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COVAX, the vaccines pillar of the Access to Covid-19 Tools Accelerator (ACT-A), has been promoted as ‘the only global solution' to vaccine equity and ending the Covid-19 pandemic. ACT-A and COVAX build on the public-private partnership (PPP) model that dominates global health governance, but take it to a new level, constituting an experimental form that we call the ‘super-PPP'. Based on an analysis of COVAX's governance structure and its difficulties in achieving its aims, we identify several features of the super-PPP model. First, it aims to coordinate the fragmented global health field by bringing together existing PPPs in an extraordinarily complex Russian Matryoshka doll-like structure. Second, it attempts to scale up a governance model designed for donor-dependent countries to tackle a health crisis affecting the entire world, pitting it against the self-interest of its wealthiest government partners. Third, the super-PPP's structural complexity obscures the vast differences between constituent partners, giving pharmaceutical corporations substantial power and making public representation, transparency, and accountability elusive. As a super-PPP, COVAX reproduces and amplifies challenges associated with the established PPPs it incorporates. COVAX's limited success has sparked a crisis of legitimacy for the voluntary, charity-based partnership model in global health, raising questions about its future.
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COVAX and the rise of the super public private partnershipfor
global health
Katerini Tagmatarchi Storeng
a,b
, Antoine de Bengy Puyvallée
a
and Felix Stein
a
a
Centre for Development and the Environment, University of Oslo, Oslo, Norway;
b
London School of Hygiene &
Tropical Medicine, London, UK
ABSTRACT
COVAX, the vaccines pillar of the Access to Covid-19 Tools Accelerator
(ACT-A), has been promoted as the only global solutionto vaccine
equity and ending the Covid-19 pandemic. ACT-A and COVAX build on
the public-private partnership (PPP) model that dominates global health
governance, but take it to a new level, constituting an experimental
form that we call the super-PPP. Based on an analysis of COVAXs
governance structure and its diculties in achieving its aims, we
identify several features of the super-PPP model. First, it aims to
coordinate the fragmented global health eld by bringing together
existing PPPs in an extraordinarily complex Russian Matryoshka doll-like
structure. Second, it attempts to scale up a governance model designed
for donor-dependent countries to tackle a health crisis aecting the
entire world, pitting it against the self-interest of its wealthiest
government partners. Third, the super-PPPs structural complexity
obscures the vast dierences between constituent partners, giving
pharmaceutical corporations substantial power and making public
representation, transparency, and accountability elusive. As a super-PPP,
COVAX reproduces and amplies challenges associated with the
established PPPs it incorporates. COVAXs limited success has sparked a
crisis of legitimacy for the voluntary, charity-based partnership model in
global health, raising questions about its future.
ARTICLE HISTORY
Received 28 June 2021
Accepted 1 September 2021
KEYWORDS
Global health governance;
public-private partnerships;
Covid-19; vaccines
Introduction
COVAX and the Covid-19 pandemic
COVAX was established as the vaccines pillar of the Access to Covid-19 Tools Accelerator (ACT-A),
which describes itself as a ground-breaking global collaboration to accelerate the development, pro-
duction, and equitable access to Covid-19 tests, treatments, and vaccines(Gavi, 2020e). COVAXs
original aim was to secure access to a diverse portfolio of vaccine doses for at least 20% of participating
countriespopulations, delivered as soon as they became available, in order to end the acute phase of
the pandemic and rebuild economies (WHO, 2021a). Its leaders claimed it was the only global sol-
utionfor vaccine equity, i.e. the fair distribution of vaccines to all populations (Gavi, 2020e).
COVAX quickly helped establish normative acceptance of the need for a global collaboration
to accelerate vaccine development and access, mobilising resources from government and
© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group
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CONTACT Katerini Tagmatarchi Storeng katerini.storeng@sum.uio.no
GLOBAL PUBLIC HEALTH
2023, VOL. 18, NO. 1, 1987502
https://doi.org/10.1080/17441692.2021.1987502
philanthropic sources to stimulate research and development (R&D) and facilitating large-scale
vaccine procurement and distribution. COVAX delivered its rst dose in Ghana on 24 February
2021 less than three months after the UK became the worldsrst country to start a mass vacci-
nation campaign. It reached over 100 countries with vaccine doses within 42 days, many of which
would not otherwise have gained access to vaccines (WHO, 2021b).
However, COVAX soon turned out to be insucient to bring about global vaccine equity. At the
time of writing, in June 2021, COVAX had distributed less than 5% of its 2 billion target (89 million
vaccine doses) (Covax, 2021). Meanwhile, 90% of Covid-19 vaccines had been administered in the
richest G20 countries, leading Dr Tedros Adhanom Ghebreyesus, Director-General of the World
Health Organization (WHO), to conclude that, the rapid development of Covid-19 vaccines is a
triumph of science, but their inequitable distribution is a failure of humanity(UN, 2021).
In this paper, we argue that COVAXs failure so far to ensure global vaccine equity is not merely
the result of outside forces but results from limitations related to its governance structure. As we
show, COVAX is not just another global collaboration; It is an extraordinarily complex multista-
keholder public-private partnership (PPP), co-led by existing PPPs as one pillar of an even more
complex PPP, ACT-A. We show that it constitutes an experimental institutional form for dealing
with global health crises that we call the super-PPP, which structurally resembles a series of Rus-
sian Matryoshka dolls of decreasing sizes nested inside each other.
PPPs: The main governance mechanism for addressing global health challenges
PPPs can be thought of as lasting institutional arrangements in which private and public sector enti-
ties share decision-making power (Andonova, 2017; Buse & Harmer, 2004,2007; Rushton & Wil-
liams, 2011). The rise of PPPs over the past two decades marks a revolution in the governance of
global health, away from internationalhealth cooperation between nation states through forums
and channels set-up by multilateral organisations such as the WHO or the United Nations Chil-
drens Fund (UNICEF), towards a much more fragmented eld of globalhealth incorporating
non-state actors (Brown et al., 2006). Philanthropic foundations, non-governmental organisations
(NGOs) and businesses played a key role in implementing international health programmes in the
twentieth century, yet overall responsibility and coordinating power lay with public entities (Birn,
2006). This was in line with the post-World War II multilateral cooperation system of the United
Nations, centred on nation states. Yet, at the end of the 1990s, non-state actors radically gained
power, their inuence formalised through the establishment of global health PPPs. This shift was
driven by the systemic underfunding of existing national and multilateral health institutions and
the ideology of new public management, which promoted modelling public institutions on actual
and perceived virtues of the private sector.
Gavi, the Vaccine Alliance and the Global Fund to ght HIV/AIDS, Tuberculosis and Malaria,
established in 2000 and 2002 respectively, quickly became models for public-private cooperation to
address health challenges aecting poor countries, often with substantial philanthropic support
from the Bill & Melinda Gates Foundation. In Gavis own words, it combines the technical exper-
tise of the development community with the business know-how of the private sector(Gavi,
2020a). Todays global health PPPs vary signicantly in size, budget, and institutional structure.
For example, both the Global Fund and Gavi are institutionalised as their own legal entities,
with independent secretariats, a large degree of autonomy and substantial budgets, and inuence
rivalling that of the WHO. Other partnerships are less autonomous, and may be hosted by inter-
governmental agencies, sometimes as mere programmes (Andonova, 2017). Though most focus
on providing access to health technologies in low-income countries, newer partnerships, like
CEPI, which funds vaccine development to stop future epidemics, espouse the notion of global
public goodsto emphasise a joint benet for countries everywhere.
As a governance innovation, PPPs have raised unprecedented political will and resources to
address neglected health challenges, bringing with them a focus on individual diseases, a business
2K. T. STORENG ET AL.
ethos prioritising measurable results and a penchant for technological solutions such as vaccines
(Birn, 2005). While also associated with the promotion of verticaldisease-specic initiatives
that erode broader health system development and donor-driven decision-making challenging
country ownership, they are generally considered an ecient way of achieving health targets
(WHO, 2009). The Sustainable Development Goals (SDGs) in 2015 called for more multi-stake-
holder partnerships (goal #17), providing the PPP model with even greater international endorse-
ment (UN, 2015). It is thus not surprising that it became the blueprint for global cooperation during
the Covid-19 pandemic too.
