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Fit for life

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Abstract

Lack of physical activity (PA) is a highly modifiable risk factor for the development of chronic disease and premature mortality. Guidelines around the world for recommended activity levels are consistent, suggesting 150 minutes per week of moderate-intensity exercise, yet the majority of adults fail to reach this target. Regular PA causes cardiovascular, respiratory and musculoskeletal adaptations, alters the blood lipid profile and reduces systemic inflammation. These changes are thought to contribute to a reduced risk of developing chronic disease, including ischaemic heart disease, stroke, type 2 diabetes and certain cancers. Regular PA alters the course of chronic disease, conveying a survival advantage and reducing morbidity and mortality. When counselling patients, it is advisable to formally quantify their activity levels using a rating scale, employ motivational interviewing techniques and consider the social, cultural, economic and disability-related barriers that may limit access to exercise.

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This study was designed to define the effect of different levels of leisure time physical activity on cardiorespiratory fitness and progression of coronary atherosclerotic lesions in unselected patients with coronary artery disease. It has been shown in various studies that regression of coronary atherosclerotic lesions can be achieved by means of lipid-lowering drugs, reduction of fat consumption and physical exercise. Patients were prospectively randomized either to an intervention group (n = 29) participating in regular physical exercise or to a control group (n = 33) receiving usual care. Energy expenditure in leisure time physical activity was estimated from standardized questionnaires and from participation in group exercise sessions. After 12 months of participation, repeat coronary angiography was performed; coronary lesions were measured by digital image processing. After 1 year, patients in the intervention group achieved an increase in oxygen uptake at a ventilatory threshold of 7% (p < 0.001) and peak exercise of 14% (p < 0.05), whereas a significant decrease was observed in patients in the control group. To achieve significant improvement in cardiorespiratory fitness, approximately 1,400 kcal/week had to be expended in the form of leisure time physical activity (p < 0.001). The mean energy expended in such activity was 1,876 +/- 163 kcal/week in the intervention group and 1,187 +/- 97 kcal/week in the control group (p < 0.001). In the intervention group, regression of coronary artery disease was noted in 8 patients (28%), progression of disease in 3 (10%) and no change in coronary morphology in 18 (62%). In contrast, coronary artery disease progressed at a significantly faster rate in patients in the control group (progression in 45%, no change in 49% and regression in 6%) (p < 0.001 vs. intervention). When the two groups were combined, the lowest level of leisure time physical activity was noted in patients with progression of disease (1,022 +/- 142 kcal/week) as opposed to patients with no change (1,533 +/- 122 kcal/week) or regression of disease (2,204 +/- 237 kcal/week) (p < 0.005). Measurable improvement in cardiorespiratory fitness requires approximately 1,400 kcal/week of leisure time physical activity; higher work loads are necessary to halt progression of coronary atherosclerotic lesions (1,533 +/- 122 kcal/week), whereas regression of coronary lesions is observed only in patients expending an average of 2,200 kcal/week in leisure time physical activity, amounting to approximately 5 to 6 h/week of regular physical exercise.
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Physical Activity Readiness Questionnaire (PARQ) clearance has been recommended prior to low-to-moderate exercise involvement. The measure, however, appears to exclude a high proportion of older adults due to false positive responses. To improve this situation, a revised PARQ was developed (rPARQ). The purpose of this study was to compare the number exclusions resulting from the PARQ and rPARQ in 60- to 69-yr-old adults. Participants were recruited from Community Nutrition Centers (97 males, 96 females; mean age = 64.82 yr, SD +/- 2.85). At random, half completed the PARQ or rPARQ on day 1 and the respective opposite instrument on day 2. There was a significant decrease in the number of exclusions resulting from the PARQ as compared to the rPARQ (146 to 128, P < 0.001). Percentage of agreement regarding exclusion/inclusion status between the two measures was 87.6% (kappa = 0.71). Responses for the six matched questions were significantly (P < 0.0001) related with contingency and phi coefficients ranging from 0.40 to 0.58 and 0.43 to 0.71, respectively. These results support the concurrent validity of the rPARQ and suggest the revisions have had their intended effect.
