Wound Healing Efficacy of Honey, Aloe Vera, And Turmeric

Abstract

Skin naturally acts as a body's protective layer and external environmental factors that can harm internal body organs are protected by it.So, maintaining skin integrity is vital for normal
physiological functioning.In our daily lives, the bodies of both animals and humans are subjected to various forms of violence, some of which are severe enough to destroy the skin's continuity.A
wound is a breakdown in the continuity of the skin. When the skin's continuity is disrupted, the
body's interior organs are exposed.There's a risk of death in this case.There's a risk of death in
this case. The skin's immediate response to a wound is the 􀃯rst step in the healing process, which begins automatically after the injury has been in􀃰icted.It is possible to speed up this process in a variety of ways, including keeping the wound free of bacterial infection, moisture, and dirt.A number of antiseptic dressings are available for this purpose, and when applied topically,they help to speed up the healing process of wounds.They protect the wound from
contamination by microorganisms and speed up the healing process.Among these are Aloe
vera, honey, and turmeric, all of which have considerable wound healing capabilities.Turmeric,
honey, and Aloe vera are all considered good for promoting wound healing.They are involved in
the prevention of platelet aggregation, myocardial infarction, tumour formation, in􀃰ammatory
cytokine release, oxidative stress, and metastasis.Several studies have demonstrated that they
play a critical function in the promotion of wound healing. Their use for wound dressing has
proven to be a successful method. The primary goal of this review is to summarise previous
scientists' 􀃯ndings with authentic concluding verse for the use of Aloe vera,Turmeric and Honey
that are safe, readily available, and less expensive.

Full text

DOI: https://doi.org/10.54393/pbmj.v4i2.141
A R T I C L E I N F O A B S T R A C T
Key Words:
Aloe vera, honey, turmeric, phytomedicine,
wounds, and healing
Skin naturally acts as a body's protective layer and external environmental factors that can harm
internal body organs are protected by it.So, maintaining skin integrity is vital for normal
physiological functioning.In our daily lives, the bodies of both animals and humans are subjected
to various forms of violence, some of which are severe enough to destroy the skin's continuity.A
wound is a breakdown in the continuity of the skin. When the skin's continuity is disrupted, the
body's interior organs are exposed.There's a risk of death in this case.There's a risk of death in
this case. The skin's immediate response to a wound is the rst step in the healing process,
which begins automatically after the injury has been inicted.It is possible to speed up this
process in a variety of ways, including keeping the wound free of bacterial infection, moisture,
and dirt.A number of antiseptic dressings are available for this purpose, and when applied
topically,they help to speed up the healing process of wounds.They protect the wound from
contamination by microorganisms and speed up the healing process.Among these are Aloe
vera, honey, and turmeric, all of which have considerable wound healing capabilities.Turmeric,
honey, and Aloe vera are all considered good for promoting wound healing.They are involved in
the prevention of platelet aggregation, myocardial infarction, tumour formation, inammatory
cytokine release, oxidative stress, and metastasis.Several studies have demonstrated that they
play a critical function in the promotion of wound healing. Their use for wound dressing has
proven to be a successful method. The primary goal of this review is to summarise previous
scientists' ndings with authentic concluding verse for the use of Aloe vera,Turmeric and Honey
that are safe, readily available, and less expensive.
An external or internal insult can cause a wound. External
assaults such as mechanical trauma, thermal, UV, or gamma
radiation therapy produce many acute wounds. Inadequate
circulation deprives tissues of nutrients and elevates pro-
inammatory cytokines, resulting in necrosis in chronic
injuries (leg, pressure ulcers, and diabetic). Wound curing is
tr aditiona lly sep arated i nto 4 phases : hem ost asis,
inammation, proliferation, and remodeling. The above
steps overlap a lot During the inammatory phase, waste [2].
