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Pseudoskeptical and pseudoscientific strategies used in attacks on homeopathy

Authors:
  • University of São Paulo, School of Medicine

Abstract

Homeopathy is often attacked in several countries by groups of individuals who call themselves "sceptics", who autocratically and systematically disparage and deny any scientific evidence which underlies the homeopathic model. In fact, this posture defines them as "pseudosceptics", because the true sceptic doubts, investigates and accepts the existing evidence with an agnostic and neutral posture, with an open mind and free from prejudice. In unmasking these impostors, Marcelo Truzzi and Marcoen Cabbolet describe several "tell-tale signs" through which the conduct of these pseudosceptics disguised as pseudoscientists can be notably recognized. After the publication of the Special Dossier "Scientific Evidence for Homeopathy" in Brazil (2017), pseudosceptics made unfounded and fallacious criticisms of it in the media and social networks, in which the use of these pseudosceptical and pseudoscientific strategies to undermine the vast body of evidence presented is clearly demonstrating. Knowledge of the "tell-tale signs of pseudoscepticism" can be of great use in the differentiation between the true and the false scepticism.
Volume 67, Number 6, June, 2021
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774 University indigenous uses social media to report
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LETTER TO THE EDITOR
777 Pseudoskeptical and pseudoscientific strategies used
in attacks on homeopathy
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781 Pulmonary rehabilitation: a unfairly forgotten
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Journal of e Brazilian Medical Association ISSN 0104-4320
ISSN 1806-9282 (On-line)
777
Rev Assoc Med Bras 2021;67(6):777-780
Pseudoskeptical and pseudoscientic
strategies used in attacks on homeopathy
Marcus Zulian Teixeira1*
LETTER TO THE EDITOR
https://doi.org/10.1590/1806-9282.20210367
Dear Editors,
In October 2020, a manifesto against European legislation
was posted on social networks, which supports the practices of
Complementary/Alternative Medicine (CAM; “First worldwide
manifesto against pseudosciences in health”), written by “pseu-
doskeptical” associations or groups without scientic expres-
siveness, and which present in their associative body individ-
uals who are assumed to have the rights to criticize the health
practices that they do not accept by personal, dogmatic, and
autocratic opinions, systematically disparaging and denying
any scientic evidence that substantiates them. In view of its
wide acceptance, use, and worldwide recognition, homeopa-
thy was the preferred target of this manifesto.
I say “pseudoskeptical” associations because the doctrinal
current of true “skepticism” (sképsis in Greek means “exam-
ination” or “evaluation”), founded in ancient Greece by the
Philosopher Pyrrhus (4th-century BC), argues, “it is not pos-
sible to arm the absolute truth of anything, with it being
necessary to be in constant questioning.”1 e term “pseudo-
skepticism” emerged in the second half of the 19th century,
indicating the explicit tendency toward negationism, instead
of evaluation and ethical and objective questioning proposed
by Greek skepticism.
In 1987, Marcelo Truzzi (1935–2003), a Danish sociologist
and professor of sociology based in the USA (Eastern Michigan
University), elaborated a very illuminating analysis of the term
“pseudoskepticism” or “pathological skepticism,” saying that it
is used to denote the forms of skepticism which deviate from
objectivity, dogmatically denying everything which is not
known, instead of doubting, investigating, and accepting the
evidence that appears with an agnostic and neutral position,
with an open mind, and free from prejudice2,3.
“Since ‘skepticism’ properly refers to doubt rather than
denial–nonbelief rather than belief–critics who take the negative
rather than an agnostic position but still call themselves ‘skep-
tics’ are actually ‘pseudoskeptics’ and have, I believed, gained
a false advantage by usurping that label”2.
“Critics who assert negative claims, but who mistakenly call
themselves ‘skeptics,’ often act as though they have no burden
of proof placed on them at all, though such a stance would be
appropriate only for the agnostic or true sceptic. A result of this
is that many critics seem to feel it is only necessary to present a
case for their counter-claims based upon plausibility rather than
empirical evidence. […] Showing evidence is unconvincing is
not grounds for completely dismissing it. If a critic asserts that
the result was due to artifact X, that critic then has the burden
of proof to demonstrate that artifact X can and probably did
produce such results under such circumstances.2
In his isolated analysis, Marcello Truzzi described the strat-
egies used by pseudoskeptics to deny and disqualify new ideas
and their respective scientic evidence: the tendency to deny,
rather than doubt; double standards in the application of crit-
icism; the making of judgments without full inquiry; ten-
dency to discredit rather than to investigate; use of ridicule or
ad hominem attacks; presenting insucient evidence or proof;
pejorative labeling of proponents as “promoters,” “pseudosci-
entists,” or practitioners of “pathological science”; assuming
criticism requires no burden of proof; making unsubstantiated
counter-claims; counter-claims based on plausibility rather than
empirical evidence; suggesting that unconvincing studies are
grounds for dismissing it; and tendency to dismiss all evidence2,3.
Marcoen Cabbolet, researcher at the Department of
Philosophy, Centre for Logic and Philosophy of Science,
Vrije Universiteit Brussel, scholar of elementary particle phys-
ics4, in his essay “Tell-Tale Signs of Pseudoskepticism (Bogus
Skepticism),”5 warned that “pseudoscepticism, which typically
is portraying someone’s work as despicable with scientically
1Universidade de São Paulo, School of Medicine – São Paulo (SP), Brazil.
*Corresponding author: marcus@homeozulian.med.br
Conicts of interest: the authors declare there are no conicts of interest. Funding: none.
Received on April 01, 2021. Accepted on April 26, 2021.
Pseudoskeptical strategies in attacks on homeopathy
778
Rev Assoc Med Bras 2021;67(6):777-780
unsound polemics, is a modern day threat to the traditional
standard of discussion in science and popular science.”
us, “where the sceptic merely states that he doesnt believe
in someone else’s claims, the pseudosceptic comes himself up
with claims and these are always (very) negative. But pseu-
doscepticism is not just making negative claims: the keywords
are ‘dishonesty’ and ‘foul play’. And it is not aimed at nding
out the truth, but at discrediting someone’s research.”5
In another article6, Cabbolet addressed this “pseudosci-
ence,” clearly and objectively describing “scientic misconduct”
with several classic examples that lead to “negative conclusions
about someone else’s work that are downright false.” He clari-
ed that “three known issues are identied as specic forms of
such scientic misconduct: biased quality assessment, smear,
and ocially condoning scientic misconduct.”
Cabbolet reiterated that pseudoskepticism is the central
focus of this scientic misconduct, which has the objective of
“uttering negative conclusions about someone else’s work that
are downright false,” further suggesting that this posture may
be “a calculated strategy,” rather than a passionate attitude, and
provides recommendations for preventing and dealing with
these three forms of scientic misconduct through educational
and punitive measures6.
