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Chouhan et al., IJPSR, 2021; Vol. 12(7): 3632-3642. E-ISSN: 0975-8232; P-ISSN: 2320-5148
International Journal of Pharmaceutical Sciences and Research 3632
IJPSR (2021), Volume 12, Issue 7 (Review Article)
Received on 18 May 2021; received in revised form, 11 June 2021; accepted, 12 June 2021; published 01 July 2021
MEDICINAL PROPERTIES OF RICINUS COMMUNIS: A REVIEW
Hitendra Singh Chouhan, Gayatri Swarnakar * and Babita Jogpal
Department of Zoology, Government P. G. Meera Girls College, Mohan Lal Sukhadia University, Udaipur
- 313001, Rajasthan, India.
ABSTRACT: The medicinal plant Ricinus communis is one of the
effective plants which offer a solution to several kinds of diseases.
Owing to this, the present research aims to review the medicinal
properties of one of such common herbal plants, Ricinus communis, its
possible role as herbal medicine, and assessment for pharma-
covigilance. Related research articles were collected from Google
Scholar, Pub Med, Science direct, Scientific information Database,
and Scopus. For the present study purpose, using the term Ricinus
communis, the castor bean, and castor oil plant in the title of all
articles published to 2021 were observed. Phytochemical constituents
of R. communis like saponins, flavonoids, alkaloids, steroids, and
glucosides. Leaves of the plant have shown the presence of major
phenolic compounds. Whereas roots test has presented the Indole-3-
acetic. The findings reflect that the plant contains high medicinal
benefits, which offer a solution for several kinds of diseases like
cancer, diabetes, ulcer and anthelmintic, etc. Also, the plant is anti-
inflammatory property of the plant facilitates therapeutic use.
Therefore, all parts of the medicinal plant R. communis are considered
highly beneficial in the medicinal field.
INTRODUCTION: Herbal plants have always
been a viable source of medicine since prehistoric
ages. Some of the isolated rural areas of developing
and underdeveloped countries are still unable to get
synthetic drugs easily. Traditional medicinal plants
being easily available are used by many people to
treat numerous illnesses. In India, 65-70% of the
rural population rely on medicinal plants in the
form of various indigenous ethnic systems like
Ayurveda, Siddha, Unani, etc.
QUICK RESPONSE CODE
DOI:
10.13040/IJPSR.0975-8232.12(7).3632-42
This article can be accessed online on
www.ijpsr.com
DOI link: http://dx.doi.org/10.13040/IJPSR.0975-8232.12(7).3632-42
Not only in India, but the margin of herbal
medicine utilization has become quite fascinating
worldwide. The estimated global herbal market was
63.05 billion US$ in 2014, which became 71.9
billion US$ in 2016 1. Herbal components are
considered more effective and less risky than
conventional chemical derivatives. Still, the
absolute absence of any adverse effect might not be
possible 2.
Countless no. of plants have been reported for their
medicinal effects. Current research work aims to
consolidate the medicinal properties of one of such
common herbal plants Ricinus communis, its
possible role as herbal medicine, and assessment
for pharmaco-vigilance. Ricinus communisis an
evergreen, fast-growing small tree (shrub)
belonging to the Euphorbiaceous family. The genus
Keywords:
Medicinal plant, Medicinal properties,
Phytochemical constituents, Ricinus
communis
Correspondence to Author:
Dr. Gayatri Swarnakar
Associate Professor,
Department of Zoology,
Government P. G. Meera Girls
College, Mohan Lal Sukhadia
University, Udaipur - 313001,
Rajasthan, India.
E-mail: gswarn9@yahoo.co.in
Chouhan et al., IJPSR, 2021; Vol. 12(7): 3632-3642. E-ISSN: 0975-8232; P-ISSN: 2320-5148
International Journal of Pharmaceutical Sciences and Research 3633
Ricinus L. is comprised of sole type species i.e., R.
communis. It is included in the subfamily
Acalyphoideae which consists of approx 99 genera
and 1865 species 3. The pharmacological property
of the plant is very high 4; thus, it was decided to
review some of its major medicinal properties in
this article.
Methods: The present review was conducted in
2021 by reviewing from international and national
search web sides of Google Scholar, Pub Med and
Science Direct, scientific information database, and
Scopus and collected all full-text research papers
published in English language medicinal properties
of Ricinus communis. The medicinal plant Ricinus
communis was collected from Udaipur (Rajasthan).
The plant was identified and authenticated by Dr.
Asha Arora, Associate Professor, Department of
Botany, Bhupal Nobels' University, Udaipur
(Rajasthan). The herbarium sheet was prepared and
deposited in the department for future reference
Fig. A, B, C, and D.
RESULTS:
Morphology: Ricinus communis is a perennial
soft-wooded shrub that can attain a height of about
1-5 m and has remarkable lateral roots and sturdy
tap roots. Leaves of the shrub are spirally arranged,
green in color or acquire dark green color when
getting older, 1-3 cm long united stipules to a
sheathing bud that are deciduous.
FIG. 1: MEDICINAL PLANT RICINUS COMMUNIS A - PLANT (WHOLE), B - LEAF, C - FRUIT, AND D- ROOT
Classification of Ricinus Communis:
Kingdom:
Plantae
Phylum:
Spermatophyta
Subphylum:
Angiospermae
Class:
Dicotyledonae:
Order:
Euphorbiales
Family:
Euphorbiaceae
Genus:
Ricinus
Species:
communis
Distribution: The species is drought resistant, very
well adaptable to diverse climatic conditions,
highly prolific, and hence widely distributed
throughout tropics and warm temperate areas.
Although it is considered native to northeast Africa
Chouhan et al., IJPSR, 2021; Vol. 12(7): 3632-3642. E-ISSN: 0975-8232; P-ISSN: 2320-5148
International Journal of Pharmaceutical Sciences and Research 3634
(probably Somalia), it is widely naturalized across
Asia, (sub) tropical America, and temperate
Europe. The plant is quite common in the jungles
of India and cultivated primarily for castor oil
production throughout India. There is 2 known
variety of plant one bushy perennial shrub with
large red seeds and large fruits, seeds yielding
about 40% oil; another comparatively much shorter
annual shrub having grey-white seeds with brown
spots over them which yield about 37% of oil 5.
