Shelf-life evaluation of Marichyadi Lepa prepared with Agnipaki and Bhanupaki method: A preliminary assessment

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Acne, eczema, psoriasis, vitiligo, hyper pigmentation, seborrhic dermatitis, etc. have been found with high prevalence in Gujarat. There are so many effective formulations in Ayurveda prescribed by Ayurvedic physicians in various skin disorders for many ages. IPGT & RA, the leading institutes of Ayurveda is working on the aims to generate evidences of safety and efficacy of Ayurvedic classical and modified formulations. Present work is a compilation of clinical research works carried out in RSBK department of IPGT and RA at MD and PhD level on different skin disorders. Various popular herbal and herbomineral formulations were clinically evaluate on five skin diseases under the headings Kshudra kushtha (common skin diseases), Vicharchika (Eczema), Ekakushtha (Psoriasis), Mukhadushika (Acne) and Shvitra (Vitiligo). Ayurvedic classical formulations showed significant results on different skin diseases. Modifications of classical formulations into contemporary forms are convenient and also effective. Herbo mineral formulations prepared from metals and minerals were also found safe and efficacious internally as well as externally. These studies are reflecting the methodologies in current Ayurvedic clinical research and drug development.
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Stability studies ensuring the maintenance of product quality, safety and efficacy throughout the shelf life are considered as pre-requisite for the acceptance and approval of any pharmaceutical product. These studies are required to be conducted in a planned way following the guidelines issued by ICH, WHO and or other agencies. Importanceof various methods followed for stability testing of pharmaceutical products, guidelines issued for stability testing and other aspects related to stability of pharmaceutical products have been presented in a concise manner in the present review.
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Concept of Saviryta Avadhi (shelf-life) of Ayurvedic dosage forms is well-defined in classics of Ayurveda. Information on this is scattered in initial classics of Ayurveda like Charaka Samhita, but focused well after 13(th) Century AD in texts such as Vangasena Samhita, Sharangadhara Samhita and Yogaratnakara. Though the concepts have a strong background; considering the pharmaceutical development, a need is felt to re-evaluate the age old concepts by following current norms. To evaluate shelf-life of two samples of Rasayana Churna. Raw material was procured from The Pharmacy, Gujarat Ayurved University and authenticated at Pharmacognosy Laboratory. Individual drugs were powdered and blended in specified ratio to obtain Rasayana Churna (RC). RC was levigated with decoction of Amalaki, Guduchi and Gokshura to prepare Bhavita Rasayana Churna (BRC). Both the samples were subjected to accelerated stability studies by following standard guidelines. Both the samples are bitter and astringent with characteristic odor. RC is creamish brown in colour, while BRC is dark blackish brown. These Organoleptic characters were unchanged till the 6(th) month of study. On comparision, BRC is found to be more stable than RC. This signifies that, Bhavana not only incorporates additional therapeutic attributes, but also helpful in increasing shelf-life.
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Trikatu Churna (TC) is an ancient traditional Ayurvedic preparation prescribed for a wide range of disorders. Though TC is an age old formulation, there are very few references on its quality control and standardization. In this work, an attempt has been made to standardize TC by qualitatively evaluating the preliminary phytochemicals. Piperine content of TC was determined using HPTLC. Evaluation of safety potential of TC samples and stability evaluation by comparative study of the in house TC formulation with marketed TC formulations with respect to their piperine content is a value addition to the current work.
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INTRODUCTION Herbal drugs may be comminuted or powdered drugs, extracts, tinctures, fatty or essential oils, expressed juices, processed resins or gums etc. which may be prepared by fractionation, purification or concentration process. Other components such as solvents, diluents, preservatives may form part of preparation. We are all aware that India is one of the richest sources of medicinal and aromatic plants. [1, 2] Advancement of synthetic drugs has somewhat suppressed the interest in herbal medicines. It is believed that most of the modern drugs which are therapeutically active are derived synthetically. This in fact is not true. Actually plant itself is a chemical laboratory. It synthesizes biologically active secondary metabolites. Most of the modern medicines have originated from plant metabolites. Herbal formulations may contain single or several plant materials. These can be in any dosage form like Capsules, Tablets, Pills, Syrups, and Avaleha etc. [2, 3] Selection of Herbal product depending upon pharmacological action is required and it can be done by phytochemical investigation of each part of plant and/or by clinical traits of extract of different plant parts. The medical properties of the herb can be potentiated by means of extract preparation. Crude extracts of the herbs are used as therapeutic agents, often proven efficacy and less toxicity. Drying of extracts is achieved by different conventional methods including tray drying, vacuum drying, spray drying and freeze drying. Ideal method of drying for herbal extract would be that which takes minimum period at a minimum temperature, with a minimum cost and still have a maximum yield and is capable of handling large quantities of extract. Most common dosage form is tablet. Herbal powders or their dried extracts contain a range of natural compounds. Many of these compounds are excipients of allopathic tablet formulation. These are carbohydrates, proteins, lipids etc. Many of these compounds are known to act as binder, disintegrator and/or lubricant in tablet formulation. Therefore chemical and physical analysis and standardization is very important for herbal tablet formulation.
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