The Covid-19 pandemic as the age of the super-PPP
When the Covid-19 pandemic struck, global health policy makers deployed considerable political
and diplomatic eorts to institute global coordination mechanisms. From the start, the Gates
Foundation and the World Bank argued that this could not be achieved without the close invol-
vement of existing global health PPPs and the private sector (Yamey et al. 2020). This led them
to draft plans for another global PPP for Covid-19 medical technologies, ACT-A, which was
announced at a G20-meeting on 24 April 2020, by the European Commission (EC) and the
Gates Foundation, with separate pillars for diagnostics, therapeutics, and vaccines and a health
systems connector. Many world leaders quickly embraced this development. Writing in The
Guardian in June 2020, Gro Harlem Brundtland, former Director General of the WHO, and Eli-
zabeth Cousens, President of the UN Foundation, called for us to embrace the unprecedented
scale of partnership between governments, business, international organisations such as the
UN and WHO, non-prots, and scientists and researchers, seeing them as essential to ending
the pandemic (The Guardian, 2020).
In bringing together actors from the public and private sectors to focus squarely on techno-
logical solutions (diagnostics, therapeutics, and vaccines) for a single disease, ACT-A has the key
features normally associated with PPPs. However, we argue that its creation signals a new phase
or iteration of this model, as the rst example of an allianceof major established PPPs intended
to benet not just developing countries, but the entire world. Under ACT-As umbrella struc-
ture, several established PPPs have responsibility for overseeing dierent pillars, drawing on
their established comparative advantage: Gavi and CEPI the vaccines pillar; Unitaid the thera-
peutics pillar; Find the diagnostics pillar; and The Global Fund the crosscutting health systems
connector. These PPPs work alongside multilateral organisations (WHO, UNICEF, the Pan
American Health Organization (PAHO) and the World Bank), as well as the largest global
health philanthropic foundations (the Wellcome Trust, the Gates Foundation) and governments
to acceleratethe development and equitable distribution of Covid-19 tools (Figure 1).
How does global governance change when various PPPs are combined and set to work together
at this unprecedented scale and scope? Which dilemmas arise? What are the strengths and weak-
nesses of the experimental form we call a super-PPP? Below, we address these questions by honing
in on ACT-As vaccines pillar COVAX, its most prominent and best-funded pillar. Based on an
analysis of COVAXs governance structure as a super-PPP, we unpack how this structure has
enabled national and corporate interests to take precedence over genuine partnership, challenging
COVAXs vision of global cooperation. Specically, we discuss how COVAX failed to institute safe-
guards against its government partners pursuing policies that directly undermine its goals, namely
vaccine nationalism,i.e. privileging vaccination on a national scale to the detriment of multilateral
vaccine eorts, and vaccine diplomacy, sharing excess vaccine doses in the pursuit of direct pol-
itical gains. Moreover, we show how its voluntary, partnership-based model has given too much
power to pharmaceutical companies, doing little to dissuade them from using their privileged pos-
ition to boost prot and shareholder value by keeping vaccine supply limited. Rather than consti-
tuting mere outside forces, however, we argue that these challenges were enabled by COVAXs
institutional design and the nature of the super-PPP model itself.
GLOBAL PUBLIC HEALTH 3
Based on this, we identify core features of the super-PPP model. First, it aims to coordinate a
fragmented global health eld by bringing together existing PPPs under one umbrella, making pub-
lic representation, transparency, and accountability elusive. Second, it attempts to scale up a gov-
ernance model designed for donor-dependent countries to tackle a health challenge aecting the
entire world, pitting it against the immediate self-interest of its wealthiest partners. Third, it is
so complex that it obscures the vast dierences in mandate and public accountability between its
constituent partners, imbuing corporate partners with substantial power.
In conclusion, we discuss how the limited success of COVAX has created a crisis of legitimacy
for the notion that voluntary partnership between public and private actors is the obvious solution
to global health crises. A growing contingency of civil society actors and world leaders reject its
charity-based model as a sign of complicity between wealthy country governments and Big
Pharma, and advocate instead for alternative solutions, including for a Peoples Vaccine. While
focused on the governance of global health, our analysis holds lessons for other highly fragmented
and partnership-dominated governance elds such as nutrition and environment (Andonova,
2017).
Methods
This paper is part of a Research Council of Norway-funded project that examines the rise of new
forms of cooperation between public authorities and private actors in pandemic preparedness
and response, focusing on Norway. Norway plays an important role in promoting such
cooperation. It hosts CEPI and was central to forming the COVAX initiative and co-leads
(with South Africa) the ACT-A Facilitation Council, and plays a signicant role in Gavi, with
the current Norwegian Ambassador of Global Health being a Gavi Board member. We draw
on data from three main sources: an analysis of COVAXs governance structure; a literature
and media review; and in-depth interviews with individuals associated with COVAX.
Our quantitative analysis of the institutional and demographic make-up of COVAX was con-
ducted in March 2021, using publicly available datasets from Gavis website on COVAX, notably
Figure 1. COVAX within ACT-As structure (simplied). Source: ACT-A Accelerator Impact Report Summary, available at https://
www.who.int/publications/m/item/act-accelerator-impact-report-summary.
4K. T. STORENG ET AL.
COVAXsStructures and Principles document (Gavi, 2021b). We analysed the level of represen-
tation of dierent institutions and countries across COVAXs workstreams and committees.
To identify whether a country was self-nancing, potentially self-nancingor eligible for donor
subsidy, Gavis source was used (Gavi, 2021a). Where individuals or countries were listed as repre-
sentatives of certain workstreams, we conducted a Google search to identify individualsroles, for
example, whether a representative was an MP, a health minister, or a private businessperson in their
country.
Our media and literature review focused on COVAX documents and press reports, and expert
analysis of COVAX published between May 2020 and July 2021 in leading international newspapers
and periodicals (e.g. The New York Times, Washington Post, The Guardian, Le Monde, The Atlan-
tic), editorials in scientic journals (e.g. The Lancet) and specialist online reporting (e.g. Geneva
Health Files, Development Today, Devex). We also observed evolving debates about COVAX,
gleaned from expert and public consultations, webinars, exchanges with civil society organisations
and social media discussions.
We interviewed 26 prominent actors involved in COVAX or in the wider global pandemic
response between September 2020 and February 2021. Interviewees included CEPI, Gavi and
COVAX sta, government ministers and diplomats involved in ACT-A, public health authorities,
pharmaceutical company representatives and members of international civil society organisations
involved in debates about vaccine equity. This includes 10 Norwegian actors directly involved in
ACT-A and COVAX. All interviews were recorded with intervieweesconsent and transcribed ver-
batim. We approached the Gates Foundation multiple times for an interview given their signicant
role in shaping both ACT-A and COVAX (The New Republic, 2021) but were denied and only
received a succinct email reply to our questions.
Our sources allow us to provide a rst overview of the emergence of COVAX and its super-PPP
structure, but it is beyond the scope of the paper to consider in-depth the internal political processes
within each constituent organisation, or the interaction between ACT-Asdierent pillars.
COVAXs governance structure as a super-PPP
Fifteen years ago, Buse and Harmer identied as a key shortcoming of global health PPPs their con-
tested legitimacy, due to private sector involvement, and failure to provide legitimate stakeholders a
voice in decision-making, most notably constituencies from low- and middle-income countries
(LMICS) and civil society, who are under-represented on governing bodies relative to the corporate
sector (Buse & Harmer, 2004,2007). In the years since, PPPs have made piecemeal eorts to redress
some of these imbalances by increasing the diversity of board members and enlisting civil society
engagementthrough formal representation for example (Puyvallée & Storeng, 2017; Storeng, 2014;
Storeng & de Bengy Puyvallée, 2018). Nevertheless, our analysis shows that COVAX reproduces at
the super-PPP scale many of the issues identied in previous analyses of the PPPs it incorporates,
including dominance by wealthy governments and philanthropic foundations, signicant pharma-
ceutical company inuence, and circumscribed roles for the WHO or other UN agencies (Shiman,
2017). It even amplies these challenges, because they are in part hidden within an overly complex
governance structure.
COVAX is loosely organised but institutionally complex (Figure 1). Its structure is in ux, and
we describe its makeup at the time of writing, in June 2021, roughly one year after its formation. It
combines Gavi, CEPI and the WHO as co-leads, with UNICEF and PAHO as implementing part-
ners. It does not have its own board or its own budget. Instead, donations to COVAX are funnelled
to its leading entities, most notably Gavi and CEPI, who by late June 2021 had received 80% and
13% of its mostly public donations respectively (WHO, 2021). COVAXs main decision-making
forum is the COVAX Coordination Meeting(CCM), co-chaired by CEPI and Gavi board chairs
Jane Halton and Jose Manuel Barroso. Halton and Barroso are formally accountable to their
respective boards rather than to COVAX partners. Permanent CCM members include the co-leads
GLOBAL PUBLIC HEALTH 5
executive directors (CEPIs Richard Hatchett, Gavis Seth Berkley and WHOs Chief Scientist Sou-
mya Swaminathan); workstream leaders (listed below), two representatives of the pharmaceutical
industry, a member of UNICEF and a civil society representative.