In the rst quoted essay5, Cabbolet explains “seven tell-tale
signs of pseudoskepticism” in detail (Table 1), most of which
were initially described by Marcelo Truzzi, through which the
conduct and strategy of pseudoskeptics can be notably recognized.
Expanding the tell-tale signs of pseudoskepticism, Cabbolet
also warned of the fact that “pseudosceptics never publish a
retraction”: “Usually in science, if researcher A publishes a claim
and researcher B refutes the proof, then A publishes a retraction
of the claim. But not so the pseudosceptic. Even when con-
fronted with conclusive proof that his allegations are false, he
will refuse to publish a retraction or to publicly acknowledge
that the claims were fabricated: the typical pseudosceptic will
stick to his fabrications as if not a word has been said […]”5.
As Cabbolet described5, pseudoskepticism is also observed
in the reports of peer reviews of scientic publications, in all
areas of knowledge, when the prejudiced and pseudoscien-
tic opinion of a reviewer denies the publication of an article
which disagrees with their dogmatic view, even if it fullls all
the requirements of the scientic method. is is commonly
observed when we forwarded homeopathic scientic articles
to non-homeopathic journals. Paradoxically, following a pseu-
doskeptical ruse (#7: straight to the mass media)5, the biased
and prejudiced allegations against homeopathy are repeatedly
transmitted through articles and opinion interviews in news-
papers and various popular media, refraining from following
the usual scientic path of submitting them to a peer-reviewed
scientic journal.
erefore, pseudoskeptics act according to two weights and
two measures: they require homeopathic researchers to publish
their studies in non-homeopathic scientic journals (although
studies related to any medical specialization are published in
specialized journals), but they discard this premise, dissemi-
nating their criticisms of homeopathy, propagating them in
nonscientic mass media as “double standards in the applica-
tion of criticism.”
Brazilian homeopathy also suers constant attacks from
pseudoskeptical groups just as in Europe. In order to demystify
the pseudoskeptical fallacy that “there is no scientic evidence
for homeopathy,” the Technical Chamber for Homeopathy
(TC-Homeopathy), Regional Medical Council of the State
of São Paulo (Cremesp, Brazil) prepared a Special Dossier in
2017 entitled “Scientic Evidence for Homeopathy7,8, which
is available online in Portuguese and English in the Revista de
Homeopatia, the scientic journal of the São Paulo Homeopathic
Medical Association (APH).
e dossier encompasses nine narrative reviews in several
lines of homeopathic research (i.e., historical, social, medical
education, pharmacological, basics, clinical, patient safety, and
pathogenetic) and two randomized clinical trials developed by
TC-Homeopathy members contain hundreds of scientic arti-
cles published in several peer-reviewed and indexed scientic
journals; it seeks to highlight the state-of-the-art in homeo-
pathic research7,8.
Bothered by the excellence of these lots of evidence, in
November 2020, a group of Brazilian pseudoskeptics dis-
closed a derisory and fallacious manuscript (“Counter-dossier
of Evidence on Homeopathy”) in the media and social net-
works to evaluate some of the articles published in the referred
dossier according to “the best scientic rigor” and “inform the
population about what science says about the supposed eec-
tiveness of Homeopathy.”
Unfortunately, none of this happened in the aforementioned
manuscript. Contrary to the announced “best scientic rigor”
in the analysis of the articles of the dossier, what is observed
throughout the text is a set of criticisms based on “pseudoskep-
tical strategies” to debunk and disqualify any scientic work:
the tendency to deny, rather than doubt; double standards in
the application of criticism; the making of judgments without
full inquiry; use of ridicule or ad hominem attacks; presenting
insucient evidence or proof; pejorative labeling of authors;
assuming criticism requires no burden of proof (absence of
proof); making unsubstantiated counter-claims (nonspecic
comments); suggesting that unconvincing studies are grounds
for dismissing it; tendency to dismiss all evidence; vitriolic tone;
Teixeira, M. Z. et al.
779
Rev Assoc Med Bras 2021;67(6):777-780
Table 1. Seven tell-tale signs of pseudoskepticism according to Marcoen Cabbolet5.
Seven tell-tale signs of pseudoskepticism
#1: Ad hominem
attacks
Typically, a pseudoskeptic is so eager to portray the author of the targeted work as an amateur that he resorts
to ad hominem attacks: this is a rhetorical technique that is absolutely inadmissible in a scientic discourse, and
therefore this is the number one tell-tale sign that a piece is nothing but a pseudoskeptical attack. It is thus a
real giveaway when the author of the targeted work is called “incompetent,” an “amateur,” a “charlatan,” a
“crackpot,” “ignorant,” “only out to brag about it in a pub,” etc. So, the occurrence of any of these words alone
is already an indication that the entire piece is of doubtful merit.
#2: Vitriolic tone
Typically, a pseudoskeptical attack portrays the targeted work as despicable: usually this is done by riddling
the text with belittling phrases and strong pejoratives. Consequently, the piece has a vitriolic or even libelous
tone that is immediately evident even from a quick supercial reading: that tone is the tell-tale sign of
pseudoskepticism. The archetypical belittling phrase is “every rst-year student could have come up with the
same thing.” Illustrative examples of strong pejoratives are “nonsense,” “perverse,” “a disgrace,” “worth-
less,” “meaningless,” “inferior,” “devoid of content,” “complete rubbish,” and the like, which are then
typically said about the targeted work as a whole.
#3: Nonspecic
comments
In science, when commenting on someone else’s work, one very specically addresses the details of the work
in question. A pseudoskeptic, however, typically doesn’t go through the hard work of really understanding
the targeted work. This feature manifests itself in superciality of the comments. It is therefore a tell-tale
sign of pseudoskepticism when a piece concerns nothing but negative allegations at the metalevel, that is,
negative allegations about the targeted work as a whole, without going into the details of the targeted work.
#4: Absence of
proof
Another typical feature of pseudoskeptics is that they have no shame: one of the most shameless ways to attack
someone else’s work is to put forward outright fabrications, which, if true, would imply gross incompetence of
the author of the targeted work. But fabrications cannot be proven by their very nature. Consequently, absence
of proof of the (usually grave) allegations in a piece is a sure tell-tale sign of pseudoskepticism at its worst, and a
strong indication that the piece may contain fabricated allegations. An illustrative example is an absence of proof
of the one statement that is probably the most abused phrase of all in modern science: “this work is of insufcient
scientic quality.” In a pseudoskeptical attack, this is typically said of the targeted work without specifying which
criteria of scientic quality are not met, and why or how they are not met–there are peer-reviewed reports that
consist of just this one phrase.
