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Combination of hyaluronic acid fillers and personalized skincare as a perfect tool in aesthetic medicine

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Dermatologic Therapy
Authors:
Wioletta Baranska-Rybak at Medical University of Gdansk
Wioletta Baranska-Rybak
Magdalena Antoszewska at Medical University of Gdansk
Magdalena Antoszewska
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Abstract and Figures

Introduction Nowadays the desire to look younger has increased. The most popular noninvasive rejuvenation method is hyaluronic acid filler injection. However, aging of the skin involves multiple pathological processes which can be managed by using topical formulations with sophisticated active agents addressing problems such as extracellular matrix degradation, textural variances, and dyschromias. Objective A single site experience trial was conducted to assess the efficacy of hyaluronic acid dermal filler injections combined with personally prepared, bespoke formulations on epidermis and dermis condition. Materials and methods A total of 15 female participated in the study. Mid and lower face were treated with Saypha® hyaluronic acid fillers injection with volume chosen by the investigator performed with 25G/50mm cannula. The formulations for topical skincare consisted of substances chosen from 19 active agents which were scientifically proven. The subjects were supposed to use them for 6 weeks. Results 14 subjects completed the study, and one subject was lost to follow-up. The age of the study population ranged from 36–58 years. The average amounts of Saypha Volume Plus, Saypha Volume and Saypha Filler used per subject were 2.8 mL, 2.25 mL and 1.7 mL, respectively. The most typical skin dysfunctions were loss of elasticity (12 subjects), hyperpigmentation (9 subjects), erythema (8 subjects), and hyperseborrhea with enlarged pores (5 subjects). After completing the study all subjects were satisfied. Conclusion Combined therapies based on HA fillers and personalized skincare with Universkin™ products show promising results in patients with skin problems due to aging.
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SHORT REPORT
Combination of hyaluronic acid fillers and personalized
skincare as a perfect tool in aesthetic medicine
Wioletta Bara
nska-Rybak | Magdalena Antoszewska
Department of Dermatology, Venereology and
Allergology, Medical University of Gda
nsk,
Gda
nsk, Poland
Correspondence
Wioletta Bara
nska-Rybak, Department of
Dermatology, Venereology and Allergology,
Medical University of Gda
nsk,
Smoluchowskiego 17 str, 80-214 Gda
nsk,
Poland.
Email: wioletta.baranska-rybak@gumed.edu.pl
Abstract
Nowadays the desire to look younger has increased. The most popular noninvasive
rejuvenation method is hyaluronic acid (HA) filler injection. However, aging of the
skin involves multiple pathological processes, which can be managed by using topical
formulations with sophisticated active agents addressing problems such as extracellu-
lar matrix degradation, textural variances, and dyschromias. A single site experience
trial was conducted to assess the efficacy of HA dermal filler injections combined
with personally prepared, bespoke formulations on epidermis and dermis condition.
A total of 15 female participated in the study. Mid and lower face were treated with
Saypha
®
HA fillers injection with volume chosen by the investigator performed with
25G/50mm cannula. The formulations for topical skincare consisted of substances
chosen from 19 active agents, which were scientifically proven. The subjects were
supposed to use them for 6 weeks. Fourteen subjects completed the study, and one
subject was lost to follow-up. The age of the study population ranged from 36 to
58 years. The average amounts of Saypha volume plus, Saypha volume, and Saypha
filler used per subject were 2.8 ml, 2.25 ml and 1.7 ml, respectively. The most typical
skin dysfunctions were loss of elasticity (12 subjects), hyperpigmentation (nine sub-
jects), erythema (eight subjects), and hyperseborrhea with enlarged pores (five sub-
jects). After completing the study all subjects were satisfied. Combined therapies
based on HA fillers and personalized skincare with Universkin™products show prom-
ising results in patients with skin problems due to aging.
KEYWORDS
aesthetic medicine, antiaging, functional therapies, hyaluronic acid, personalized skincare
1|INTRODUCTION
The aging process starts at the age of 20 and accelerates after turning
40 years old. It is influenced by genetic factors and lifestyle, especially
sun exposure and smoking. The typical signs of skin aging include dry-
ness, loss of elasticity, roughness, paleness, wrinkles, telangiectasia,
and seborrheic keratosis.
1
In the young skin, collagen and elastic fibers form a regular net-
work together with a large number of fibroblasts flooded in proteogly-
cans gel rich in hyaluronic acid (HA). In the older skin, collagen, and
elastic fibers are thinner, shorter, and fragmented. The amount of
fibroblasts is much lower, as well as the HA content. The rate of skin
aging also differs among different ethnicities.
2
HA is a glycosaminoglycan, which has a great ability to bind water
and is completely biodegradable and safe. It has been used in Europe
since 1996 for skin and soft tissue augmentation. Facial volumization
with HA is widely applied for minimally invasive facial rejuvenation.
3,4
Croma Saypha HA
®
products range has been used in the current
study and personalized skincare was based on Universkin™products.
This brand consists of 19 active ingredients addressing eight skin
problems (oxidative stress, dermis aging, inflammation, dryness, kerati-
nization disorders, hyperseborrhea, hyperpigmentation, and skin flora
Received: 12 May 2021 Revised: 28 June 2021 Accepted: 5 August 2021
DOI: 10.1111/dth.15092
Dermatologic Therapy. 2021;34:e15092. wileyonlinelibrary.com/journal/dth © 2021 Wiley Periodicals LLC. 1of4
https://doi.org/10.1111/dth.15092
... HA is a completely biodegradable molecule that confers great overall safety. 5 Myomodulation, achieved through strategic filler positioning, is an additional benefit that can enhance cosmetic outcomes in dynamic evaluations and potentially Fig. 1. Illustration of the facial areas treated, detailing the volume used (mL) and the injectable products used for each specific facial region. ...