COVAX has three main workstreams each overseen by a co-lead organisation and with both
direct and indirect ties to the pharmaceutical industry (Figure 2). CEPI oversees the Development
and Manufacturingworkstream that decides which vaccine candidates are worthy of nancial sup-
port and subsequent procurement. This workstream is led by CEPIs Melanie Saville, who pre-
viously worked for the UKs National Health Service and various pharmaceutical companies.
Voting members in this workstreams main decision-making body, called the Research and Devel-
opment and Manufacturing Investment Committee, include representatives of Gavi, CEPI, the
Gates Foundation and the Africa CDC, as well as ve individuals who are venture capitalists and
current and former pharmaceutical company executives. Civil society is not represented on this
committee.
Gavi leads COVAXs second workstream for vaccine Procurement and Delivery at Scalewith
Aurélia Nguyen, a former pharmaceutical executive and subsequent Gavi employee as managing
director. It is based within the Gavi Secretariat and the Gavi Board has ultimate responsibility
for the decisions and implementation of this workstream. The nal workstream, which focuses
on vaccine Policy and Allocation, is led by WHOs Strategic Advisory Group of Experts
(SAGE) on Immunization. The workstream advises other workstreams, as well as the WHO and
its member states on vaccine science and ethics. It consists of members of universities, public health
bodies, UN organisations, CEPI, Gavi, the Gates Foundation and NGOs. COVAXs three work-
streams are further divided into 31 sub-committees or working groups. The top ve institutions
represented as chairs of these committees are WHO, CEPI, Gavi, UNICEF and the Gates
Foundation.
Publicly available documents list 464 individuals as part of COVAXs governance structure
(Gavi, 2021b). Only 63 (14%) of these represent governments. Remarkably, an overwhelming
majority of country representatives (81%) are from self-nancing countries (HICs and UMICs).
Figure 2. COVAXs three workstreams (simplied & subject to change due to COVAXs evolving nature). Source: Gavi (2021b).
6K. T. STORENG ET AL.
Industry representatives account for 6% of COVAX listed participants, and only 16 individuals
(3.4%) represent NGOs or civil society. There is no publicly available information about how com-
mittee members are selected, and several sub-committees have been established on paper only, as
their membership is yet to be determined.
While Gavi, CEPI and the Gates Foundation strongly inuence decision making within COVAX
by leading and dominating the key working groups where decisions are taken, UN agencies widely
populate working groups and sub-committees, but seem to hold more marginal normative and
technical roles. Like the PPPs it incorporates, COVAX was also initially reluctant to include civil
society in its decision-making structures. Ahead of Gavis board meeting on 30 July 2020, over
175 civil society organisations and individuals, including the Médecins Sans Frontières (MSF)
Access Campaign, wrote an open letter to the Gavi board noting the complete absence of civil
society in COVAX and demanding better representation (MSF, 2020). By end of October 2020,
however, Gavi welcomed civil society representatives to COVAX working groups, including
from MSF, Save the Children, the International Rescue Committee (Gavi, 2020b).
In the next section, we analyse how despite COVAXseorts to improve representation, its com-
plex and fragmented governance structure has enabled national and corporate interests to take pre-
cedence over the genuine partnership.
COVAX and vaccine nationalism
Trying to cater to wealthy and poor countries alike, COVAX invited HICs and UMICs to join a
buyersclubcalled the COVAX Facility and purchase a shared portfolio of vaccines (Eccleston-
Turner & Upton, 2021). This promised them lower vaccine prices and a reduction of all kinds of
risks to do with vaccine development and procurement (Stein, 2021). 92 low income and lower
middle-income countries (LICs and LMICs) were grouped into a separate purchasing club called
the COVAX Advance Market Commitment (Gavi COVAX AMC), subsidised by donorsoverseas
development budgets, a model originally developed for purchasing pneumococcal vaccines for low-
income countries eligible for Gavi support.
Although public funders have supported COVAX generously, COVAX simultaneously allowed
its members to strike bilateral vaccine purchase agreements that undermined its supply and
reduced its purchasing power. Shortly after COVAX was created, the US, Canada, the EU (Euro-
pean Union), the UK, Israel, and oil-rich Gulf countries engaged in a race to sign bilateral deals
with Western pharmaceutical companies, while China, Russia and India secured early contracts
with their own domestic vaccine industries. As in previous pandemic outbreaks (Eccleston-Turner
& Upton, 2021), COVAXs high-income country partners used advance purchase agreements to
secure early and extensive vaccine access for domestic populations. They paid higher prices per
vaccine dose than COVAX was able to, often combined with legal concessions, vast corporate sub-
sidies, unforeseen public data provision to vaccine companies and sometimes export restrictions.
They bought up global vaccine production capacity even before COVAX secured its rst nancial
instalments and was t to start negotiation with industry. By November 2020, a widely reported
analysis found that HICs and UMICs had already reserved 3.8 billion doses, with options for 5
billion more, even before any vaccine candidates had been approved (Duke Global Health Inno-
vation Centre, 2021). This was rapidly condemned by global health leaders within the WHO and
the African Union as a form of vaccine nationalismand a betrayal of COVAXs vision of vaccine
equity.
Some high- and middle-income countries (e.g. Canada, New Zealand, Japan, Australia South
Africa, and Mexico) bought vaccine options from COVAXs self-nancing window alongside
their bilateral deals. Within Europe however, only the UK and Norway did. Team Europe(the
European Commission (EC) and some EU member states) approached vaccine procurement in a
paradoxical manner by rst taking the initiative to launch COVAX, but then deciding not to buy
their vaccines through the global procurement mechanism. Opting instead to develop a joint EU
GLOBAL PUBLIC HEALTH 7
procurement mechanism in June 2020 (Schaik et al., 2020), Team Europeonly supported the
COVAX Gavi AMC fund for LICs and LMICs. In the words of a middle-income country diplomat
whom we interviewed in the summer of 2020:
[Europeans] made a huge eort in this pledging event in May [2020] [] with all heads of state and everybody
giving this declarations or solidarity, pledging millions and billions of dollars. This whole event was based on
this idea of solidarity and equitable universal access to the vaccine. And very soon after that, the very same
countries that led that pledging event broke the agreement and went their own way. I mean they betrayed
their own leadership [] in my opinion that was very serious, that was a big treason, a big betrayal of
multilateralism.
Unlike the EU joint procurement mechanism, for example, COVAX membership did not require
countries to refrain from striking bilateral deals, competing directly for the same doses COVAX was
trying to purchase. On the contrary, the head of Gavi had actively promoted COVAX as a fallback
option for those who had struck bilateral deals, to broaden their vaccines portfolio and in case such
bilateral deals were to fall through (Gavi, 2020e).
The concessions that COVAX made to its self-nancing country members must be seen in light
of its struggle to garner support from the worlds major geopolitical powers. Team Europewas an
early sponsor and promoter, along with Japan, the UK, Canada, and Norway, which was appointed
co-chair of ACT-As Facilitation Council together with South Africa. However, the US under Pre-
sident Donald Trump refused to join COVAX, pursuing instead an America Firstpolicy to vaccine
development and procurement through its own domestic PPP, Operation Warpspeed. It was only
once President Biden was inaugurated in 2021, that the US joined COVAX and became its single
biggest donor, followed by Team Europe, Japan, the UK, Canada, and Norway. Together they
account for around 89% of ACT-As public funding commitments (WHO, 2021).
Individual countries justied their decision to purchase vaccines directly from manufacturers
rather than through COVAX with reference to the initiatives slow start (it took over four months
for contract negotiations to begin as countries rst had to join and fund COVAX), their responsi-
bilities to prioritise their own populations, and claims that doing so was not at odds with showing
global solidarity. Team Europe, for example, defended itself against accusations of vaccine nation-
alism by pointing to its substantial nancial pledges to the Gavi COVAX AMC and to the fact that it
had exported over half of the vaccines produced in its territory by mid-2021 (EEAS, 2020). This
contrasts with the US, which only lifted export bans on vaccines and essential vaccine components
in May 2021, and the UK, which, at the time of writing, has not exported any domestically produced
vaccines (Development Today, 2021a).
