Jackfruit is considered as the largest edible fruit in the world and found to contain large quantities of nutrients, such as carbohydrates, proteins, vitamins, minerals, and phytochemicals. Both the fruits and the seeds of jackfruit have been consumed widely. Most importantly, several countries have developed food products namely jam, jellies, marmalades, and ice creams using jackfruit. In addition, several parts of jack tree such as, latex, leaves, and barks have been extensively used in traditional medicine as well. Studies by various research groups documented the anticarcinogenic, antimicrobial, antifungal, antiinflammatory, wound healing, and hypoglycemic effects along with digestive and immunological benefits of jackfruit. Therefore, this book chapter intends to disseminate the evidence on nutritional, digestive, and immunological benefits of jackfruit/seeds to promote its utilization for commercial scale food production.