The comparison of injection site reactions caused by two commercial multivalent clostridial vaccines
Two groups of cattle were used in this study comparing injection site reactions caused by two commercial multivalent clostridial vaccines: product A (Bar-Vac 7; Anchor Laboratories) and product B (Vision 7 with Spur; Bayer Corporation). Injection procedure, bodyweight, injection reaction, and subcutaneous depth were considered. Significant differences in injection reaction size between the two vaccines were demonstrated. While the majority of cattle had some swelling at the injection site 7 and 30 days after vaccination, subcutaneous injection with product B resulted in a smaller injection reaction area and subcutaneous depth 30 days after vaccination, when compared with product A. Furthermore, there was a significant reduction in injection reaction area and subcutaneous depth between Days 7 and 30 after treatment with product B; whereas there was no significant change seen with product A during that time. While the relative efficacy of the vaccines was not addressed in this study, both products have satisfied appropriate approval requirements. Assuming similar potency and efficacy, usage of less reactive products, which are cost-competitive, would be an obvious advantage to the cattle industry.