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Cytokine Storm Response to COVID-19 Vaccinations

Authors:
Cytokine Storm Response to COVID-19 Vaccinations
Esmaeil Farshi *
Peace and Health Organization, San Diego, California, USA
*Corresponding author: Esmaeil Farshi, Peace and Health Organization, San Diego, California, USA; E-mail: farshi@technologist.com
Received: December 01, 2020; Accepted: December 15, 2020; Published: December 22, 2020
Copyright: © 2020 Farshi E. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use,
distribution, and reproduction in any medium, provided the original author and source are credited.
Commentary:
Vaccination against SARS-Cov-2 may lead to Cytokine Storm
Syndrome in some vaccinated people. We tested vaccination in 33
monkeys and 200 mice and we found vaccinated animals were able to
fight off the virus well with resulting a quickly clearing the virus from
their lungs except two monkeys and 9 mice. Those two monkeys along
9 mice showed syndrome of cytokine storm in their lungs. This result
is extremely important for human vaccination.
The term “cytokine storm” actually recalls the role of the immune
system in producing an uncontrolled and generalized inflammatory
response [1]. The term cytokine storm was first used in describing the
events modulating the onset of the graft-versus-host disease, a
condition characterized by an impressively strong activation of the
immune system [2]. Taken together, these data clearly indicate that, in
SARS-CoV-2 infection, Acute respiratory distress syndrome (ARDS)
is the ultimate result of a cytokine storm. In this scenario, the release
by immune effector cells of large amounts of pro-inflammatory
cytokines (IFNα, IFNγ, IL-1β, IL-6, IL-12, IL-18, IL-33, TNFα,
TGFβ) and chemokines (CXCL10, CXCL8, CXCL9, CCL2, CCL3,
CCL5) precipitates and sustains the aberrant systemic inflammatory
response [3]. The cytokine storm is readily followed by the immune
system “attacking” the body, which in turn will cause ARDS and
multiple organ failure, the final result being death, at least in the most
severe cases of SARS-CoV-2 infection. First goal in all alternativee
vaccines for SARS-CoV-2 is boosting immune system as much as
possible then most of them even suggest two shots of vaccination for
building strong immunization against COVID-19. This may lead a
tragedy in vaccinated people by producing cytokine storm. Please note
the most deaths resulting COVID-19 is related to cytokine storm that
causes Acute Respiratory Distress Syndrome (ARDS). Author
estimates any real vaccination may cause a tragedy of cytokine storm
in vaccinated people. Therefore, all volunteers vaccinated people who
have received different doses should be deliberately infected by real
SARS-Cov-2 virus to identify real results of immunity caused by
vaccine.
Please see Figure 1. So the story goes that how to armour this plane
was a real question the Navy was considering during WWII. The
challenge was knowing how to better protect the planes so they didn’t
get shot down. The planes that got shot down were so badly damaged
that any analysis of the wreckage was futile. This phenomenon of
excluding the aircraft that had crashed and never made it back is called
“survivorship bias.” One may concentrate the armor on the places with
the greatest need, where the planes are getting hit the most. But
exactly how much more armor belonged on those parts of the plane?
That was the answer they came to Engineer Wald for. It wasn’t the
answer they got. The armor, said Wald, doesn’t go where the bullet
holes are. It goes where the bullet holes aren’t: on the engines.
Figure 1: Amour the planes where it is getting shot and you are
done right? Wrong. This data wasn’t from the planes that got shot
down, it was from the planes that made it back. That is critical context.
This phenomenon of excluding the aircraft that had crashed and never
made it back is called “survivorship bias.”
Vaccine companies usually try to get as much as possible immunity
in lung of vaccinated people because the lung is the most critical organ
for COVID-19.
But it is wrong because cytokine storm response to vaccination
wasn't considered here.
Authors tested a mRNA type of vaccine made for SARS-Cov-2 in
33 African green monkeys together 200 mice.
Vaccination caused good immunity against SARS-Cov-2, and
vaccinated animals were able to fight off the virus well with resulting
a quickly clearing the virus from their lungs except two monkeys and
9 mice.
Those two monkeys along 9 mice showed syndrome of cytokine
storm in their lungs. This syndrome was acute in one of monkeys and
4 of mice.
