The construction of high-rise buildings in urbanized area can be subject to several constraints. When the loads transferred to the foundations become high a shallow foundation becomes insufficient. This is where piles are used to transfer the loads to deeper soil layers or to reduce the settlement. The design of the structure and the foundations starts by a good understanding of the behavior of the ground, the piles and the pile-soil interface subjected to high loads. In the framework of the project “Fondasilex”, this thesis proposes the study of the pile foundations in the tower “Silex2” built in Lyon, France. It is founded on 20 piles, 1.22 m in diameter and 15.5 m deep, which are bored into three layers of fluvial alluviums and anchored in the Miocene molasse. The soil in Lyon is poorly characterized in the literature, which is likely to lead to an oversizing of the foundations and consequently a high increase in construction costs. This thesis presents the geotechnical auscultation and numerical modeling performed within this project which aim to characterize the soil of Lyon and the pile-soil interaction, to predict the long-term behavior of the structure, the foundations and the soil and then to constitute a base of experience to help in the study of other towers planned on the Part-Dieu neighborhood. This work was accompanied by laboratory testing carried out on the alluvial and molasse samples extracted from the site. In the first part, an instrumentation of the foundations and the soil was set up to enable the real-time monitoring of their behavior. It consists of a fiberglass rod extensometer connected to 6 displacement sensors that measure the settlement of the soil at six different depths, concrete pressure cells and strain gages of two types (electrical resistance and vibrating wire) which measure respectively the stress on the head of the piles and the deformation at three positions. At the same time, the pile deformation was also measured using fiber optic sensors using the OFDR technique based on Rayleigh scattering. These measurements were analyzed in the light of the construction progress of the steel structure. In the second part, numerical models were carried out on FLAC3D, based on the finite difference method. A sensitivity analysis performed on an isolated pile model helped to understand the influence of each of the model parameters on the pile’s response. Models with two or more piles were also used to study the group effect that may occur. A perfectly plastic elastic law with a Mohr-Coulomb criterion and the Plastic-Hardening Model were found suitable to represent the behavior of the alluviums and molasse respectively. These laws have been calibrated and validated using the instrumentation and laboratory tests (triaxial, oedometer and shear box tests) carried out, due to the absence of a static pile load test.