Autism is the most well-known disorder that received high interest from researchers recently. This disorder may be in all ages of people. All exist datasets suffer from low quality for data analysis. Most of the related works focus on base classifiers. In this article, we suggested a comprehensive comparison to improve the diagnosis of autism disorder using effective pre-processing and ensemble methods. The pre-processing stage consists of resolving missing values and outliers. Also, the ensemble methods include voting, boosting, bagging, and stacking. For the evaluation of comparisons, two popular data mining tools are applied. The obtained results prove that our work promotes classification performance rather than the base methods in terms of precision, recall, accuracy, and F1. The highest values for these criteria are obtained 100%.