In practice, wealthy countriesvaccine purchasing outside of COVAX meant that the initiative
quickly became, in the eyes of global health leaders, commentators and its European founders,
reduced from a global procurement mechanism to an aid project for subsidising vaccine pur-
chase for poor countries. This helps to explain why Canada, as the rst G7 country to purchase
vaccines through COVAX in February 2021, was branded a vaccine piratestealing from the
poor, even though it was purchasing doses it was technically entitled to as a self-nancing mem-
ber (Toronto Sun, 2021; Usher, 2021).
Combined with trade restrictions that constrained manufacturing and supply to COVAX, high-
and middle-income countrieshoarding of vaccine doses is now widely acknowledged to have
undermined COVAXs capacity to secure timely access to vaccine doses in sucient quantities.
In January 2021, COVAX nevertheless forecasted that it would roll out 2.3 billion vaccine doses
in 2021, with an expected 1.8 billion doses for the 92 lower-income economies (the Gavi
COVAX AMC-eligible countries), at least 1.3 billion of these being oered at no cost to their gov-
ernments (Gavi, 2021d). During the spring of 2021, however, COVAX faced huge supply issues
after the Serum Institute of India (SII), which it had been heavily relying on for delivery of Astra-
Zeneca vaccines, diverted doses to deal with Indias domestic Covid-19 crisis. Even with large parts
of their populations vaccinated, wealthy governments continue to sign advance purchase
8K. T. STORENG ET AL.
agreements with vaccine manufacturers for the delivery of booster shots in 2022 and 2023 that com-
pete with COVAX for supply (Reuters, 2021b). To our knowledge, these condential agreements,
which are treated as trade secrets still do not include clauses on equitable access.
COVAX and vaccine diplomacy
Without the means to stop its wealthy country partners from pursuing vaccine nationalistic pol-
icies, COVAX asked countries who had hoardedvaccines to at least share excess vaccine doses
with it. The COVAX secretariat developed principlesfor how countries could do so shortly
after the rst vaccines had been approved for use, in December 2020. These principles entailed
ve main requirements: vaccines should be safe and ecacious (WHO approved); available early
on (preferably rst half of 2021); rapidly deployable; unearmarked (to comply with COVAXs equi-
table allocation mechanism); and available in high quantities. COVAX also expected donor
countries to nance vaccine donations (Gavi, 2020d). However, complying with these principles
was voluntary, as COVAX lacked any enforcement mechanism and has had to rely on the variable
goodwill of its wealthiest partners.
In December 2020, EU countries tried, but failed, to reach agreement on how to implement a
plan to share 5% of their reserved doses (Reuters, 2020), In January 2021, Norway became the
rst country to transfer its options to buy vaccines through COVAX to the Gavi COVAX AMC,
though this fell short of transferring vaccine doses from its own vaccination programme (Develop-
ment Today, 2021b). In April 2021, France decided to proceed independently despite the absence of
a joint EU sharing scheme, announcing an initial donation of 105,600 vaccine doses taken from its
vaccination programme to the Gavi COVAX AMC and committing to share 500,000 doses by mid-
June, and up to at least 5% of its total doses by the end of 2021 (Gavi, 2021c). Throughout spring
2021, the US was heavily criticised for having millions of unused doses in storage (including the
AstraZeneca vaccine that was not authorised by the US regulator) (The New York Times, 2021).
At the G7 meeting of June 2021, President Biden announced that the US would be purchasing
500,000 Pzer doses to donate to COVAX (The White House, 2021)more than half of the
870 million doses pledged by G7 countries. Critics derided the G7, claiming their pledges were
just a drop in the ocean (Buse & Bertram, 2021), and noted that the US donation of Pzer-
doses was partly nanced by USD 2 billion already pledged to COVAX in February 2021 (Reuters,
2021c).
Vaccine donations have been dicult for three main reasons. First, domestic political pressure
on leaders to prioritise their own population has been a major impediment. In Norway, for
example, the news in early 2021 that the government had transferred its COVAX options to
the Gavi COVAX AMC led opposition politicians to argue that these options should have
been used for Norways domestic vaccination programme (Development Today, 2021). Second,
in some cases vaccine producers have imposed contractual conditions and other legal barriers
preventing resale or donations of doses. The US decision to loandoses of AstraZeneca vaccine
to Canada and Mexico in March 2021 for example was reportedly a workaround to evade such
conditions (Vanity Fair, 2021). Third, and most importantly, countries have opted to donate vac-
cine doses bilaterally instead of through COVAX to reap diplomatic and geopolitical benet, an
approach that has been coined vaccine diplomacyand that directly competes with COVAX.
Although initially used as a pejorative term to describe Russia, China, and Indias vaccine
donation policies, vaccine diplomacy is also practiced by COVAXs largest funders including
the US and EU. Besides pledging to channel excess doses through COVAX, the EU has also
set up its own vaccine sharing mechanism for allied and neighbouring countries. Potentially
in breach of its principles for vaccine donations, COVAX has been forced to accept smaller
donations made at the latest stages of wealthy countriesvaccination programmes and has
allowed individual donor countries branding visibility through, for example, national ags on
shipments.
GLOBAL PUBLIC HEALTH 9
Accommodating corporate interests
The lack of safeguards within COVAX against participating countries pursuing policies that under-
mine its goals is reproduced in its voluntary approach to partnershipthat has struggled to enlist
for-prot pharmaceutical companies as genuine partners. COVAX has accommodated corporate
concerns for prot and shareholder value, providing major pharmaceutical companies with a range
of push and pull subsidies and amplifying the already substantial public sector nancing for R&D
and manufacturing both before and during the pandemic (Stein, 2021). Public subsidies are widely
understood to have been a major driver of the impressive innovation that resulted in several safe
and eective vaccines being developed at record speed. According to interviewees, the unprece-
dented levels of public sector support and the scale of the crisis had led many to hope that industry
partnerswould, at least temporarily, forfeit established prot-maximising business practices in the
interest of equitable access to the gains of vaccine innovation and marketing. Doing so would
strengthen their brands, improve their research, and live up to their frequently altruistic rhetoric.
However, the pharmaceutical industry has not fullled these expectations. Oxford University,
which developed the vaccine produced by AstraZeneca, originally pledged to donate the rights
to its promising coronavirus vaccine to any drugmakerthrough open licensing (Medscape,
2020). In the end, AstraZeneca obtained exclusive rights to produce the vaccine, facilitated by
the Gates Foundation who provided substantial funding to expand manufacturing capacity and
technology transfer to SII, the worlds largest vaccine manufacturer (Gavi, 2020c,2021e). Although
Astra-Zeneca had pledged that it would make its vaccine available at costduring the pandemic, its
commitment to vaccine equity took a blow after leaked revelations that South Africa has paid more
than double the EU price for the AstraZeneca Vaccine, in a bilateral deal outside of the COVAX
Facility (The Guardian, 2021a). Campaigners who gained access to Astra-Zenecas contracts have
shown that its claim to provide fair prices to developing countries in perpetuityis full of holes
(Fortune, 2020).
Nevertheless, AstraZeneca and Johnson & Johnson, which signed an advanced purchase agree-
ment with COVAX in May 2021, scored better than mRNA vaccine manufacturers Moderna and
Pzer on rankings such as the vaccine access test, which grades how world leaders and companies
are improving access by supporting global cooperation, including COVAX, and increasing supply
for all (One.org, 2021). Moderna reserved most of its doses for bilateral deals with wealthy
countries, even though it received a grant from CEPI early in the pandemic (January 2020) that
included provisions on equitable access, as well as substantial US public funding (The Washington
Post, 2021). The company only entered a deal with COVAX on 3 May 2020, for up to 500 million
doses to be delivered in the second half of 2021 through 2022 and only after committing to deli-
vering billions of doses rst in bilateral deals (Gavi, 2021f).
Pzer, in turn, initially claimed that its motivation for developing a Covid-19 vaccine was to nd
a medical solution to the crisis, rather than a return on investment. However, in July 2020, its CEO
Albert Bourla was quoted saying it was radicalto suggest pharma should forego prots on future
Covid-19 vaccines (Fierce Pharma, 2021). Pzer subsequently reported to the US Securities and
Exchange Commission that it expected a prot margin in the high twenty percenton its Covid-
19 vaccine and over USD 15 billion in revenues for 2021 only (Pzer, 2021). The founders of
Pzers biotech partner BioNTech became billionaires within just a few months, and BioNTech
is reportedly on track to give the German economy an extraordinary boost, contributing about
half a percentage point in German gross domestic product in 2021 (Bloomberg, 2021).
