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IMPORTANCE OF MEDICINAL PLANTS AND HERBS AS AN IMMUNITY BOOSTER FOR PANDEMIC COVID-19

Authors:
  • Bharati Vidyapeeth college of Pharmacy, Kolhapur,(M.S.), India
  • Krishna Institute of Pharmacy, Krishna Vishwa Vidyapeeth (Deemed to be University) Karad MS
  • Bharati vidyapeeth college of pharmacy, kolhapue

Abstract and Figures

The whole world facing COVID-19 pandemic, so there has been a lot of interest in ways to boosting our immune system, and thus build a first line of defense against the deadly virus. Since ancient times, medicinal plants, herbs and spices were well known for their medicinal properties. Therefore, the medicinal plants and herbs playing a critical role to boosting our immunity during the COVID-19 pandemic. it is also very important to consume supplements in the form of immune nutrients such as vitamin A, C, E, D, B-complex, Zinc and copper that will support your body to fight against the pathogens. This paper presents an analysis of popular immune-boosting medicinal plants and herbs.
Content may be subject to copyright.
*Corresponding Author: © 2021 The Authors. Tropical Journal of Pharmaceutical and Life Sciences (TJPLS)
Dr. Firoj A.Tamboli, Published by Informative Journals (Jadoun Science Publishing Group India)
Head, Department of Pharmacognosy, This article is an open access article distributed under the
Bharati Vidyapeeth College of Pharmacy, terms and conditions of the CC BY-NC-ND 4.0
Near Chitranagari, Kolhapur -41601, International License (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Maharashtra, India
Pa ge | 1
Review Article Open Access
ISSN: 2349-9818
January - February 2021, Vol. 8 (1), 01-09
Tropical journal of
Pharmaceutical and Life Sciences
(An International Peer Reviewed Journal)
Journal homepage: http://informativejournals.com/journal/index.php/tjpls
IMPORTANCE OF MEDICINAL PLANTS AND HERBS AS
AN IMMUNITY BOOSTER FOR PANDEMIC COVID-19
Firoj A. Tamboli*, Harinath N. More, Shivani S. Khairmode, Dhanashri R. Patil,
Prajakta D. Tambare, Anilkumar J. Shinde, Namdeo R. Jadhav
Department of Pharmacognosy, Bharati Vidyapeeth College of Pharmacy,
Kolhapur -416 013 Maharashtra, India.
ARTICLE INFO:
Received: 14th Jan. 2021; Received in revised form: 28th Jan. 2021; Accepted: 9th Feb. 2021; Available online: 27th Feb. 2021
ABSTRACT
The whole world facing COVID-19 pandemic, so there has been a lot of interest in ways to boosting our
immune system, and thus build a first line of defence against the deadly virus. Since ancient times,
medicinal plants, herbs and spices were well known for their medicinal properties. Therefore, the medicinal
plants and herbs playing a critical role to boosting our immunity during the COVID-19 pandemic. it is also
very important to consume supplements in the form of immune nutrients such as vitamin A, C, E, D, B-
complex, Zinc and copper that will support your body to fight against the pathogens. This paper presents an
analysis of popular immune-boosting medicinal plants and herbs.
Keywords: Medicinal herbs, Medicinal plants, COVID-19, Coronavirus, Immunity, SARS-CoV-2,
Immunity booster.
INTRODUCTION
Covid-19 attacks people with low immune systems and people especially people of under and over ages.
