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ГЛЮТЕНОВАЯ АТАКСИЯ – РАСПРОСТРАНЕННОЕ, ПЛОХО ДИАГНОСТИРУЕМОЕ ЗАБОЛЕВАНИЕ

October 2021
East European Journal of Parkinson`s Disease and Movement Disorders 7(1):3-6

DOI:10.33444/2414-0007.7.1-2.3-7

Authors:

Yevgen Trufanov

Shupyk National Healthcare University of Ukraine

Natalia Svyrydova

Shupyk National Healthcare University of Ukraine

Целью нашей работы было повысить осведомленность неврологов и семейных врачей о глютеновой атаксии, усовершенствовать диагностический подход и улучшить диагностику. Материал и методы. При написании обзорной статьи использовались ресурсы PubMed и Google Scholar. Результаты. При проведении дифференциальной диагностики атаксий невероятно важным является не пропустить заболевания, которые поддаются лечению. Одним из таких заболеваний является глютеновая атаксия, ранняя диагностика которой и своевременное лечение (безглютеновая диета) приводит к значительному уменьшению клинических симптомов и предотвращает их прогрессирование. Глютеновая атаксия является одним из наиболее распространенных и в тоже время плохо диагностируемых заболеваний, проявляющихся атаксией. По данным исследований ее распространенность среди всех атаксий составляет 15% и достигает 40% среди всех идиопатических спорадических атаксий (Hadjivassiliou M., Sanders D.D., Aeschlimann D.P., 2015). Ключевые слова: глютеновая атаксия, целиакия, расстройства, связанные с глютеном. Gluten ataxia - a common, commonly misdiagnosed disease Trufanov Y.O., Svyrydova N.K., Martynovsky M.M. Department of Neurology and Reflexology, the Shupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine The objective of our research was to raise awareness of neurologists and family physicians about gluten ataxia and improve the diagnostic approaches. Methods. PubMed and Google Scholar resources were used to write the review article. Discussion. It is incredibly important not to overlook treatable courses of ataxia. One of these diseases is gluten ataxia. Early diagnosis and timely treatment (gluten-free diet) of gluten ataxia leads to a significant improvement of clinical symptoms and prevents their progression. Gluten ataxia is one of the most common and commonly misdiagnosed ataxia. Its prevalence among all ataxias is 15% and reaches 40% among all idiopathic sporadic ataxias (Hadjivassiliou M., Sanders D.D., Aeschlimann D.P., 2015). Keywords: gluten ataxia, celiac disease, gluten-related disorders.

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East European Journal of Parkinson’s Disease and Movement Disorders. – 2021. – Vol. 7, No. 1-2

Целью  

   

  

   

  

 



.

Материал и ме-

тоды   

 Google Scholar.

Результаты.      



 





         

    



Hadjivassiliou M., Sanders D.D., Aes-

chlimann D.P., 2015).

Ключевые слова: 

.

Abstract

GLUTEN ATAXIA - A COMMON, COMMONLY MISDIAGNOSED DISEASE

Trufanov Y.O., Svyrydova N.K., Martynovsky M.M.

Department of Neurology and Reflexology, the Shupyk National Healthcare University of

Ukraine, Kyiv, Ukraine

The objective of our research was to raise awareness of neurologists and family physi-

cians about gluten ataxia and improve the diagnostic approaches.

Methods. PubMed and Google Scholar resources were used to write the review article.

Discussion. It is incredibly important not to overlook treatable courses of ataxia. One

of these diseases is gluten ataxia. Early diagnosis and timely treatment (gluten-free diet) of

gluten ataxia leads to a significant improvement of clinical symptoms and prevents their pro-

gression. Gluten ataxia is one of the most common and commonly misdiagnosed ataxia. Its

https://doi.org/10.33444/2414-0007.7.1-2.3-7 УДК 616.831.71-009.26-039.3-02-07-08

ГЛЮТЕНОВАЯ АТАКСИЯ – РАСПРОСТРАНЕННОЕ, ПЛОХО

ДИАГНОСТИРУЕМОЕ ЗАБОЛЕВАНИЕ

Труфанов Е.А., Свиридова Н.К., Мартыновский М.М.

