Nocturnal enuresis is defined as nighttime bedwetting in children five years of age or older in the absence of neurological or structural problems affecting the bladder. A wide variety of interventions are used to treat nocturnal enuresis include simple behavioral intervention, enuresis alarm, and pharmacological treatment—the aim of the study to assess the management of nocturnal enuresis in children. A prospective cross-sectional study included 150 children attend the advanced diagnostic center. Data collected by direct interview questionnaire was tested –coded and analyzed by SPSS version 20 in tables and graph &excel. The result of this study showed that the highest treatment adopted was simple-cognitive behavioral therapy (87%), with the highest (94.7%) of patient surveyed adopted lifting and awaking technique,(38%) of patient surveyed have taken imipramine, (26%) of patient surveyed have taken 75mg dose of imipramine, (37%)of patients surveyed had a full response from imipramine therapy. The study showed that the first-line treatment that is needed is simple-cognitive behavioral therapy with instruction regarding diet and fluids, and it is very useful. The main drug was used in the treatment of nocturnal enuresis is imipramine with a dose of 75mg.