The immune system is built on beneficial live bacteria that lives in the gut which protect the human body
from various diseases. When the immune system response is low, weak, or damaged, it becomes an open
invitation for infections such as coronavirus or other diseases like diabetes, heart disease, or cancer.1 In this
article we discussing about various medicinally important plants and herbs which can serve as boon in the
fight against COVID-19 e.g. Garlic (Allium sativum), Margosa neem (Azadirachta indica), Tulsi (Ocimum
sanctum), Giloy (Tinospora Cordifolia), clove (Syzygium aromaticum), ginseng (Panaxquinquefolius L.),
Betel vine (Piper betel), Black paper (Piper nigrum), Black cumin (Black cumin L.), Ashwagandha
(Withania somnifera), Licorice astragalus (Astragalus glycyphyllos), turmeric (Curcuma domestica),
elderberry (Sambucus nigra), Giloy (Tinospora Cordifolia)etc. These plants are known to be rich in
antioxidants, vitamins, proteins, carbohydrates, dietary fibers, amino acids, minerals, steroids, alkaloids,
antiviral, antibacterial phytochemicals which will help in rejuvenating the immune system and also helps in
Firoj A. Tamboli / Tropical Journal of Pharmaceutical and Life Sciences 2021, Vol. 8 (1), 01-09
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killing the invaded viruses. Figure 1 shows pictures of different herbs that may be helpful in prevention and
treatment of COVID-19.2
Figure 1: Different plants and herbs that can help in the fight against COVID-19. (a) Elderberry,
Sambucuss nigra (b) Garlic, Allium sativum (c) Ginger, Zingiber officinalis (d) Giloy, Tinosporacordifolia
(e) Tulsi, Ocimum sanctum (f) Betalvive, Piper betal (g) Margosa, Azadirachtin indica (h) Turmeric,
Curumadomestica (i) Clove, Syzgiumaromaticum (j) Black paper, Piper nigrum (k) Ginseng,
Planaxquinquefolius (l) Black cumin, Black cumin L. (m) Licorice astragalus, Astragalus glycyphyllos (n)
Aswagandha, Withaniasomnifera (o) Cinchona (Cinchona officinalis).2
IMMUNITY
The immune system protects our body from diseases and infections (invading pathogenic microorganisms)
and cancer. It's the bodily system that produces the immune response to defend your body from foreign
substances, cells, and tissues. The immune system includes various parts of the body including the thymus,
spleen, lymph nodes, special deposits of lymphoid tissue (such as those in the gastrointestinal tract and
bone marrow), macrophages, lymphocytes including the B cells and T cells, and antibodies.1 Immunity, the
state of protection from infectious disease has both a less specific or innate and a more specific or adaptive
component. Therefore, the immune system has two components: innate and adaptive immunity. The innate
immunity is present in all metazoans, while the adaptive immunity only occurs in vertebrates.
Innate Immunity
This provides the first line of defence against infection. It is a rapid response (minutes); it is not specific to
a particular pathogen. It has no memory and does not confer long-lasting immunity to the host. It has 4
main components and is found in all classes of plant and animal life.2 The innate immune system is made
of defences against infection that can be activated immediately once a pathogen attacks. The innate immune
system is essentially made up of barriers that aim to keep viruses, bacteria, parasites, and other foreign
particles out of your body or limit their ability to spread and move throughout the body. The innate immune
system includes:
Physical Barriers
Such as skin, the gastrointestinal tract, the respiratory tract, the nasopharynx, cilia, eyelashes and other
body hair.
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Defense Mechanisms
Such as secretions, mucous, bile, gastric acid, saliva, tears, and sweat.
General Immune Responses
such as inflammation, complement, and non-specific cellular responses. The inflammatory response
actively brings immune cells to the site of an infection by increasing blood flow to the area. Complement is
an immune response that marks pathogens for destruction and makes holes in the cell membrane of the
pathogen.3
Adaptive Immunity
This provides a specific immune response directed at an invading pathogen. Following exposure to a
foreign organism there is an initial effector response that eliminates or neutralizes a pathogen. Later re-
exposure to the same foreign organism induces a memory response with a more rapid immune reaction that
eliminates the pathogen and prevents disease. This response is found only in vertebrates.4
Adaptive immunity is an immunity that occurs after exposure to an antigen either from a pathogen or a
vaccination. This part of the immune system is activated when the innate immune response is insufficient to
control an infection. In fact, without information from the innate immune system, the adaptive response
could not be mobilized. There are two types of adaptive responses: the cell-mediated immune response,
which is carried out by T cells, and the humoral immune response, which is controlled by activated B cells
and antibodies. Activated T cells and B cells that are specific to molecular structures on the pathogen
proliferate and attack the invading pathogen. Their attack can kill pathogens directly or secrete antibodies
that enhance the phagocytosis of pathogens and disrupt the infection. Adaptive immunity also involves a
memory to provide the host with long-term protection from reinfection with the same type of pathogen; on
re-exposure, this memory will facilitate an efficient and quick response.5
Natural immunity
Antibodies generated due to a normal infection. Includes antibodies provided by mother through their
colostrum, the initial breastmilk. Only protects for short time, but when infant is most vulnerable.