Pzer has consistently prioritised bilateral deals with wealthy country governments and did not
agree to supply COVAX before the end of January 2021, initially oering a meagre 40 million doses
(2% of its projected 2021 supply) (Reuters, 2021a). Pzer subsequently agreed to sell 500 million
doses (for 2021 and 2022) to the US for donation to COVAX ahead of the G7 in June 2021, announ-
cing in a full-page ad in the New York Times that equity was its North Star. This claim, however, is
undermined by Pzers negotiation tactics vis-a-vis poor and middle-income countries who have
10 K. T. STORENG ET AL.
sought bilateral deals outside of COVAX. The company reportedly demanded that Latin American
governments put up state assets, such as embassy building and military bases, as guarantee against
the cost of any potential legal cases against the rm (The Bureau of Investigative Journalism, 2021).
To justify its high prices relative to manufacturers of other WHO-approved vaccines, Pzer denied
that its vaccine has beneted from public investment, even though its biotech partner BioNTech
received substantial EU funding to develop the mRNA technology, and advance purchase agree-
ments oset the companys risk of scaling up production (Storeng & de Bengy Puyvallée, 2020).
Overall, COVAX has had limited success in instilling a commitment among the major vaccine
producers to the ideal of partnership. In fact, pharmaceutical companies have not only prioritised
bilateral deals over COVAX but have also articially constrained supply by refusing to share tech-
nology, e.g. via the WHOs Covid-19 Technology Access Pool (C-TAP) (Project Syndicate, 2021).
They have exploited their powerful position as the suppliers of essential goods (The Loop, 2021) and
engaged in rent seeking by lobbying to keep full patent protection despite WTO (World Trade
Organization) emergency provisions that would suspend those and enable expanded production
(Project Syndicate, 2021).
This helps to explain why growing criticism is being directed towards COVAXs co-leads Gavi
and CEPI and the governments that fund and have a major inuence within these institutions
for failing to exercise sucient leadership in protecting the global public interest (Usher, 2021).
They have accepted industry demands for secrecy around prices and contracts, making it dicult
to ensure accountability for COVAXs spending. Wealthy countries who say they support COVAX
have, at the same time, contributed billions in funding to R&D and advance market commitments
that oset corporate risk, without imposing suciently strong conditions on companies for fair pri-
cing or technology transfer necessary to expand production capacity (Storeng et al., 2021). In Feb-
ruary 2021, for example, ACT-A co-lead Norway published 4 principles for urgent pharma action
to combat Covid-19(World Economic Forum, 2021) that merely made non-committal recommen-
dations for action, but no actual demands, on rapid registration, fair pricing, expanded production
and transparency. The recommendations were largely unheeded. Strikingly, a year into COVAXs
existence, even CEPIs CEO Richard Hatchett conceded that voluntary action is insucient. At the
COVID-19 Global Research & Innovation Forum in May 2021, he said that the great missed oppor-
tunity of 2020 is that the funders of vaccine development did not include access provisions in their
funding agreementsand called for dierent funders to develop common approaches (Geneva
Health Files, 2021).
Discussion: The rise of a new PPP model
The creation of COVAX and the larger ACT-A structure of which it is part shows the extent to
which PPPs have become a default solution to ghting global health problems. However, COVAX
and ACT-A do not simply replicate the existing PPP governance model, but also exemplify a new
iteration of it: The super-PPP. The super-PPP is like established global health PPPs in many ways,
which focus on a single disease, privilege technological solutions over attention to health systems
and structural determinants of health, monitor themselves, and heavily advocate their own suc-
cesses. At the same time, the super-PPP comes with distinct strengths and weaknesses, related to
both scale and unprecedented institutional complexity.
Coordinating global health governance?
We propose that a distinctive feature of the experimental institutional super-PPP form is the ambi-
tion to unite several global health PPPs within a single institutional frame, as ACT-A and COVAX
illustrate. In this respect, the super-PPP model constitutes a remarkable attempt to coordinate what
has become a highly fragmented, competition-driven and frequently ineective governance eld, in
which multiple PPPs develop investment casespresented at replenishment eventsto convince
GLOBAL PUBLIC HEALTH 11
donors to continue their support. Gavi, the Global Fund and the like compete against each other to
attract the largest possible share of donor countriesocial development assistance and philanthro-
pic and corporate donations. Their narrow focus has created blind spots, redundancies and over-
lapping mandates.
There have been previous attempts to coordinate this fragmented eld. For example, the Inter-
national Health Partnership (IHP+), which has since developed into UHC2030, brings global health
PPPs together in a multi-stakeholder discussion forum that aims to support health system strength-
ening (Bartsch, 2011; Holzscheiter et al., 2016). However, COVAX and ACT-A, within which it is
embedded, are qualitatively dierent. They are not only a platform for discussion and advocacy
but work towards a single operational mandate by harnessingeach constituent PPPsdistinctcom-
parative advantage. It is thus a more tightly institutionalised attempt to coordinate what has been
coined market multilateralism(Bull & McNeill, 2007,2019). The model draws on the democratic
and procedural (input) legitimacy of the WHO, and the results and metrics oriented (output) legiti-
macy of existing PPPs. Their coordinating role at the highest level of governance puts the super-PPP
model in direct competition with the UN and its specialised health agency the WHO, which nds
itself relegated as one of many super-PPP parts and partners, and with no direct authority over them.
So far, the super-PPP model has not resolved core global health governance challenges. Estab-
lished PPPs still compete against each other through investment cases, fund raising, and replenish-
ment events. ACT-Asdierent pillars received widely dierent degrees of support, the vaccines
pillar being by far the most successful at attracting funding. In fact, as a governance approach,
the super-PPP model appears chaotic, extraordinarily complex, and lacks transparency and
accountability mechanisms. Whereas established PPPs are composed of mostly distinct entities
like governments, philanthropic foundations, industry, NGOs and UN agencies, the super-PPP
consist of other PPPs. This adds a layer of complexity (as PPPs themselves are heterogeneous),
and it means that the super-PPP represents various organisations twice or even three times over.
For instance, the WHO and the Gates Foundation are described as ACT-A partners but are also
partners within each of the established PPPs like Gavi, CEPI, the Global Fund etc. Partnersthere-
fore have several channels of inuence both within the super-PPP coordinating mechanism and
within the boards and committees. Therefore, we say the super-PPP structure resembles a series of
Russian Matryoshka dolls.
Scaling up partnerships to the global level
Another important feature that denes the super-PPP model is the vast scale of its mandate, geogra-
phy, and available nancing. It emerges out of an ongoing qualitative shift from traditional charity-
based PPPs that aim to solve health challenges in poor countries with support from donors (e.g.,
Gavi) to an attempt to tackle global challenges in ways that benet wealthy and poor countries
alike. This shift is exemplied by the creation of CEPI in 2017 to tackle epidemic diseases in
poor countries with the potential to spread worldwide, but the super-PPP model takes this a step
further by targeting an acute global health crisis aecting rich and poor countries alike.
The eort to scale-up PPPs to the global level, however, has reinforced power-asymmetries
already present in the traditional aid and charity-based model. Wealthy countriesimmediate
self-interests, which are in traditional PPPs at least partly attenuated by charitable intentions,
have moved centre stage, as COVAX internalised the international competition for the same scarce
commodities vaccines. To appeal to wealthy governments, COVAX did not implement the safe-
guards necessary to prevent self-nancing countries from operating outside of it, and eectively
competing with it for vaccine supplies. Despite high-level political pledges to support COVAX,
these countries have adopted inward-oriented and diplomatic strategies that benet their national
interests and are at odds with COVAXs commitment to global collaboration. Pharma partners
prot-maximising strategies are also at odds with COVAXs aim of globally equitable vaccine
access.
12 K. T. STORENG ET AL.
In response to these challenges, COVAX has gradually lowered its ambition. From being a global
procurement mechanism providing access to all countries simultaneously, COVAX has become in
practice an aid-funded scheme primarily providing a limited number of vaccines to protect a small
proportion of the population of its AMC-eligible countries (Usher, 2021). This makes it now func-
tionally similar to Gavis traditional focus on subsidising childhood immunisations for countries
unable to aord them.
This narrowing of COVAXsraison dêtre has been buttressed by the skewed representation of
stakeholders in its governance structure. As we have shown, LICs, LMICs and civil society voices
are marginal, whereas governments, organisations and individuals from the global North dominate
COVAX. It is thus not surprising that COVAX has overly accommodated wealthy country and cor-
porate interests. This issue of skewed representation reproduces shortcomings of the PPP model
identied over 15 years ago that remain unresolved to date (Buse & Harmer, 2007; Storeng & de
Bengy Puyvallée, 2018).