Photochemical Constituents: The medicinal
properties of the plant are due to the presence of
key phytochemical constituents like saponins,
flavonoids, alkaloids, steroids, and glucosides.
Leaves of the plant have shown the presence of
major phenolic compounds such as monoterpenoids
(1, 8-cineole), camphor, and α sesquiterpenoid (β-
caryophyllene), gallic acid, quercetin, gentilic acid,
rutin, epicatechin, and ellagic acid. Whereas roots
test has presented the Indole-3-acetic and the
several forms of ester have been identified in the
form of palmitic, stearic, arachidic-hexadecenoic,
oleic, linoleic (3.4) ricinoleic, and dihydroxy
stearic acids through the study of castor oil.
Moreover, the α-thujone and 30-Norlupan-3β-of-
20-one are beans have been identified 6, 7.
Medicinal Properties:
Anticancer: The fruit extract of Ricinus communis
is a potent contender for the treatment of breast
cancer. Ricinus communis fruit extract has high
efficacy on estrogens-positive MCF-7 and
extremely aggressive, triple-negative breast cancer
cells (MDA-MB-231 cell line). The extract has
anti-metastatic property; it remarkably inhibits the
adhesion, invasion, migration, and expression of a
metalloproteinase from the matrix of both cell
lines. Further, the extract induces apoptosis in such
cells.
The four detected compounds of Ricinus communis
fruit extract- Ricinine, Epigallocatechin, p-
Coumaric acid, and Ricinoleic acid individually
have migration-inhibitory and cytotoxic properties
8. The Zinc oxide characterizes the anti-cancer
feature of R. Communis that has been demonstrated
by the crystalline hexagonal stage of the plant
extracts. Here, the syntheses of the nano-particles
create the high surface zone for the evaluation of
anticancer activity. In regards to this, the hexagonal
Wurtzite type of zinc oxide has been confirmed by
The HRTEM that is the core reason behind the
extensive use of the Ricinus communis against
cancer treatment. Further, the antioxidant activity
and free radical scavenging promot tehe anti-cancer
feature of the Ricinus communis 9.
Reversible Anti-fertility Property: When treated
with 50% of ethanol extracts of Ricinus communis,
male rats showed a heavy reduction in the
epididymal sperm count. There was an alteration in
the morphology, motility, and mode of motion of
sperm cells. It was suggested by the author that the
reproductive ability of rats was reduced as there
was a reduction in the fructose and testosterone
levels. This anti-fertility effect of Ricinus
communis was entirely reversible on the removal of
the drug, and it doesn't cause any hepatotoxicity as
it was found that GPT and GOT levels were
unchanged. In another study, three different seed
varieties of Ricinus communis exhibited an anti-
implantation effect on white albino mice and were
found to be potential oral contraceptives 10, 11.
Anti-diabetic: The 50% ethanol extract of roots of
Ricinus communis 500 mg per kg body weight has
shown a significant lowering of blood glucose level
both in Type 1 diabetic and normal animals. An
effective dose of root extract of Ricinus communis
also showed a favorable response on total lipid
profile, kidney, and liver functions when given for
ten to twenty days. Root extract was found to be
unharmed as there was no statistically notable
difference in serum bilirubin, alkaline phosphatase,
creatinine, serum glutamate pyruvate transaminase,
serum glutamate oxaloacetate transaminase, and no
mortality was observed.
In another study antidiabetic property of aqueous-
ethanolic and ethanolic extract of Ricinus
communis leaves on streptozotocin-induced
diabetic rats was investigated. For 14 days, diabetic
rats were given both aqueous-ethanolic and
ethanolic extracts at doses of 300
mg/kg/bodyweight & 600 mg/kg/body weight, and
good results were observed. The doses of 300
mg/kg/BW of both the extracts showed remarkable
reverse body weight loss property. The ethanol
extract at 600 mg/kg/BW significantly leads to a
reduction in blood glucose levels. Oral
administration of the extract at 600 mg/kg/BW
Chouhan et al., IJPSR, 2021; Vol. 12(7): 3632-3642. E-ISSN: 0975-8232; P-ISSN: 2320-5148
International Journal of Pharmaceutical Sciences and Research 3635
inhibited any alteration in total proteins, total
bilirubin, albumin, urea, and creatinine levels, thus
proved to be a good alternative for managing
Diabetes mellitus. The author validates the
traditional usage of Ricinus communis in treating
Diabetes in the kingdom of Saudi Arabia 12, 13.
Leishamicidial: The extracts of Ricinus communis
have significant antileishmanial properties. The
combination of Ricinus communis and Azadirachta
indica extracts has synergistic effects in the therapy
of leishmaniasis. The optimal antiparasitic efficacy
of Ricinus communis and A. indica is 59.5% and
72%, respectively, while the combination of both
mixtures has 88% efficacy. The inhibitory
concentration i.e., IC50 of Ricinus communis and A.
indica is 16.5 μgmL-1 and 11.5 μgmL-1,
respectively, while a mixture of both has IC50 of
9.0 μgmL-1. The combination treatment of both
plant extract can be used for isolation of bioactive
compounds, their fortification and bioassay-guided
fractionation, and this could serve as new medicinal
lead structures 14.
Hepatoprotective: Methanolic extracts of Ricinus
communis were studied for their hepatoprotective
role against D-galactosamine-induced acute
hepatitis in albino rats. A single intra peritoneal
dose of D-galactosamine (800 mg/kg.BW) was
given to induce hepatitis in rats. It was found that
serum markers viz, Aspartate amino transferase
(AST), Alanine amino transferase (ALT),
Malondialdehyde (MDA) and Alkaline phosphatase
(ALP) were notably increased and the effect of
antioxidant enzymes Catalase (CAT), Superoxide
dismutase (SOD), Glutathione Peroxidase (GPx),
Glutathione Reductase (GR), non-enzymatic
Glutathione (GSH) levels were reduced in the liver
of rat model.
