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Treatment of periapical lesion with platelet rich fibrin

Authors:
Paromita Mazumdar at Gurunanak Institute of Dental Sciences & Research and Proprietor of Evershine Dental Clinic
Paromita Mazumdar
  • Gurunanak Institute of Dental Sciences & Research and Proprietor of Evershine Dental Clinic
debabrata Nag
debabrata Nag
debabrata Nag
  • This person is not on ResearchGate, or hasn't claimed this research yet.
sanjib bhunia
sanjib bhunia
sanjib bhunia
  • This person is not on ResearchGate, or hasn't claimed this research yet.
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... 2 Successful treatment for peri-apical lesion depends on removal of lesion and granulation tissue followed by achieving complete wound healing and regeneration of the bone and periodontal tissue. 3,4 Formation of new bone can occur with repair or regeneration. The most commonly used technique for regeneration is the use of platelet rich fibrin and bone graft materials which can promote tissue or bone regeneration through variety of mechanisms. ...
... Postsurgically, blood clots in defect area initiate the healing and regeneration of the hard and soft tissue. 4 Xenograft is protein extract of bovine bone which results in trabecular structure of hydroxyapatite similar to human cancellous bone. It act as substrate for cell migration and proliferation, hence prove its biologically active nature and role in regeneration. ...
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... Major challenges involved in achieving the above-mentioned goal are the microorganism induced biofilms and the limitations associated with the currently used intracanal medicaments and irrigants in eliminating the bacteria located inside the dentinal tubules and other root canal ramifications such as delta, isthmus, etc. [6] Biofilms belonging to E. faecalis group are specifically very resistant to elimination because of its ability to tolerate high pH, stress, starvation, and high salt concentration. [7] PRP contains several growth factors at high levels. In this vitro study has further suggested that PRP effectively modulates cell proliferation probably by a mechanism dependent on these growth factors at sites of injury. ...
to evaluate the antimicrobial activity of prp and.18 (2)
Article
Full-text available
  • Aug 2023
Aim: To evaluate the antimicrobial activity of PRP and PRF with and without nanosilver. Materials and Methods: The materials were tested in powdered form is nanosilver. The nanosilver particles was mixed to form with PRP and PRF so as to placed in a wells followed the groups are experimental groups; Group I: PRP + nanosilver particles, Group II: PRF + nanosilver and control group: PRP and PRF and normal saline. Silver nanoparticles was tested at concentrations of 50 µ gram per mL. The powder was prepared for each group with identical amount of the powder (milligram/mg) and then mixed with 1 milliliter liquid. The plates are then incubated at 37°C under appropriate atmospheric conditions (80% N2 , 10% CO2, 10% H2 ) for 24 hours, 48 hours, and 72 hours under anaerobic conditions in a CO2 incubator. The diameters of the zones of bacterial and fungal growth inhibition around the wells containing the test substances are then recorded after the period of incubation. The inhibitory zone determined in millimeter by measuring scale the shortest distance between the outer margin of the well and initial microbial as well as fungal growth. The experiments were performed 20 times and the mean and standard deviations of the inhibitory zones were calculated. Result: Platelet rich fibrin is mixed with nanosilver particles showed higher antimicrobial efficacy than platelet rich plasma with nanosilver and simple platelet rich plasma and platelet rich fibrin are equivalent when it is placed against the anaerobic bacteria E.faecalis and yeast like fungi Candida albicans, respectively. Conclusion: Groups presented with antimicrobial efficacy in this order‑ Group IV > Group II > Group III > Group I.
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... It is a second-generation platelet concentrate whose growth factors promote good healing [9,20,21]. Dentistry has created a novel idea involving the enhancement of the human body's restorative process by employing the patient's own blood [22]. ...
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To Evaluate the Antimicrobial Activity of PRP and PRF with and without Nanosilver
Article
  • Jul 2023
A BSTRACT Aim To evaluate the antimicrobial activity of PRP and PRF with and without nanosilver. Materials and Methods The materials were tested in powdered form is nanosilver. The nanosilver particles was mixed to form with PRP and PRF so as to placed in a wells followed the groups are experimental groups; Group I: PRP + nanosilver particles, Group II: PRF + nanosilver and control group: PRP and PRF and normal saline. Silver nanoparticles was tested at concentrations of 50 μ gram per mL. The powder was prepared for each group with identical amount of the powder (milligram/mg) and then mixed with 1 milliliter liquid. The plates are then incubated at 37°C under appropriate atmospheric conditions (80% N 2 , 10% CO 2, 10% H 2 ) for 24 hours, 48 hours, and 72 hours under anaerobic conditions in a CO 2 incubator. The diameters of the zones of bacterial and fungal growth inhibition around the wells containing the test substances are then recorded after the period of incubation. The inhibitory zone determined in millimeter by measuring scale the shortest distance between the outer margin of the well and initial microbial as well as fungal growth. The experiments were performed 20 times and the mean and standard deviations of the inhibitory zones were calculated. Result Platelet rich fibrin is mixed with nanosilver particles showed higher antimicrobial efficacy than platelet rich plasma with nanosilver and simple platelet rich plasma and platelet rich fibrin are equivalent when it is placed against the anaerobic bacteria E.faecalis and yeast like fungi Candida albicans, respectively. Conclusion Groups presented with antimicrobial efficacy in this order- Group IV > Group II > Group III > Group I.
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Counseling for Down’s Syndrome, Are We Doing it Right?
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Full-text available
  • Feb 2023
The chapter discusses the counseling of the parents of children with Down's syndrome receive and how the families rate the counseling experience
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