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Bioactive compounds and their future therapeutic applications

Authors:
Kriti Shrinet at IFTM University
Kriti Shrinet
Ritika Kumari Singh at Banaras Hindu University
Ritika Kumari Singh
Avinash Chaurasia at Banaras Hindu University
Avinash Chaurasia
Alok Tripathi at Banaras Hindu University
Alok Tripathi
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Abstract

Natural bioactive compounds, plant secondary metabolites, are not necessary for the normal survival of the plants but required for inter- or intragenus/species competition, defense, attraction, and signaling in plants. These compounds play a crucial role in the life of animals with having great potential for human well-fare, mostly with pharmacological or toxicological effects, against microbial pathogens and diseases including cancer in humans and animals. Bioactive compounds involve a broad variety of chemical structures and functions that facilitate a better way for the production of nutraceuticals, functional foods, and food additives. Some bioactive compounds found in nature are significantly high in concentration such as polyphenols; examples are phenolic compounds, flavonoids, anthocyanidins, flavans, tannins, and so on, and other concentrations are nonsignificant, but with high commercial values. Bioactive compounds have diverse pharmacological activities and applications for treatment of many diseases. These compounds act as antidiabetic, antipyretic, anticancerous, antidiuretic, antiatherosclerotic, and so on for the human beings. However, the inherent difficulties in screening and manufacturing these compounds have led to the development of advanced technologies. Frequently used methods for their extraction from plants and their parts are the conventional liquid–liquid or solid–liquid extraction, and the advanced methods include pressurized-liquid extraction, subcritical, and supercritical extractions and microwave- and ultrasound-assisted extractions. Extracted compounds are further characterized by MALDI-TOF-MS based on their specific absorption spectra to be used for the formulation of various drugs.
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Book: Natural Biotechnological Compounds: Technological Advancements.
Publisher: Elsevier
By
Donat Häder and R P Sinha
Chapter 17: Bioactive Compounds and their Future Therapeutic Applications
Kriti Shrinet1, 2, Ritika K Singh1, Avinash K Chaurasia1, Alok Tripathi1 and Arvind Kumar1*
1School of Biotechnology, Institute of Science, Banaras Hindu University, Varanasi, India
2School of Biotechnology, IFTM University, Moradabad, UP, India
*Corresponding Author:
Arvind Kumar, Ph.D.
School of Biotechnology,
Institute of Science,
Banaras Hindu University, Varanasi, U.P.-221005, India
Phone No. 91-542-2368331; Fax No. 91-542-2368693
E-mail:arvindkumararvind8@gmail.com; k_arvindk@rediffmail.com
CONCLUSION/Abstract
Bioactive compounds derived from medicinal plants are going to be the great sources of
therapeutic drugs along withexisting natural therapies in the worldwide health systems. These
natural therapies could be most important and essential source of drugs to treat diseases as
well as to maintain good health. Although a few recent years these indigenous medicines are
came into limelight, but they are known since thousands of years in old literature and native
people of different civilizations have a vast knowledge and great experience about them.
However, in-depth scientific study and identification of bioactive compounds are required, in
order to develop next generation of therapeutics based on natural formulations. Different
aspects are needed to be focused like quality assessment of raw extracts and their
combinations to enable them to compete with modern medicines. Moreover new and
advanced techniques for their purification, and efficient animal studies along with appropriate
clinical trials are required for justified use of these medicinal plant extracts with safety and
efficacy.
... Phytochemicals are bioactive substances found in plants that play a key role in their survival and metabolism [1][2][3]. There are several chemical properties and structures associated with these substances, including antioxidants [4], anti-inflammatory [5], anti-cancer [6], and antimicrobial properties [7-10]. ...
... NMR spectra of HPLC fraction containing phloroglucinol compound isolated from seed extraction of Vitis vinifera (a)1 H NMR (500 MHz, DMSO-d6) δ 8.94 (s, 1 H), 6.11 (s, 1 H); (b) 13C NMR (125 MHz, DMSO-d6) δ 163.11, 97.24. ...
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... Fundamental and translational studies developed in ethnopharmacology and nutritional research procedures provide data as a multimodal molecule to combat multidrug pathogens. From our perspective, there was a need to better understand these molecular interactions, beyond the conventional wisdom of treating traditional ethnomedical applications [29,30]. ...
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The Clinical Efficacy and Safety of Tulsi in Humans: A Systematic Review of the Literature
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Prediction of Lignin Content in Ruminant Diets and Fecal Samples Using Rapid Analytical Techniques
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