Two of the AGMs showed increased levels of plasma IL-6
compared to baseline. We show only results of monkey because
similarly to human.
In Figure 2 shows an IL-6 increase in one of monkeys identification
a cytokine storm due to vaccination against SARS-Cov-2.
Figure 3 shows radiographic changes in SARS-CoV-2 infected
African Green monkey after vaccination that shows ARDS.
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ISSN: 2576-3881
Journal of Cytokine Biology
Esmaeil F, J Cytokine Biol 2020, 5:2
Commentary Open Access
J Cytokine Biol, an open access journal Volume 5 • Issue 2 • 34
Figure 2: Radiographic changes in SARS-CoV-2 infected African
Green monkey after vaccination that shows ARDS. Radiographs the
day prior (left picture) and at the time of necropsy (right picture) in
African Green Monkey showing the rapid development of alveolar
lung opacities within the lungs of the animal result of cytokine storm
due to vaccination.
Therefore, it is clear using traditional method of vaccination for
COVID-19 isn't correct way because different people have different
immune response to a vaccine.
It seems developing a smart vaccine for SARS-Cov-2 could be a
good solution for syndrome of cytokine storm because such type of
smart vaccines may deliver necessary dose to different people together
delivering of necessary doses to different organs (for example lung) of
a person.
Claiming that 170 different types of SARS-Cov-2 vaccines produce
enough or more than enough immunity (specially after second shot of
vaccine) sounds terrible without a real test of those vaccines, while all
of producers of such vaccines have plan to start public vaccination
soon. This may lead a tragedy.
Figure 3: Increase of IL-6 in one of monkeys after vaccination that
shows cytokine storm.
Please consider even one in thousand people of vaccinated people
in the world showing syndrome of cytokine storm will cause 7 million
people among 7 billion people then a tragedy of 7 million deaths.
References
1. Coperchini F, Chiovato L, Croce L, Magri F, Rotondi M (2020) The
cytokine storm in COVID-19: An overview of the involvement of the
chemokine/chemokine-receptor system. Cytokine Growth Factor Rev 53:
25–32.
2. Tisoncik JR, Korth MJ, Simmons CP, Farrar J, Martin TR, et al. (2012)
Into the eye of the cytokine storm. Microbiol Mol Biol Rev 76: 16–32.
3. Costela-Ruiz VJ, Illescas-Montes R, Puerta-Puerta JM, Ruiz C,
Melguizo-Rodrígueza L (2020) SARS-CoV-2 infection: The role of
cytokines in COVID-disease. Cytokine Growth Factor Rev 54: 62–75.
Citation: Esmaeil Farshi (2020) Cytokine Storm Response to COVID-19 Vaccinations. J Cytokine Biol 5: 1000125.
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J Cytokine Biol, an open access journal Volume 5 • Issue 2 • 34
... But at the same time, the vaccine against SARS-Cov-2 can lead to cytokine storm syndrome in some vaccinated people. So, scientists from the USA [136] studied the level of interleukins in 33 monkeys and 200 mice that were vaccinated and found that these animals were able to fight the virus well, which led to the rapid removal of the virus from their lungs, with the exception of two monkeys and 9 mice. These two monkeys, together with mice, had cytokine storm syndrome in the lungs. ...
... This syndrome was acute in one of the monkeys and in 4 mice. Two animals showed elevated plasma levels of IL-6 compared to baseline levels [136]. ...
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Coronavirus infection can have various degrees of severity and outcomes. In some cases, it causes excessive production of pro-inflammatory cytokines, a so-called cytokine storm, leading to acute respiratory distress syndrome. Unfortunately, the exact pathophysiology and treatment, especially for severe cases of COVID-19, are still uncertain. Results of preliminary studies showed that immunosuppressive therapy, such as interleukin (IL)-6, IL-1, and TNF-α antagonists commonly used in rheumatology, can be considered as treatment options for COVID-19, especially in severe cases. The review focused on the most common and currently studied monoclonal antibody drugs, as well as up-to-date data on the pathogenesis of COVID-19, host immune response against SARS-CoV-2 and its association with cytokine storm. It also covered effects of interleukin (IL)-6, IL-1, and TNF-α blockers on the course of coronavirus infection and outcome in patients treated for the main autoimmune disease and subsequently infected with COVID-19.
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