Histopathological results also showed curative and
protective properties of Methanolic extracts of
Ricinus communis leaves against D-galactosamine
intoxication. This observation suggests that
methanolic extract of castor plant remarkably
protected the liver from hepatitis, enhance the
curative reaction in the liver and thus can be used
as a potential hepatoprotective medicine in future
15. The hepatoprotective activity of the Ricinus
communis is due to the membrane-stabilizing and
antiperoxidative effect of flavonoids that increase
the regenerative and reparative capacity of the
liver. Further, the hepatoprotective activity of
Ricinus communis is protective against the necrosis
of the liver along with the fatty changes 16.
Antioxidant: The antioxidant property of Ricinus
communis varies significantly depending upon
extraction method and plant part. Leaves and seeds
showed higher antioxidant activity than other plant
parts. Among different extracts of acetone n-
hexane, methanol, and dichloromethane (quantified
by ABST+ method), methanol solvent extract has
the highest free radical scavenging activity of about
95%, followed by acetone, dichloromethane, and n-
hexane having free radical property of 91%, 62%,
and 50% respectively 17. The stems of Ricinus
communis have flavonoids present in their extracts.
Flavanoids is beneficial against carcinogenesis as it
inhibits oxidative damage. The untargeted
metabolomic profiling and polyphenol showed the
excess of phytoconstituents such as (+) catechin
and ellagic acid, both of which are associated with
antioxidant mechanism 18, 19.
Insecticidal: The Crude methanols (Coleoptera:
Brauchidae) extract from Ricinus communis has a
notable insecticidal effect against Callosobruchus
maculatus adult. The methanol extracts of Ricinus
communis remarkably affect the survival rate of
adult insect Callosobruchus maculatus (Coleoptera:
Brauchidae) at 100%.
The relation between treatment and exposure
period is very significant, i.e., p < 0.05. The
methanol extracts have 31 active phytoconstituents,
which perform the following pharmacological
actions- Anti-inflammatory, antimicrobial,
antioxidant, analgesic, antitumor, ant-diabetic and
anti-asthmatic, antipyretic, antibacterial. The wild
species of Ricinus communis have shown
insecticidal properties due to the existence of the
flavonoids, quercetin, and kaempferol that have
been scanned in the ultraviolet region that has been
further confirmed by the HPLC, IR, and UV
spectrometry.
Here, the hydrolyzed aqueous leaves have high
shown the majority of the flavonoids; however, the
seeds of castor oils are poisonous for people,
mammals, and insects due to the presence of the
toxic proteins.
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International Journal of Pharmaceutical Sciences and Research 3636
The chemical treatment of the extracts of the
Ricinus communis plant parts for the medicinal
properties under consideration to the philosophy of
medical science. In regards to this, flavonoids are
the major components of the Ricinus communis that
supported the exerting of toxic effects against the
insects and reported the biogenesis response of the
Ricinus communis plants 20, 21.
Acaricidal: Acaricidal properties of Ricinus
communis leaf extracts along with other medicinal
plants were tested against Rhipicephalus
decoloratus and Rhipicephalus pulchelus for the
eco-friendly herbal control of ticks. It was
concluded that with an increase in exposure time,
more and more ticks were killed. At this juncture,
the cardiac activity of the Ricinus communis is
promoting sustainable development for the
immunological and biological control of vector and
vector-borne disease that create the threat for the
manufacturing of the leather; the Ricinus communis
has shown the presence of the quercetin, Gallic
acid, flo-von and kaempferol which have been
evaluated to have synergetic acardinal action 22, 23.
Lipolytic Activity: The lipolytic activity of ricin
from Ricinus sanguineous and Ricinus communis
was conducted on neutral lipids. Lipolytic activity
experimented on various subtracts such as-analog
of triacylglycerol BAL-TC-4, chromogenic subtract
p-NP esters of aliphatic chain acids, and pure
natural diacylglycerol in the membrane-like model.
The study concluded that Ricinus communis act as
lipase that has the capabilities for the hydrolyzing
of several lipid classes. The maximum lipolytic
activity was shown at pH 7.0 in the presence of the
0.2 M galactose at the surface of the leaves. And
also, the lipolytic step might be involved in the
poisoning of the cell by ricin 24.
Anthelmintic: Helminthiasis is a major prevalent
worm disease in the world due to poor management
practices. The anthelmintic activity of Ricinus
communis leaves was observed by using a different
type of solvent. In an attempt to prepare a cost-
effective anthelmintic drug, three concentrations
(50, 75, and 100 mg/ml) of aqueous, ethanol, ethyl
acetate, methanol, and chloroform extracts from
leaves of Ricinus communis were studied on
Pheretimaposthuma. All the extracts showed a
significant death rate of the worm.
The paralysis and mortality of worms were found
to be significantly increased with an increase in
concentration. Methanol, aqueous, and ethanol
extract were found to be most effective and took
the least time in both killing and paralyzing worms
at higher concentrations (100 mg/ml) 25.
Toxicological Property: Studies were observed on
the medicinal and toxicological properties of
Cajanuscajan, Ricinus communis, and Thymus
vulgaris leaf extracts. Leaves of Ricinus communis
contain tannins, flavonoids, cardiac glycosides,
steroids, saponins, phlorotannis, and terpenoids that
are considered the essential bioactive constituents
of any medicinal plants. Methanolic extract of
leaves from Ricinus communis, when studied on the
rat (100 mg and 200 mg/kg b.w.), showed that the
extract was non-toxic and did not cause any
damage to vital organs. It can be concluded that the
leaves of the plant were safe to ingest and also have
anti-bacterial properties when consumed in a
limited amount. Unlike leaves and other parts of
plants, seeds are highly toxic when inhaled or
ingested orally. Seeds of Ricinus communis have
Ricin toxin that is a Type-II ribosome-inactivating
agent and well-reported bioterrorism agent 26-28.
