Wildlife biodiversity is often vulnerable to anthropogenic threats of various kind due to uncontrolled human activities resulting into habitat loss, degradation or fragmentation. Also, with human settlements coming into wild or protected habitats, emanates the introduction of domestic or invasive species. Studies conducted worldwide have concluded that interactions of such species with the wild ... [Show full abstract] ones have negative impacts on the later. In rural areas, especially those near to protected ranges, feral dogs that are a resultant of human excesses, interact with wild medium and small-sized carnivores such as Desert fox directly and indirectly as predators, prey, and pathogen reservoirs. In context with pathogen reservoir, both of them may act as a vector and host for a range of viral, bacterial and parasitic infections that can be transmitted to humans, their livestock as well as to each other and vice-versa. One such prominent contagious disease is Sarcoptic mange which is caused by infestation of mites. Desert fox, in and around Desert National Park of Jaisalmer district, where there are considerable human settlements has been observed to be infected with mange. Also, a good population of domestic animals like camels, sheep and feral dogs are observed to be infected with mange especially in village near to the wild species Desert Fox. On the contrary, regions devoid of human and domestic animal presence, no mange infected Desert Fox reported. This highlights the need for understanding to mitigate this problem and can help as a part of wildlife management.