Artificial immunity
Antibodies generated by receiving antigen in a vaccine/serum rather than a normal infection. Generally
does not last as long as when generate antibodies from a natural infection.
Active immunity
Immunity derived from antibodies generated by own body. Generated in response to normal infection or in
response to vaccine antigens.
Passive immunity
Immunity derived from antibodies from another body, such as given through mother's milk or artificial
means (antivenom antibodies). Generally does not last as long as active immunity as antibodies are not
supplied by the body. The diagram below summarizes these divisions of immunity.6-7
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Medicinal plants are considered as rich resources of ingredients which can be used in drug development
pharmacopoeial, non- pharmacopoeial or synthetic drugs. There are many benefits of Herbal Medicine like
easier to obtain than prescription medicine, Stabilizes hormones and metabolism, Natural healing, Strength
in immune system. According to the World Health Organisation, around 80% of the world’s population
uses herbal medicines for primary health care, particularly across Europe and South Asia. Research
indicates that many of these herbs not only have anti-inflammatory properties, they also help build up the
body’s natural immunity. And unlike allopathic medicines like antibiotics, which can have serious side
effects, most of these herbs and spices are relatively safe.
Medicinal Plants and Herbs
Sambucus nigra (Elderberry)
Elderberry, scientific name Sambucus nigra, is an intense purple berry and widely present in Europe and
Western Asia. It has been in use for many years due to its enormous health benefits. Chemically it is rich in
polyphenolic compound (Anthocyanins, Flavonols, Phenolic acid), terpenes, carbohydrate (mainly glucose
and fructose), citric acid, malic acid and lectins and other essential nutrients.2 Liquid elderberry extract is
characterized by antiviral action in vitro against influenza, as well as respiratory bacterial pathogens. There
is preclinical evidence that elderberry (Sambucus nigra L. (Adoxaceae)) inhibits the replication and viral
attachment of the human coronavirus NL63 (HCoV-NL63), which di_ers from COVID-19 but also belongs
to coronaviruses. Elderberry is the most effective means of preventing or combating coronavirus infections
at an early stage.8 One cup of elderberries contains 106 calories.9 However, their nutrient values in per 100
grams are as ~870 mg Vitamin A, 34.10 mg Vitamin C, 391.33 mg Potassium, 28.06 mg Calcium, 1.86 mg
Iron, 217 mg Sodium as well as some amount of other minerals, folic acid, amino acids, dietary fibers are
also present. This fruit is enriched with flavonoids having antioxidant and anti-inflammatory properties that
help protecting the healthy cells from the attack of harmful free radicals thus have implications in skin care,
boosting immune system which will supports the body to fight against flu, cold and other respiratory
infections.10
Allium sativum (Garlic, Lahsun)
Garlic has potent anti-oxidant properties, and helps in reducing stress and high blood pressure. It also helps
to enhance thiamine (vitamin B1) absorption in the body and prevents beriberi. The antiviral property may
be helpful in reducing the severity of colds, flu or COVID-19 infection. Hence, Garlic boosts the immune
system and helps in fighting against viruses and other diseases. It has Allicin which is board spectrum
antibiotics.11 It is reported to enhance immune health by stimulating protective white blood cells like NK
cells and macrophages.12 In an in vitro study13, Allium sativum L. (Amaryllidaceae) extract inhibited
influenza A (H1N1) virus by inhibiting the synthesis of viral nucleoproteins and polymerase activity. The
paper recommended a decoction of Allium cepa L. (Amaryllidaceae) for colds .8,14 It is always best to chop
or crush garlic before consuming it, because it works better when in contact with oxygen. Garlic is used to
add flavour to almost every form of cuisine across the world.2
Zingiber officinalis (Ginger)
Zanjabeel or Adrak is also known as Zingiber officinale Roscoe. Among other, it’s also a very important
medicinal plant which belongs to the family of Zingiberaceae. Ginger is well known for its anti-
inflammatory, antifungal, and anti-cancer properties. In traditional medicine, ginger has been extensively
used for curing colds and coughs, nausea, asthma, travel sickness, morning sickness, arthritis,
gastrointestinal complaints and even depression. Consume it as ginger tea, which involves crushing ginger
and boiling it with tea leaves and water. Powdered ginger mixed with pulverized cloves, cardamom and
caraway has been used for digestive ailments since ancient times.