and germs are eliminated from the injury. In the proliferation
phase, blood vascular invasion, connective tissue, and
epithelial regeneration wound contraction, and wound
*Corresponding Author:
Muhammad Jamil
PARC Arid Zone Research Centre, Dera Ismail
Khan-29050-Pakistan
jamilmatrah@gmail.com
1PARC Arid Zone Research Centre, Dera Ismail Khan-29050-Pakistan
2Department of Clinical Sciences, Sub Campus Jhang, University of veterinary and Animal Sciences, Lahore, 54000, Pakistan
3Department of Plant Protection,University of Agriculture, Peshawar-25130-Pakistan
4Sardar Bahadur Khan Womenn,s University Quetta-87300-Pakistan
5PARC Adaptive Research Cum Demonstration Institute Miranshah- 21776 -Pakistan
6PARC Adaptive Research Cum Demonstration Institute Wana- 21776 –Pakistan
7Faculty of Veterinary and Animal Sciences, Gomal University, Dera Ismail Khan-29050-Pakistan
8Animal science Institute, National Agricultural Research Center, -Islamabad- 54000-Pakistan
9Institute of Food and Nutritional Sciences, Pir Mehr Ali Shah Arid Agriculture University Rawalpindi
* jamilmatrah@gmail.com
Reciew Article
Wound Healing Efcacy of Honey, Aloe Vera, And Turmeric
PAKISTAN BIOMEDICAL JOURNAL
https://www.pakistanbmj.com/journal/index.php/pbmj/index
Volume 4, Issue 2 (Jul-Dec 2021)
Wound Healing Ecacy Of Honey, Aloe Vera, And Turmeric
I N T R O D U C T I O N
Jamil et al.
1 2 3 4 5 6
Muhammad Jamil , Muhammad Kashif ,Bashir Ahmad ,Bibi Sadia ,Imtiaz Khan ,Imran Qazi , Muhammad Fahimullah
7 8 8 9
Khan ,Mubarik Ali ,Muhammad Rasheed , Muhammad Rehan Arif
How to Cite:
Jamil, M., Kashif, M. ., Ahmad, B. ., Sadia, B. .,
Khan, I. ., Qazi, I. ., Khan, M. F. ., Ali, M. ., Rasheed,
M. . , & Ari f, M. R. . ( 2021). Woun d He aling
E  c a c y o f H o n e y , A l o e V e r a , A N D
TURMERIC. Pakistan BioMedical Journal, 4(2).
https://doi.org/10.54393/pbmj.v4i2.141
PBMJ VOL.4 Issue 2 Jul-Dec 2021

healing occur. Apoptosis is used to remove superuous
tissue during the rebuilding period Infection, aging, and [3].
deprived circulation are thought to slow healing. Wound care
involves removing the harmful insult rst, then providing the
best possible environment for wound healing. Controlling a
wound's bacterial burden is critical to promoting healing.
Bacterial counts of over 105 organisms per gram of wound
tissue have been shown to impair wound healing in surgical
and chronic wounds Many topical treatments with [4,5].
diverse qualities are now used to promote wound healing.
Surprisingly, most of these products lack convincing
evidence to support their usage To help clinicians [6-9].
better understand the complexities of clinical use of
medical-grade honey, Aloe Vera and turmeric, evidence
indicators like Cochrane reviews can be used to evaluate the
lack of evidence to support their use, as well as select
clinical entities in patients who may benet from treatment
with these therapeutic agents based on their clinical
outcomes. All of these medicinal therapies' biochemical
pr operties, their independent wound healing, and
bacterial/inammatory processes will also be discussed.
HONEY: Honey is gaining popularity in wound care,
especially for burn wounds. Honey has been utilized for
nourishment and healing since prehistoric times [6].
