In the face of the 2020 global pandemic caused by COVID-19, governments have taken several measures to stop COVID-19’s spread. These measures include teleworking, cancelling major events, and limited or no access to restaurants, bars, movie theatres, and so forth. Along with COVID-19-related health concerns, these measures led to increased stress levels, but also to an increased use of media entertainment. This increased use might be related to the instrumental use of media entertainment as a coping mechanism for this stressful and emotionally challenging situation. The present study takes a closer look at how individuals select media entertainment – specifically TV series – during the potentially stressful COVID-19 lockdown situation, by integrating the perspectives of stress and coping, mood management, and hedonic and eudaimonic media entertainment. An online vignette survey among 336 individuals was conducted. Results based on four three-way mixed ANOVA’s suggest that people select entertainment media based on their existing hedonic and eudaimonic preferences, but also in function of their coping strategies. People who use humor as a coping mechanism prefer television programmes that address the current crisis in a less meaningful, but funny way. Those who use religion as a coping mechanism actually prefer meaningful and moving content but are less likely to select television programmes about the current crisis. This study includes important insights in the instrumental use of entertainment media during challenging times, and illustrates how both humor and religion are coping mechanisms that are highly personal and context-related.