Immunomodulatory (boost up the immune system of the patients which further prevent load of infection).15
Ginger is beneficial in to fight respiratory problems (relieve congestion associated with the common cold),
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strength immunity (due to high level of anti-oxidant), Relieve stress (due to combination of the strong
aroma and healing property), improve blood circulation (due to presence of vitamin, minerals and amino
acids in ginger it can help restore and improve blood circulation and prevent fat from deposition in arteries
helping to prevent heart from Cardiac Vascular Disorder.16
Tinospora cordifolia (Giloy, Guduchi)
Giloy or Guduchi, scientific name Tinospora cordifolia, is a plant being used from centuries for its
medicinal values. Many studies have reported the hypolipidemic, hypoglycemic, hepatoprotective,
antibacterial, anti-inflammatory, antiosteoporotic, antiobesity, anticarcinogenic and antimutagenic
properties of giloy.17 Guduchi or Giloy herb is suggested to contain various diterpene compound and
polysaccharides including arabinogalactan polysaccharide. These polysaccharides and terpenoids are
immunomodulating and adaptogenic in nature. Various studies on Giloy herbal extract revealed that it
could cause imperative enhancement in IgG antibodies in the serum and activation of macrophages,
induction of cell regulated immunity and humoral immunity.18
Ocimum sanctum (Holy Basil, Tulsi)
Tulsi, also called as holy, basil. Many in-vitro and in-vivo reports on animals and humans have proven its
therapeutic potential as Antioxidant, anti-aging, anticancer, antiviral, antimicrobial properties,
immunomodulatory activity, immunomodulatory activity, antipyretic activity, anti-arthritic activity,
treatment of gum ulcers, kidney problems, earache, menstrual irregularities, arthritis, anorexia and malaria
and used as a haemostypticin childbirth etc.19 Interestingly, the role of tulsi for scientific evidence against
COVID-19 has also been elucidated.18
Curcuma domestica (Turmeric, Haldi)
Turmeric, scientific name Curcuma domestica is a perennial herb and belongs to the family Zingiberaceae.
The “Indian saffron” is a yellow orange spice and medicinal herb that has been used for thousands of years.
Turmeric contains a bioactive compound known as curcumin, which acts as an anti-inflammatory agent.
Commonly used in India for curries and other dishes, it can also be consumed as a decoction (kadha) made
from grated ginger, tulsi and turmeric once daily to improve immunity as recommended by AYUSH. It is
one of the most well researched spice, explored for its therapeutic properties. The main phytochemical
includes diarylheptanoids such as curcumin. Curcumin is very helpful in addressing such issues and
enhancing the immunity system. Previous finding has proven that it has therapeutic potential as antifungal,
antiviral, antioxidant, anti-inflammatory, cardiovascular and anti-diabetic effects, gastrointestinal effects,
anticancer effect, antimicrobial activity, hepatoprotective and renoprotective effects, photo-protector
activity and in the treatment of inflammatory and edematic disorders and alzheimer disease.20
Syzygium aromaticum (Clove, Laung)
Clove, scientific name Syzygium aromaticum. The consuming whole cloves can help boost the immune
systemperfectly. Clove essential oil may have Nutritional Therapeutic Potential effects due to its various
effects, which includes antimicrobial, anti-fungal, anti-viral, an-ti-inflammatory, cytotoxic, analgesic,
anesthetic activities, very potent as antioxidants, and inhibits post binding en-try of severe acute respiratory
syndrome (SARS) coronavi-rus into cells. Besides, anti-platelet activities; prevent the formation of a
thrombus or a blood clotting. Therefore, essential oil of cloves may be considered the most candi-dates to
combat the coronavirus and protecting against sudden death seen in some patients infected by Coro-navirus
(COID 19), resulting from embolism associated with hypercoagulable formation. Clove Oil should only be
diffused in well-ventilated places, and diffusing treat-ments shouldn’t exceed more than 60 minutes each
time.21
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Withania somnifera (Ashwagandha)
It is a small shrub with pale green flowers, simple leaves, and red berries. More commonly known as
ashwagandha, Indian ginseng. Most of the benefits from Ashwagandha are from the root and the leaves.
