This paper investigates what we acknowledge to be meaningful and new knowledge. It refers to examples from history, illustrating how human knowledge and knowledge produced by machines were often opposed to each other. Taking into account that knowledge is confirmed by reciprocal processes, it argues that by acknowledging and integrating the results of machine processes into our daily lives, this ... [Show full abstract] knowledge also becomes “meaningful” for humans. The acceptance of machine-produced knowledge depends on the cultural network of knowledge confirmation. The strict difference between the two kinds of knowledge, that which is produced by human beings and that which is produced by machines, is vanishing.