Article

COVID-19 RNA Based Vaccines and the Risk of Prion Disease

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Abstract

Development of new vaccine technology has been plagued with problems in the past. The current RNA based SARSCoV-2 vaccines were approved in the US using an emergency order without extensive long term safety testing. In this paper the Pfizer COVID-19 vaccine was evaluated for the potential to induce prion-based disease in vaccine recipients. The RNA sequence of the vaccine as well as the spike protein target interaction were analyzed for the potential to convert intracellular RNA binding proteins TAR DNA binding protein (TDP-43) and Fused in Sarcoma (FUS) into their pathologic prion conformations. The results indicate that the vaccine RNA has specific sequences that may induce TDP-43 and FUS to fold into their pathologic prion confirmations. In the current analysis a total of sixteen UG tandem repeats (ΨGΨG) were identified and additional UG (ΨG) rich sequences were identified. Two GGΨA sequences were found. Potential G Quadruplex sequences are possibly present but a more sophisticated computer program is needed to verify these. Furthermore, the spike protein, created by the translation of the vaccine RNA, binds angiotensin converting enzyme 2 (ACE2), a zinc containing enzyme. This interaction has the potential to increase intracellular zinc. Zinc ions have been shown to cause the transformation of TDP-43 to its pathologic prion configuration. The folding of TDP-43 and FUS into their pathologic prion confirmations is known to cause ALS, front temporal lobar degeneration, Alzheimer’s disease and other neurological degenerative diseases. The enclosed finding as well as additional potential risks leads the author to believe that regulatory approval of the RNA based vaccines for SARS-CoV-2 was premature and that the vaccine may cause much more harm than benefit.

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... Due to the rapid release of these gene-altering vaccines, the long-term consequences are unknown. The vaccine RNA has specific sequences that could fuse into pathologic prion conformations (misfolded proteins) (35,56). Furthermore, the spike protein itself, created by the translation of the vaccine RNA, binds to the angiotensin converting enzyme 2 (ACE2) receptor, a zinc containing enzyme. ...
... Furthermore, the spike protein itself, created by the translation of the vaccine RNA, binds to the angiotensin converting enzyme 2 (ACE2) receptor, a zinc containing enzyme. This interaction has the potential to increase intracellular zinc, thereby enhancing prion conformation (56). Together, the outcome could result in serious neurological diseases including ALS, frontotemporal lobar degeneration, Alzheimer's disease, and others (56). ...
... This interaction has the potential to increase intracellular zinc, thereby enhancing prion conformation (56). Together, the outcome could result in serious neurological diseases including ALS, frontotemporal lobar degeneration, Alzheimer's disease, and others (56). Production of the spike protein, a toxin to the body that can desulfate the cell's glycocalyx and impair its first line immune response, has the potential to contribute to a wide range of both acute and long-term induced pathologies, such as blood disorders, neurodegenerative diseases, and autoimmune diseases (35). ...
Article
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In a relatively short timeframe, millions of deaths and illnesses associated with COVID-19 have been reported, accompanied by substantial economic losses, and overall, negatively impacting society. This experience should serve as a wakeup call to those in public health and healthcare, along with politicians and citizens: COVID-19 is considered a predictable and preventable disaster. While various reactive responses to address the pandemic were implemented, some with adverse effects, proactive measures in the years before COVID-19 were neglected. Predominately this involved the development of a preventable overfat pandemic, which played a key role in both rising rates of chronic disease, the comorbidities that increase the risk for COVID-19, along with associated inflammation and malnutrition. This increased the risk of infection in billions of people worldwide, which, in essence, primed society for high rates of COVID-19 infection. Excess body fat evolves primarily from poor nutrition, particularly the overconsumption of sugar and other refined carbohydrates, which replace the vital nutrients needed for optimal immune function. Sugar and refined carbohydrates must be considered the new tobacco, as these foods are also devoid of nutrients, and underly inflammatory chronic diseases. A balanced diet of nutrient-dense wholefood must be emphasized to combat infectious and inflammatory diseases. Implementing proactive preventive lifestyle changes must begin now, starting with simple, safe, and inexpensive dietary modifications that can quickly lead to a healthier population.
... Many have raised the alarm about the wisdom of wide spread immunization campaigns using COVID-19 vaccines without first performing long term human safety studies and well-planned animal toxicity studies. Concern has been raised regarding evidence that the SARS-CoV-2 virus, which causes COVID-19, is actually a lab derived bioweapon [1][2][3][4]. Several peer reviewed papers [3,5,6] have indicated that the spike protein of the SARS-CoV-2 virus and its nucleic acid sequence are actually prion forming toxins. ...
... Concern has been raised regarding evidence that the SARS-CoV-2 virus, which causes COVID-19, is actually a lab derived bioweapon [1][2][3][4]. Several peer reviewed papers [3,5,6] have indicated that the spike protein of the SARS-CoV-2 virus and its nucleic acid sequence are actually prion forming toxins. A toxicity study in monkeys infected with SARS-CoV-2 showed the formation of Lewy Bodies [8] and supports these findings. ...
