With the increasing number of samples, the manual clustering of COVID-19 and medical disease data
samples becomes time-consuming and requires highly skilled labour. Recently, several algorithms
have been used for clustering medical datasets deterministically; however, these definitions have not
been effective in grouping and analysing medical diseases. The use of evolutionary clustering
algorithms may help to effectively cluster these diseases. On this presumption, we improved the
current evolutionary clustering algorithm star (ECA*), called iECA*, in three manners: (i) utilising the
elbow method to find the correct number of clusters; (ii) cleaning and processing data as part of iECA*
to apply it to multivariate and domain-theory datasets; (iii) using iECA* for real-world applications in
clustering COVID-19 and medical disease datasets. Experiments were conducted to examine the
performance of iECA* against state-of-the-art algorithms using performance and validation measures
(validation measures, statistical benchmarking, and performance ranking framework). The results
demonstrate three primary findings. First, iECA* was more effective than other algorithms in grouping
the chosen medical disease datasets according to the cluster validation criteria. Second, iECA*
exhibited the lower execution time and memory consumption for clustering all the datasets, compared to
the current clustering methods analysed. Third, an operational framework was proposed to rate the
effectiveness of iECA* against other algorithms in the datasets analysed, and the results indicated that
iECA* exhibited the best performance in clustering all medical datasets. Further research is required
on real-world multi-dimensional data containing complex knowledge fields for experimental
verification of iECA* compared to evolutionary algorithms.