There is a limited number of existing literature exploring the nuanced relationship between online learning, academic performance and mental health among Chinese students in the COVID-19 epoch (Chi X, Liang K, Chen S, Huang Q, Huang L, Yu Q, Jiao C, Guo T, Stubbs B, Hossain M, Yeung A, Kong Z, Zou L Int J Clin Health Psychol 21:100218, 2020). The limited amount of available research prompts the development of this chapter, where the author systematically reviews, evaluates and summarises relevant studies, for the purpose of presenting a broad understanding of how the digitalisation of learning approaches is associated with Chinese students’ academic and psychological performance. As per the framework of this systematic review, existing literature focusing on (1) digital learning, (2) academic performance and (3) mental health in Chinese contexts during the outbreak of the pandemic is exclusively examined. Since 30 January 2020, China has been one of the first countries to apply school closures and massification of digital learning (Ma Z, Idris S, Zhang Y, Zewen L, Wali A, Ji Y, Pan Q, Baloch Z, BMC Pediatrics 21:1–8, 2021). Thus, understanding if the digital pedagogies result in positive outputs regarding Chinese students’ development would be conducive to shedding light on whether a similar digitalisation process in academic settings should be delivered in contexts beyond China. In this chapter, the author explores available Chinese literature that assesses the nuanced relationship between digital learning, academic performance and mental health during the pandemic. He analyses how Chinese students undertaking e-learning are, positively and negatively, impacted by digital, non-face-to-face education. In addition, the author suggests interventions on how the design and delivery of digital education can be modified or improved, and how social support can be better arranged, in order to optimise Chinese students’ academic and psychological development.