The emergence of transnational criminal actors challenges national law enforcement and intelligence agencies. Global criminals are involved in traditional organized crime activities, e.g., theft, smuggling, and dealing in all types of contraband. These criminal networks, however, also engage in activities that can fuel domestic and international conflicts, potentially creating threats that can ... [Show full abstract] undermine state actors and existing security regimes. The tensions created by what amounts to the "darker side" of globalization challenge existing mechanisms of cooperation among various national police organizations. The purpose of this article is to explore how transnational criminal networks are creating incentives to change traditional police operations and to describe how law enforcement officers can better coordinate their activities as they adapt to contain and eliminate global criminal threats. To accomplish this objective, the article first describes the global, networked dimension of this threat. It then describes the differences between current practice of "international policing" and an emerging approach to countering the criminal threat, best described as "global metropolitan policing." The article concludes by offering several suggestions on how law enforcement agencies can acquire the skill sets and practices needed to address the global criminal enterprise.