Larvicidal and Mosquitocidal Activity:
Larvicidal activity of Ricinus communis extract was
found against different mosquito larvae. Studies
were carried out on different species of mosquitoes
such as Anopheles gambiae, Anopheles stephens,
Anaphole salbopictus, and Culexquin quefasciatus,
with a fatality rate of 100%. The poisonous
concentration of seed extracts of R. communis is
shown on different larval species 29. Malaria is one
of the life-threatening diseases which are caused by
bites of certain species of infected Anopheles
mosquitoes, which transmit parasites to the human
body. Malaria is considered being a worldwide
contagious disease which is resulting in hundreds
of thousands of death annually.
Plasmodium falciparum is commonly known to
show resistance to different available anti-malarial
medications. Among all, Ricinus Communis is
found to have the maximum activity against the
Anopheles gambiae which is a route to malaria.
Male and female larvae of Anopheles gambiae are
persuadable to Ricinus Communis extracts.
Chouhan et al., IJPSR, 2021; Vol. 12(7): 3632-3642. E-ISSN: 0975-8232; P-ISSN: 2320-5148
International Journal of Pharmaceutical Sciences and Research 3637
With the increase in Larvae exposure, it was found
that the larvicidal activity of the different extracts
was also increasing. The extraction from Ricinus
was found to be useful against Anopheles
arabiensis and Culex quinquefasciatus 30. An
important study based on Ricinus Communis
suggests that the leaves and stems of Ricinus
Communis were mainly used to reduce the
infection and fever caused by mosquito bites in
European countries.
The juice extracted and stored after neutralization
is highly beneficial in treating body rashes and
redness caused due to mosquito bites. Ricinus
communis is useful in treating malaria caused due
to any species of the female anopheles mosquito.
The Indian community is well aware of the
medicinal properties associated with Ricinus
communis. Since 1900, Ricinus communis is one of
the most widely used medicine in treating bacterial
infections, fever, and skin problems 31.
Anticonvulsant Activity: Researchers were
Screened for Ricinus Communis leaves for
anticonvulsant and Analgesic activity. Epilepsy is
a pervading disorder that results in seizure
formation because of neuronal discharges of the
brain. Various secluded compounds of Ricinus
Communis have shown positive results for
anticonvulsant activity and proved to be upright
epileptic after the tests were conducted.
All the animals showed convulsions after receiving
electric shock treatment. Dosage of 60 mg/kg of a
compound from Ricinus Communis seeds was
given to the animals, which showed inhibition of
seizure to about 80% as compared to the normal
drug, which showed 8.89% seizure inhibition.
Researchers reveal that epilepsy is a neurological
disorder that is commonly seen in the UK, United
States, India, and Africa. Until 1940, it was not
known that Ricinus Communis can be used to treat
seizures caused in different parts of the brain.
Exclusive research on Ricinus Communis suggested
that it contained an enormous level of
anticonvulsant properties that can easily reduce the
after-effects of seizures. Though many people do
not consider the anticonvulsant properties of
Ricinus Communis as beneficial, doctors and other
medical professionals widely use this drug to treat
multiple epilepsy cases. Ricinus Communis is not
only considered effective in treating seizures and
epileptic attacks but is also used to treat other
neurological problems such as headaches due to
sinusitis and migraine. Indian researchers claim
that consuming castor oil mixed with lukewarm
treats headaches and a state of confusion. It is
advisable to drink castor oil with warm water to
treat headaches, watery eyes, and epilepsy 32, 33.
Laxative and Uterine Contracting: With
changing lifestyle and eating habits, constipation
has become a common abdominal issue which
every 3 out 5 individual faces in the world.
Consumption of unhealthy food and irregular meal
times are some common reasons that affect the
digestion activity of the body. Ricinus Communis
acts as a magical drug in increasing bowel
movement. Proper bowel movements help in easing
constipation issues. Constipation issues are more
common in developing countries due to less
exposure to medical assistance and knowledge.
Castor oil activates uterus contraction and laxation
by combining ricinoleic acid, which activating
prostaglandin receptors 2.
Castor oil and ricinoleic acid bring contraction of
the intestinal smooth muscle, which affects gut and
uterus motility. Prostaglandin receptors 2 are
proved to be effective drugs that help in inducing
laxation. Ricinus Communis not only acts as a
laxative but is also a well-known purgative used to
treat severe abdominal pain and constipation
problems. Doctors usually advise patients with
constipation to consume a glass full of lukewarm
water mixed with a small quantity of Ricinus
Communis juice extract.
The juice of Ricinus Communis is also available in
the form of castor oil available in a chemist shop.
The leaf extract of Ricinus Communis contains
remarkable contraction properties, which allow the
uterine movements to takes place normally. Due to
the contraction properties of Ricinus Communis, it
is also used in radio diagnosis and sonography of
males and females before surgical procedures.
The drug also plays an important role in inducing
labor pains in pregnant ladies. The uterine
contraction property of Ricinus Communis is the
same as that of oxytocin drug that helps in inducing
labor pains 34, 35.
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Anti-asthmatic Activity: Ricinus communis L.
roots showed anti-asthmatic activity. Ricinus
Communis displayed the mast cell regulating effect
due to saponin content which is present in the roots.
Flavonoids play a major role in Bronchodilation
and smooth muscle relaxant activity. The ethanolic
extract was helpful in the reduction of the milk-
induced leucocytosis and eosinophilia which is
present because of flavonoids and saponins. The
drug extracted from Ricinus Communis to treat
asthmatic and respiratory issues was not discovered
until 1930. Many researchers struggled to develop a
successful; study related to Ricinus Communis and
its antiasthmatic properties. But late in 1930, in the
UK, the university discovered that Ricinus
Communis can regulate the effect of asthma with
the help of flavonoids present on the roots.
Before the discovery of other bronchodilators, the
flavonoids on Ricinus Communis were the most
common anti-asthmatic treatment used in patients
with severe bronchial asthma. Asthma is a common
breathing problem that is associated with improper
contraction and activity of bronchioles present
alongside the lungs. Flavonoids on Ricinus
Communis proved immensely beneficial in
reversing the asthmatic condition. This drug is
more commonly used in developing countries such
as Myanmar, India, Pakistan, and Burma. Ricinus
Communis exhibit anti-asthmatic properties but it is
also used to treat other respiratory issues such as
frequent chest pain (angina pectoris), increase in
heart rate, and sweating due to irregular heartbeat
36.