, 

 , 

East European Journal of Parkinson’s Disease and Movement Disorders. – 2021. – Vol. 7, No. 1-2

prevalence among all ataxias is 15% and reaches 40% among all idiopathic sporadic ataxias

(Hadjivassiliou M., Sanders D.D., Aeschlimann D.P., 2015).

Keywords: gluten ataxia, celiac disease, gluten-related disorders.

Резюме

ГЛЮТЕНОВА АТАКСІЯ - ПОШИРЕНЕ ЗАХВОРЮВАННЯ, ЩО ПОГАНО

ДІАГНОСТУЄТЬСЯ

Труфанов Є.О., Свиридова Н.К., Мартиновський М.М.





Метою  



Матеріал і методи



Результати





  









., 2015).

Ключові слова

Введение.   



   

    

   

     

    

   

(Hadjivassiliou M., Sanders D.D., Aeschli-

mann D.P    

  

   

   

Fasano A., Berti I., Gerarduzzi T.,

et al., 2003).

 

    

   

    



 

     



    

Lionetti E., Catassi C., 2011).

 

      



  Hadjivassiliou M.,

Sanders D.D., Aeschlimann D.P., 2015).

     

   



     





Целью    

   

  

    



Материал и методы  

   

PubMed  Google Scholar.

East European Journal of Parkinson’s Disease and Movement Disorders. – 2021. – Vol. 7, No. 1-2

Результаты и их обсуждение. 

    

   



  





   

  

      



Silva R.N., Vallortigara J., Greenfield J. et al.,

2019).

     

    

  

    





   

     

    

   -

     



   



    

      



   

 -    

   

 

 

  



    

   

     

    

    



 (Lionetti E., Catassi C., 2011). 



   

      -  

       

 (Fasano A., Berti I., Gerarduzzi T., et al.,

2003).









    

 -    

 6-

  



     



    

-

    

   

    

   Hadjivassiliou M., Sanders

D.D., Aeschlimann D.P., 2015; Lionetti E.,

Catassi C., 2011).

  





     

   

(Lionetti E., Catassi C., 2011).

  

    

   

   

  





(Hadjivassiliou M.,

Sanders D.D., Aeschlimann D.P., 2015).

   









  -



--

    

D.D., Aeschlimann D.P., 2015; Mitoma H.,

Adhikari, K., Aeschlimann D., et al., 2016).





     

 (Diaconu G., Burlea M., Grigore I.,

et al., 2013). 

      

  

East European Journal of Parkinson’s Disease and Movement Disorders. – 2021. – Vol. 7, No. 1-2

 

   (Hadjivassiliou

M., Sanders D.D., Aeschlimann D.P., 2015).

 

  

     

    

    

    





.

    

  

     



   





      

   

     

    



   



  





    



   

     



Adhikari K., Aeschlimann D., et al., 2016;

Hadjivassiliou M., Sanders D.D.,

Aeschlimann D.P., 2015).

   



    

     

     

   

     

    

  



(Lionetti E., Catassi C., 2011).

Выводы.   



 

    



    



    





Литература

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Hadjivassiliou, M. (2019). Diagnosis and

management of progressive ataxia in

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ii de Medici  i Naturali ti

din Ia i, 117(1), 88-94.

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ResearchGate has not been able to resolve any citations for this publication.

Diagnosis and management of progressive ataxia in adults

Article

Full-text available

May 2019

Progressive ataxia in adults can be difficult to diagnose, owing to its heterogeneity and the rarity of individual causes. Many patients remain undiagnosed (‘idiopathic’ ataxia). This paper provides suggested diagnostic pathways for the general neurologist, based on Ataxia UK’s guidelines for professionals. MR brain scanning can provide diagnostic clues, as well as identify ‘structural’ causes such as tumours and multiple sclerosis. Advances in molecular genetics, including the wider and cheaper availability of ‘next-generation sequencing’, have enabled clinicians to identify many more cases with a genetic cause. Finally, autoimmunity is probably an under-recognised cause of progressive ataxia: as well as patients with antigliadin antibodies there are smaller numbers with various antibodies, including some associated with cancer. There are a few treatable ataxias, but also symptomatic treatments to help people with the spectrum of complications that might accompany progressive ataxias. Multidisciplinary team involvement and allied health professionals’ input are critical to excellent patient care, including in the palliative phase. We can no longer justify a nihilistic approach to the management of ataxia.

