This is a duplicate record, please see https://www.researchgate.net/publication/350278122_Developing_and_implementing_novel_techniques_during_primary_space_medicine_data_systematic_reviews for the original record. Andrew Winnard has been leading systematic review methods for space medicine projects many years to facilitate high quality and transparent synthesis of primary data to enable evidence-based practice. You can find the most up to date methods here: https://sites.google.com/view/sr-methods/home This paper outlines evolution of space medicine synthesis methods and discussion of their initial application. Space medicine systematic review guidance has been developed for protocol planning, quantitative and qualitative synthesis, sourcing grey data, and assessing quality and transferability of space medicine human spaceflight simulation study environments. Decision algorithms for guidance and tool usage were created based on usage. Six reviews used quantitative methods in which no meta analyses were possible due to lack of controlled trials or reporting issues. All reviews scored the quality and transferability of space simulation environments. One review was qualitative. Several research gaps were identified. Successful use of the developed methods demonstrates usability and initial validity. The current space medicine evidence base resulting in no meta analyses to be possible shows the need for standardized guidance on how to synthesize data in this field. It also provides evidence to call for increasing use of controlled trials, standardizing outcome measures and improving minimum reporting standards. Space medicine is a unique field of medical research that requires specific systematic review methods.