Bone Regeneration: Ohio State University
depicted that bone regeneration and bone repairs
required adequate time to heal and shape the bone
normally. In the early years, when there was no
effective treatment was used to address bone-
related issues, the ancient people used the extracted
oil of Ricinus Communis to repair the bone
deformities. Oil of Ricinus Communis was known
to be used in treating different bone-related
diseases in ancient times as herbal and mythic
medicine. Bone deformities, acute osteomyelitis,
articular pains and afflicted limbs are some bone-
related diseases that were treated by R. communis.
Ricinus Communis has the unique property of bone
regeneration without leaving any scar following its
damage.
Polyurethane resin formation promotes fibroblastic
neoformation which effectively replaces the bone
from inside and around the porosities of the
biomaterial in which delayed inflammatory
reaction is absent. Due to this absence, no signs of
systematic toxic effects were observed both in
rabbit skulls and rat alveolus. Subsequently,
incubating in synthetic body fluids can improve the
biological properties of Ricinus Communis
polythene.
Calcium phosphate, when mixed with R. communis
polyurethane could be helpful in matrix
mineralization and can be of immense interest
while preparing biocompatible material in
comparison to the demineralized bone. The slower
re-absorption process is one of the benefits of
Ricinus Communis polythene. Ricinus Communis
oil does not contain a lot of medicinal properties
such as anticonvulsant, anti-inflammatory, anti-
asthmatic, laxative, purgative, antibacterial, and
bone regeneration; hence it is widely used across
the world 37-39.
Antimicrobial and Anti-inflammatory
Properties: Inflammatory action due to any drug
reaction or injury needs to be treated to stop the
spread of bacterial infections. Increased bacterial
infection caused due to inflammation can lead to
gangrene in the affected part. Anti-inflammatory
and free radical scavenging activity were observed
from the root extract of Ricinus communis.
Different divisions like ethanolic, methanolic, or
hexane have been used to measure the anti-
inflammatory potential of Ricinus Communis In
one of the studies, hexane acetone and methanol
fractions were tested to study the anti-inflammatory
action of Ricinus Communis extract. Significant
anti-inflammatory activity was shown by the
methanolic extract, which may be because of the
presence of flavonoids. In another study anti-
inflammatory and pro-inflammatory activity after
reapplication and was found to be intervened by
ricinolein. Due to the cost-effective drug, it is more
commonly used to reduce inflammation as
compared to any other anti-inflammatory drug.
Compared to any other medicine, Ricinus
Communis is reported to show a faster therapeutic
effect on inflammation. It also reduces burning,
rashes, itching, and swelling associated with
inflammation.
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International Journal of Pharmaceutical Sciences and Research 3639
A good amount of extracted Ricinus Communis oil
is advisable to rub on parts that have inflammation.
The application of Ricinus Communis on the
injured part not only reduces rashes and
inflammation but also inhibits the bacterial growth
on the infected area 40-44.
Ophthalmic Properties: The eyes are one of the
most sensitive organs in a body that needs to be
taken care of. Irritation, burning, redness, and
swelling are some of the issues that can cause
various reasons. As eyes make our world look
colorful, it is important to maintain the ophthalmic
properties of eyes. Ricinus Communis was studied
for more than 50 years to identify its medicinal
properties. Researchers suggest that Ricinus
Communis contains oil that can be used as a
lubricant to treat dry eyes. The lubrication property
not only maintains the hydration level in the eyes
but also reduces muscle strain in them. Proper eye
muscle contraction and expansion lead to better
vision in an individual. Ricinus Communis oil is
also used to remove foreign body particles present
in the eye due to accidental reasons. The oil not
only soothes eye muscles but also cleans the eyes
for better visualization. Usually, ophthalmic
solutions are very costly and need regular doses if a
person is dealing with an eye infection or retinal
trauma. But due to the low cost of oil of Ricinus
Communis, people prefer this drug against other
lubricants available on the market. An eye drop
containing the oil of Ricinus Communis is generally
used to cure dry eyes, inflammation, redness,
swelling, and watery eyes. Various allopathic drugs
such as carboxymethyl cellulose, sodium
hyaluronate, polyethylene glycol 400 are some
common eye lubricants that can treat eye ailments
and dryness 45, 46.
Antiulcer: The antiulcer property of castor oil was
evaluated in rats by administration of aspirin or
ethanol or pyloric ligation. It was reported that
Ricinus communis possess noticeable antiulcer
properties at a dose of 500 mg/kg & 1000 mg/kg.
This might be due to either enhancing mucosal
defense by strengthening gastric mucosa or
cytoprotective action of drug 47.
DISCUSSION: The Ricinus communis (castor
plant) is a widely used and potent medicinal plant
among thousands of herbal plants which are
commonly used in the treatment of various
diseases. The medicinal properties of the plant are
due to the presence of key phytochemical
constituents like saponins, flavonoids, alkaloids,
steroids, and glucosides 6, 7. Medicinal plants have
been performed the following pharmacological
actions-Anti-inflammatory, antimicrobial, anti-
oxidant, analgesic, antitumor, anti-diabetic and
anti-asthmatic, antipyretic, antibacterial activity 20,
21, 28.
The fruit extract of Ricinus communis is a potent
contender for the treatment of breast cancer 8.
Leaves of Ricinus communis contain tannins,
flavonoids, cardiac glycosides, steroids, saponins,
phlorotannis, and terpenoids that are considered as
the essential bioactive constituents of any
medicinal plants 19, 26, 29. Ricinus communis leaves
were screened for anthelmintic, anticonvulsant, and
analgesic activity by many scientists 22, 23, 25. The
stem, leaves, and seed extracts of R. communis
showed significant mortality against larvicidal and
mosquitocidal activity 31. Antiasthmatic, anti-
inflammatory, and free radical scavenging activity
were observed from the root extract of Ricinus
communis 36, 42, 43. Plant-based medicines such as R.
communis have been used as an efficient treatment
of various diseases 48-58.
