Article

Ultrasensitive Optical Label-Free Biosensing and Fluorescent Measurements using UV Surface Plasmons in Gold Nanolayers Launched with the Support of a Specially Designed Photonic Crystal

February 2021
Biophysical Journal 120(3):364a

DOI:10.1016/j.bpj.2020.11.2247

Authors:

Kirill Prusakov

Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency

Dmitry V. Basmanov

Federal Research and Clinical Center of Physical-Chemical Medicine named after Y.M. Lopukhin

Federal Research and Clinical Center of Physical-Chemical Medicine named after Y.M. Lopukhin

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Article

Biosensing based upon molecular confinement in metallic nanocavities

June 2004 · Proceedings of SPIE - The International Society for Optical Engineering

We describe the basis for an affinity biosensor platform in which enhanced fluorescence transduction occurs through the optical excitation of molecules located within metallic nanocavities. These nanocavities are about 200 nm in diameter and are arranged in a periodic or random two-dimensional (2D) arrays, which are fabricated in 70 nm-thick gold films by e-beam lithography using negative e-beam ... [Show full abstract] resist. The experimental results show that both periodic and randomly placed metallic nanoapertures can be used to enhance the output of a fluorescing molecular monolayer by more than a factor of 10.