Blurring the lines between public and private interests
The super-PPP model includes private actors in its decision-making, in order to use private sector
resources, assumed innovation capacity and skills. However, the institutional complexity high-
lighted above has contributed to a lack of clear safeguards and accountability mechanisms to secure
that private interests do not take precedence over the public good.
First, as our analysis of COVAX shows, the super-PPP model relies on a form of conceptual slip-
page whereby any organisation that is rich or inuential enough to claim a leading role in global
health is considered a public health organisationor a stakeholderand invited to the highest eche-
lons of decision-making. Using the term global health organisationsto describe philanthropies,
PPPs and intergovernmental agencies obscures their vast dierences in mandate and public
accountability, and further blurs the line between public and private spheres. This conceptual slip-
page obscures the critical role that philanthropic partners like the Gates Foundation play in shaping
and governing COVAX (The New Republic, 2021), beyond their self-described role as a mere facil-
itatoror catalyticpartner. This further challenges the remnants of democratic representation in
todays global health governance landscape.
Second, although the global pharmaceutical industry is consistently described as an essential
partner, there are no clear criteria governing the behaviour of COVAXs partners and, as we
have seen, the major vaccine producers support policies, and engage in tactics that directly work
against COVAXs access to vaccines. Finally, COVAX accomodates pharmaceutical industry
requirements and has kept secret most contracts and subsidies provided to the private sector. It
is unclear, for instance, how much COVAX pays for vaccine doses, or what at-costpricing agreed
upon with several providers entails. This lack of transparency and information asymmetry about
the true vaccine production costs and prot margins has been a key issue during the pandemic
beyond COVAX. Inadequate performance monitoring and narrowly selected objectives make pub-
lic scrutiny challenging, if not impossible.
Conclusion
Although COVAX has achieved only limited results so far, its leaders continue to brand it the only
solutionto vaccine equity, setting the terms of debate and gradually reducing the notion of equity
to its bare minimum, in keeping with other PPPs that have traditionally foreclosed policy alterna-
tives (Storeng, 2014). But unlike other PPPs, COVAX has not solidied condence in the partner-
ship model, but instead created a crisis for its legitimacy. COVAXs shortcomings, especially its lack
of transparency and its incapacity to deliver on its promises, have led critics to ask whether it is part
of the problem(Devex, 2021), for example arguing that having suppliers on governing boards con-
tradicts the core principle of good governance. An African Union envoy has suggested that
GLOBAL PUBLIC HEALTH 13
COVAXs failure to deliver its promised supply to the African continent is not only a moral failure,
but a deliberate strategy, saying those with the resources pushed their way to the front of the queue
and took control of their production assets(The Guardian, 2021b). Others have argued that
COVAX reproduces a colonialmentality whereby poor countries are forced to depend on charity
and leftover doses from wealthy countries (Development Today, 2021c).
A sign of waning trust in the PPP model is that civil societys major response to the challenge of
vaccine equity has been to work outside of COVAX, developing a global movement known as the
Peoples Vaccine Alliance that brings together organisations like Global Justice Now, Oxfam and
UNAIDS to argue that vaccination should be a global public good. The Peoples Vaccine Alliance
has issued demands on Big Pharma to openly share vaccine technology and know-how. They have
also called on governments to temporarily suspend patent rules at the WTO on Covid-19 vaccines,
treatments, and testing during the pandemic, supporting a proposal rst made by India and South
Africa in October 2020. This, they claim, will help break Big Pharma monopolies and increase
supplies so that there are enough doses for everyone, everywhere(The Peoples Vaccine, 2021).
COVAXs staunchest supporter, the EU, has consistently opposed this move, maintaining that
patents are not the major barriers to scaling up manufacturing and that removing patents will
deter industry from partnering. However, over 100 countries, more than 60 former heads of
state and Nobel Prize laureates, and even US President Biden now support the proposal on a tem-
porary waiver on Covid-19 vaccines patents, providing credibility to a possible partial solution to
the impasse of vaccine apartheid. The future of the public-private partnership model may be in the
balance.
Acknowledgements
Thank you to Aurelia India Neumark for excellent research assistance. We would also like to thank our international
advisory board members and the Global Health Politics research group at the Centre for Development, University of
Oslo, especially Desmond McNeill and Thomas Neumark, for thoughtful comments on a draft of this article.
Disclosure statement
No potential conict of interest was reported by the author(s).
Funding
The Research Council of Norway (Norges Forskningsråd) provided funding for this research [grant number 301929].
ORCID
Katerini Tagmatarchi Storeng http://orcid.org/0000-0003-0032-7006
Antoine de Bengy Puyvallée http://orcid.org/0000-0002-5800-3701
Felix Stein http://orcid.org/0000-0002-0123-9895
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GLOBAL PUBLIC HEALTH 17
... In the distribution of the vaccine, priority access was granted to vulnerable populations, including healthcare workers (HCWs), who were at the forefront of the battle against COVID-19. 6,7 However, the uptake of COVID-19 vaccines initially faced various challenges, including the widespread vaccine misinformation. This prompted concerted efforts to address this obstacle and enhance vaccine coverage across diverse communities, particularly for HCWs. ...
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Background: Vaccine hesitancy hinders COVID-19 control, especially among healthcare workers (HCWs). Aim: This study examined factors influencing COVID-19 vaccine uptake and hesitancy among HCWs in Abidjan, Côte d’Ivoire. Setting: The study was conducted among healthcare workers in Abidjan, the capital city of Côte d’Ivoire. Methods: A cross-sectional study was conducted from May 2023 to June 2023 in Abidjan. A total of 240 HCWs completed a questionnaire on vaccination attitudes, hesitancy factors and willingness to recommend vaccines. Descriptive statistics and modified Poisson regression estimated adjusted prevalence ratios (aPR) at a 95% confidence interval. Results: Among participants, 57.5% were female, with a median age of 40 years (IQR: 33–45). HCWs included physicians (26.7%), nurses/midwives (22.5%) and pharmaceutical staff (19.2%). They worked in teaching hospitals (23.3%), general hospitals (30.8%) and community hospitals (45.8%). Vaccine uptake was 73.3%, with 53.3% fully vaccinated and only 4.6% receiving a booster dose. However, 42.1% exhibited vaccine hesitancy, mainly due to concerns about side effects (52.2%). While 55.0% would recommend the vaccine, only 46.3% felt confident addressing patient questions. Age was positively correlated with vaccine uptake: HCWs aged 35–44 years, 45–54 years and 55–65 years were 1.60, 1.68 and 1.78, respectively times more likely to be vaccinated, respectively, compared to those aged 22–34 years. Conclusion: Vaccine hesitancy (25%) and low booster uptake (4.6%) highlight the need for targeted education and pharmacovigilance. Strengthening HCWs vaccine knowledge and trust is essential for epidemic control. Contribution: This study underscores the importance of Ministry of Health-led interventions to improve HCWs vaccination rates in Africa.
... Governments of HICs with purchasing power signed bilateral agreements with vaccine manufacturers to secure supplies for their populations before they were made available to LMICs through COVAX, resulting in a "too little, too late" delivery to LMICs (29). Others point out governance issues inherent to PPPs, such as conflicts of interest among suppliers sitting on the governing board (30). However, the COVAX model is likely to be relevant for future pandemics, particularly as an effort to ensure the PABS mentioned above. ...
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The COVID-19 pandemic has highlighted the importance of pandemic prevention, preparedness, and response (PPPR) in global health. This review first examined global health governance (GHG) for PPPR, identifying its core-satellite structure. Key GHG functions include rule-setting, resource mobilization, medical countermeasures (MCMs) supply, surveillance and data/pathogen sharing with rapid response, and One Health. Major gaps exist in global collaboration, enforcement of the International Health Regulations (IHR), and the World Health Organization's (WHO) capacity. The most urgent issue is pathogen access and benefit-sharing (PABS). Second, the PPPR capacity across world regions were assessed using two public datasets: eSPAR and GHS Index. Sub-Saharan Africa requires urgent support to strengthen most PPPR aspects, while epidemiological and laboratory surveillance, infection prevention and control (IPC), and regulatory functions need improvement in low- and middle-income countries (LMICs) in various regions outside Europe. Japan, with its strong PPPR capacity, is well-positioned to assist. Lastly, the review explored the link between PPPR and health systems strengthening (HSS). PPPR must be firmly integrated into HSS to ensure resilience, equity, inclusiveness, continuity of care, and sustainability. Core health system components — service delivery, workforce, health information systems, MCMs access, and governance — along with communication and trust-building, effectively contribute to PPPR. However, pandemic exceptionalism and the over-securitization of PPPR and health security may hinder coordination. The enhanced GHG for PPPR, led by the empowered WHO, should effectively facilitate and coordinate technical assistance to LMICs to strengthen their PPPR capacities and promote PPPR-HSS integration by bringing together the often-divided health security and HSS communities.