Medicinal plants are safer, cheaper, and eco-
friendly than costly medicines for the treatment of
different infections. The present study will be
helpful for the documentation of the ethno
botanical library for using various diseases and
infections by herbal drugs prepared by Ricinus
communis. The current research will be helpful to
initiate the pharmacological aspect of herbal plants
Ricinus communis extracts to prepare less costly
eco-friendly drugs.
CONCLUSION: The medicinal properties were
examined in the present review confirm that the
therapeutic importance of the medicinal plant
Ricinus communis is much higher. The R.
communis is significant medical have a potential
impact on cancer and ulcer herbs that cells, micro-
organism, bacteria, insects and other parasites that
create the breeding environment inside the living
organism body and affect the health and immunity.
Based on the above literature, it may conclude that
the disease prevention and recurring characteristic
Chouhan et al., IJPSR, 2021; Vol. 12(7): 3632-3642. E-ISSN: 0975-8232; P-ISSN: 2320-5148
International Journal of Pharmaceutical Sciences and Research 3640
of the Ricinus communis made this plant highly
noticeable which provides many alternatives
solutions in medical areas. It extends the solutions
in the biological environment by covering several
fields such as agriculture, pharmacy, economic,
social by offering a solution to several health issues
which are possible to be treated through which
plant. In regards to this, the pharmacological
activities shown by the Ricinus communis have
supported the traditional use of this herb as a
medicinal plant and creating the source for
sustainable synthetic drugs. The efficient
capabilities of the plant are leading a good future in
the medical world and have built opportunities for
further investigation to find the new compounds of
Ricinus communis that would be effective against
life-threatening diseases. Nonetheless, the seeds of
this plant are highly dangerous for both animals
and humans due to their toxic properties. It may
result in fever, central nervous system depression,
and other health issues among living beings. The
seeds are the only toxic property of Ricinus
communis; otherwise, the overall plant and its other
elements are advantageous in many ways.
ACKNOWLEDGMENT: The first author
Hitendra Singh Chouhan is grateful to CSIR New
Delhi (File No. 09/172 (0107)2019-EMR I Dated:
15.11.2019) for providing financial assistance to
carry out the present research work and also
thankful to Dr. Aparna Kumawat, associate
professor, and Miss Hemlata Sen, research scholar,
Department of Zoology, Government P.G. Meera
Girls College, Udaipur for their valuable support.
CONFLICTS OF INTEREST: The author
declares no conflict of interest.
REFERENCES:
1. Choudhury PR, Talukdar AD, Nath D, Saha P and Nath R:
Traditional. folk medicine and drug discovery: prospects
and outcome in advances in pharmaceutical biotechnology
Publishur Springer Singapore 2020; 3-13.
2. Kim M, Woo Y and Han C: Current status of the
spontaneous reporting and classification/coding system for
herbal and traditional medicine in pharmacovigilance.
Integrative Medicine Research 2021; 10(1): 1-6.
3. Sen SK and Behera LM: Ethnomedicinal uses of some
wound healing plants of Bargarh district in Western
Odisha India. International Journal of Herbal Medicine
2021; 9(2): 14-17.
4. Kumar M: A review on phytochemical constituents and
pharmacological activities of Ricinus communis L. Plant.
International Journal of Pharmacognosy and
Phytochemical Research 2017; 9(4): 466-72.
5. Nadkarni KM: Indian Materia Medica. Popular Prakashan
Mumbai Edition 1976; 2(1): 1142.
6. Jena J and Gupta A: Ricinus communis Linn: A
phytopharmacological review. International Journal of
Pharmacy and Pharmaceutical Sciences 2012; 4(4): 25-29.
7. Thompson MJ and Bowers WS: Lupeol and 30-norlupan-
3β-ol-20-one from the coating of the castor bean (Ricinus
communis L.). Phytochemistry 1968; 7(5): 845-47.
8. Majumder M, Debnath S, Gajbhiye RL, Saikia R, Gogoi
B, Samanta SK, Das DK, Biswas K, Jaisankar P and
Mukhopadhyay R: Ricinus communis L. fruit extract
inhibits migration/invasion, induces apoptosis in breast
cancer cells and arrests tumor progression in-vivo.
Scientific Report 2019; 9(1): 1-4.
9. Shobha N, Nanda N, Giresha AS, Manjappa P, Sophiya P,
Dharmappa KK and Nagabhushana BM: Synthesis and
characterization of Zinc oxide nanoparticles utilizing seed
source of Ricinus communis and study of its antioxidant,
antifungal and anticancer activity. Materials Science and
Engineering 2019; 97: 842-50.
10. Sandhya kumary K, Bobby RG and Indira M: Antifertility
effects of Ricinus communis (Linn) on rats. Phytotherapy
Research 2003; 17(5): 508-11.
11. Sani UM and Sule MI: Anti-fertility activity of methanol
extracts of three different seed varieties of Ricinus
communis Linn (Euphorbiaceae). Nigerian Journal of
Pharmaceutical Sciences 2007; 6(2): 78-83.
12. Shokeen P, Anand P, Murali YK and Tandon V:
Antidiabetic activity of 50% ethanolic extract of Ricinus
communis and its purified fractions. Food and Chemical
Toxicology 2008; 46(11): 3458-66.
13. Édouard KK, Kofi N and Kouassi KC: Ethnobotanical
study of plants used to treat diabetes, in traditional
medicine, by Abbey and Krobou people of Agboville
(Côte-d’Ivoire). American Journal of Scientific Research
2009; 4: 45-58.
14. Jumba BN, Anjili CO, Makwali J, Ingonga J, Nyamao R,
Marango S, Choge JK and Khayeka-Wandabwa C:
Evaluation of leishmanicidal activity and cytotoxicity of
Ricinus communis and Azadirachta indica extracts from
western Kenya: in-vitro and in-vivo assays. BMC Research
Notes 2015; 8(1): 1-11.
