The sustainable development in librarianship is relatively a new research field. This paper aims to increase readers' understanding of sustainable development challenges in Library and Information Science (LIS) in terms of complexity and diversity. A detailed plan was drawn up from Preferred Reporting Items for the Systematic Review and Meta-analysis (PRISMA) to achieve the objectives of this study. An inclusion and exclusion criteria was established and each study item passed through identification, screening, eligibility and inclusion before being placed in the final pool of items. This paper reviewed literature chosen from LISA, LISTA, Scopus, Web of Science and Google Scholar databases spanning from 2000 to 2020. Findings revealed that there was diverse type of sustainable development challenges in Library and Information Science (LIS). Absence of sustainable strategies, lack of sustainable education in the LIS curriculum, operations, services and buildings designs and massive energy consumption due to long service hours of libraries were major challenges. More importantly, the rapid digital and technological advances have made libraries' current equipment irrelevant casting a large carbon footprint on the globe. Challenges to adaptation are compounded by clinging to old traditions and resistance to change which limit the ability to plan for long term sustainable development (SD) goals. There is need to remove these obstacles to accrue benefits for today and far reaching implications for the future. The study provides an integrative report to help library leaders and educational policy makers in Pakistan to apply SD initiatives more effectively according to the institutes' contextual needs. The results of this study will also help further the sustainability agenda in LIS by incorporating sustainability into the LIS curriculum.