Between 2600 and 2200 BCE, ancient Egyptians used honey
to treat wounds Although the actual mechanism for [6].
honey's wound healing benets is uncertain, research has
concentrated on honey's antimicrobial properties.Honey's
high sugar content makes it hygroscopic, which prevents
the development of microorganisms. Honey's antimicrobial
qualities are complex than merely greater sugar content,
according to research In addition to its antibacterial [10].
qualities, oxidation of glucose to hydrogen peroxide occurs
naturally in honey. And the antimicrobial effects of [6,11,12]
honey seem to vary by oral source. Hydrogen peroxide was
not necessary for the antibacterial properties of manuka
and v iper 's bug loss h oney The an tibacter ial [13].
characteristics of honey are thought to be due to an
unknown component Manuka honey also inhibits [14].
vancomyc in- res ist ant ente rococcus, MRSA, and P.
ae rugin osa speci es In a study, u lmo honey [15,1 6]
outperformed manuka honey against MRSA Finally, [17].
honey had antifungal action Honey increased wound [14,18].
healing in animals, according to histological research.
Histologically, honey reduced edoema, inammation,
necrosis, improved epithelialization, and wound contraction
in rabbits. Honey also increased wound healing on [19]
cutaneous wounds in mice Human studies found that [20]
honey-treated wounds promoted granulation tissue [21,22]
formation, enhanced epithelialization, and [21-24] [21,22]
decreased inammation This was in line with the [22,25].
PBMJ VOL.4 Issue 2 Jul-Dec 2021
earlier animal study data, but clinical observation without
histological proof is limited.
ACUTE WOUNDS : Although medical-grade honey has been
shown to speed up healing in animal trials, human outcomes
have been mixed. Three small randomized single-blind [27-
29] and one small randomized nonblinded controlled trial
[30] showed thathoney may safeguard cancer patients from
radiation-induced mucositis. Using honey and hydrogel
dressings to treat abrasions and minor lacerations were
shown to not affect on healing time in a blind, randomized
study An unblinded study found no difference in [31]. [32]
average healing times between paran gauze, honey, and
iodoform gauze for patients who had toenail avulsions.
Analysis of these 3 studies found no statistical difference
between honey and standard treatment in mild acute
wounds Compared to traditional dressings like silver [6].
sulfadiazine dressing and clear polyurethane lm [25,34-36]
dressing, using honey on minor burns (supercial to partial-
thickness burns) speeds up healing time Honey also [23].
outperformed unconventional treatments like potato peels
[37] [38]. and amniotic membrane Because of the lack of a
description of randomization, the validity of these studies
has bee n calle d into d oubt Meta-ana lys es [6,39].
demonstrated that honey quickened minor burn healing
relative to t he comparator A randomized [6,39,40].
controlled experiment found that early excision beat honey
dressing in mild burns However, the study's strength is [41].
qu es ti on ed du e t o t he lac k o f c la ri ty reg ar di ng
randomization. When selecting burn wound coverings,
clinicians must assess the evidence.
CHRONIC WOUNDS: As previously indicated, many chronic
wounds result from circulation issues. Because topical
medications do not effectively ad dress the primary
circulatory impairment, many currently utilized products
have limited evidence to support their use. Honey was used
to treat venous leg ulcers in two randomized open-label
trials. At 12 weeks, the honey-impregnated dressing did not
affect venous leg ulcers compared to standard dressing
[42]. Both groups used compression. Another study
compared honey dressing to hydrogel in soggy intravenous
ulcers. At 80 days, honey had a slightly higher healing rate
(44%) than hydrogel (33 percent). Both studies reported the
r an d om iz a ti o n a pp ro ac h. B as ed o n t he se t wo
investigations, a meta-analysis indicated that honey and
traditional dressing treat venous leg ulcers equally well A [6].
low-quality randomized controlled experiment indicated
that honey dressing accelerated recovery in Stage I and II
strain ulcers. Another low-quality study indicated honey to
hasten the healing of stage II or III pressure ulcers. The honey
plaster was observed to be equally effective as iodine
treatment in Wagner type II diabetic foot ulcers. None of the
M E T H O D S
DOI: https://doi.org/10.54393/pbmj.v4i2.141
Wound Healing Ecacy Of Honey, Aloe Vera, And Turmeric
Jamil et al.

