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Journal of Dermatology and Clinical Research
Cite this article: Alvin G, Chernykh V, Chan M (2020) Peptides: A Novel Approach to Enhance Eyelash and Eyebrow Growth. J Dermatolog Clin Res 8(2): 1137.
Central
*Corresponding author
Glen Alvin, Jesselton Medical Centre, Kota Kinabalu,
Malaysia, Email: alspurs2000@yahoo.com
Submitted: 01 November 2020
Accepted: 23 November 2020
Published: 25 November 2020
ISSN: 2373-9371
Copyright
© 2020 Alvin G, et al.
OPEN ACCESS
Keywords
•Peptides; Eyelash elongation; Eyebrow thickness
Research Article
Peptides: A Novel Approach to
Enhance Eyelash and Eyebrow
Growth
Glen Alvin1*, Volodymyr Chernykh2 and Mike Chan3
1Jesselton Medical Centre, Kota Kinabalu, Malaysia
2European Wellness Academy, Germany
3EW Villa Medica, Eden Koben, Germany
3FCTI Research & Development GmbH, Germany
Abstract
Purpose: Evaluate the safety and efcacy of topical peptides as a treatment to enhance eyelash and eyebrow appearance.
Subjects and methods: An open label cohort study over a period of 12 weeks was performed on healthy adult female subjects. All subjects daily applied a peptide extract
solution on their eyelids and eyebrow. They also attended a fortnightly microneedle session to apply the peptide extract solution on the eyelash and eyebrow. The length of the
eyelash was determined using an eyelash ruler while the overall eyelash appearance was assessed using the GEA scale. The eyebrows appearance was evaluated using digital
photography and assessed by two independent dermatologist while individual eyebrow follicle thickness and the presence of new eyebrow hair follicles were evaluated using the
Micro skin and hair diagnostic device (EW-EWB-1007-307, Germany).
Results: The peptide extract solution signicantly increased the length of the eyelash by 3.7± 1.4mm (p = 0.014). There was a 100% improvement in the GEA scale evaluation,
where 83% showed a one-grade improvement while the remaining 17% demonstrated a 17% improvement. Eyebrow analyser scans showed an increased thickness in individual
eyebrow thickness and there were the presence of many new eyebrow hair follicles at the end of the 12 weeks.
Conclusion: Peptide extract solution is a safe and efcient treatment to enhance eyelash and eyebrow appearance without causing any major adverse reactions.
INTRODUCTION
The eyelash and eyebrows are anatomical structures of the
face that are closely associated with beauty but also central to all
perceived human interaction [1]. The eyebrow protects the eye
and its movements bequeaths the bearers emotion and an art of
communication [1,2].
envy of all women [3,4]. The introduction of Iantropost to treat
solution was approved by the United States (US) Food and
[7,8]. An invasive and permanent method to increase eyelash
prominence is transplantation, which involves the transfer
procedures nor the undesired ocular effects of the synthetic
Peptide therapeutics commenced in medical practice since the
21. They are
be synthetic or a chain of amino acids naturally synthesized by
well as its proliferation and differentiation in adults [17].
to thickness, presence of new hair follicles and an increase in
Alvin G, et al. (2020)
J Dermatolog Clin Res 8(2): 1137 (2020) 2/6
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MATERIALS AND METHODS
This is an open label cohort study over a period of 12 weeks
Sabah, Malaysia
The protocol was approved by the institutional ethics review
board and the study was conducted in compliance with Good
period of 3 months prior to the commencement of the clinical
any time. A clinical specialist would appropriately treat adverse
study. They had normal eyelash and eyebrow hair density and
and comply with the study protocol as advised by the clinical
cancer medication or topical eye medication in the last 3 months.
Females with a history of skin or eye diseases and those with
take part in this clinical study.
laboratory rabbits from a USA FDA approved laboratory in the
United States of America (USA). The procedure was performed
in sterile conditions. The tissue specimen was then washed in
Microneedles are a minimally invasive but an effective skin
permeation enhancement method. It facilitates an effective
and sustained delivery of chemicals, hence better results [18].
when administered by trained personnel. The microneedle
technique is associated with a minimal risk of infection. Li et al
concluded that microneedles are a safe and effective method
shown that pretreatment of the skin with the microneedle
technique can enhance the delivery of topically applied solutions,
and treatment.
Alvin G, et al. (2020)
J Dermatolog Clin Res 8(2): 1137 (2020) 3/6
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were then measured and their eyelashes and eyebrows were
assessment was completed.
The 2 main parameters assessed are:
EFFICACY:
Safety and Tolerability: Presence of pain, itchiness or
Statistical Analysis
on anterior and superior eyelash observations. Further analyses
p-value that is less than or equal to
Methodolgy
COMPLETION OF TRIAL
(n=6)
STATISTICS & DATA ANALYSIS
RECRUITED SUBJECTS (n=6)
BASELINE INVESTIGATIONS & ASSESSMENT
FORTNIGHTLY FOLLOW-UP
RESULTS
the study population was 32 years old. The baseline eyelash
weeks (p
Table 1:
N =6
2 (Moderate)
3 (Marked)
83%
17%
1-grade improvement in GEA 2-grade improvement in GEA
Figure 1
0.00
1.00
2.00
3.00
4.00
5.00
6.00
BASELINE 4 8 12
Mean Change in Eyelash Length from
Baseline (mm)
Week
Figure 2
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J Dermatolog Clin Res 8(2): 1137 (2020) 4/6
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p
p
(p
discomfort was due to minor trauma, most probably due to the
of the eye drops at home. There was no ocular adverse reaction
suffered by any of the participant.
DISCUSSION
populations [18].
The eyebrow is simple to
3. The brow tends to
trends of the eyebrows revolve around its thickness, hue and the
shape of its arch [24].
p
12. The eyebrow density and thickness showed an improvement
Table 2:
Length growth from
baseline (mm)
Treatment period (week)
4 8 12
Minimum 2 2
4 4
Figure a
Figure b
study.
Figure c
in the number of new hair follicles. There was also an increase in the
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J Dermatolog Clin Res 8(2): 1137 (2020) 5/6
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evidence of an increase in the overall eyebrow follicle thickness
and the presence of new hair follicles. There were no serious
hyperaemia, ocular irritation, dry eye symptoms and erythema of
the eyelid [24].
entire duration of the 12 week study [23].
CONCLUSION
The results from this study indicate that the daily topical
the eyelash and increased the density of the eyebrows and
treatment to enhance the appearance of eyelash and eyebrow.
conclusions obtained from this study.
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Alvin G, et al. (2020)
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Alvin G, Chernykh V, Chan M (2020) Peptides: A Novel Approach to Enhance Eyelash and Eyebrow Growth. J Dermatolog Clin Res 8(2): 1137.
Cite this article
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