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Abstract

MGDrivE (Mosquito Gene Drive Explorer) is an open-source modeling framework to simulate and evaluate novel genetic control tools in spatial mosquito populations. The software has four modules (right): i) a genetic inheritance module accommodates the dynamics of gene drive systems, ii) a population dynamic module accounts for mosquito life history, iii) a landscape module generates the metapopulation by which insect populations are connected via migration, and iv) an epidemiology module (in MGDrivE 2) models reciprocal pathogen transmission between mosquitoes and humans. We intend the package to provide a flexible tool to model a range of genetic control systems both in the lab, and as they move closer to field application.
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