#5: False
metaphors
In science, comments on someone else’s work remain conned to that work: one doesn’t indulge oneself in
metaphors. In a pseudoskeptical attack, however, often the targeted work is compared with a theory that is
known to be false or that is obviously ridiculous, as if it is the same thing. Illustrative examples are phrases
like “this is the same as saying that the earth is at,” or “this is the same as saying that the phenomenon is
caused by angels”: these are tell-tale signs of a pseudoskeptical attack. There are more sophisticated cases,
but the point is that this use of metaphors is a rhetorical technique that is absolutely inadmissible in a scientic
discourse. The error is the same in all these cases: contrary to what is stated by the pseudoskeptic, it is not
at all the same.
#6: Contradiction
with history and
basic principles of
science
When attacking a new theory that has not yet been experimentally tested, a pseudoskeptical piece often
blatantly contradicts well-known facts from the history of science, as well as basic scientic principles. The
three archetypical examples that turn up time and time again are
i. stating that scientic discoveries are nowadays only made by large international collaborations, to insinuate
that the work of a single author cannot be a scientic discovery;
ii. stating that scientic theories are always developed from experimental facts, to insinuate that anything
else cannot ever be a scientic theory; and
iii. using an accepted model (other than Einstein’s Special Relativity) beyond its established area of application
as a criterion of truth, to insinuate that a work that contradicts that model cannot be a scientic theory.
The arguments (i) and (ii) completely ignore that virtually all of modern science is built on the work of individuals,
who more often than not theoretically predicted phenomena before these were experimentally observed
(Einstein: time dilation and curvature of space; Dirac: antimatter), and who often did their groundbreaking
work in relative isolation (Einstein, Bohr). The argument (iii) ignores the fact that historical breakthroughs
in science often went squarely against the accepted model of the time, and contradicts a basic principle of
science, put into words by Feynman as follows: “experiment is the sole judge of scientic truth.”
Continue...
Pseudoskeptical strategies in attacks on homeopathy
780
Rev Assoc Med Bras 2021;67(6):777-780
false metaphors; and straight to the mass media among others
(“Pseudoskeptic and pseudoscientic fallacies of the ‘Counter-
dossier of Evidence on Homeopathy’”)9.
In highlighting these pseudoskeptical strategies in the detailed
analysis of the presented criticisms9, we unmasked these pseu-
doskeptics disguised as pseudoscientists as the false and hypo-
critical image of being the “defenders of science,” as they call
themselves in the aforementioned contra-dossier. eblind-
ness caused by pseudoskepticism or pathological skepticism
caused “experienced and renowned researchers in their areas of
concentration” to incur childish errors in their prejudiced anal-
yses, such as simple attentive reading of the texts they attacked
in a fallacious way, denoting noncompliance with basic prem-
ises of the scientic method.
“e rst was never to accept anything for true which I did
not clearly know to be such; that is to say, carefully to avoid pre-
cipitancy and prejudice, and to comprise nothing more in my
judgment than what was presented to my mind so clearly and
distinctly as to exclude all ground of doubt” (René Descartes,
“Discourse on Method”).
REFERENCES
1. Dumont JP. Le scepticisme et le phénomène: essai sur la
signication et les origines du pyrrhonisme. Partie 1. Paris:
Vrin; 1972 [cited on Apr. 1, 2021]. 415 p. Available from:
https://philpapers.org/rec/DUMLSE
2. Truzzi M. On pseudo-skepticism. Zetetic Scholar. 1987 [cited
on Apr. 1, 2021]; (12-13). Available from: https://www.
anomalist.com/commentaries/pseudo.html
3. The plasma universe. Pseudoskepticism. [cited on Apr. 01,
2021]. Available from: https://www.plasma-universe.com/
pseudoskepticism/#cite_note-22
4. Cabbolet M. Elementary process theory: a formal axiomatic
system with a potential application as a foundational framework
for physics supporting gravitational repulsion of matter and
antimatter. Ann Phys. 2010;522(10):699-738. https://doi.
org/10.1002/andp.201000063
5. Cabbolet MJTF. Tell-tale signs of pseudoskepticism (bogus
skepticism). [cited on Apr. 01, 2021]. Available from: https://
philpapers.org/rec/CABTSO-3
6. Cabbolet MJTF. Scientic misconduct: three forms that directly
harm others as the modus operandi of Mill’s tyranny of the
prevailing opinion. Sci Eng Ethics. 2014;20(1):41-54. https://
doi.org/10.1007/s11948-013-9433-8
7. Teixeira MZ. Proofs that Homeopathic Medicine Works: Dossier
“Scientic Evidence for Homeopathy” (Revista de Homeopatia,
São Paulo Homeopathic Medical Association). Homeopathy.
2018;107(1):45. https://doi.org/10.1055/s-0037-1613677
8. Teixeira MZ. Special Dossier: “Scientific Evidence for
Homeopathy”. Rev Assoc Med Bras. 2018;64(2):93-4. https://
doi.org/10.1590/1806-9282.64.02.93
9. Teixeira MZ. Falácias pseudocéticas e pseudocientíficas
do “Contradossiê das Evidências sobre a Homeopatia”
[Pseudoskeptic and pseudoscientic fallacies of the “Counter-
dossier of Evidence on Homeopathy”]. São Paulo: Associação
Paulista de Homeopatia (APH); 2020 [cited on Apr. 1, 2021].
43 p. Available from: https://pesquisa.bvsalud.org/portal/
resource/pt/biblio-1145551?lang=en
Seven tell-tale signs of pseudoskepticism
#7: Straight to the
mass media
It is a bad sign when a scientic claim is taken straight to the mass media (e.g. the cold nuclear fusion
case), but it is an equally bad sign when an attack on someone else’s work is taken straight to the mass
media. When writing a scientic critical comment on a work, the right method is to rst contact its author
and discuss the criticism with him/her. When submitting the critical comment for publication in a scientic
journal, one is often required to present evidence of such a prior contact with the author of the targeted
work. But not so the pseudoskeptic. Typically, he doesn’t contact the author of the targeted work, nor
does he attempt to publish his “ndings” in a peer-reviewed journal: he takes his allegations straight to
the mass media. So an editor of a newspaper or university weekly who sees that an attack on someone’s
work is submitted for publication, can—especially when the piece contains grave accusations—simply
ask for evidence of contact with the author of the targeted work: any failure to provide such evidence
is then a tell-tale sign that the piece is nothing but a pseudoskeptical attack, and an indication that it
may contain fabrications.
Table 1. Continuation.
... which prevents a correct and prejudice-free analysis. In reality, they are pseudoskeptics masquerading as pseudoscientists 6,7 . ...
