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In silico medicine emerges in Greece just as real classical medicine did about 2.5 millennia ago

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Abstract

A brief historical tracing of the global emergence of the new scientific, technological and progressively clinical domain of in silico medicine in Greece is presented.
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In silico medicine emerges in Greece just as real classical
medicine did about 2.5 millennia ago
G. Stamatakos
Faithful to its millennia-long passion for medicine, Greece has also proved to be the
contemporary cradle of the new scientific, technological and progressively clinical domain of
in silico medicine (https://en.wikipedia.org/wiki/In_silico_medicine, last visited on 27 Oct.
2021).
The paper entitled "In Silico Radiation Oncology: combining novel simulation algorithms
with current visualization techniques" by G. Stamatakos et al. published in Proceedings of the
IEEE, the leading journal to provide in-depth review, survey, and tutorial coverage of the
technical developments in electronics, electrical and computer engineering, and computer
science, (Proceedings of the IEEE, vol. 90, no. 11, pp. 1764-1777, Nov. 2002,
https://ieeexplore.ieee.org/abstract/document/1046955), has been the first ever publication in
which the concept of "in silico medicine" (here in its concrete paradigmatic form of "in silico
radiation oncology") has been introduced, explained and demonstrated to the global scientific
community.This happened in 2002.
This along with a series of subsequent publications and the development of pioneering
"Oncosimulators" (digital twins in oncology) led by the founder and director of the Greek In
Silico Oncology and In Silico Medicine Group (https://www.in-silico-oncology.iccs.ntua.gr)
Research Professor G.Stamatakos and funded mainly by the European Commission, have
marked the generation of the broader "in silico medicine" field
(https://en.wikipedia.org/wiki/In_silico_medicine).
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Furthermore, it was in Greece and more precisely at the School of Electrical and Computer
Engineering, National Technical University of Athens, that the globally first academic course
on in silico medicine was created and introduced into the formal doctoral studies programme
of the latter by G. Stamatakos in 2014 (https://www.vph-institute.org/news/new-
postgraduate-subject-on-multiscale-cancer-modelling-and-in-silico-medicine-mscm-
ism.html). This marked the transformation of in silico medicine from an exclusively research
field into a formal university subject.
Of importance regarding the great potential of in silico medicine is the recent video created
by the international Virtual Physiological Human Institute (VPHi , https://www.vph-
institute.org/), being an advisor to the European Commission, which aims at introducing in
silico medicine to the wider public and is entitled "In Silico Medicine will be the future"
(https://www.youtube.com/watch?v=cse_GBcHcsc)
A key recent development marking the practical applicability of in silico medicine is the
inclusion of the latter in the European Centre for Disease Prevention and Control Regulation
(ECDC)
(https://www.vph-institute.org/news/in-silico-medicine-is-now-in-the-ecdc-regulation.html).
Published by Georgios S. Stamatakos on ResearchGate on 27 October 2021
Institute of Communication and Computer Systems (ICCS)
School of Electrical and Computer Engineering (SECE)
National Technical University of Athens (NTUA)
In Silico Oncology and In Silico Medicine Group (ICCS-SECE-NTUA)
E-Mail: gestam@central.ntua.gr
www.in-silico-oncology.iccs.ntua.gr
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