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مقدمهای بر واکسن های ژنی

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Abstract

این کتاب که در سال 1382 پیرو آغاز پروژه واکسن های ژنی در ایران در سال 1380 توسط دکتر علی کرمی شروع شد منتشر گردید و به توضیح نسل چهارم واکسن ها یعنی استفاده از مواد ژنتیکی شامل DNA یا RNA بجای میکرب یا پروتئین نوترکیب بعنوان واکسن برای القا سیستم ایمنی در اثر بیان ژن در داخل سلول ها می پردازد تا کنون واکسن ها شامل میکرب های کشته یا ضعیف شده یا ساب یونیتی یعنی بخشی از میکرب یا سم بودند ولی در این روش از ماده ژنتیکی رمز کننده پروتئین مورد نظر استفاده می شود در این فناوری که با استفاده از بیوتکنولوژی و مهندسی ژنتیک ژن رمز کننده پروتئین ایمنی زا به یک حامل یا پلاسمنید خاص کلون می شود این پلاسمید دارای ویژگی بیان ژن در داخل سلول است بنابر این پروتئین نوترکیب تولید شده در داخل سلول سبب القا سیستم ایمنی هومورال و سلولار شده و هم آنتی بادی ضد آنتی ژن تولید می شود و هم ایمنی دراز مدت سلولی علیه میکرب یا سم ایجاد شده و مزایای بسیاری نسبت به واکسن های نسل اوب تا سوم را دارد. دکتر کرمی در این پروژه که بنیان آن را در ایران نهادند این فرضیه را مطرح کردند که از ژن رمز کننده پروتئین های حفاظت دهنده یا ایمنی زا می توان بجای میکرب کشته یا ضعیف شده یا پروتئین نوترکیب استفاده کرد. دکتر کرمی این گون واکسن ها را تهیه و آزمایشات بسیاری بروی حیوانات آزمایشگاهی انجام دادند و مقالات بسیاری نیز منتشر کردند ولی بنا به احتیاط های ایمنی هر گز این واکسن ها در انسان ها آزمایش نشدند چون نیاز به بررسی های بیشتری برای اطمینان کامل از ایمنی آنها در تزریق به جمعیت انسانی وجود دارد. به هر حال بنیان گزار واکسن های ژنی در ایران دکتر کرمی بودند. برای اطلاع دانشمندان بخش هایی از این کتاب به شکا رایگان در اینجا منتشر می شود. اصل کتاب منتشر شده توسط انتشارات دانشگاه دانشگاه امام حسین ع می باشد.
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