Abstract 4595: SERGE- the development of an optical sensor for the detection glioblastoma recurrence

Abstract

Objective: Total gross resection is the clinical most positive prognostic treatment of brain cancer. Tumor recurrence is a frequent event in patients undergone neurosurgical removal of the primary cancer. Current surveillance of the disease requires cost-intensive and infrastructural sophisticated means and is applied in an infrequent manner. Better tools to monitor the therapy success in order to increase the chances of total gross resection of the recurrent lesion are of high clinical need.
Concept and Results: Photodynamic diagnosis (PDD) is a clinical applied procedure that exploits metabolic alterations in brain tumor cells to discriminate of cancerous tissue from healthy brain parenchyma. This project aims to develop an implant-prototype that enables the surveillance of any tumor recurrence at the primary tumor resection cavity by applying the principles of PDD. We present initial electro-engineering details and the study design to probe its functionality in vitro and . Supported by the Volkswagen Foundation the project aims to create evidences for the technological feasibility and therapeutic benefit of SERGE as a future class III medical device.
Citation Format: Igor Fischer, Daniel Hänggi, Ulf Dietrich Kahlert. SERGE- the development of an optical sensor for the detection glioblastoma recurrence [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 4595.