... The final chapter "Estratégias pseudocéticas e pseudocientíficas usadas em ataques à homeopatia" ("Pseudoskeptical and pseudoscientific strategies used in attacks on homeopathy") discusses pseudoskepticism and pseudoscience, describing the indicative signs of pseudoskepticism (false skepticism or pathological skepticism) in detail, which are topics of fundamental importance to unmask individuals who systematically maintain a denialist and dogmatic stance against homeopathy (pseudoskeptics and pseudoscientists), disregarding the countless existing scientific evidence which was presented in detail in the various chapters of this e-book 6,7 . ...
... As we reiterate throughout the study, despite the difficulties and limitations that exist in developing research in homeopathy, both due to methodological aspects and the lack of institutional and financial support, the set of experimental and clinical studies described is indisputable proof that "there is scientific evidence for homeopathy" and that "homeopathy is not placebo effect," contrary to falsely disseminated prejudice 6,7 . However, new studies must continue to be developed to improve clinical practice and elucidate characteristic aspects of the homeopathic paradigm. ...
... In reality, they are pseudoskeptics masquerading as pseudoscientists. 6 In order to enlighten everyone and demystify culturally ingrained pseudoskeptical fallacies (such as, "there is no scientific evidence for homeopathy" and "homeopathy is placebo effect"), the Technical Chamber for Homeopathy of the Regional Medical Council of the State of São Paulo (Cremesp) produced the Special Dossier "Scientific Evidence for ...
... [37][38][39][40] Concluding the book, the chapter "Pseudoskeptical and pseudoscientific strategies used in attacks on homeopathy" discusses pseudoskepticism and pseudoscience, describing the tell-tale signs of pseudoskepticism (bogus skepticism or pathological skepticism) in detail, which is a topic of fundamental importance for unmasking pseudoskeptics and pseudoscientists who systematically deny the vast amount of scientific evidence for homeopathy cited throughout the work. 6 Thus, despite the difficulties and limitations that exist in developing research in homeopathy, whether due to methodological aspects or the lack of institutional and financial support, the significant set of experimental and clinical studies described in the book is indisputable proof that "there is scientific evidence for homeopathy" and that "homeopathy is not placebo effect", contrary to the falsely disseminated prejudice. However, new studies must continue to be developed to improve clinical practice and elucidate peculiar aspects of the homeopathic paradigm. ...
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Full-text available
Highlights •Homeopathy is based on four heterodox and complementary scientific assumptions. •Pseudoskeptics deny these assumptions and any scientific evidence that proves them. •The e-book proves the scientific evidence for homeopathy. •The e-book describes hundreds of experimental and clinical studies in homeopathy. •The e-book demystifies the fallacy that “homeopathy is placebo effect”.
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This article represents the historical record of the stages of the third management of the intercultural didactic garden (medicinal and sensory) in a courtyard used by the Homeopathy Service, located in the 7th Infirmary of the Hospital Geral Santa Casa da Misericórdia in Rio de Janeiro/Brazil, whose elaboration was inter - transdisciplinary and intersectoral, voluntary and cooperative, with the purpose of cultural appreciation and intercultural and interethnic experience, as a way of promoting well-being and mental health through the preservation of intangible heritage, which is the knowledge of the people. From this stage completed in primary care, scientific initiations were carried out with the plant elements of this garden, ranging from in situ morphological knowledge to the pharmaceutical process using the Hahnemannian method of multiple bottles, to investigate circumscribed environmental issues. For the current stage, Annona muricata (Soursop) used by Traditional Knowledge, was selected based on a bibliographical review and the book by Benoit Jules Mure (1894), doctor and naturalist, who brought Homeopathic Medicine to Brazil at that time, caring for members and families of communities traditional ethnicities and indigenous peoples who were enslaved or left to fend for themselves. Fruit from the garden that bears his name has broad potential for scientific investigation, thus contributing to the expansion of perception regarding cultural diversity and biodiversity, helping to raise awareness of ethical behavior towards the environment (Environmental Ethics).
... and the reception of an Israeli anthropologist, besides a professor from INPI, members of OAB-RJ, among other professionals and representatives from diverse Traditional Communities in 2021 (Varricchio; Lage, 2023).4.5 INTERCULTURAL AND INTERETHNIC GARDENTherefore, following the creation of medicinal gardens(Varricchio, 2019), the group proceeded to revitalize the garden of the 7th Ward at the Santa Casa da Misericórdia Hospital in Rio de Janeiro (Homeopathy Service,2021;Gaspar et al., 2022). In parallel, considerations were made regarding the library being yet another space for intercultural education. ...
Article
A Homeopatia é especialidade médica reconhecida pelo Conselho Federal de Medicina no Brasil e conta com serviços de Residência Médica. Portanto, enquanto especialidade, precisa ser inserida no ensino de alguma forma durante a graduação. O presente artigo visa relatar a experiência do ensino híbrido e interdisciplinar de Homeopatia via currículo oculto a alunos de graduação para a percepção ampliada de seu potencial não apenas em clínica e em atenção primária, mas em pesquisa, também para demonstrar a distinção entre Fitoterapia e Homeopatia. A ementa e as aulas teóricas foram apresentadas pelo sítio do Projeto Saúde Ambiental, Parasitologia, Bioética da Faculdade de Farmácia da Universidade Federal do Rio de Janeiro. Na parte prática, este ensino esteve associado à metodologia ativa com tarefas para resoluções de problemas locais e focais trazidos pela oportunidade de vivência intercultural, inserindo-se o emprego de soluções ultradiluídas e dinamizadas e de extratos vegetais de maneira contextualizada e histórica em nossa sociedade, a partir de estágio ambulatorial no Serviço de Homeopatia da 7ª Enfermaria do Hospital Geral Santa Casa da Misericórdia do Rio de Janeiro. Para mais além de uma função prescritora, o acolhimento e o matriciamento em um espaço de saúde para a promoção à saúde via educação em saúde, em um serviço territorializado e intersetorializado, respeitando-se o perfil plural de nossa clientela de usuários atendidos em nível ambulatorial. Como resultado qualitativo mostra os trabalhos de iniciação científica realizados para conclusão deste curso de extensão piloto e avaliados entre pares. Apresenta ainda projeto maior de sua aula prática através do cultivo de Calendula officinalis, indo desde a semeadura até a visita à farmácia para a observação da farmacotécnica de preparo pelo método hahnemanniano clássico dos múltiplos frascos. Desta maneira, discute o potencial de um projeto de iniciação científica, enquanto exemplo de metodologia ativa de ensino prático que, para sua elaboração, discussão e reflexão precisou entrar em contato com os princípios filosóficos, fisiopatológicos e semiológicos da Homeopatia em doenças crônicas, de sua história clínica e em pesquisa no Brasil, além da sensibilização ambiental no sentido da construção do conceito sobre Saúde Única e que isto envolve o desenvolvimento de competência cultural e competência ética ambiental, expressos através da criação conjunta de um jardim intercultural, uma biblioteca a céu aberto, rica em saberes, mas também em memórias afetivas de membros de Comunidades Tradicionais Étnicas e de Povos Originários que vivem em contexto urbano no Rio de Janeiro/Brasil. Por intermédio deste jardim seguem as investigações em ecofisiologia, fitoremediação e o potencial de emprego para sustentabilidade. Para concluir, este tipo de ensino que mistura metodologias ativas (sala invertida, TBL e aprendizagem baseada em projetos) apresenta-se como promissor para a aprendizagem, porém será necessário o estabelecimento futuro de uma métrica para a sua avaliação didático-pedagógica para incrementar a robustez.