... Therefore, patients should be advised that annual assessment and potential new filler injections should be part of the followup plan. 5 Facial asymmetry has a substantial impact on the quality of life for patients. In cases resulting from neurological disorders, such as facial nerve paralysis, the use of botulinum toxin for cosmetic enhancement has demonstrated promising outcomes. ...
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... In addition, TR has paved the way for personalised treatment approaches in aesthetic medicine. Advances in genetics, skin analysis, and Artificial Intelligence (AI) patient profiling enable practitioners to tailor interventions to individual needs, optimising outcomes and patient satisfaction with a more focused, personalised approach [35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50]. ...
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Aesthetic medicine and plastic surgery encompass a broad spectrum of procedures aimed at enhancing physical appearance and psychological well-being. This field’s allure lies in its potential to align external appearance with internal identity, making it profoundly relevant in contemporary society. The advancement and credibility of aesthetic medicine are anchored in Translational Medicine (TM), particularly Translational Research (TR) and Translational Science (TS). These processes translate laboratory discoveries into clinical applications, ensuring treatments are safe and effective. Despite significant progress, there remains a significant gap in understanding TS’s comprehensive impact on the practical and ethical dimensions of aesthetic medicine. This study employed a literature review approach to critically examine the relationship between TM and aesthetic medicine. A systematic review was considered inappropriate due to the complex and varied nature of the research question. The existing literature comprises diverse study designs, including qualitative studies, case reports, clinical trials, and reviews. This heterogeneity necessitated a literature review to synthesise the breadth of evidence on TS’s impact on aesthetic medicine effectively. The review identified substantial advancements driven by TR, including personalised interventions, regenerative therapies, and the integration of artificial intelligence. However, it also highlighted critical ethical and practical challenges. The rapid pace of innovation often surpasses the establishment of robust long-term safety data, raising concerns about patient safety and treatment efficacy. Furthermore, ethical dilemmas such as informed consent, patient autonomy, and data privacy remain inadequately addressed, necessitating stringent regulatory oversight and ethical vigilance. The future of TR in aesthetic medicine is poised for significant advancements through greater precision in treatments, interdisciplinary collaboration, and global standardisation. Nevertheless, the field must navigate the delicate balance between harmony and hype, ensuring that the pursuit of innovation does not compromise scientific integrity or ethical standards. Only by addressing these critical challenges can aesthetic medicine fulfil its promise of transformative patient outcomes and maintain public trust. Level of evidence: Not gradable
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... HA is widely used as a therapeutic agent in orthopaedic, ophthalmological, dermatological, cardiovascular, and immunological applications (Abatangelo et al., 2020;Dovedytis et al., 2020;Graça et al., 2020;Salwowska et al., 2016;Zhai et al., 2020). Moreover, HA is a popular implant in aesthetic medicine (Barańska-Rybak & Antoszewska, 2021;Lipko-Godlewska et al., 2021). Therapeutic and biomedical applications of HA are stipulated to a big extent by the extraordinary mechanical and viscoelastic properties of HA solutions and hydrogels (Levett et al., 2014;Ouasti et al., 2011), whose formation is defined by physicochemical properties of individual HA molecules. ...
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... Otherwise, for example if only the volume would be restored without skin rejuvenation, the effect will not be satisfactory. 2 Hyaluronic acid is one of the most commonly used products to restore volume in the midface. Nonetheless, one should consider that it is a highly hydrophilic product, that can be used to improve skin condition. ...
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p>Aging is a complex process influenced by both extrinsic and intrinsic factors. Premature signs of aging due to cumulative UV exposure represent a major concern of the cosmetic patient. Skin of color is less susceptible to photodamage and thus signs of aging are less pronounced and occur later than in Caucasians. Understanding structural and functional differences among different racial/ethnic groups is important to achieve favorable treatment outcomes when addressing aging concerns. <em<J Drugs Dermatol. 2017;16(6 Suppl):s77-80. .
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This third article of a three-part series addresses techniques and recommendations for aesthetic treatment of the lower face. The lower face is considered an advanced area for facial aesthetic treatment. In this region, soft-tissue fillers play a more important role than neuromodulators and should be used first to provide structure and support before neuromodulators are considered for treatment of dynamic lines. Treatment of the lip, perioral region, and chin, in addition to maintaining balance of the lower face with the face overall, is challenging. Procedures on the lip should avoid overcorrection while respecting the projection of the lips on the profile view and the ratio of lip size to chin. The chin is often neglected, but reshaping the jawline can provide dramatic improvement in facial aesthetics. Both profile and anterior views are critical in assessment and treatment of the lower face. Finally, rejuvenation of the neck region requires fillers for structural support of the chin and jawline and neuromodulators for treatment of the masseter and platysma.
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Lower Face
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The use of injectable fillers enables facial sculpting through treatment of volume depletion and modeling of facial contours. Injectable fillers are among the most frequently performed minimally invasive cosmetic procedures.However, treatment of the lower third of the face can be challenging and requires expertise in facial anatomy. In this article, the authors provide a comprehensive review of the anatomy of the lower third of the face, highlighting danger zones. In addition, the authors describe their preferred approach and detailed technique used in the treatment of each specific area, namely the jawline, prejowl sulcus, melomental folds, and lips.
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Lower face: clinical anatomy and regional approaches with injectable fillers
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