preceding cited research revealed their randomization
process, raising concerns about their validity.
ALOE VERA PHARMACOLOGY: Wound healing is aided by a
perennial green herb from the Liliaceae family, Aloe vera,
which is the most effective. Located at the top of the stem,
the thick and juicy leaves form clusters. Slightly toothed
lanceolate leaves cover the plant. Red, yellow, or speckled
with red are the colors of the owers. A versatile crop, it is
currently farmed all over the world These include [43,44].
cancer prevention, antioxidation, anti-bacteria, and lipid-
lowering. Antihypertensive. Antioxidant. Antibacterial. Anti-
inammatory. Antiulcer. Antiviral. These are only a few
examples It is also frequently used in the treatment [45–47].
of wounds, burns, ulcers, tumors, constipation, dental
diculties, metabolic syndrome, AIDS, herpes, diabetes,
and psoriasis. For its cosmetic properties, it is utilized in
cosmetics and skincare products, as well as in the food
business, to make health drinks As a medicinal [48–50].
herb, A. vera's leaves are the most commonly utilized portion
of the plant. Syne rgistic effect s of mor e th an 2 00
physiologically active compounds, including carbohydrates,
anthraquinones, and chromones and avones, and alkaloids
as well as amino acids and lipids have been proven to be
responsible for numerous pharmacological activities
[51 ,5 2] . T hr ee se ct ion s m ake up th e A lo e l ea f.
Photosynthesis occurs in the green leaf epidermis, which is
the outermost layer. Phloem and xylem make up the layer's
structure. The xylem transports water, whereas the phloem
transports carbohydrates and other tiny organic materials,
such as cellulose. Leaf epidermis pericyclic cells secrete the
reddish-yellow latex in the center of the structure. As a
laxative, latex can be applied to the skin. Chrysophanol,
emodin, and anthraquinone make up the bulk of the active
component list Tubular cells in the parenchyma [53–55].
form a clear and smooth gel at the heart of the Aloe leaf. Skin
wounds can be treated with gel. With a water concentration
of 98%, polysaccharides are the primary active ingredient in
this formula. In addition, organic acids, vitamins, and
minerals abound in gels [56–58].
ALOE VERA AND SKIN WOUND HEALING: Acne vera is a
mature medicinal plant for treating skin sores. Aloe gel and
Aloe extract can be used for wound healing in the same way
[59,60]. Glucomannan and acetylated polymannan are two
examples of polysaccharides that are essential for wound
healing. Aloin, rhein, emodin, and aloesin are also important.
These compositions have antibacterial, antioxidant,
immunomodulatory, and anti-inammatory effects [61–63].
Wound healing is facilitated by these qualities. Different
growth factors i.e., FGF, epidermal, TGF, VEGF, and
interleukin (IL), inuence cell signaling and ECM activity
during wound healing (IGF). The migration and proliferation
PBMJ VOL.4 Issue 2 Jul-Dec 2021
of epithelial, endothelial, and broblast cells are all
inuenced by basic FGF (bFGF). TGF-b1 inhibits degradation
of the extracellular matrix (ECM), regulates broblast
spread, and stimulates the formation of elastin, collagen,
and bronectin (collagen-like proteins). A. vera's enhanced
synthesis of bFGF and TGF-b promotes collagen deposition,
broblast proliferation, and angiogenesis It is [64,65].
believed that IL-1b, an anti-inammatory cytokine abundant
in phagocytes, epithelial cells, and vascular endothelial
cells, is responsible for activating T lymphocytes. The anti-
inammatory action of A. vera is due to the reduction of
proinammatory cytokines such as IL-1b For example, [66].
the inammatory period can be signicantly shortened and
malondialdehyde, tumor necrosis factors (TNF-A) levels are
reduced. glucose transporter 1, IGF-1, VEGF, and FGF-2 can
also be considerably increased, which promotes cell
production, collagen production, and angiogenesis The [67].
anti-inammatory and immunomodulatory properties of
aloe polysaccharides found in A. vera make them ideal for
wound healing. Glucomannan, acetylated poly-mannan, and
acemannan are anti-inammatory polysaccharides that
lower MMP-9, IL-10, and IL-05 Aloe polyose impacts [68].
granulation tissue development and wound healing by
enhancing glycosaminoglycan and collagen synthesis [69].
