This chapter provides an overview of the most important skin exposome factors impacting skin aging and discusses the role of exposome factors in specific skin conditions such as atopic dermatitis, and acne. It includes some suggestions on how to limit impact of the exposome on skin. Skin aging combines two processes: intrinsic aging, the normal genetic processes that occur with time, and extrinsic aging, or accelerated aging, from exposure to skin exposome factors. The chapter focuses on exposome factors directly implicated in skin aging: exposure to solar radiation, air pollution, and tobacco smoking. The skin is directly affected by climate change, such as fluctuating humidity and temperature, and changes in the amount and type of irradiation. Climate change is expected to increase the impact of solar rays resulting in accelerated photoaging and increased incidences of certain skin cancers. A daily cosmetic skin care routine can help correct and prevent the negative effects of exposome exposure.