The leaves are most commonly used in teas preparation. The root can be taken in many ways but it's most
commonly dried, powdered, and taken as a supplement these days. The extract of Ashwagandha can reduce
blood sugar levels, cortisol levels, symptoms of depression, and inflammation. It helps increase strength,
muscle mass, and improve brain function as well. Ashwagandha improves the body's defense against
disease by improving the cell-mediated immunity. It also possesses potent antioxidant properties that help
protect against cellular damage caused by free radicals. It also shown inhibitory properties against many
cancers, (breast, colon, prostate, colon, ovarian, lung, brain), along with their mechanism of actions and
pathways involved.22,23 Ashwagandha extracts, has shown a strong effect related to immune health and
stress reduction.24
Planax quinquefolius (Ginseng)
Ginseng is a plant in the family Araliaceae and the genus Panax with the formal name of Panax ginseng C.
A. Meyer and the treasure of traditional herbal medicine resources as the “King of Herbs.” 2526 Acute
respiratory tract infection induced by COVID-19, influenza or chronic diseases causes the horrible threat to
human health in the whole world. Based on the effect of benefiting Qi, ginseng can strengthen human
immunity against acute respiratory tract infection.27
Fenugreek is a well-known herb in the Ayurvedic system of medicine which acts a natural anti-oxidant and
strengthens immune system. It is not only used as an herb (dried or fresh leaves), spice(seeds), vegetable
(fresh leaves) but also as a condiment in artificial flavoring of maple syrup or in the production of
steroids.28
Nutraceuticals and Herbal Extracts29
Vitamins.
A daily intake of 20-50 μg of vitamin D was recently recommended for obese individuals, healthcare
workers and smokers in order to enhance their resistance to COVID-19 infection.
Dietary minerals
Selenium
The importance of selenium for optimal immune function.
Zinc
Elderly individuals are often deficient in zinc, which is essential for immune function.
Iron
The strict regulation of serum iron concentration could thus provide favorable clinical outcomes for patients
with COVID-19.
N-acetyl-cysteine (NAC)
NAC, which is derived from the naturally occurring amino acid, cysteine, is most commonly prescribed to
patients suffering from various respiratory complications.
Probiotics
Nutritional supplementation with probiotics has been reported to be beneficial for patients suffering from
respiratory tract infections.
Omega-3 fatty acids
omega-3 fatty acids have proven to be effective in reducing airway inflammation and bronchoconstriction,
have also exhibited efficacy against viral infections (102,103), their potential for use against COVID-19
warrants further investigation
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β-glucans
β-glucans, which are potent activators of immune cells, β-glucans can help to reduce morbidity and
mortality associated with COVID-19.
CONCLUSION
Medicinal plants and herbs are better alternatives to treat several diseases. During the COVID-19 pandemic
in december 2019 when no proper allopathethic medicine was available to treat COVID-19, various
traditional medicinal plants and herbs have been used as medicines and resulted in positive health effects
among COVID-19 patients. In the present review, we have discussed the possible potential uses of
medicinal plants and herbs to boosting immunity against these viruses and also prevent or even treat
COVID-19 infections.
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Published by:
Informative Journals
Jadoun Science Publishing Group India
How to cite this article: Tamboli, F., More, H., Khairmode, S., Patil, D., Tambare, P., & Shinde, A. (2021). IMPORTANCE OF
MEDICINAL PLANTS AND HERBS AS AN IMMUNITY BOOSTER FOR PANDEMIC COVID-19. Tropical Journal of
Pharmaceutical and Life Sciences, 8(1), 01-09. Retrieved from https://informativejournals.com/journal/index.php/tjpls/article/view/65.
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The medicinal plant Digitalis purpurea produces cardiac glycosides that are useful in the pharmaceutical industry. These bioactive compounds are in high demand due to ethnobotany’s application to therapeutic procedures. Recent studies have investigated the role of integrative analysis of multi-omics data in understanding cellular metabolic status through systems metabolic engineering approach, as well as its application to genetically engineering metabolic pathways. In spite of numerous omics experiments, most molecular mechanisms involved in metabolic pathways biosynthesis in D. purpurea remain unclear. Using R Package Weighted Gene Co-expression Network Analysis, co-expression analysis was performed on the transcriptome and metabolome data. As a result of our study, we identified transcription factors, transcriptional regulators, protein kinases, transporters, non-coding RNAs, and hub genes that are involved in the production of secondary metabolites. Since jasmonates are involved in the biosynthesis of cardiac glycosides, the candidate genes for Scarecrow-Like Protein 14 (SCL14), Delta24-sterol reductase (DWF1), HYDRA1 (HYD1), and Jasmonate-ZIM domain3 (JAZ3) were validated under methyl jasmonate treatment (MeJA, 100 μM). Despite early induction of JAZ3, which affected downstream genes, it was dramatically suppressed after 48 hours. SCL14, which targets DWF1, and HYD1, which induces cholesterol and cardiac glycoside biosynthesis, were both promoted. The correlation between key genes and main metabolites and validation of expression patterns provide a unique insight into the biosynthesis mechanisms of cardiac glycosides in D. purpurea.