... Apesar das dificuldades e limitações existentes para o desenvolvimento de pesquisas na área, tanto pelos aspectos metodológicos quanto pela ausência de apoio institucional e financeiro, as centenas de estudos experimentais e clínicos citados no referido Dossiê, os quais fundamentam os pressupostos científicos homeopáticos e confirmam a eficácia e a segurança da terapêutica, é prova inconteste de que "a homeopatia não é efeito placebo" e de que "existem evidências científicas em homeopatia", ao contrário do preconceito falsamente disseminado por pseudocéticos e pseudocientistas [6,7]. ...
Technical Report
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Ao discorrermos sobre a homeopatia, em diversas situações, frequentemente, notamos que as pessoas reagem com manifestações de desconfiança, questionando sua comprovação científica e a validade terapêutica do método. Proclamadas em todos os meios, de forma indistinta e reiterada, as falácias ou notícias falsas (fake news) de que "a homeopatia é efeito placebo" ou de que "não existem evidências científicas em homeopatia" acaba se incorporando ao inconsciente da coletividade, servindo como estratégias pseudocéticas para aumentar preconceitos e radicalizar posicionamentos contrários a essa prática médica bissecular. Fruto da desinformação ou negação dos estudos científicos que fundamentam o modelo homeopático em vários campos da pesquisa científica moderna, esses preconceitos se retroalimentam, periodicamente, com matérias e artigos depreciativos e contrários à homeopatia publicados nas mídias de massa (jornais, sites e revistas não científicas) e redes sociais, as quais, raramente, divulgam os trabalhos científicos com resultados favoráveis à homeopatia. Com o intuito de esclarecer médicos, profissionais da saúde, entidades de classe, pesquisadores, gestores, pacientes e a sociedade em geral, buscando desmistificar essas posturas dogmáticas e inverídicas culturalmente arraigadas, em 2017, a Câmara Técnica de Homeopatia do Conselho Regional de Medicina do Estado de São Paulo (CT-Homeopatia do CREMESP) elaborou o Dossiê Especial: "Evidências Científicas em Homeopatia" [1]. Esse projeto contou com o apoio da Associação Médica Homeopática Brasileira (AMHB) e da Associação Paulista de Homeopatia (APH), com a sua publicação na Revista de Homeopatia (São Paulo) da APH em três edições independentes de livre acesso: online em português [2], online em inglês [3] e impressa em português [4]. Expandindo sua divulgação para o público de língua espanhola, este dossiê acaba de ser publicado na revista científica La Homeopatía de México em uma edição especial comemorativa do 90º aniversário da mesma [5].
... A contribuição brasileira ao debate sobre os ensaios patogenéticos homeopáticos discorre sobre o desenvolvimento histórico e o estado da arte da experimentação patogenética homeopática, utilizada para se evidenciar as propriedades curativas das substâncias (efeitos patogenéticos em indivíduos sadios) que possibilitam a aplicação do princípio da similitude terapêutica. Apesar das dificuldades e limitações existentes para o desenvolvimento de pesquisas na área, tanto pelos aspectos metodológicos quanto pela ausência de apoio institucional e financeiro, as centenas de estudos experimentais e clínicos citados no referido dossiê, que fundamentam os pressupostos científicos homeopáticos e confirmam a eficácia e a segurança da terapêutica, é prova inconteste de que existem evidências científicas em homeopatia, ao contrário do preconceito falsamente disseminadopor pseudocéticos e pseudocientistas[6]. No entanto, novos estudos devem continuar a ser desenvolvidos, para aprimorar a prática clínica e elucidar aspectos singulares ao paradigma homeopático. ...
Article
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A o discorrermos sobre a homeopatia em diversas situa-ções, frequentemente, notamos que as pessoas reagem com manifestações de desconfiança, questionando sua comprovação científica e a validade terapêutica do método. Proclamada em todos os meios, de forma indistinta e reiterada, a falácia ou pós-verdade de que "não existem evidências cien-tíficas em homeopatia" acaba se incorporando ao inconsciente da coletividade, servindo como estratégia para aumentar pre-conceitos e radicalizar posicionamentos contrários a essa prática médica bissecular. Fruto da desinformação ou negação dos estudos que fundamentam o modelo homeopático em vários campos da ci-ência, esse preconceito se retroalimenta, de tempos em tempos, com matérias e artigos depreciativos publicados nas mídias e redes sociais, as quais, raramente, divulgam os trabalhos com resultados favoráveis à homeopatia. Com o intuito de esclarecer a classe médica e a socieda-de em geral, buscando desmistificar posturas dogmáticas cultu-ralmente arraigadas, em 2017, a Câmara Técnica de Homeopa-tia do Conselho Regional de Medicina do Estado de São Paulo (CT-Homeopatia do Cremesp) elaborou o Dossiê Especial Evi-dências Científicas em Homeopatia [1]. Esse projeto contou com o apoio da Associação Mé-dica Homeopática Brasilei-ra (AMHB) e da Associa-ção Paulista de Homeopatia (APH), com a sua divulgação na Revista de Homeopatia (São Paulo) da APH em três edi-ções independentes, de acesso aberto: on-line em português [2], on-line em inglês [3] e impressa em português [4]. Expandindo sua divulgação para o público de língua espa-nhola, esse dossiê acaba de ser publicado na revista científica La Homeopatía de México em uma edição especial, come-morativa do 90º aniversário da mesma [5]. Além de trazer o panorama mundial da homeopatia
Article
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Resumen: La Homeopatía es una práctica médica reconocida mundialmente desde hace más de dos siglos, que desarrolla actividades asistenciales, docentes y de investigación en diversas instituciones sanitarias y facultades de medicina. Emplea un enfoque clínico basado en principios científicos heterodoxos y complementarios (principio de similitud terapéutica, experimentación patogenética homeopática, uso de medicamentos individualizados y dosis dinamizadas o potenciadas), con el objetivo de despertar una respuesta curativa en el organismo contra sus propios trastornos y/o enfermedades. Basada en premisas diferentes de las utilizadas por la práctica médica convencional, la Homeopatía suele ser objeto de críticas infundadas y generalizadas por parte de individuos que niegan sistemáticamente los supuestos homeopáticos y cualquier evidencia científica que los demuestre, debido a su postura pseudoescéptica y pseudocientífica, que impide un análisis correcto y libre de prejuicios. Con el objetivo de ilustrar a médicos, investigadores, profesionales de la salud y público en general, desmitificando las posiciones dogmáticas culturalmente arraigadas y las falacias pseudoescépticas de que “no hay evidencia científica para la Homeopatía” y “la Homeopatía es efecto placebo”, la Cámara Técnica de Homeopatía del Consejo Regional de Medicina del Estado de São Paulo (TC-Homeopatía, Cremesp) elaboró el “Dossier Especial: Evidencia Científica de la Homeopatía” en 2017, disponible en ediciones trilingües (portugués, inglés y español). Abarcando nueve revisiones narrativas sobre las diversas líneas de investigación en Homeopatía y conteniendo cientos de artículos científicos que describen estudios experimentales y clínicos, el Dossier destacó el estado del arte de la ciencia homeopática. Al