... While analysis is challenging a clear signal of a specific prion disease, Parkinson's disease, was found as discussed below. The findings are consistent with knowledge of the spike protein and its nucleic acid sequence [3][4][5][6][7], well accepted pathophysiology of prion disease, and animal toxicity data in monkeys [8]. The findings in this paper represent an urgent warning to halt mass immunization with COVID vaccines until proper safety studies are complete. ...
Article
Many have argued that SARS-CoV-2 spike protein and its mRNA sequence, found in all COVID-19 vaccines, are priongenic. The UK’s Yellow Card database of COVID-19 vaccine adverse event reports was evaluated for signals consistent with a pending epidemic of COVID vaccine induced prion disease. Adverse event reaction rates from AstraZeneca’s vaccine were compared to adverse event rates for Pfizer’s COVID vaccines. The vaccines employ different technologies allowing for potential differences in adverse event rates but allowing each to serve as a control group for the other. The analysis showed a highly statistically significant and clinically relevant (2.6-fold) increase in Parkinson’s disease, a prion disease, in the AstraZeneca adverse reaction reports compared to the Pfizer vaccine adverse reaction reports (p= 0.000024). These results are consistent with monkey toxicity studies showing infection with SARS-CoV-2 results in Lewy Body formation. The findings suggest that regulatory approval, even under an emergency use authorization, for COVID vaccines was premature and that widespread use should be halted until full long term safety studies evaluating prion toxicity has een complete. Alternative vaccines like the Measles Mumps Rubella (MMR) vaccine should be explored for those desiring immunization against COVID-19.Many have argued that SARS-CoV-2 spike protein and its mRNA sequence, found in all COVID-19 vaccines, are priongenic. The UK’s Yellow Card database of COVID-19 vaccine adverse event reports was evaluated for signals consistent with a pending epidemic of COVID vaccine induced prion disease. Adverse event reaction rates from AstraZeneca’s vaccine were compared to adverse event rates for Pfizer’s COVID vaccines. The vaccines employ different technologies allowing for potential differences in adverse event rates but allowing each to serve as a control group for the other. The analysis showed a highly statistically significant and clinically relevant (2.6-fold) increase in Parkinson’s disease, a prion disease, in the AstraZeneca adverse reaction reports compared to the Pfizer vaccine adverse reaction reports (p= 0.000024). These results are consistent with monkey toxicity studies showing infection with SARS-CoV-2 results in Lewy Body formation. The findings suggest that regulatory approval, even under an emergency use authorization, for COVID vaccines was premature and that widespread use should be halted until full long term safety studies evaluating prion toxicity has been complete. Alternative vaccines like the Measles Mumps Rubella (MMR) vaccine should be explored for those desiring immunization against COVID-19.
... A previous peer reviewed paper [16] described in detail the risk of the mRNA based COVID-19 vaccines. The paper specifically evaluated Pfizer's vaccine mRNA sequence but expressed concern with the Moderna's mRNA vaccine due in part to sequence homology between the vaccines. ...
... The most important issue with the COVID-19 outbreak that is being ignored is whether the outbreak is a bioweapon attack, and who is behind the attack. The author [16,25,31] and others have presented evidence supporting a bioweapon etiology for the outbreak of COVID-19. There is concern that that some of the perpetrators are high up in the US government. ...
... If the COVID-19 epidemic is indeed the result of an bioweapon attack originating from within the US government, as was the anthrax attack of 2001, then one or more of the COVID vaccines could also be bioweapons. Criticism in the lay press comprising false and misleading statements from non-experts regarding a scientifically sound peer reviewed paper linking the COVID-19 vaccines to risk of prion disease [16] suggests the paper's conclusion are on the mark! The potential vaccine recipient must think carefully about the real risk of COVID-19 to him or herself before receiving a COVID-19 specific vaccine. ...
Article
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Many have argued that the outbreak of COVID-19 is the result of the release of a viral based bioweapon. Vaccines to COVID-19 have been developed and a policy of universal immunization has been initiated with total disregard to the fact that the virus may be a bioweapon. The potential risk of a catastrophe exists in part because all the vaccines contain the spike protein and or the mRNA/DNA encoding for the COVID-19 associated spike protein. These vaccines were designed and placed on the market with little knowledge of how the spike protein or its nucleic acid causes disease and without knowledge of long-term adverse effects of the vaccines. This paper reviews many of the potential long-term risks that could result from receiving one of the COVID-19 vaccines. The potential for the spike protein and its mRNA to cause prion disease is reviewed as well as reasons why the vaccine could be much more dangerous than the natural infection. Adenoviral derived COVID-19 vaccines are particularly risky because of their potential to recombine with human DNA or viruses already in the human recipient. The result could be new infectious adenoviral species containing spike proteins that could infect humans and farm animals used for food. Some of the COVID-19 vaccines utilize novel technology including nanotechnology and novel adjuvants that increase intracellular penetration of cells and can potentially exacerbate chronic toxicity from the spike protein. Governments should consider suspending sale of the COVID-19 vaccines until they have a better understanding of their risks.
... [38]. Already, there are emerging reports regarding COVID-19 mRNA vaccination association with acceleration of Parkinson's disease [39,40] and prion disease [41]. ...