Consensus Paper: Neuroimmune Mechanisms of Cerebellar Ataxias

Article

Full-text available

Mar 2015
CEREBELLUM

In the last few years, a lot of publications suggested that disabling cerebellar ataxias may develop through immune-mediated mechanisms. In this consensus paper, we discuss the clinical features of the main described immune-mediated cerebellar ataxias and address their presumed pathogenesis. Immune-mediated cerebellar ataxias include cerebellar ataxia associated with anti-GAD antibodies, the cerebellar type of Hashimoto's encephalopathy, primary autoimmune cerebellar ataxia, gluten ataxia, Miller Fisher syndrome, ataxia associated with systemic lupus erythematosus, and paraneoplastic cerebellar degeneration. Humoral mechanisms, cell-mediated immunity, inflammation, and vascular injuries contribute to the cerebellar deficits in immune-mediated cerebellar ataxias.

Prevalence of Celiac Disease in At-Risk and Not-At-Risk Groups in the United States

Article

Full-text available

Mar 2003
ARCH INTERN MED

Celiac disease (CD) is an immune-mediated enteropathic condition triggered in genetically susceptible individuals by the ingestion of gluten. Although common in Europe, CD is thought to be rare in the United States, where there are no large epidemiologic studies of its prevalence. The aim of this study was to determine the prevalence of CD in at-risk and not-at-risk groups in the United States. Serum antigliadin antibodies and anti-endomysial antibodies (EMA) were measured. In EMA-positive subjects, human tissue transglutaminase IgA antibodies and CD-associated human leukocyte antigen DQ2/DQ8 haplotypes were determined. Intestinal biopsy was recommended and performed whenever possible for all EMA-positive subjects. A total of 13 145 subjects were screened: 4508 first-degree and 1275 second-degree relatives of patients with biopsy-proven CD, 3236 symptomatic patients (with either gastrointestinal symptoms or a disorder associated with CD), and 4126 not-at-risk individuals. In at-risk groups, the prevalence of CD was 1:22 in first-degree relatives, 1:39 in second-degree relatives, and 1:56 in symptomatic patients. The overall prevalence of CD in not-at-risk groups was 1:133. All the EMA-positive subjects who underwent intestinal biopsy had lesions consistent with CD. Our results suggest that CD occurs frequently not only in patients with gastrointestinal symptoms, but also in first- and second-degree relatives and patients with numerous common disorders even in the absence of gastrointestinal symptoms. The prevalence of CD in symptomatic patients and not-at-risk subjects was similar to that reported in Europe. Celiac disease appears to be a more common but neglected disorder than has generally been recognized in the United States.

Celiac disease with neurologic manifestations in children. Revista medico-chirurgi-cală̆̆̆ a Societă̆̆̆t ̧ii de Medici s i Naturalis ti din Ias i

Jan 2013
88-94

G Diaconu
M Burlea
I Grigore
D T Anton
L M Trandafir

Diaconu, G., Burlea, M., Grigore, I., Anton, D. T., & Trandafir, L. M. (2013). Celiac disease with neurologic manifestations in children. Revista medico-chirurgi-cală̆̆̆ a Societă̆̆̆t ̧ii de Medici s i Naturalis ti din Ias i, 117(1), 88-94.

New clues in celiac disease epidemiology, pathogenesis, clinical manifestations, and treatment. International reviews of immunology

Jan 2011
219-231

E Lionetti
C Catassi

Lionetti, E., & Catassi, C. (2011). New clues in celiac disease epidemiology, pathogenesis, clinical manifestations, and treatment. International reviews of immunology, 30(4), 219-231.