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DISSOLUTION PROFILE OF METRONIDAZOLE TABLET IN DIVERSE FATTY DISSOLUTION MEDIUMS.
... [5] Metronidazole indication FDA-approved MTZ for the treatment of a broad range of infections such as intestinal amebiases, liver amebiasis, bacterial septicemia, bone and joint infections, central nervous system (CNS) infections (meningitis and brain abscess), endocarditis, gynecologic infections (endometritis, tuboovarian abscess, bacterial vaginosis), intra-abdominal infections, lower respiratory tract infections, skin structure infections, and surgical prophylaxis surgeries. [7] Mechanism of action Metronidazole diffuses into the organism, inhibits protein synthesis by interacting with DNA and causing a loss of helical DNA structure and strand breakage. Therefore, it causes cell death in susceptible organisms. ...
In recent years the growing interest in drug stability problems has been observed. However, the studies that reported on the stability of drugs past their expiration dates were limited. If analysis of tablet stability is considered, the most important ones are content determination and dissolution test. The objective of the current study was to examine the Percent of drug release for both expired and valid Metronidazole tablets through a dissolution test. According to IP the valid drug has an acceptable dissolution rate and excepted good bioavailability. In contrast, the expired Metronidazole tablet listed 71% percent of drug release as the highest rate at 30 min. This study suggested that the expired tablet is not equivalent to or similar to a valid tablet and recommended using the valid one to give the therapeutic effect.
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