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Glutamic acid promotes hair growth in mice

Authors:
Carlos P Jara at University of Nebraska Medical Center
Carlos P Jara
  • University of Nebraska Medical Center
Beatriz de Andrade Berti
Beatriz de Andrade Berti
Beatriz de Andrade Berti
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Natália Ferreira Mendes at State University of Campinas (UNICAMP)
Natália Ferreira Mendes
Daiane F Engel at Federal University of Ouro Preto
Daiane F Engel
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Abstract

Glutamic Acid is the main excitatory neurotransmitter in neurons. Abnormal distributions of the glutamic acid receptors have been shown in hyper proliferative models such as psoriasis and skin regeneration. However, the biological function of glutamic acid in the skin remains unclear. Using ex vivo, in vivo and in silico approaches, we showed for the first time that exogenous glutamic acid promotes hair growth and keratinocyte proliferation. Topical application of glutamic acid decreased expression of genes related to apoptosis signaling in the skin. Also, we showed Glutamic acid increased viability and proliferation in cultured human keratinocyte. For the first time, we identified the excitotoxic GA concentration and we provided evidence for the existence of a novel skin signaling pathway mediated by a neurotransmitter controlling keratinocyte and hair follicle proliferation. In perspective, we anticipate our results could be the starting point to elucidate how exogenous glutamic acid from food intake or even endogenous GA from neuropsychiatric disorders modulate skin diseases.
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(which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission.
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(which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission.
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(which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission.
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(which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission.
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(which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission.
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(which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission.
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Polyglutamate: Unleashing the Versatility of a Biopolymer for Cosmetic Industry Applications
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  • May 2024
Polyglutamic acid (PGA), a biopolymer comprising repeating units of glutamic acid, has garnered significant attention owing to its versatile applications. In recent years, microbial production processes have emerged as promising methods for the large-scale synthesis of PGA, offering advantages such as sustainability, efficiency, and tailored molecular properties. Beyond its industrial applications, PGA exhibits unique properties that render it an attractive candidate for use in the cosmetic industry. The biocompatibility, water solubility, and film-forming characteristics of PGA make it an ideal ingredient for cosmetic formulations. This article explores the extensive potential cosmetic applications of PGA, highlighting its multifaceted role in skincare, haircare, and various beauty products. From moisturizing formulations to depigmentating agents and sunscreen products, PGA offers a wide array of benefits. Its ability to deeply hydrate the skin and hair makes it an ideal ingredient for moisturizers, conditioners, and hydrating masks. Moreover, PGA’s depigmentating properties contribute to the reduction in hyperpigmentation and uneven skin tone, enhancing the overall complexion. As the demand for sustainable and bio-derived cosmetic ingredients escalates, comprehending the microbial production and cosmetic benefits of PGA becomes crucial for driving innovation in the cosmetic sector.
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