The AKT/mTOR signaling pathway enhances the synthesis of
cycl in D1, which not only stimulates skin broblast
proliferation but also shifts the cell cycle from the G1 to the S
phase. Increased VEGF and type I collagen synthesis are two
mechanisms through which Acemannan enhances wound
healing M6 P is an aloe pol yose involved in [70–72].
epithelialization. Adiponectin promotes collagen deposition
and skin regeneration via binding to mannose-6-phosphate
receptors. It also inhibits TGF-1 and TGF-2 activation,
reducing brosis and encouraging epithelialization [73,74].
Anthraquinone also helps protect the skin and cure wounds.
The ability to heal wounds and promote angiogenic growth.
Anthraquinone is an antibacterial agent that inhibits the
dehydrogenation and oxidation of bacterium sugars and
metabolic intercedes, as well as the production of protein
and nucleic acid. Aloin can improve wound healing by
increasing angiogenesis and broblast proliferation via
increasing EGF expression. Aloin also makes the skin's
collagen bers more regular after healing, minimizing
scarring A-loin also protects the skin by decreasing [75,76].
lipid peroxidation and reactive oxygen species while
enhancing SOD and glutathione peroxidase activity [77,78].
Aloin reduces IL-6, TNF-a, iNOS, and cyclooxygenase-2
express ion i n resp onse to LPS (COX-2). Aloin a lso
suppresses caspase-3 activation and apoptosis generated
by LPS. Aloin reduces inammation by decreasing NF-
kappaB signaling Aloe-emodin can aid wound [79,80].
M E T H O D S
DOI: https://doi.org/10.54393/pbmj.v4i2.141
Wound Healing Ecacy Of Honey, Aloe Vera, And Turmeric
Jamil et al.

healing by increasing cutaneous vascular-related growth
fa ctor expr ession. A loe -emo din i s a pote nt a nti-
inammatory. It reduces inammation by inhibiting iNOS
and COX-2 ex pression. Allergic to Rhein? It [48,81]
inuences cell cycle and death via MAPK and PI3K-AKT
signaling pathways Other compounds in A. vera aid in [82].
wound healing. 5.5 kDa glycoprotein has been demonstrated
to enhance keratinocyte proliferation and epidermal tissue
formation in vitro and in vivo. This glycoprotein improved
wound healing in bald mice b-Sitosterol enhances [83].
injury healing and angiogenesis by boosting VEGF and its
receptor gene expression It also possesses anti-[84].
inammatory properties, inhibiting TNF-a, LPS-induced
keratinocytes, peptidoglycan, and macrophages from
secreting inammatory factors, and inhibiting caspase-1
activation Alo esin promote s wound curing by [85].
activating Smad and MAPK/Rho signaling pathways. It
promotes cell motility by phosphorylating Cdc42 and Rac1
and modulates growth factors and cytokine release in
macrophages. Aloesin promotes collagen deposition,
angiogenesis, and granulation tissue development in
hairless mice The vitamins in A. vera help heal wounds. [86].
Vitamin E is a strong antioxidant that can reduce ROS
damage. It also modulates transcription and expression of
the gene to protect wounds agai nst infec tions like
methicillin-resistant Staphylococcus aureus. Vitamin C
enhances collagen formation by hydroxylatingproline and
lysine resid ues i n proc oll agen. I ts a bil ity to boost
immunological activity is also vital in wound healing [87,88].