... Some examples of bioactive found in herbs and spices are polyphenols, carotenoids, and nonflavonoid phenolics. The effect of these bioactive components on diseases such as cardiovascular disease, diabetes, hypertension, obesity, and osteoporosis has been well documented [17][18][19][20]. India is regarded as the "Botanical Garden of the World" and "Land of spices" as it is the world's largest producer of traditional medicinal herbs [21]. ...
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... . Ginger contains a high level of antioxidant, vitamins, minerals, strong aroma and healing properties. The chemical constituents of ginger, such as Gingerol (C 17 H 26 O 4 ) and Shogaol (C 17 H 24 O 3 ), are significantly active against COVID-19 with remedial possibilities[112,113]. ...
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The main herbal components and their possible immune-boosting effects are covered in detail in this comprehensive assessment. The review emphasises the definition of immunity, many forms of immunity, The properties and roles of immune-related cells T and B lymphocytes. The immune system is shielded from infection by the anti-inflammatory, antioxidant, and immunomodulatory qualities of these herbs, which also have an impact on immune system signs and symptoms. Additionally, it investigates the effectiveness and safety of herbal immune boosters while taking into account both modern scientific research and traditional wisdom. The increasing popularity of herbal immune boosters—natural treatments made from plants—is covered in this abstract. Cardamom, Ashwagandha, Tulsi, Gingseng, Garlic, Ginger, Amla, and Black Pepper are well-liked natural immunity enhancers.
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Today world is facing an unprecedented pandemic COVID 19 caused by SARS COV 2. In present scenario it’s become more important to build our defense system more strong against it as no evidence-based treatment for COVID-19 is developed yet. Since time immemorial, traditional spices and herbs have played a vital role as immuno-boosters in Indian cuisine. Herbs and spices were well known from ancient times for their medicinal properties. More than 80 spices are grown in different parts of the world, particularly in Asia. India is home to several spices that are used extensively in traditional medicine. Spices like turmeric, saffron, cloves, cinnamon, carom seeds, ginger and garlic are known to have a plethora of beneficial properties. Herbs like mint, tulsi (Holy Basil), leaves of neem, ashwagandha, giloy are said to have several health benefits. Herbs and spices are wonderful because, unlike drugs, we don’t need to “take” them. Instead, we can add them to our favorite dishes for a kick of flavor and increased immunity.
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The development of new effective anti-coronavirus drugs and therapies is important, but it requires significant human, financial and, most importantly, time expenditures. The current pandemic is neither the first nor the last. Humanity has already accumulated considerable survival experience. We cannot do without prevention and epidemiological protection measures. This study reviews medicinal plants that grow in Northeast Asia and whose antioxidant, antiviral, anti-inflammatory and immunomodulatory characteristics are already known, also in the framework of the prevention and treatment of pneumonia of various etiologies. The need for a comprehensive approach to maintaining immunodefences, including functional foods and positive emotions, is emphasized. In the period of pandemics, it is important to research various areas that allow to us accumulate a critical mass of information and cope with the next global disease.
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COVID- 19 has created a lot of hazardous health issues worldwide. Research fraternity around the world is trying to find out vaccine or medicines against the virus. In this pandemic situation, there is a need for remedies to boost the immunity to fight against the virus. Ayurveda treatises have described several herbal drugs which are used as home remedies and are said to be effective against all microorganisms and effective in boosting immunity. Home remedies can be played a vital role as immunomodulant. Hence in this paper, an attempt is made to review such home remedies and identify its efficacy on various conditions. The relevant references were searched on the internet to find out the scientific data available on home remedies. Fumigation, Rasayan drugs, a decoction of herbal medicines found more useful. Tinospra cordifolia, Glycyrrhiza glabra, Ocimum sanctum, Withania somnifera, Curcuma longa are most decorated single herbal drugs used as home remedies for boosting the immunity. Considering the global disease burden caused by COVID-19, there is an urgent need to explore and widened the use of home remedies to fight against COVID-19 menace effectively.