15. Babu PR, Bhuvaneswar C, Sandeep G, Ramaiah CV and
Rajendra W: Hepatoprotective role of Ricinus communis
leaf extract against d-galactosamine induced acute
hepatitis in albino rats. Biomedicine & Pharmacotherapy
2017; 88: 658-66.
16. Shukla B, Visen PKS, Patnaik GK, Kapoor NK and
Dhawan BN: Hepatoprotective effect of an active
constituent isolatedfrom the leaves of Ricinus communis
Linn. Drug Development Research 1992; 26(2): 183-93.
17. Abbas M, Ali A, Arshad M, Atta A, Mehmood Z, Tahir
IM, and Iqbal M: Mutagenicity, cytotoxic and antioxidant
activities of Ricinus communis different parts. Chemistry
Central Journal 2018; 12(1): 1-9.
18. Singh RK, Gupta MK, Katiyar D, Srivastava A and Singh
P: In-vitro antioxidant activity of the successive extracts of
Ricinus communis stems. International Journal of
Pharmaceutical Sciences and Research 2010; 1(8): 100-03.
19. Vasco-Leal JF, Cuellar-Nuñez ML, Luzardo-Ocampo I,
Ventura-Ramos E, Loarca-Piña G and Rodriguez-García
ME: Valorization of mexican Ricinus communis L. Leaves
as a source of minerals and antioxidant compounds. Waste
and Biomass Valorization 2021; 12(4): 2071-88.
20. Hussein H, Ubaid JM and Hameed I: Insecticidal activity
of methanolic seeds extract of Ricinus communis on adults
of Callosobruchus maculatus (Coleoptera: Brauchidae)
Chouhan et al., IJPSR, 2021; Vol. 12(7): 3632-3642. E-ISSN: 0975-8232; P-ISSN: 2320-5148
International Journal of Pharmaceutical Sciences and Research 3641
and analysis of its phytochemical composition.
International J of Pharmacognosy and Phytochemical
Research 2016; 8(8): 1385-97.
21. Sotelo-Leyva C, Salinas-Sánchez DO, Peña-Chora G,
Trejo-Loyo AG, González-Cortázar M and Zamilpa A:
Insecticidal compounds in ricinus communis l.
(euphorbiaceae) to control melanaphissacchari zehntner
(hemiptera: aphididae). Florida Entomologist 2020;
103(1): 91-95.
22. Kemal J, Zerihun T, Alemu S, Sali K, Nasir M, Abraha A
and Feyera T: In-vitro acaricidal activity of selected
medicinal plants traditionally used against ticks in Eastern
Ethiopia. Journal of Parasitology Research 2020; 1-10.
23. Ghosh S, Tiwari SS, Srivastava S, Sharma AK, Kumar S,
Ray DD and Rawat AKS: Acaricidal properties of Ricinus
communis leaf extracts against organophosphate and
pyrethroids resistant Rhipicephalus (Boophilus) microplus.
Veterinary parasitology 2013; 192(1-3): 259-67.
24. Lombard S, Helmy ME and Pieroni G: Lipolytic activity
of ricin from Ricinus sanguineus and Ricinus communis on
neutral lipids. Biochemical Journal 2001; 358(3): 773-81.
25. Mahadev ND and Vitthal BP: An evaluation of
anthelmintic activity of Ricinus communis Linn. leaves by
using different type of solvent. Journal of Pharmacognosy
and Phytochemistry 2017; 6(4): 1845-47.
26. Owoseni AA and Faboro EO: Studies on medicinal and
toxicological properties of Cajanuscajan, Ricinus
communis and Thymus vulgaris leaf extracts. Journal of
Medicinal Plants Research 2010; 4(19): 2004-06.
27. Lopez Nunez OF, Pizon AF and Tamama K: Ricin
poisoning after oral ingestion of castor beans: a case report
and review of the literature and laboratory testing. The
Journal of Emergency Medicine 2017; 53(5): e67-e71.
28. Bhaskaran M, Didier PJ, Sivasubramani SK, Doyle LA,
Holley J and Roy CJ: Pathology of lethal and sublethal
doses of aerosolized ricin in Rhesus macaques.
Toxicologic Pathology 2014; 42(3): 573-81
29. Sogan N, Kapoor N, Singh H, Kala S, Nayak A and
Nagpal BN: Larvicidal activity of Ricinus communis
extract against mosquitoes. Journal of Vector Borne
Diseases 2018; 55(4): 282-90.
30. Wachira SW, Omar S, Jacob JW, Wahome M, Alborn HT,
Spring DR, Masiga DK and Torto B: Toxicity of six plant
extracts and two pyridone alkaloids from Ricinus
communis against the malaria vector Anopheles gambiae.
Parasites & vectors 2014; 7(1): 1-8.
31. Elimam AM, Elmalik KH and Ali FS: Larvicidal, adult
emergence inhibition and oviposition deterrent effects of
foliage extract from Ricinus communis L against
Anopheles arabiensis and Culex quinquefasciatus in
Sudan. Tropical Biomedicine 2009; 26(2): 130-39.
32. Ladda PL: Screening of Ricinus Communis Linn. leaves
for anticonvulsant and analgesic activity. Asian Journal of
Pharmaceutical and Clinical Research 2014; 7(3): 110-14.
33. Tripathi AC, Gupta R and Saraf SK: Phytochemical
investigation, characterisation and anticonvulsant activity
of Ricinus communis seeds in mice. Natural Product
Research 2010; 25(19): 1881-84
34. Tunaru S, Althoff TF, Nüsing RM, Diener M and
Offermanns S: Castor oil induces laxation and uterus
contraction via ricinoleic acid activating prostaglandin EP3
receptors. Proceedings of the National Academy of
Sciences 2012; 109(23): 9179-84.
35. Abdul WM, Hajrah N, Sabir SM, Sabir JM, Saini SK and
Bora RS: Therapeutic role of Ricinus communis L. and its
bioactive compounds in disease prevention and treatment
2018; 11(3): 177-85.
36. Taur DJ and Patil RY: Antiasthmatic activity of Ricinus
communis L. roots. Asian Pacific Journal of Tropical
Biomedicine 2011; 1(1): 13-16.
