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Mathematical Evaluation of Covid Vaccination Safety and Efficacy
Preprints and early-stage research may not have been peer reviewed yet.
Abstract
In a given country, we have the set of alive people and the subset of vaccinated people. During a period of 4 weeks, some people that are Covid-19 positive died. Thus, we have another set of Covid-19 positive dead persons that has as its subset Covid-19 positive dead vaccinated persons. We will compare the statistical number of Covid-19 positive dead vaccinated persons with the proportional number of Covid-19 positive dead vaccinated persons, valid in case the vaccines do not affect health. The proportional number must be always bigger than the number of Covid-19 positive dead vaccinated persons provided by official statistical data. In this case, covid vaccines are safe and efficient in saving human lives.
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Human The COVID-19 pandemic necessitated the rapid production of vaccines aimed at the production of neutralizing antibodies against the COVID-19 spike protein required for the corona virus binding to target cells. The best well-known vaccines have utilized either mRNA or an adenovirus vector to direct human cells to produce the spike protein against which the body produces mostly neutralizing antibodies. However, recent reports have raised some skepticism as to the biologic actions of the spike protein and the types of antibodies produced. One paper reported that certain antibodies in the blood of infected patients appear to change the shape of the spike protein so as to make it more likely to bind to cells, while other papers showed that the spike protein by itself (without being part of the corona virus) can damage endothelial cells and disrupt the blood-brain barrier. These findings may be even more relevant to the pathogenesis of long-COVID syndrome that may affect as many as 50% of those infected with SARS-CoV-2. In COVID-19, a response to oxidative stress is required by increasing anti-oxidant enzymes. In this regard, it is known that polyphenols are natural anti-oxidants with multiple health effects. Hence, there are even more reasons to intervene with the use of anti-oxidant compounds, such as luteolin, in addition to available vaccines and anti-inflammatory drugs to prevent the harmful actions of the spike protein.
SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2
- Y Lei
- J Zhang
Lei Y, Zhang J, et al. SARS-CoV-2 Spike Protein Impairs Endothelial Function via
Downregulation of ACE 2. Circ Res. 2021;128:1323-1326.
Comparing SARS-CoV-2 natural immunity to vaccine-induced immunity: reinfections versus breakthrough infections
- S Sivan Gazid
- R Shlezinger
Sivan Gazid S, Shlezinger R, et al. Comparing SARS-CoV-2 natural immunity to
vaccine-induced immunity: reinfections versus breakthrough infections, August 25,
2021 https://www.medrxiv.org/content/10.1101/2021.08.24.21262415v1.full.pdf