demostrar y ampliar esta evidencia científica en 13 capítulos interactivos, la obra actual pretende actualizar y clarificar los conocimientos en la materia. Además de dilucidar en detalle las premisas epistemológicas del modelo homeopático, la obra describe los diversos aspectos de la investigación básica y clínica que avalan la práctica y el tratamiento homeopáticos en un continuo de información, datos y referencias bibliográficas. La obra aborda diversos temas relacionados con la investigación en Homeopatía, abarcando desde la “epidemiología clínica homeopática” hasta las “estrategias pseudoescépticas y pseudocientíficas utilizadas en los ataques a la homeopatía”, pasando por las “bases farmacológicas del principio de similitud”, los “estudios experimentales en modelos biológicos”, los “ensayos clínicos controlados aleatorizados”, las “revisiones sistemáticas, metaanálisis e informes globales” y los “estudios observacionales”, entre otros. Actuando como terapia integradora y complementaria de otras especialidades, la Homeopatía puede añadir eficacia, efectividad, eficiencia y seguridad a la práctica médica, actuando de forma curativa y preventiva, reduciendo las manifestaciones sintomáticas y la predisposición a enfermar, con bajo coste y mínimos eventos adversos.
Book
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La homeopatía es una práctica médica reconocida mundialmente desde hace más de dos siglos que emplea un enfoque clínico basado en principios científicos heterodoxos y complementarios (principio de similitud terapéutica, experimentación patogénica homeopática, uso de medicamentos individualizados y em dosis dinamizadas o potenciadas), con el objetivo de despertar una respuesta curativa en el organismo. Basada en premisas diferentes a las utilizadas por la práctica médica convencional, la homeopatía es a menudo objeto de críticas. Con el objetivo de esclarecer a médicos, investigadores, profesionales de la salud y el público en general, desmitificando cualquier posición dogmática, este trabajo tiene como objetivo actualizar y clarificar el conocimiento en el área. Además de dilucidar en detalle las premisas epistemológicas del modelo homeopático, el trabajo describe los diversos aspectos de la investigación básica y clínica, que avalan la práctica y el tratamiento homeopático en un continuo de información, datos y referencias bibliográficas. El trabajo aborda varios temas relacionados con la investigación en homeopatía, que van desde la “epidemiología clínica homeopática” hasta las “estrategias pseudoescépticas y pseudocientíficas utilizadas en los ataques a la homeopatía”, pasando por la “base farmacológica del principio de similitud”, “estudios experimentales en modelos biológicos”, “ensayos clínicos controlados aleatorios”, “revisiones sistemáticas, metaanálisis e informes globales” y “estudios observacionales”, entre otros. Actuando como una terapia integradora y complementaria a otras especialidades, la homeopatía puede agregar eficacia, efectividad, eficiencia y seguridad a la práctica médica, actuando de manera curativa y preventiva, reduciendo las manifestaciones sintomáticas y la predisposición a la enfermedad, con bajo costo y mínimos eventos adversos.
Book
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Homeopathy has been a medical practice recognized worldwide for more than two centuries, performing care, teaching and research activities in several health institutions and medical schools. It employs a clinical approach based on heterodox and complementary scientific principles (principle of therapeutic similitude, homeopathic pathogenetic experimentation, use of individualized medicines and dynamized or potentiated doses), with the aim of awakening a curative response in the body against its own disorders and/or diseases. Based on different premises from those used by conventional medical practice, homeopathy is often the target of unfounded and widespread criticism from individuals who systematically deny homeopathic assumptions and any scientific evidence that proves them due to their pseudoskeptical and pseudoscientific stance, which prevents a correct and bias-free analysis. In order to enlighten doctors, researchers, health professionals and the general public, demystifying culturally rooted dogmatic positions and the pseudoskeptical fallacies that "there is no scientific evidence for homeopathy" and "homeopathy is placebo effect", the Technical Chamber of Homeopathy of the Regional Council of Medicine of the State of São Paulo (TC-Homeopathy, Cremesp) prepared the "Special Dossier Scientific Evidence for Homeopathy" in 2017, made available in three independent editions (online in Portuguese and English; printed in Portuguese) in the Revista de Homeopatia (São Paulo). Then, the dossier was published in Spanish in the La Homeopatía de México journal in 2023 in an edition commemorating the journal's 90th anniversary. Encompassing nine narrative reviews on the various lines of homeopathy research and containing hundreds of scientific articles describing experimental and clinical studies, the Dossier highlighted the state of the art of homeopathic science. Proving and expanding this scientific evidence in 13 chapters, the current work aims to update and clarify knowledge in the area. In addition to elucidating the epistemological premises of the homeopathic model in detail, the work describes the various aspects of basic and clinical research which endorse homeopathic practice and treatment in a continuum of information, data and bibliographic references. The work discusses various topics related to research in homeopathy, covering everything from "homeopathic clinical epidemiology" to "pseudoskeptic and pseudoscientific strategies used in attacks on homeopathy", including "pharmacological basis of the principle of similitude", "experimental studies in biological models", "randomized controlled clinical trials", "systematic reviews, meta-analyses and global reports" and "observational studies", among others. In view of the fact that it becomes fruitless and tiring to describe and analyze all the studies and experiments from the different research lines, we suggest and systematize in the different chapters for those who want to delve deeper into the areas of interest, bibliographical surveys of existing literature through the different databases. As we reiterate throughout the work, despite the difficulties and limitations that exist in developing research in homeopathy due to both methodological aspects and the lack of institutional and financial support, the set of experimental and clinical studies described is indisputable proof that "there is scientific evidence for homeopathy" and "homeopathy is not placebo effect", contrary to falsely disseminated prejudice. However, new studies must continue to be developed to improve clinical practice and elucidate peculiar aspects of the homeopathic paradigm. Acting as an integrative and complementary therapy to other specialties, homeopathy can add efficacy, effectiveness, efficiency and safety to medical practice, acting in a curative and preventive manner, reducing symptomatic manifestations and the predisposition to falling ill, with low cost and minimal adverse events, helping doctors to fulfill their "highest and only mission, which is to make sick people healthy, which is called healing" (Samuel Hahnemann, Organon of Medicine, § 1).
