vera leaf extract against 74 S. aureus was 94 ± 41.23 mg/ml and against 73 Enterobacterales, it was 45.6 ± 20 mg/ml p < 0.001. Mean MBC of Aloe vera leaf extract against 74 S.aureus isolates was 188 ± 82.46 mg/ml and against 73 En-terobacterales was 91.18±40 mg/ml p < 0.001.
Conclusion
Aloe vera ethanol leaf extract showed a good antibacterial effect against the different strains of bacteria causing wound infection. The present article shows the possi-bility of future use of natural products for the treatment of wound infections.
Aloe barbadensis is a drought-tolerant perennial medicinal plant with both nutritional and cosmetic uses. Drought is one of the main abiotic stresses limiting plant growth and development. However, the use of drought-resistant plants combined with beneficial soil micro-organisms could improve the effectiveness of biological methods to mitigate drought damage. This research aims to evaluate the effects of Funneliformis mosseae (MF), plant growth-promoting rhizobacteria (PGPR) (including Pseudomonas putida and Pantoea agglomerans), and their co-inoculation on the macronutrient status, antioxidant enzyme activities, and other morphophysiological traits of A. barbadensis under four irrigation regimes [25%, 50%, 75% and 100% of water requirement (WR)]. Three harvests were conducted, revealing that inoculation enhanced the survival rate and shoot fresh weight (SFW) compared to the control plants. However, at 25% WR, the SFW was reduced by 43% more than the control. across all harvests, while the PGPR + MF treatment showed increases of more than 19%, 11%, and 17% compared to the control, MF, and PGPR treatments, respectively. The results also showed that A. barbadensis exhibited innate drought tolerance up to a 50% WR level by enhancing physiological defenses, such as antioxidant enzyme activity. Inoculation increased the macronutrient status of the plant at all levels of irrigation regimes especially under severe drought conditions. The highest levels of nitrogen (N) (16.24 mg g⁻¹ DW) and phosphorus (P) (11.29 mg g⁻¹ DW) were observed in the PGPR + MF treatment at 100% WR. The maximum relative water content under MF inoculation and 75% WR (98.24%) (98.24%) was reached. PGPR + MF treatment alleviated drought-induced osmotic stress, as indicated by reduced antioxidant enzyme activities and electrolyte leakage. However, P. putida and P. agglomerans strains alone or in combination with F. mosseae increased plant yield, macronutrient uptake and antioxidant enzyme activity. This study underscores the potential of these PGPR and MF strains as invaluable biological tools for the cultivation of A. barbadensis in regions with severe drought stress.
Chemical, Material Sciences & Nano technology book series aims to bring together leading academic scientists, researchers and research scholars to exchange and share their experiences and research results on all aspects of Chemical, Material Sciences & Nano technology. The field of advanced and applied Chemical, Material Sciences & Nano technology has not only helped the development in various fields in Science and Technology but also contributes the improvement of the quality of human life to a great extent. The focus of the book would be on state-of-the-art technologies and advances in Chemical, Material Sciences & Nano technology and to provides a remarkable opportunity for the academic, research and industrial communities to address new challenges and share solutions.
p>In the wake of the COVID-19 pandemic, the imperative to mitigate pathogen transmission has catalyzed the innovation of soaps imbued with antimicrobial and antibacterial properties. Diverging from conventional reliance on synthetic chemicals, often associated with adverse dermatological reactions, this study explores the formulation of organic liquid soaps. These soaps leverage naturally occurring antibacterial and antimicrobial compounds from readily accessible plants, presenting a viable alternative to commercially available inorganic body washes predominantly manufactured by small to medium-sized enterprises. Specifically, this research harnesses papaya and aloe vera extracts for their antimicrobial attributes, augmented with turmeric and piper betel for enhanced antibacterial efficacy. Despite the recognized potency of turmeric and piper betel, variability in their effectiveness necessitates rigorous validation against the Indonesian National Standards (SNI) to ensure product quality and safety. This includes comprehensive evaluations of pH levels, density, Total Plate Count (TPC), and Mold and Yeast Count (MYC) to certify the soap's inhibitory capacity against bacterial and fungal proliferation. Employing maceration and hot processing techniques, the formulated papaya-based soap adhered to SNI 4085:2017 criteria for pH and MYC, although initially failing the TPC test. Subsequent incorporation of turmeric extract facilitated compliance with all SNI benchmarks. Conversely, aloe vera formulations only satisfied pH requirements under the SNI, even after adding piper betel. However, substituting piper betel with turmeric extract enabled the aloe vera soap to fulfill the requisite SNI parameters. These findings underscore turmeric extract's superior antibacterial properties, positioning it as a pivotal component in papaya and aloe vera soap formulations. Contrary to prevalent assumptions regarding piper betel's antimicrobial and antibacterial effectiveness, our investigation substantiates turmeric's superior role in bacterial growth inhibition within organic soap matrices.</p
Diabetes mellitus (DM) is a chronic condition characterized by elevated blood glucose levels, leading to nerve and blood vessel damage, organ failure, and impaired wound healing. Wound healing in diabetic patients is further complicated by reduced cytokine responses and delayed healing processes, which can lead to severe complications such as sepsis and gangrene if left untreated.
