An increasing number of data science approaches that take advantage of deep learning in computational medicine and biomedical engineering require parallel and scalable algorithms using High-Performance Computing systems. Especially computational methods for analysing clinical datasets that consist of multivariate time series data can benefit from High-Performance Computing when applying computing-intensive Recurrent Neural Networks. This paper proposes a dynamic data science platform consisting of modular High-Performance Computing systems using accelerators for innovative Deep Learning algorithms to speed-up medical applications that take advantage of large biomedical scientific databases. This platform’s core idea is to train a set of Deep Learning models very fast to easily combine and compare the different Deep Learning models’ forecast (out-of-sample) performance to their past (in-sample) performance. Considering that this enables a better understanding of what Deep Learning models can be useful to apply to specific medical datasets, our case study leverages the three data science methods Gated Recurrent Units, one-dimensional convolutional layers, and their combination. We validate our approach using the open MIMIC-III database in a case study that assists in understanding, diagnosing, and treating a specific condition that affects Intensive Care Unit patients, namely Acute Respiratory Distress Syndrome.