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Within the past several decades, the emergence of new viral diseases with severe health complications and mortality is evidence of an age-dependent, compromised bodily response to abrupt stress with concomitantly reduced immunity. The new severe acute respiratory syndrome coronavirus 2, SARS-CoV-2, causes coronavirus disease 2019 (COVID-19). It has increased morbidity and mortality in persons with underlying chronic diseases and those with a compromised immune system regardless of age and in older adults who are more likely to have these conditions. While SARS-CoV-2 is highly virulent, there is variability in the severity of the disease and its complications in humans. Severe pneumonia, acute respiratory distress syndrome, lung fibrosis, cardiovascular events, acute kidney injury, stroke, hospitalization, and mortality have been reported that result from pathogen–host interactions. Hallmarks of aging, interacting with one another, have been proposed to influence healthspan in older adults, possibly via mechanisms regulating the immune system. Here, we review the potential roles of the hallmarks of aging, coupled with host–coronavirus interactions. Of these hallmarks, we focused on those that directly or indirectly interact with viral infections, including immunosenescence, inflammation and inflammasomes, adaptive immunosenescence, genomic instability, mitochondrial dysfunction, epigenetic alterations, telomere attrition, and impaired autophagy. These hallmarks likely contribute to the increased pathophysiological responses to SARS-CoV-2 among older adults and may play roles as an additive risk of accelerated biological aging even after recovery. We also briefly discuss the role of anti-aging drug candidates that require paramount attention in COVID-19 research.
Preprint
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Aging is one of the key contributing factors for chronic obstructive pulmonary diseases (COPD) and other chronic inflammatory lung diseases. Cigarette smoke is a major etiological risk factor that has been shown to alter cellular processes involving mitochondrial function, cellular senescence and telomeric length. Here we determined how aging contribute to the alteration in the gene expression of above mentioned cellular processes that play an important role in the progression of COPD and IPF. We hypothesized that aging may differentially alter the expression of mitochondrial, cellular senescence and telomere genes in smokers and patients with COPD and IPF compared to non-smokers. Total RNA from human lung tissues from non-smokers, smokers, and patients with COPD and IPF were processed and analyzed based on their ages (younger: <55 yrs and older: >55 yrs). NanoString nCounter panel was used to analyze the gene expression profiles using a custom designed codeset containing 112 genes including 6 housekeeping controls (mitochondrial biogenesis and function, cellular senescence, telomere replication and maintenance). mRNA counts were normalized, log2 transformed for differential expression analysis using linear models in the limma package (R/Bioconductor). Data from non-smokers, smokers and patients with COPD and IPF were analyzed based on the age groups (pairwise comparisons between younger vs. older groups). Several genes were differentially expressed in younger and older smokers, and patients with COPD and IPF compared to non-smokers which were part of the mitochondrial biogenesis/function (HSPD1, FEN1, COX18, COX10, UCP2 & 3), cellular senescence (PCNA, PTEN, KLOTHO, CDKN1C, TNKS2, NFATC1 & 2, GADD45A) and telomere replication/maintenance (PARP1, SIRT6, NBN, TERT, RAD17, SLX4, HAT1) target genes. Interestingly, NOX4 and TNKS2 were increased in the young IPF as compared to the young COPD patients. Genes in the mitochondrial dynamics and other quality control mechanisms like FIS1 and RHOT2 were decreased in young IPF compared to their age matched COPD subjects. ERCC1 (Excision Repair Cross-Complementation Group 1) and GADD45B were higher in young COPD as compared to IPF. Aging plays an important role in various infectious diseases. Elderly patients with chronic lung disease and smokers were found to have high incidence and mortality rates in the current pandemic of SARS-CoV-2 infection. Immunoblot analysis in the lung homogenates of smokers, COPD and IPF subjects revealed increased protein abundance of important proteases and spike proteins like TMPRSS2, furin and DPP4 in association with a slight increase in SARS-CoV-2 receptor ACE2 levels. This may further strengthen the observation that smokers, COPD and IPF subjects are more prone to COVID-19 infection. Overall, these findings suggest that altered transcription of target genes that regulate mitochondrial function, cellular senescence, and telomere attrition add to the pathobiology of lung aging in COPD and IPF and other smoking-related chronic lung disease in associated with alterations in SARS-CoV-2 ACE2-TMPRSS2-Furin-DPP4 axis for COVID-19 infection.
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The medical, public health, and scientific communities are grappling with monumental imperatives to contain COVID‐19, develop effective vaccines, identify efficacious treatments for the infection and its complications, and find biomarkers that detect patients at risk of severe disease. The focus of this communication is on a potential biomarker, short telomere length (TL), that might serve to identify patients more likely to die from the SARS‐CoV‐2 infection, regardless of age. The common thread linking these patients is lymphopenia, which largely reflects a decline in the numbers of CD4/CD8 T cells but not B cells. These findings are consistent with data that lymphocyte TL dynamics impose a limit on T‐cell proliferation. They suggest that T‐cell lymphopoiesis might stall in individuals with short TL who are infected with SARS‐CoV‐2.
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Bipolar disorder (BD) may be associated with accelerated cellular aging. However, previous studies on telomere length (TL), an important biomarker of cellular aging, have yielded mixed results in BD. We aimed to evaluate the hypothesis that BD is associated with telomere shortening and whether this is counteracted by long-term lithium treatment. We also sought to determine whether long-term lithium treatment is associated with increased expression of telomerase reverse transcriptase (TERT), the catalytic subunit of telomerase. We determined TL and TERT expression in 100 BD I patients and 100 healthy controls. We also genotyped three single nucleotide polymorphisms associated with TL. TERT expression was significantly increased in BD I patients currently on lithium treatment. TERT expression was also significantly positively correlated with duration of lithium treatment in patients treated for 24 months or more. However, we did not find any significant effect of lithium treatment on TL. Neither did we find significant differences in TL between BD patients and controls. We suggest that long-term lithium treatment is associated with an increase in the expression of TERT. We hypothesize that an increase in TERT expression may contribute to lithium's mood stabilizing and neuroprotective properties by improving mitochondrial function and decreasing oxidative stress.
