France and Germany are the core countries of the European Union and have played an essential role in promoting the historical process of European integration. The two countries have a deep friendship and cooperation. However, in recent years, with Europe facing multiple crises and challenges, there have been a series of differences and conflicts between France and Germany in energy, defense, ... [Show full abstract] economy, diplomacy, and other aspects, which have brought uncertainties and risks to the prospect of European integration. This reflects the strategic differences, the leadership struggle, and the solidarity crisis within Europe. The paper aims to analyze the political differences and conflicts between France and Germany in the European Union. These challenges not only affect the friendship and cooperation between France and Germany but also adversely affect the unity and development of Europe. Therefore, France and Germany need to strengthen communication and coordination, seek common interests and goals, enhance mutual trust and understanding, and contribute to the prospect of European integration.