The treatment and management of female offenders provide unique challenges to even the most experienced clinicians. Incarcerated women, in addition to exhibiting multiple mental health issues, trauma histories, and chronic substance use, provoke strong countertransference reactions that if not managed, threaten the integrity of any treatment endeavor. Diagnosis and assessment are essential to guiding interventions and managing the antisocial woman’s distinctive psychodynamics (Gacono, Nieberding, Owen, Rubel, & Bodholdt, 2001; see Chapters 3 and 4Chapter 3Chapter 4). In this chapter, we discuss essential clinical issues, a conceptual model of female psychopaths, management versus treatment, a treatment process including managing transference/countertransference, and effective treatment interventions. We conclude by offering a case example of the use of the assessment process in treating Anna, an incarcerated non-psychopathic woman.