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Exceptionally long-lived individuals (ELLI) who are the focus of many healthy longevity studies around the globe are now being studied in Israel. The Israeli Multi-Ethnic Centenarian Study (IMECS) cohort is utilized here for assessment of various DNA methylation clocks. Thorough phenotypic characterization and whole blood samples were obtained from ELLI, offspring of ELLI, and controls aged 53–87 with no familial exceptional longevity. DNA methylation was assessed using Illumina MethylationEPIC Beadchip and applied to DNAm age online tool for age and telomere length predictions. Relative telomere length was assessed using qPCR T/S (Telomere/Single copy gene) ratios. ELLI demonstrated juvenile performance in DNAm age clocks and overall methylation measurement, with preserved cognition and relative telomere length. Our findings suggest a favorable DNA methylation profile in ELLI enabling a slower rate of aging in those individuals in comparison to controls. It is possible that DNA methylation is a key modulator of the rate of aging and thus the ELLI DNAm profile promotes healthy longevity.
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Objective: Telomeres are protective sequences of DNA capping the ends of chromosomes that shorten over time. Leukocyte telomere length (LTL) is posited to reflect the replicative history of cells and general systemic aging of the organism. Chronic stress exposure leads to accelerated LTL shortening, which has been linked to increased susceptibility to and faster progression of aging-related diseases. This study examined longitudinal associations between LTL and experiences of racial discrimination, a qualitatively unique source of minority psychosocial stress, among African Americans. Method: Data are from 391 African Americans in the Coronary Artery Risk Development in Young Adults (CARDIA) Telomere Ancillary Study. We examined the number of domains in which racial discrimination was experienced in relation to LTL collected in Years 15 and 25 (Y15: 2000/2001; Y25: 2010/2011). Multivariable linear regression examined if racial discrimination was associated with LTL. Latent change score analysis (LCS) examined changes in racial discrimination and LTL in relation to one another. Results: Controlling for racial discrimination at Y15, multivariable linear regression analyses indicated that racial discrimination at Y25 was significantly associated with LTL at Y25. This relationship remained robust after adjusting for LTL at Y15 (b = −.019, p = .015). Consistent with this finding, LCS revealed that increases in experiences of racial discrimination were associated with faster 10-year LTL shortening (b = −.019, p = .015). Conclusions: This study adds to evidence that racial discrimination contributes to accelerated physiologic weathering and health declines among African Americans through its impact on biological systems, including via its effects on telomere attrition.
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Telomerase has become one of the new popular targets for the development of anti-tumor drugs. Based on the structural characteristics of the BIBR1532 which has entered the stage of clinical research, six series total of 64 new compounds with diverse structural characteristics were designed and synthesized. The inhibitory activity against SGC-7901, MGC-803, SMMC-7721, A375 and GES cell lines and their telomerase inhibitory activity were tested. Among them, eight compounds showed good activity against cancer cells, among them compounds 56, 57 and 59 also showed low toxicity. Some of them showed excellent telomerase inhibitory activity with IC50 values ranging from 0.62 μM to 8.87 μM. Based on above, in depth structure-activity relationships were summarized, the compounds by replacing methyl group with cyanide and retaining amide moiety had good anti-tumor activity, moderate cytotoxicity, and better telomerase inhibitory activity. The results should be used for reference in BIBR1532-based structural optimization for further development of small molecule telomerase inhibitors.
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Cancer, characterized by uncontrolled malignant neoplasm, is a leading cause of death in both advanced and emerging countries. Although, ample drugs are accessible in the market to intervene with tumor progression, none are totally effective and safe. Natural anthraquinone (AQ) equivalents such as emodin, aloe-emodin, alchemix and many synthetic analogs extend their antitumor activity on different targets including telomerase, topoisomerases, kinases, matrix metalloproteinases, DNA and different phases of cell lines. Nano drug delivery strategies are advanced tools which deliver drugs into tumor cells with minimum drug leakage to normal cells. This review delineates the way AQ derivatives are binding on these targets by abolishing tumor cells to produce anticancer activity and purview of nanoformulations related to AQ analogs.
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Cancer, a global havoc is a group of debilitating diseases that strikes family as well as society. Cancer cases are drastically increasing these days. In spite of many therapies and surgical procedures available cancer is still difficult to control. These are due to limited effective therapies or targeted therapies. Natural products can produce lesser side effects to the normal cells which are the major demerit of chemotherapies and radiation. Wogonin, a natural product extracted from plant, Scutellaria baicalensis has been studied widely and found with a high caliber to tackle most of the cancers via several mechanisms that include intrinsic as well as extrinsic apoptosis signaling pathways, carcinogenesis diminution, telomerase activity inhibition, metastasis inhibition in the inflammatory microenvironment, anti-angiogenesis, cell growth inhibition and arrest of cell cycle, increased generation of H2O2 and accumulation of Ca2+ and also as an adjuvant along with anticancer drugs. This article discusses the role of wogonin in various cancers, its synergism with various drugs and the mechanism by which wogonin controls tumor growth.
Article
Purpose We aimed to analyze and compare leukocyte telomere length (LTL) and age-dependent LTL attrition between childhood cancer survivors and noncancer controls, and to evaluate the associations of LTL with treatment exposures, chronic health conditions (CHC), and health behaviors among survivors. Experimental Design We included 2,427 survivors and 293 noncancer controls of European ancestry, drawn from the participants in St. Jude Lifetime Cohort Study (SJLIFE), a retrospective hospital-based study with prospective follow-up (2007–2016). Common nonneoplastic CHCs (59 types) and subsequent malignant neoplasms (5 types) were clinically assessed. LTL was measured with whole-genome sequencing data. Results After adjusting for age at DNA sampling, gender, genetic risk score based on 9 SNPs known to be associated with telomere length, and eigenvectors, LTL among survivors was significantly shorter both overall [adjusted mean (AM) = 6.20 kb; SE = 0.03 kb] and across diagnoses than controls (AM = 6.69 kb; SE = 0.07 kb). Among survivors, specific treatment exposures associated with shorter LTL included chest or abdominal irradiation, glucocorticoid, and vincristine chemotherapies. Significant negative associations of LTL with 14 different CHCs, and a positive association with subsequent thyroid cancer occurring out of irradiation field were identified. Health behaviors were significantly associated with LTL among survivors aged 18 to 35 years (Ptrend = 0.03). Conclusions LTL is significantly shorter among childhood cancer survivors than noncancer controls, and is associated with CHCs and health behaviors, suggesting LTL as an aging biomarker may be a potential mechanistic target for future intervention studies designed to prevent or delay onset of CHCs in childhood cancer survivors. See related commentary by Walsh, p. 2281