... With a specific focus on the rapid development, production, procurement, and equitable access to COVID-19 vaccines, COVAX was the brainchild of GAVI and CEPI, with support from the WHO and UNICEF. As a "super public-private partnership" (Storeng, de Bengy Puyvallée and Stein, 2023), COVAX was intended to be a powerful buyers' pool (Yamey et al., 2022). According to this pooling logic, participating governments would collectively channel their financial resources through COVAX, which would enable this mechanism to fund vaccine research, development, and manufacturing, as well as reduce the cost of vaccines through large collective purchases from pharmaceutical suppliers. ...
... The COVID-19 pandemic is perhaps one of the clearest examples of how capitalist profiteering is exploiting populations' health needs. It is also worth reminding that even in the case of the Oxford University vaccine, which was developed under the promise of being available at cost price, the relevant promise was never fulfilled; under the pressure of Bill Gates, the manufacturing rights of this publicly developed vaccine were granted to the AstraZeneca for-profit manufacturing corporate that determined its final price using market criteria (Storeng, Puyvallée, and Stein 2023). Table 4 presents data on public funding for vaccine research and development, preorders, and range of prices of vaccines by pharmaceutical corporates, illustrating the multiple methods applied during the COVID-19 pandemic in order to ensure the global pharmaceutical industry's profitability. ...
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The COVID-19 pandemic revealed and exacerbated the global inequalities regarding the availability and access to vaccines. Many terms have appeared in the academic literature (“vaccine colonialism,” “vaccine nationalism,” “vaccine apartheid”) trying to capture and interpret these inequalities, failing in most cases to realistically explain the upstream causes of the observed injustices. A Marxist perspective on the contrary emphasizes the structural causes of inequalities in capitalism and attributes them to the existence of economic exploitation. “Vaccine imperialism,” which refers to the control that advanced industrialized countries exert on the development, production, and distribution of vaccines at the expense of less-developed economies, can describe and explain in a more realistic way the observed inequalities during the pandemic. Our study proposes a circuit of vaccine imperialism that explains how economic imperialist exploitation takes place via transfers of value from less-developed economies (vaccine recipient countries) to imperialist economies (vaccine producing and patent holder countries) using four different channels: (a) protection of intellectual property (IP) rights (patents), (b) earnings from royalty payments for the use of vaccines (monopolistic prices and profits), (c) exercise of monopoly power on the production and distribution of vaccines (control over the quantity of vaccines supplied, exclusion of competitors through vaccine licensing), and (d) public debt servicing. JEL Classification: I14, I18, D43, F54, F55, H51
... Recent studies highlight the scarcity of experimental studies investigating interactions between SARS-CoV-2 and other pathogens, particularly in animal models. 149,150 However, existing research indicates that coinfections with SARS-CoV-2 and influenza can exacerbate the severity of COVID-19. The effects of coinfection on viral loads varied across studies, possibly due to differing methodologies. ...
Chapter
This chapter focuses on the cosmopolitanism of the COVID-19 vaccine as a promising approach to collectively curb the borderless COVID-19 pandemic and promote shared humanity. Since the end of 2019 till 2021, the world experienced an exponential spread of COVID-19 virus that claimed many lives irrespective of the race, age, gender of people. In response to combat the pandemic, the world has been unanimously united around cosmopolitan health regulations and political determinants of health as concerted efforts towards saving lives. These include, the WHO’s declaration on the race for COVID-19 vaccine and recommendation for human solidarity for the needy, social distancing between people of at least one metre, washing hands with soap or alcohol-based sanitizers, wearing of masks in public, quarantining infected people. Countries also enforced strict measures that restricted human mobility such as closures of nation-state borders and imposition of curfews. The chapter argues that the COVID-19 pandemic has reminded the world that we are all one and all lives matter. Thus, divisions based on race, gender, sex etc. should not stand in the way of finding collective solutions to problems which afflict humanity today and possibly going into the future. Through desktop research and content analysis, the study extensively reviews the notion of cosmopolitanism, politics of vaccine, and COVID-19 pandemic to understand the necessity of a cosmopolitan approach to vaccine to combat the pandemic and promote collective and shared humanity. It was found that the world was interconnected by concerted cosmopolitan regulations to combat the COVID-19 pandemic. Using vaccine cosmopolitanism constitutes a promising approach to save live globally irrespective of physical and symbolic borders separating humanities. It is necessary to include countries from the Global South in both production and distribution of the COVID-19 vaccine. People should not be reminded that they are all the same because a disaster is raging and consuming them like a wild conflagration, but this should be always the norm/standard- cosmopolitanism and a shared humanity.
Article
To close persistent global health financing gaps, policymakers have in recent years promoted the idea of 'blended finance', i.e. the strategic use of public funds to attract additional private sector investment. To better understand this trend, this paper studies three major blended finance instruments, namely vaccine bonds, advanced market commitments, and matching funds. In doing so, this paper makes two important contributions. On a practical level, it shows that these three blended finance instruments tend to be expensive and of questionable effectiveness. Their high costs favour large corporate actors, private investors and middlemen, while their benefits for potential beneficiaries in low- and middle-income countries and for public donors remain unclear. On a theoretical level, the paper asks why these instruments remain popular in policy circles despite their shortcomings. It finds that blended finance mechanisms proliferate thanks to their seemingly innovative nature, a constant emphasis on urgency or crisis, and the promise of combining market-based self-interest with positive social impact. The paper ends on a call for much greater critical scrutiny concerning blended financing mechanisms.
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As traditional approaches to global governance face increasing gridlock due to institutional inertia and divergent national interests, non-state actors have emerged as vital catalysts for change. Drawing on Ostrom's (2010) theoretical framework, this chapter explores how polycentric governance—characterized by multiple, semi-autonomous decision-making centers—offers a promising alternative to conventional monocentric or anarchic systems. Through analysis of recent scholarship and case studies across climate change, resource management, and sustainable development initiatives, this research examines how polycentrism's adaptability and emphasis on diverse governance structures fosters innovation and enhances resilience. The findings demonstrate that polycentric approaches enable locally tailored yet globally coordinated responses to transnational challenges, contributing to our understanding of how international cooperation can evolve beyond current governance limitations to address the multifaceted challenges of our increasingly interdependent world.
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Partnership is essential for solving complex global challenges. In global health, however, partnership has become associated with a specific model: public-private partnerships (PPPs), in which the key actors are donor governments, philanthropic foundations, and the private firms that produce drugs and vaccines. As this model comes under strain in the face of cuts to international aid and criticisms of the lack of transparency and accountability in some of the biggest global health PPPs, we should look not only to make incremental reforms but also to engage in more fundamental questions about the kinds of partnership we need to tackle current and future global health challenges. This involves thinking about who the appropriate partners are for particular purposes, and what we want these partnerships to do. We suggest that existing organizations need to reform to stay fit for purpose, but we caution against the risk that these reform efforts constrain our ability to think creatively by limiting the conversation to the partnerships we have, rather than discussing what partnerships we need to pursue an ambitious post 2030 agenda. Free access to the piece until March 19th: https://authors.elsevier.com/a/1kWO5V-4XOxG2
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COVID-19 placed global health governance under unprecedented strain. The World Health Organization (WHO) became severely questioned and got caught in the crossfire of great-power competition, whereas other entities vaulted into the limelight. This chapter delves into the European Union’s (EU) consolidation as an actor within this increasingly complex governance domain, whose fragmentation long predates COVID-19. We analyse the degree to which relevant political-institutional developments in the EU’s burgeoning (global) health policy, as well as the broader evolution of the global health architecture, have elicited Europeanist, Atlanticist and nationalist responses within the EU and its Member States. We find that European actors tend to signal a rejection of fragmentation in global health governance, while accepting it in practice.