In this study, we explored the potential of acemannan, an herbal extract from aloe gel incorporated into niosomes, for wound healing. Acemannan exhibits antihyperglycemic, antiseptic, and anti-inflammatory properties with discrete delivery mechanisms and minimal side effects.
The aim of this study was to develop herbal-loaded niosomes for wound healing. Niosomes, self-assemblies of nonionic surfactants with or without cholesterol, offer versatile delivery systems for both hydrophilic and hydrophobic substances. The formulation consisted of Span 60, cholesterol, chloroform, methanol, buffer, and spray-dried aloe vera powder, prepared using the Thin Hydration methodThe resulting herbal niosomes were evaluated for entrapment efficiency, particle size, and zeta potential. A batch with a 2:2 ratio of Span 60 and cholesterol exhibited favorable characteristics with a particle size of 144.1 nm and a zeta potential of -17.1 mV.
In conclusion, the developed herbal-loaded niosome formulation shows promise for wound healing, offering a potentially safer and more effective alternative to traditional antibiotic treatments for diabetic wounds.
The use of herbal drugs as alternative and complementary medicine has increased in popularity, raising concerns about their safety profile. Aloe vera, a plant with diverse therapeutic properties, has been extensively used for centuries. This review aims to assess the therapeutic activity and safety profile of Aloe vera. A comprehensive literature search was conducted to gather relevant information from various biomedical databases. The chemical composition, mechanism of action, and therapeutic activities of Aloe vera were analyzed. Aloe vera contains numerous active components such as vitamins, enzymes, minerals, sugars, lignin, saponins, and anthraquinones. Its mechanisms of action involve collagen synthesis, anti-inflammatory effects, immune modulation, laxative properties, and antiviral activity. Aloe vera has demonstrated potential therapeutic benefits in wound healing, diabetes management, liver and kidney protection, and glycemic control. However, it is essential to consider potential side effects, such as skin irritation and allergic reactions. This review provides evidence-based information to improve patient safety and promote informed decisions regarding the use of Aloe vera as a therapeutic agent.
Background
Skin diseases are among the common problems in the world. For centuries folk medicine and medicinal plants were employed by ethnic communities as medicines. A survey was carried out to document the medicinal plant diversity and folk formulation traditionally practiced by the Ao (Naga) tribe in Mokokchung district, Nagaland, India for the treatment of skin diseases.
Materials and Methods
The survey was carried out from September, 2021 to September, 2023. The information was gathered using a pre-structured questionnaire format. Discussion with the traditional healers was conducted.
Results
A total of 32 plant species belonging to 30 families were documented. Among the 32 plant species, 16 are herbs, 10 are shrubs, 4 are trees, and 2 are climbers. A total of 12 distinct skin disorders are reported commonly occurring among the Ao (Naga) tribes, which are treated traditionally. Among the different plant parts, leaves are most frequently used part for the treatment of various skin diseases followed by roots, latex, fruit, stems, bulbs, rhizomes and seeds. A total of 9 folk formulations that are used for the treatment of skin disease are also documented.
Conclusion
This study documented the traditional knowledge and folk medicine for the treatment of skin disorders, which will be helpful for further investigation in the field of pharmacognosy in the aspect of drug design and development.
The aim of the present article is to analyze the role of emollients in the topical management of atopic dermatitis and psoriasis and also to review the clinical studies available on the beneficial effect of co-therapy of emollients and topical corticosteroids. Understanding the stratum corneum's key involvement in the pathophysiology of atopic dermatitis and psoriasis has led to the development of new therapeutic approaches for treating not just inflammation but also restoring a healthy skin barrier. While topical corticosteroids are the cornerstones of treatment for atopic dermatitis and psoriasis, the potential risks of overuse (including atrophy, striae, dyspigmentation, and loss in epidermal barrier homeostasis) must be weighed against the benefits. These risks futher increase the necessity of finding non-steroidal treatments. Emollients aid the epidermal barrier function as they improve the oil and lipid levels and restore its protective function. Used regularly, emollients may reduce flare-ups and may also have a direct anti-inflammatory effect and may reduce the need to use topical corticosteroids, i.e. they have a ‘steroid sparing effect’.