Preprint
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Background The findings of a sequence embedded in Human DNA that was almost identical to a sequence in the SARS-CoV-2 genome, and the identification of plausible integration of SARS-CoV-2 RNA into human DNA by endogenous reverse transcriptase activity expressed by Long Interspersed Nuclear Element (LINE)-1 (17% of Human DNA) have raised concerns about the long-term safety of messenger-RNA (mRNA) based vaccination. Recent data demonstrate that SARS-CoV-2 RNA sequences can be transcribed into DNA and may be actively integrated into the genome of affected human cells, mediated by retrotransposons. Complementarily, in some SARS-CoV-2 infected patient specimens, there is evidence for a large fraction SARS-CoV-2 sequence integration and subsequent generation of SARS-CoV-2-human chimeric transcripts. 2 Results In this review, the potential role of mobile genetic elements in the etiopathogenesis of cardiovascular, neurological, immunological, and oncological disease and the possibilities of human DNA interference by SARS-CoV-2 vaccination are repositioned. Vulnerable human stem cells as well as gametocytes can presumably be the first targets for unwanted RNA interference. Given the many genetic manipulations of the RNA coding for the SARS-CoV-2 spike glycoprotein in the vaccines, manipulations designed to increase stability and efficiency of spike protein translation, much remains uncertain about the potential disruptions to cellular physiology and homeostasis that could ensue. The predicted consequences pose serious risks to human health that are in need of clarification. Conclusion Further toxicity evaluations are urgently needed to quantify potential emergence of interference with canonical DNA processes that could detrimentally impact the mRNA-vaccinated population.
... Patone et al. [33] reported an increased risk of hemorrhagic stroke with Pfizer vaccine. Classen [34] signaled the connection between COVID-19 RNA-based vaccines and the risk of prion disease. ...
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Kenkyu Journal of Nanotechnology & Nanoscience 8:40-46 (2022) https://www.kenkyugroup.org/article/29/222/The-other-side-of-nano-medicines-and-nano-vaccines
... Brojne pojave reaktivacije latentnog herpesa zostera sugeriraju da ta cjepiva dovode do supresije urođenog imunosnog sustava [49] što sugerira i jedno drugo nerecenzirano istraživanje [711]. [49,713,714]. Prioni su pogrešno savijeni i/ili fragmentirani proteini koji obilježavaju izrazito progresivne i uvijek smrtonosne neurodegenerativne bolesti. U tom kontekstu zabrinjava da je Pfizer u svojoj dokumentaciji poslanoj Europskoj agenciji za lijekove (EMA-i) za odobrenje cjepiva naveo da u njegovim injekcijama postoje "fragmentirani specijesi" virusne RNK te da je u injekcijama korištenima za klinička ispitivanja bilo znatno manje tih "fragmentiranih specijesa" u injekcijama. ...
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... The second RBD region of interest potentially allows the spike protein to bind to amyloid-forming heparin-binding proteins, which could lead to accelerated aggregation of amyloid proteins within the brain [81]. This supports Classen's concern that COVID-19 vaccines could potentially induce prion disease [82]. The third region of interest within the RBD contains seven predicted molecular sites that share similarities to different toxins or virulence factors from 12 different bacterial species, 2 malarial parasites and influenza A [83] (Figure 1). ...
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... In this case, the potential vaccine-induced adverse reaction could be even more debilitating than the viral infection. 66,67 The adjuvants used in vaccines, including anti-SARS-CoV-2, might be responsible for potential neurologic adverse effects. 68 Another potential neurological adverse event that may result from vaccination is the immunisation stress-related response (ISRR), which manifests itself as psychogenic non-epileptic seizures (PNES). ...
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The hemophilus vaccine has been linked to the development of autoimmune type 1 diabetes, insulin dependent diabetes (IDDM) in ecological studies. We attempted to determine if the Hemophilus influenza B (HiB) vaccine was associated with an increased risk of IDDM by looking for clusters of cases of IDDM using data from a large clinical trial. All children born in Finland between October 1st, 1985 and August 31st, 1987, approximately 116,000 were randomized to receive 4 doses of the HiB vaccine (PPR-D, Connaught) starting at 3 months of life or one dose starting after 24 months of life. A control-cohort included all 128,500 children born in Finland in the 24 months prior to the HiB vaccine study. Non-obese diabetic prone (NOD) mice were immunized with a hemophilus vaccine to determine if immunization increased the risk of IDDM. The difference in cumulative incidence between those receiving 4 doses and those receiving 0 doses is 54 cases of IDDM/100,000 (P = 0.026) at 7 years, (relative risk = 1.26). Most of the extra cases of IDDM appeared in statistically significant clusters that occurred in periods starting approximately 38 months after immunization and lasting approximately 6-8 months. Immunization with pediatric vaccines increased the risk of insulin diabetes in NOD mice. Exposure to HiB immunization is associated with an increased risk of IDDM. NOD mice can be used as an animal model of vaccine induced diabetes.
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Classen JB. COVID-19, MMR vaccine, and bioweapons. Diabetes & its Complications.2020; 4: 1-8.
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