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Background During the first year and a half of the COVID-19 pandemic, COVAX has been the world’s most prominent effort to ensure equitable access to SARS-CoV-2 vaccines. Launched as part of the Access to COVID-19 Tools Accelerator (Act-A) in June 2020, COVAX suggested to serve as a vaccine buyers’ and distribution club for countries around the world. It also aimed to support the pharmaceutical industry in speeding up and broadening vaccine development. While COVAX has recently come under critique for failing to bring about global vaccine equity, influential politicians and public health advocates insist that future iterations of it will improve pandemic preparedness. So far COVAX’s role in the ongoing financialization of global health, i.e. in the rise of financial concepts, motives, practices and institutions has not been analyzed. Methods This article describes and critically assesses COVAX’s financial logics, i.e. the concepts, arguments and financing flows on which COVAX relies. It is based on a review of over 109 COVAX related reports, ten in-depth interviews with global health experts working either in or with COVAX, as well as participant observation in 18 webinars and online meetings concerned with global pandemic financing, between September 2020 and August 2021. Results The article finds that COVAX expands the scale and scope of financial instruments in global health governance, and that this is done by conflating different understandings of risk. Specifically, COVAX conflates public health risk and corporate financial risk, leading it to privilege concerns of pharmaceutical companies over those of most participating countries – especially low and lower-middle income countries (LICs and LMICs). COVAX thus drives the financialization of global health and ends up constituting a risk itself - that of perpetuating the downsides of financialization (e.g. heightened inequality, secrecy, complexity in governance, an ineffective and slow use of aid), whilst insufficiently realising its potential benefits (pandemic risk reduction, increased public access to emergency funding, indirect price control over essential goods and services). Conclusion Future iterations of vaccine buyers’ and distribution clubs as well as public vaccine development efforts should work towards reducing all aspects of public health risk rather than privileging its corporate financial aspects. This will include reassessing the interplay of aid and corporate subsidies in global health.
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Policy Points Equitable access to a COVID-19 vaccine in all countries remains a key policy objective, but experience of previous pandemics suggests access will be limited in developing countries, despite the rapid development of three successful vaccine candidates. The COVAX Facility seeks to address this important issue, but the prevalence of vaccine nationalism threatens to limit the ability of the facility to meet both its funding targets and its ambitious goals for vaccine procurement. A failure to adequately address the underlying lack of infrastructure in developing countries threatens to further limit the success of the COVAX Facility. Context: Significant effort has been directed toward developing a COVID-19 vaccine, which is viewed as the route out of the pandemic. Much of this effort has coalesced around COVAX, the multilateral initiative aimed at accelerating the development of COVID-19 vaccines, and ensuring they are equitably available in low- and middle-income countries (LMICs). This paper represents the first significant analysis of COVAX, and the extent to which it can be said to have successfully met these aims. Methods: This paper draws on the publicly available policy documents made available by the COVAX initiatives, as well as position papers and public statements from governments around the world with respect to COVID-19 vaccines and equitable access. We analyze the academic literature regarding access to vaccines during the H1N1 pandemic. Finally, we consider the WHO Global Allocation System, and its principles, which are intended to guide COVAX vaccine deployment. Findings: We argue that the funding mechanism deployed by the COVAX Pillar appears to be effective at fostering at-risk investments in research and development and the production of doses in advance of confirmation of clinical efficacy, but caution that this represents a win-win situation for vaccine manufacturers, providing them with opportunity to benefit regardless of whether their vaccine candidate ever goes on to gain regulatory approval. We also argue that the success of the COVAX Facility with respect to equitable access to vaccine is likely to be limited, primarily as a result of the prevalence of vaccine nationalism, whereby countries adopt policies which heavily prioritize their own public health needs at the expense of others. Conclusions: Current efforts through COVAX have greatly accelerated the development of vaccines against COVID-19, but these benefits are unlikely to flow to LMICs, largely due to the threat of vaccine nationalism.
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The Covid-19 pandemic marks a shift in the EU’s approach to the multilateral system. Just at a time when the EU aspires to avoid being crushed between the US and China, the World Health Organization (WHO) became one of the new battlegrounds in world politics. This norm-setting international organization for health was already under pressure due to a plethora of other organizations trespassing its mandate, reduced core funding and weak governance, reinforced by a strongly decentralized structure. This article will use the exit, voice and loyalty approach to analyse how the EU operated in the multilateral system during the first phase of the Covid-19 crisis with the WHO and vaccines race as case studies. A comparison is made with the EU’s positioning on global health in the previous decade. Is the EU truly committed to upholding multilateralism in global health through the WHO, and has the Covid-19 pandemic made a structural change?
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Business has been involved in cooperation with multilateral organizations through public-private partnerships (PPPs) since the late 1990s. With their adoption of the sustainable development goals (SDGs), multilateral institutions increasingly consider partnerships as a means to achieve their goals given their own limited implementation capacity. However, the global economic order has changed significantly since the first expansion of PPPs, particularly due to growing participation by non-western states and companies. This article asks how this shift has changed the eagerness to form partnerships, as well as their qualitative content. It analyzes the 3964 partnerships in the SDG partnership registry, focusing on the subset of them that includes business partners. We divide these into five groups: local implementation, resource mobilization, advocacy, policy, and operational partnerships. We study PPPs involving companies from different varieties of capitalism—private, market based forms, and state-led forms of capitalism. We find that PPPs are still dominated by companies and other actors from Western countries. Moreover, business participate more in U.S.- and Canadian-led partnerships than others. We also find strong differences regarding what category of PPPs that companies from different backgrounds engage in, and discuss the linkages between varieties of capitalism and PPP participation.
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The growth of global public-private partnerships for health has opened up new spaces for civil society participation in global health governance. Such participation is often justified by the claim that civil society organizations, because of their independence and links to communities, can help address democratic deficits in global-level decision-making processes. This article examines the notion of 'civil society engagement' within major public-private partnerships for health, where civil society is often said to play a particularly important role in mediating between public and private spheres. How do major global health partnerships actually define 'civil society', who represents civil society within their global-level decision-making bodies, and what formal power do civil society representatives hold relative to other public and private-sector partners? Based on a structured analysis of publicly available documents of 18 of the largest global public-private partnerships for health, we show that many of them make laudatory claims about the value of their 'civil society engagement'. Most use the term 'civil society' to refer to non-governmental organizations and communities affected by particular health issues, and state that they expect these actors to represent the needs and interests of specific populations in global-level decisions about strategies, funding models and policies. Yet, such civil society actors have a relatively low level of representation within the partnerships' boards and steering committees, especially compared with private-sector actors (10.3 vs 23.7%). Moreover, there is little evidence of civil society representatives' direct and substantial influence within the partnerships' global-level governing bodies, where many decisions affecting country-level programmes are made. Rather, their main role within these partnerships seems to be to implement projects and advocate and raise funds, despite common discourses that emphasise civil society's watchdog function and transformative power. The findings suggest the need for in-depth research into the formal and informal power of civil society within global health governance processes.
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Norway has played a critical role in the recent launch of the new Coalition for Epidemic Preparedness Innovation, revealing Norway's powerful position in global health. But how will Norway help put the coalition's governance principles - political legitimacy, representation and accountability - into practice? And how will a more security-based approach impact Norwegian global health policy and research? On January 19, 2017, a new Coalition for Epidemic Preparedness Innovation entered the global health architecture. Launched at the World Economic Forum by Norwegian Prime Minister Erna Solberg and Bill Gates, the coalition aims to finance the development of vaccines against emerging infectious diseases. In the coalition's own words, its objective is nothing short of "outsmarting epidemics" and giving the world "an insurance against epidemics" (1). The coalition is designed as a public-private partnership with representation from governments, philanthropies, nongovernmental organisations, pharmaceutical companies, research institutes, regulatory bodies and multilateral organisations (box 1). Although branded as a global initiative, it is very much "made in Norway," with its creation highlighting Norway's financial and agenda-setting power as a major global health actor.
Book
Offers a nuanced analysis of the interaction between the Rockefeller Foundation's International Health Division and Mexico's Departamento de Salubridad Pública as they jointly promoted public health through campaigns against yellow fever and hookworm disease, organized cooperative rural health units, and educated public health professionals in North American universities and Mexican training stations.
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Global partnerships have transformed international institutions by creating platforms for direct collaboration with NGOs, foundations, companies and local actors. They introduce a model of governance that is decentralized, networked and voluntary, and which melds public purpose with private practice. How can we account for such substantial institutional change in a system made by states and for states? Governance Entrepreneurs examines the rise and outcomes of global partnerships across multiple policy domains: human rights, health, environment, sustainable development and children. It argues that international organizations have played a central role as entrepreneurs of such governance innovation in coalition with pro-active states and non-state actors, yet this entrepreneurship is risky and success is not assured. This is the first study to leverage comprehensive quantitative and qualitative analysis that illuminates the variable politics and outcomes of public-private partnerships across multilateral institutions, including the UN Secretariat, the World Bank, UNEP, the WHO and UNICEF.