Background: The anti-inflammatory, antioxidant, antiviral, antibacterial, antitumor, antiarthritic, and anti-diabetic properties of aloe vera has been well documented in the literature. Considering its antibacterial properties evaluating its benefits as mouth rinse in the oral diseases may facilitate the patients in getting cheaper and safer herbal remedy to clean their oral cavities. Objective: To evaluate the Antibacterial efficacy of aloevera peel extract against Streptococcus mutans and P. gingivalis. Methodology: It was a preclinical experimental study conducted at Baqai Medical and Dental College Karachi, from February to March 2023. Calculated sample size was n =60. The participants were given an envelope for group randomization. S. mutant samples and P. gingivalis were incubated on appropriate media. The Aloe Vera leaves were washed and gel was removed the peels were shed dried and lastly was grinded to powder form. Ethanol (70%) were used for soaking for 15 days with intermittent shaking. The extract was diluted in distilled water in 1:4 (Extract: Distilled water) concentration.
Background: Vitiligo is a condition that causes a patchy loss of skin pigmentation. The Aloe Vera plant has been used to treat a wide range of ailments, including skin diseases; however, little is known about its effectiveness in vitiligo. This study aimed to assess the efficacy and safety of natural Aloe Vera in stable vitiligo. Methods: A retrospective review of medical records was conducted on vitiligo patients who recommended natural Aloe Vera between July 2021 and August 2022. All patients were advised to apply natural Aloe Vera leaf pulp thrice daily for 6 months, along with sunlight exposure. Efficacy was measured as the proportion of patients achieving ≥75% re-pigmentation of the target lesion at the end of 24 weeks, which constituted a ''good response,'' while 50% or higher re-pigmentation constituted a ''better response.'' The extent of re-pigmentation was assessed as per the protocol and graded from 0 to 5. Safety was assessed as the proportion of patients reporting ≥1 adverse event at 24 weeks. Results: The results revealed that 19 (86.3%) patients responded positively after receiving 3 months of treatment: 4 patients repigmented 50–74%, 8 patients repigmented 25–49%, 7 patients repigmented 1–24%, and 3 patients didn't repigment at all. After completion of 6 months of therapy, 3 patients repigmented 75–99%, 4 patients repigmented 50–74%, 10 patients repigmented 25–49%, 2 patients repigmented 1–24%, and 3 patients didn't show any change in re-pigmentation. Only 2 (9%) patients showed 90% re-pigmentation (grade 6) at the end of the study. Stinging or burning sensations and pruritus were experienced by 3 patients within the first week of treatment. Conclusion: Natural Aloe Vera was found to be safe and fairly effective in the treatment of stable vitiligo. However, randomized controlled trials with larger sample size are recommended to verify the efficacy and safety of Aloe Vera in the treatment of vitiligo.
Aloe L. includes plants of economic interest worldwide for their medicinal
properties and ornamental character. In this study, morphological and cytogenetic
traits were evaluated in a hybrid obtained using Aloe jucunda Reyn. as pollen donor
and A. vera (L.) Burm. f. as female parent, to characterize it, determine its ornamental and agronomic potentialities and aspects related to its reproduction. Conventional protocols for morphometric studies and cytogenetic analysis described for succulent plants were applied. Progeny showed intermediate expressiveness in most of the characteristics, except in the colour of the leaves and flowers (hybrid = A. jucunda), as well as for the length of teeth, number, and area of leaf spots and angle between continuous leaves, where it surpassed the expression of both parents, giving it a high ornamental value. The length, width, and thickness of the leaves improved with respect to the paternal genome, so its potential for the exploitation of the gel and latex of its leaves cannot be ruled out. Root tip cells showed a karyotype 2n = 2x = 14 = 8L + 6S = 1L(smsat) + 1L(sm) + 3L(st) + 3L(smsat) + 1S(m) + 5S(sm). Microsporogenesis showed chromosomal abnormalities in 47.4% of the meiocytes, the most frequent being micronuclei in prophase-I, sticky chromosomes in metaphase-I, one or two dicentric bridges accompanied or not by acentric fragments in anaphase-I, -II, and telophase-I, - II, as well as one or two additional microspores. These abnormalities reduce the fertility of their pollen grains and limit their sexual reproduction, providing a better explanation for their sterility.
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