Arrhythmias and Device Therapy – Arrhythmias, General, Diagnostic Methods 299
Device for modeling of intra-arterial circulation: application in experimental cardiology
O. Germanova1, V.A. Germanov1, Y.V. Shchukin1, A.V. Germanov1, G. Galati2
1Samara State Medical University, Samara, Russian Federation; 2San Raffaele Hospital, Milan, Italy
Funding Acknowledgement: Type of funding sources: None.
Purpose of study: Using an original device for modeling of intra-arterial
blood circulation, to study the features of intravascular hemodynamics with
a regular heart rhythm and with various rhythm disturbances.
Material and methods: We used an original device developed by us to
simulate intra-arterial circulation (Document of invention No. RU 202780
U1). The main part of the device is a glass tube of a rotameter with a
length of 365 mm, an inlet end with a diameter of 20 mm, an outlet end of
16.5 mm, which is a model of an arterial vessel. Flexible silicone tubes are
attached to the rotameter on both sides, with free ends connected to an
electric pump, with various modes of operation (imitation of pulse waves
with regular rhythm, premature ventricular contractions (PVCs), atrial ﬁbril-
lation (AF). An aqueous solution of glycerin was introduced into a closed
system diluted with water corresponding to the viscosity of the blood. A 5
mm long silk thread was alternately installed inside the tube, an intravascu-
lar piezoelectric crystal pressure probe connected to an oscilloscope. Also
it was injected inside the tube a dye - clerical ink.
Results: With electric pump, we simulated the spreading of the pulse wave
in regular heart rate, PVCs and AF. We observed the effect of a pressure
wave (deﬂection of a silk thread, the appearance of a turbulent ﬂow when
using a dye) on the walls of the rotameter, with the formation of standing,
reﬂected waves during the PVCs and AF. The pressure probe registered
an increase in pressure inside the tube during the spread of the 1st post-
extrasystolic contraction wave up to 58%, the wave after a long pause of
more than 2 seconds with AF by 44% compared to the regular rhythm.
Conclusion: A device for modeling of intra-arterial circulation allows a
wide range of experimental work in cardiology, normal and pathological
physiology, and biophysics.
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