37. Scarpa A and Guerci A: Various uses of the castor oil
plant (Ricinus communis L.) a review. Journal of
Ethnopharmacology 1982; 5(2): 117-37.
38. Morais J, Pacheco I and Martins A: Polyurethane derived
from castor oil monoacylglyceride (Ricinus communis) for
bone defects reconstruction: characterization and in-vivo
testing, Journal of Materials Science Materials in Medicine
2021; 32(4): 1-9.
39. Ziaei A, Sahranavard S, Gharagozlou MJ and Faizi M:
Preliminary investigation of the effects of topical mixture
of Lawsoniainermis L. and Ricinus communis L. leaves
extract in treatment of osteoarthritis using MIA model in
rats. DARU Journal of Pharmaceutical Sciences 2016;
24(1): 1-10.
40. Lindauer M, Wong J and Magun B: Ricin toxin activates
the NALP3 Inflammasome. Toxins 2010; 2(6): 1500-14.
41. Basha S and Raj S: Uses of medicinal plants for anti-
inflammatory activity - a review. European Journal of
Molecular & Clinical Medicine 2020; 7(1): 1839-43.
42. Ilavarasan R, Mallika M and Venkataraman S: Anti-
inflammatory and free radical scavenging activity of
Ricinus communis root extract. Journal of
Ethnopharmacology 2006; 103(3): 478-80.
43. Srivastava P, Jyotshna, Gupta N, Maurya AK and Shanker
K: New anti-inflammatory triterpene from the root of
Ricinus communis. Natural Product Research 2014; 28(5):
306-11.
44. Saini AK, Goyal R, Gauttam VK and Kalia AN:
Evaluation of anti-inflammatory potential of Ricinus
communis Linn. leaves extracts and its flavonoids content
in Wistar rats. Journal of Chemical and Pharmaceutical
Research 2010; 2(5): 690-95.
45. Sandford EC, Muntz A and Craig JP: Therapeutic potential
of castor oil in managing blepharitis, meibomian gland
dysfunction and dry eye. Clinical and Experimental
Optometry 2021; 104(3): 315-22.
46. Ramanjaneyulu AV, Anudradha G, Raman MV, Vishnu A,
Reddy V and Gopal NM: Multifarious uses of castor
(ricinus communis l. International Journal of Economic
Plants 2017; 4(4): 170-76.
47. Nath S, Choudhary MD, Choudhary S and Talukdar AD:
Male contraceptive efficacy of Ricinus communis L.
extract. Journal of Ethnopharmacology 2013; 149(1): 328-
34.
48. Awatif AM and Mohammed BS: Antibacterial activity and
fatty acid composition of sudanese castor bean (Ricinus
communis L) seed oil. Arabian Journal of Medicinal and
Aromatic Plants 2018; 4(1): 1-8.
49. Hajrah N, Abdul WM, Sabir J, Al-Garni SM, Sabir M, El-
hamidy SM, Saini KS and Bora RS: Anti-bacterial activity
of Ricinus communis L. against bacterial pathogens
Escherichia coli and Klebsiella oxytoca as evaluated by
Transmission electron microscopy. Biotechnology &
Biotechnological Equipment 2018; 32(3): 686-91.
50. Ahmed F and Iqbal M: Antioxidant activity of Ricinus
communis. Organic & Medicinal Chemistry International
Journal 2018; 5(4): 107-12.
51. Javanshir A, Karimi E and Tabrizi MH: Investigation of
antioxidant and anti-bacterial potential of Ricinus
communis L. nano-emulsions. Jundishapur Scientific
Medical Journal 2020; 19(1): 1-9.
52. Mohammed NI and Albozachri JM: Use of Iraqi castor
(Ricinus Communis) leaf extract as anti inflammatory in
Chouhan et al., IJPSR, 2021; Vol. 12(7): 3632-3642. E-ISSN: 0975-8232; P-ISSN: 2320-5148
International Journal of Pharmaceutical Sciences and Research 3642
treatment of skin wounds in rabbits. Medico Legal Update
2020; 20(3): 1321-25.
53. Sotelo-Leyva C, Salinas-Sánchez DO, Peña-Chora G,
Trejo-Loyo AG, González-Cortázar M and Zamilpa A:
Insecticidal compounds in ricinus communis l.
(euphorbiaceae) to control melanaphissacchari zehntner
(hemiptera: aphididae). Florida Entomologist 2020;
103(1): 91-95.
54. Waris M, Nasir S, Rasule A and Yousaf I: Evaluation of
larvicidal efficacy of Ricinus communis (Castor) plant
extract and synthesized green silver nanoparticles against
Aedes albopictus. Journal of Arthropod-Borne Diseases
2020; 14(2): 162-72.
55. Joshua PE, Chukwuka RS, Arazu AV, Godfrey N,
Ogwuegbu MC and Cosmas S: Phytochemical and
Toxicity Analysis of Ricinus communis. Asian Journal of
Biology 2020; 27: 34-41.
56. Raharjo T, Utami W, Fajr A, Swasono R and Haryadi W:
Antibacterial peptides from tryptichydrolysate of ricinus
communis seed protein fractionated using cation exchange
chromatography. Indonesian Jour of Pharma 2021: 74-85.
57. Shafiq N, Arshad U, Yaqoob N, Khan J, Khan A, Saleem
K, Rashid M, Rafiq N, Ahmad R, Javaid I and Noreen S:
Structure-based experimental and theoretical analysis of
Ricinus communis for their HepG2 human carcinoma cell
line inhibitors. Process Biochemistry 2021; 104: 152-60.
58. Galal TM, Essa B and Al-Yasi H: Heavy metals uptake
and its impact on the growth dynamics of the riparian
shrub Ricinus communis L. along Egyptian heterogenic
habitats. Env Science and Pollution Res 2021; 12: 1-4.
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Chouhan HS, Swarnakar G and Jogpal B: Medicinal properties of Ricinus communis: a review. Int J Pharm Sci & Res 2021; 12(7): 3632-
42. doi: 10.13040/IJPSR.0975-8232.12(7).3632-42.