TURMERIC: Curcuma odora is the common name for this
plant. Species of curcumin are known as wild turmeric
(vanaharidra) or yellow zedoary (Salisb) (Curcuma longa
Linn.). The plant is indigenous to India, where it is commonly
grown in Kerala and West Bengal It is both an aromatic [89].
medicinal cosmetic as well as a potential therapeutic drug.
Traditional Chinese medicine uses Curcuma aromatic (CA)
as a powerful anti-cancer herb. Uses in traditional medicine
include treating skin conditions, sprains, bruises, snake
venom, and enhancing the appearance of skin. The Chemical
and aroma attributes of the volatile oil are different from
Curcuma long it's (4-8%) volatile oil. CA's volatile oil includes
camphene, camphor, and high-boiling alcohol that C. longa
does not [90].
CHEMICA L COMPOSITIO N :
curcumin), d-camphor, germacrene D, p-methoxycinnamic
acid, curzerene, , and pinenes, germacrone, bborneol, ,
and Terpeniol, -Terpenolene, Myrcene, and -Thujonene,
limonine, -thujone, , and Copoaenes and -Bisabolene
are also present. A total of eighteen different compounds
were detected in the oil: alpha and beta-pinene, isofurano-
germacrene, 1,8-cineol, borneol, and its isoforms, -
PBMJ VOL.4 Issue 2 Jul-Dec 2021
curcumene, -curcumene, germacrone, xanthorrhizol, and
curzerenone.
MEDIC INAL IMPO RTAN CE: Skin, cardiovascular, and
respiratory system ailments are among the conditions for
which the medication is prescribed in Ayurveda. There are
many uses for CA in cosmetics and traditional medicine,
including as an anti-inammatory agent, a stimulant of
blood ow, and an anti-cancer agent. It is common to utilize
rhizomes with astr ingent and fragrant herbs in the
treatment of a variety of ailments, such as bruising and skin
eruptions. There are many uses for CA rhizomes, including in
snake poison. Home remedies for headaches include a paste
of CA rhizomes Carbamazepine (CA) is conventionally [91].
used as an anti-provocative medication. According to
several research, Wild turmeric has immunological, anti-
tumor, anti-inammator y, wound healing, antifungal,
antioxidant, anti -microbia l, antiplatelet, and insect
repellent properties. Preventing coronary heart disease,
treating epilepsy, acting as an anti-allergy, and treating
auto-immune disease are all uses of CA. In the therapy of
cholecystitis, biliary calculi, and other related illnesses
extracts of CA roots are used. In mice with Ehrlich ascites
tumor cells, ethanol extract had powerful anti-angiogenic
and pro-apoptotic actions. Anti-proliferative activity
against human cancer cells was established by methanol
extracts of CA. An in vitro estrogenic effect was also seen.
Rhizomes produce 6.1 percent essential oil and have been
shown to have anti-tumor properties. Rhizomes. Cervical
cancer in its early stages can also be treated with oil. An in
vivo inhibitory impact of volatile oil on hepatocellular growth
was observed in mice. In vitro antihelmintic action was also
demonstrated using essential oil Curcumin's anti-[92].
inammatory properties, the anti-diabetic effects of
( 4S , 5S ) –( + )– ge r ma cr o ne –4 , 5– ep o xi d e, a nd th e
antiarrhythmic properties of aqueous extract due to the
presence of dipotassium magnesium dioxalatedihydrate are
just some of the other activities that have been linked to
essential oils. The oil and the methanol extract have
powerful radical-scavenging properties. – In addition, the
extracts showed impressive superoxide radical scavenging
properties. A number of the curcuminoids in CA have been
shown to have antibacterial, antifungal, antioxidant, and
antitumor properties In the following part, we'll go into [91].
more detail about each of these. Mice tested the anti-
inammatory effects of aqueous and alcoholic extracts. In
arachidonic acid-induced ear inammations, the ethanol
extracts and formulations showed considerable anti-
inammatory action. The anti-inammatory activity was
attributed to the impacts on various mediators and
arachidonic acid metabolism including the cyclo-oxygenase
pathway An investigation of the volatile oil from [93].