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Ashwagandha (Withania Somnifera, WS), belonging to the family Solanaceae, is an Ayurvedic herb known worldwide for its numerous beneficial health activities since ancient times. This medicinal plant provides benefits against many human illnesses such as epilepsy, depression, arthritis, diabetes, and palliative effects such as analgesic, rejuvenating, regenerating, and growth-promoting effects. Several clinical trials of the different parts of the herb have demonstrated safety in patients suffering from these diseases. In the last two decades, an active component of Withaferin A (WFA) has shown tremendous cytotoxic activity suggesting its potential as an anti-carcinogenic agent in treatment of several cancers. In spite of enormous progress, a thorough elaboration of the proposed mechanism and mode of action is absent. Herein, we provide a comprehensive review of the properties of WS extracts (WSE) containing complex mixtures of diverse components including WFA, which have shown inhibitory properties against many cancers, (breast, colon, prostate, colon, ovarian, lung, brain), along with their mechanism of actions and pathways involved.
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Current scenario depicts that world has been clenched by COVID-19 pandemic. Inevitably, public health and safety measures could be undertaken in order to dwindle the infection threat and mortality. Moreover, to overcome the global menace and drawing out world from moribund stage, there is an exigency for social distancing and quarantines. Since December, 2019, coronavirus, SARS-CoV-2 (COVID-19) have came into existence and up till now world is still in the state of shock.At this point of time, COVID-19 has entered perilous phase, creating havoc among individuals, and this has been directly implied due to enhanced globalisation and ability of the virus to acclimatize at all conditions. The unabated transmission is due to lack of drugs, vaccines and therapeutics against this viral outbreak. But research is still underway to formulate the vaccines or drugs by this means, as scientific communities are continuously working to unravel the pharmacologically active compounds that might offer a new insight for curbing infections and pandemics. Therefore, the topical COVID-19 situation highlights an immediate need for effective therapeutics against SARS-CoV-2. Towards this effort, the present review discusses the vital concepts related to COVID-19, in terms of its origin, transmission, clinical aspects and diagnosis. However, here, we have formulated the novel concept hitherto, ancient means of traditional medicines or herbal plants to beat this pandemic.
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Ginseng is a plant in the family Araliaceae and the genus Panax with the formal name of Panax ginseng C. A. Meyer and the treasure of traditional herbal medicine resources as the “king of herbs”. Ginseng has been traditionally used for over 2,000 years in Asian countries, especially in China and Republic of Korea. During the ginseng industry chain, the cultivation in farmland and seed breeding are important for sustainable development of ginseng resources. Active components in ginseng including ginsenosides, polysaccharides, phenolic compound and their therapeutic benefits for multiple diseases are being studied. This paper aimed to review current research status and problem-solving strategies for each step of ginseng industry, including ginseng growing cultivation and seed resources, basic and clinical studies as well as comparison of ginseng industry between China and Republic of Korea, hoping to provide a reference for research direction and future development of ginseng industry.
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Context: Human beings have long utilized the plants for medicinal purposes. Investigation of these plants has led to the discovery of several modern drugs. Objective: This paper documents and evaluates traditional knowledge on medicinal plants used by the local people of Mihalgazi district of Eskişehir, Turkey. Materials and methods: Six villages of the study area were visited between February 2014 and April 2015 to collect the data. Hundred and eighty-nine informants were interviewed by the survey method and face to face semi-structured interviews. Taxonomic identification, the most commonly used plant parts, preparation and administration methods were evaluated. Ethnomedicinal data were analyzed quantitatively with relative importance (RI) and the informant consensus factor (FIC). Results: This paper reported a total of 52 medicinal plants (37 wild, 15 cultivated) belonging to 34 families. Some uses of 22 plants were not found in the literature and are reported for the first time in this study. Furthermore, one of the plants, Calamagrostis arundinacea (L.) Roth (Poaceae), was reported for the first time as being used within the scope of traditional therapies. Discussion and conclusion: This study recorded traditional knowledge on medicinal plants used in Mihalgazi, Turkey. This paper provides a basis for further investigations to discover efficient pharmaceuticals.