My dissertation delves into the challenges and opportunities of implementing genetic services in Africa, focusing on accessibility, affordability, and cultural acceptance. The primary objective is to provide evidence-based recommendations for policymakers and healthcare organisations, addressing obstacles hindering the integration of genetic services into healthcare systems across African countries. The research methodology involved an extensive analysis of peer-reviewed studies in English spanning the period from 2003 to 2023. Utilizing databases such as PubMed, Scopus, and Africa-wide information, the study employed well-defined inclusion and exclusion criteria. Data extraction and analysis used a comprehensive form and NVIVO 14 software, enabling a thorough framework analysis of identified themes. The results chapter outlines eight studies conducted between 2016 and 2023 in various African countries, addressing challenges and solutions related to genetic counselling and testing. These studies cover diverse topics, including hearing impairment and cancer in Cameroon, genetic service delivery in Kenya, prenatal diagnosis and premarital screening for sickle cell disease in Nigeria, breast cancer in Rwanda, schizophrenia in South Africa, and sickle cell disease in Tanzania. I identified challenges such as a need for genetic disease awareness and education, barriers to genetic testing, resource limitations, ethical dilemmas, and difficulties in follow-up and retention. However, this dissertation also underscores opportunities and strategies for implementing genetic services, emphasizing preventive measures through community engagement, supportive networks, community empowerment, and advocacy. The dissertation highlights the business implications of implementing genetic services in Africa, offering opportunities to healthcare, biotechnology, and related industries. To seize market opportunities, companies can invest in educational programs, collaborate with local institutions, and leverage digital platforms to address disease awareness and education. Innovative and cost-effective models, such as affordable testing kits and telemedicine solutions, can overcome barriers related to high costs and limited accessibility. On a concluding note, facilitating dialogue between healthcare providers, geneticists, genetic counsellors, and communities through online forums or mobile applications is recommended. Collaborative partnerships, engagement with Community Advisory Boards, and prioritizing ii informed consent are essential for navigating ethical considerations and building community trust. Overall, the dissertation provides a constructive framework for policymakers and healthcare organizations to integrate genetic services into healthcare systems across African countries.