In recent years, the diversity of pharmaceutical residuals found in aquatic environments has raised concerns. Different paths have been proposed to reduce their presence. However, there are still uncertainties on which strategies, upstream or downstream, preventive or technical, global or local, should or could be applied. Among them is the classification of certain pharmaceutical treatments as requiring specific attention and precaution measures, including collecting patients’ body substances containing pharmaceutical residuals. This study assessed the existing status of patients’ excreta,
examined the social barriers and solutions for limiting pharmaceutical residuals missions through an upstream strategy. We used ethnographic (n=57) and quantitative (n=428) approaches among health professionals. Body substances were associated with taboo, and subject to recommendations in health sectors. Among field workers, attitudes of reluctance, skepticism, but also openness towards collecting body substances emerged. Health managers’ views were biased towards wastes from non-consumed pharmaceuticals. Currently, European regulation offers limited opportunities for effective measures. Encouraging the reanalysis of public health and environmental concerns together emerges as a promising path regarding pharmaceutical residuals.