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Type 2 diabetes affects approximately 8 percent of adults in the United States. Some risk factors--elevated plasma glucose concentrations in the fasting state and after an oral glucose load, overweight, and a sedentary lifestyle--are potentially reversible. We hypothesized that modifying these factors with a lifestyle-intervention program or the administration of metformin would prevent or delay the development of diabetes. We randomly assigned 3234 nondiabetic persons with elevated fasting and post-load plasma glucose concentrations to placebo, metformin (850 mg twice daily), or a lifestyle-modification program with the goals of at least a 7 percent weight loss and at least 150 minutes of physical activity per week. The mean age of the participants was 51 years, and the mean body-mass index (the weight in kilograms divided by the square of the height in meters) was 34.0; 68 percent were women, and 45 percent were members of minority groups. The average follow-up was 2.8 years. The incidence of diabetes was 11.0, 7.8, and 4.8 cases per 100 person-years in the placebo, metformin, and lifestyle groups, respectively. The lifestyle intervention reduced the incidence by 58 percent (95 percent confidence interval, 48 to 66 percent) and metformin by 31 percent (95 percent confidence interval, 17 to 43 percent), as compared with placebo; the lifestyle intervention was significantly more effective than metformin. To prevent one case of diabetes during a period of three years, 6.9 persons would have to participate in the lifestyle-intervention program, and 13.9 would have to receive metformin. Lifestyle changes and treatment with metformin both reduced the incidence of diabetes in persons at high risk. The lifestyle intervention was more effective than metformin.
Article
Prescribing exercise for cardiac patients is comparable in many ways to prescribing medications; that is, one recommends an optimal dosage according to individual needs and clinical status. Recent research has shown that it is more accurate to prescribe exercise as a percentage of the oxygen uptake reserve (VO2R), which is the difference between resting and maximal or peak oxygen consumption, rather than as a percentage of the VO2 max. Moreover, it appears that a minimum of 1600 kcal/week of leisure-time physical activity may halt the progression of coronary artery disease, whereas regression may be achieved with a gross energy expenditure of 2200 kcal/week. Upper body and resistance training have also been shown to be safe and effective for clinically stable patients. Aerobic capacity serves as an independent predictor of all cause and cardiovascular mortality in patients referred to an outpatient cardiac rehabilitation program, with each 1 metabolic equivalent increase in aerobic fitness conferring an approximate 10% reduction in mortality. The goal of preventing recurrent cardiac events is, to a large extent, based on sustained compliance to multifactorial interventions, which can be influenced by numerous socioeconomic and clinical variables, and enhanced by home-based or group cardiac rehabilitation programs that are designed to circumvent or attenuate barriers to participation and adherence, so that many more individuals may realize the benefits that secondary prevention can provide.
Article
Walking is associated with reduced diabetes incidence, but few studies have examined whether it reduces mortality among those who already have diabetes. To estimate the association between walking and the risk for all-cause and cardiovascular disease (CVD) mortality among persons with diabetes. Prospective cohort study of a representative sample of the US population. Interviewer-administered survey in the general community. We sampled 2896 adults 18 years and older with diabetes as part of the 1990 and 1991 National Health Interview Survey. All-cause and CVD mortality for 8 years. Compared with inactive individuals, those who walked at least 2 h/wk had a 39% lower all-cause mortality rate (hazard rate ratio [HRR], 0.61; 95% confidence interval [CI], 0.48-0.78; 2.8% vs 4.4% per year) and a 34% lower CVD mortality rate (HRR, 0.66; 95% CI, 0.45-0.96; 1.4% vs 2.1% per year). We controlled for sex, age, race, body mass index (calculated as weight in kilograms divided by the square of height in meters), smoking, and comorbid conditions. The mortality rates were lowest for persons who walked 3 to 4 h/wk (all-cause mortality HRR, 0.46; 95% CI, 0.29-0.71; CVD mortality HRR, 0.47; 95% CI, 0.24-0.91) and for those who reported that their walking involved moderate increases in heart and breathing rates (all-cause mortality HRR, 0.57; 95% CI, 0.41-0.80; CVD mortality HRR, 0.69; 95% CI, 0.43-1.09). The protective association of physical activity was observed for persons of varying sex, age, race, body mass index, diabetes duration, comorbid conditions, and physical limitations. Walking was associated with lower mortality across a diverse spectrum of adults with diabetes. One death per year may be preventable for every 61 people who could be persuaded to walk at least 2 h/wk.
Article
More than 18 million Americans currently have diabetes mellitus. The economic and human cost of the disease is devastating. In the United States, diabetes is the most common cause of blindness among working-age adults, the most common cause of nontraumatic amputations and end-stage renal disease, and the sixth most common cause of death. For the cohort of Americans born in 2000, the estimated lifetime risk for diabetes is more than 1 in 3. In the next 50 years, the number of diagnosed cases of diabetes is predicted to increase by 165% in the United States, with the largest relative increases seen among African Americans, American Indians, Alaska Natives, Asian and Pacific Islanders, and Hispanic/Latino persons. Compelling scientific evidence indicates that lifestyle change prevents or delays the occurrence of type 2 diabetes in high-risk groups. This body of evidence from randomized, controlled trials conducted in 3 countries has definitively established that maintenance of modest weight loss through diet and physical activity reduces the incidence of type 2 diabetes in high-risk persons by about 40% to 60% over 3 to 4 years. The number of persons at high risk for type 2 diabetes is similar to the number of persons who have diabetes. This paper summarizes scientific evidence supporting lifestyle intervention to prevent type 2 diabetes and discusses major policy challenges to broad implementation of lifestyle intervention in the health system.
Exercise energy systems: a primer
  • S Colberg
Cardiorespiratory fitness and stroke mortality in men
  • Lee