This paper examines how the practice of mindfulness can serve as a generative resource in transformative and compassionate healthcare. I present a view of mindfulness that acknowledges its common usage in contemporary research but also includes other characteristics that originate from Buddhist tradition and are congruent with a socio-constructionist and a relational orientation. It includes qualities such as inquiry, discernment, and compassion and expands our understanding of its practice into the relational domain, viewing it as an invitation to participate in a form of life that acknowledges our basic interconnectedness and emerges from and thrives in relationship. I discuss how mindfulness can operate as an embodied relational presence that is attuned to the changing manifestations of the relational field. I examine how its practice can help craft relational processes in health care that are both compassionate and caring. Focusing on the creation of relationally responsive relationships between caretakers and patients, where the latter can feel included, listened to, and attended in ways that respect their humanity and allow them to be full participants in their care.