M E T H O D S
DOI: https://doi.org/10.54393/pbmj.v4i2.141
Wound Healing Ecacy Of Honey, Aloe Vera, And Turmeric
Jamil et al.

Ca lifornia's anti-inammato ry properties was also
conducted. In rabbits, the powdered rhizome of CA was
found to have wound-healing properties. Studies using
excision wound models, which were used to evaluate the
wound healing activity of topical application of CA rhizome
extracts and its cream formulations likewise revealed [93],
considerable wound healing activity. A key bioactive
component of CA, Germacrone has been shown to have anti-
tumor activities. CA's most essential bioactive component is
this. An investigation into the anti-proliferative and
molecular mechanisms of germacrone's cytotoxicity on
glioma cells found that germacrone inhibits the proliferation
of cancerous cells by causing apoptosis and cell cycle arrest
in the cells. By regulating the expression of proteins
associated with apoptosis and G1 cell cycle arrest,
Germacone may be an effective and new chemopreventive
treatment for gliomas Researchers also looked at the [94].
anti-t umor properties of beta -elemen e, which was
extracted from the roots of agave plants in California. Two
tumor inhibitory tests on hepatoma in mice were carried out
as part of the study to investigate the inhibitory effects of
Curcuma aromatic oil (CAO) on hepatoma in mice's cell
proliferation. Proliferating cell nuclear antigen (PCNA)
immunohistochemical labeling was utilized to assess the
effects of CAO on hepatocarcinoma proliferation in mice
(PCNA). In two experiments, the tumor inhibitory rates of
CAO were 52 percent and 51 percent, respectively, as a result
of the consequent tumor inhibitory rates. Both variations
were statistically substantial (P 0.01) when compared to the
results of the saline-treated control groups. The [95].
researchers concluded that CAO's prevention of hepatoma
growth in mice may be connected with its suppression of
cellular proliferative activity.
PBMJ VOL.4 Issue 2 Jul-Dec 2021
C O N C L U S I O N
When it comes to healing skin wounds, there is a wide range
of medicinal plants and natural therapies that are used.
These have been utilized for centuries to treat trauma,
infection, disease, and damage. For millennia, humans have
mastered the art of harvesting and preparing edible and
medicinal plant materials from their local surroundings.
Medicinal practices have been examined for clinical ecacy
and economic viability based on their bioactivities. As a
result, not all the mechanisms of action of each plant have
been established.For the most part, we believe that
traditions still have a lot to offer us, including the potential
for developing novel drugs and treatments for today's
therapeutic challenges. There is no escaping the fact that
modern medicine and pharmaceuticals remain out of the
reach of most people. Traditional medicine is often the
primary and only therapy choice for many people because of
this. Traditional ways will become more widely accepted and
appreciated as people grow more familiar with them. This
information should not be rejected by "modern medicine,"
but rather put to good use for the benet of humanity. There
are no adverse effects associated with using Aloe vera,
tur meric, and h oney to c ure wounds. Healing a nd
regeneration of lost tissues are facilitated by numerous
processes in these herbal creams. However, these herbal
ointments must be evaluated scientically, standardised,
and evaluated for safety. Aloe vera's high tonicity and acidic
pH are thought to be the major elements that speed up
wound healing in earlier studies, which found that wounds
treated with Aloe vera healed quickly. The wound healing
process may be accelerated by Turmeric, Honey and aloe
vera's ability to boost glycolytic enzyme activity and provide
enough energy for cell repair. To treat wounds, Turmeric,
Honey and Aloe vera can be a cost-effective option that is
safe, readily available, and has powerful healing properties.
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