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Natural products in diabetes research: quantitative literature analysis
Abstract
The current study aimed to identify which natural products and which research directions are related to the major contributors to academic journals for diabetes therapy. Bibliometric data were extracted from the Web of Science online database using the search string TOPIC = (‘‘natural product*’ OR ‘‘natural compound*’ OR ‘‘natural molecule*’ OR ‘phytochemical*’ OR ‘‘secondary metabolite*’) AND TS = (‘diabet*’) and analysed by a bibliometric software, VOSviewer. The search yielded 3694 publications, which were collectively cited 80,791 times, with an H-index of 117 and 21.9 citations per publication on average. The top-contributing countries were India, the USA, China, South Korea and Brazil. Curcumin, flavanone, resveratrol, carotenoid, polyphenols, flavonol, flavone and berberine were the most frequently cited natural products or compound classes. Our results provide a brief overview of the major directions of natural product research in diabetes up to now and hint on promising avenues for future research.
... Lipoxygenases and their catalysis products have been reported to be associated with carcinogenic processes such as tumor cell proliferation, differentiation, and apoptosis [6]. Diabetes is a chronic metabolic disease characterized by high blood sugar levels [7,8]. It has been reported that there is a strong link between hyperglycemia, oxidative stress, inflammation, and the development and progression of type 2 diabetes. ...
... High blood glucose levels cause the overproduction of ROS by the electron transport chain of the mitochondria [9]. Inhibition of α-glucosidase and αamylase and regulation of oxidative stress in the digestive system are antidiabetic mechanisms of action in the treatment of diabetes [8]. When exposed to ultraviolet radiation, human skin produces an abundance of ROS, which activates a variety of biological responses. ...
... However, it was observed that the leaf ethyl acetate extract (IC50: 93.00 ± 1.54 µg/mL) was more active than the root ethyl acetate extract. Inhibition of α-glucosidase and α-amylase in the digestive system, and regulation of oxidative stress, are very important as antidiabetic mechanisms of action in the treatment of diabetes [8]. A strong link has been reported between hyperglycemia, oxidative stress caused by hyperglycemia, inflammation, and the development and progression of type 2 diabetes [9]. ...
Arctium minus (Hill) Bernh. (Asteraceae), which has a wide distribution area in Turkey, is a medicinally important plant. Eighty percent methanol extracts of the leaf, flower head, and root parts of A. minus were prepared and their sub-fractions were obtained. Spectrophotometric and chromatographic (high-performance liquid chromatography) techniques were used to assess the phytochemical composition. The extracts were evaluated for antioxidant activity by diphenyl-2-picrylhydrazil radical (DPPH●), 2,2′-Azino-bis 3-ethylbenzothiazoline-6-sulfonic acid (ABTS●+) radical scavenging, and β-carotene linoleic acid bleaching assays. Furthermore, the extracts were subjected to α-amylase, α-glucosidase, lipoxygenase, and tyrosinase enzyme inhibition tests. The cytotoxic effects of extracts were investigated on MCF-7 and MDA-MB-231 breast cancer cell lines. The richest extract in terms of phenolic compounds was identified as the ethyl acetate sub-fraction of the root extract (364.37 ± 7.18 mgGAE/gextact). Furthermore, chlorogenic acid (8.855 ± 0.175%) and rutin (8.359 ± 0.125%) were identified as the primary components in the leaves’ ethyl acetate sub-fraction. According to all methods, it was observed that the extracts with the highest antioxidant activity were the flower and leaf ethyl acetate fractions. Additionally, ABTS radical scavenging activity of roots’ ethyl acetate sub-fraction (2.51 ± 0.09 mmol/L Trolox) was observed to be as effective as that of flower and leaf ethyl acetate fractions at 0.5 mg/mL. In the β-carotene linoleic acid bleaching assay, leaves’ methanol extract showed the highest antioxidant capacity (1422.47 ± 76.85) at 30 min. The enzyme activity data showed that α-glucosidase enzyme inhibition of leaf dichloromethane extract was moderately high, with an 87.12 ± 8.06% inhibition value. Lipoxygenase enzyme inhibition was weakly detected in all sub-fractions. Leaf methanol extract, leaf butanol, and root ethyl acetate sub-fractions showed 99% tyrosinase enzyme inhibition. Finally, it was discovered that dichloromethane extracts of leaves, roots, and flowers had high cytotoxic effects on the MDA-MB-231 cell line, with IC50 values of 21.39 ± 2.43, 13.41 ± 2.37, and 10.80 ± 1.26 µg/mL, respectively. The evaluation of the plant extracts in terms of several bioactivity tests revealed extremely positive outcomes. The data of this study, in which all parts of the plant were investigated in detail for the first time, offer promising results for future research.
... The reported cases are expected to rise to 592 million by the year 2035 [3]. In 2019, DM was considered the ninth leading cause of death because of the associated life-threating complications, including cardiovascular, cerebrovascular and renal disorders [4]. Type 2 DM is the most common type of DM, representing approximately 95% of all cases [1]. ...
... Herbs and herbal-derived drugs are estimated to be an important defense line against numerous illnesses and their complications [8,9]. Recent reports highlighted and summarized the common natural products that have been extensively employed to control blood glucose levels in diabetic patients [4,[10][11][12]. Coumarins and their derivatives, as examples of bioactive metabolites, contributed to drug research and development owing to their multiple targets, varied biological activities and safety [13]. ...
Type 2 diabetes mellitus is considered to be a substantial socioeconomic burden worldwide on both patients and governments. Coumarins are biomolecules with a diversity of biological activities. The current investigation aimed to explore the ameliorative effects of cichoriin, which is a type of coumarin, on high-fat diet/streptozotocin (HFD/STZ)-induced diabetic rats.
Methods:
Rats were allocated into five groups. Group I was considered as the control group, while the other groups were HFD/STZ-induced diabetic rats. Group II was assigned as the diabetic control. Groups III and IV were treated with cichoriin (50 or 100 mg/kg, respectively). Group V received glibenclamide (5 mg/kg) (as a positive control). The blood glucose (BG), serum insulin, triglycerides (TG), total cholesterol (TC), total antioxidant capacity (TAC), catalase, hepatic superoxide dismutase (SOD) and content of malondialdehyde (MDA) were assessed. Histopathological and immunohistochemistry analysis of pancreatic tissue were performed. mRNA and protein expressions of GLUT4, AMPK, and PI3K were estimated.
Results:
Cichoriin treatment ameliorated HFD/STZ-induced diabetic conditions and mitigated the histopathological characteristics of the pancreas, as well as increasing pancreatic insulin expression. This decreased the levels of BG, TG, TC, and MDA and improved the TAC, catalase and SOD contents. Cichoriin demonstrated upregulation of mRNA and protein expressions of GLUT4, AMPK, and PI3K. The in silico binding of cichoriin with GLUT4, AMPK, and PI3K supported the possible current activities.
Conclusion:
Collectively, this work highlighted the potential role of cichoriin in mitigating HFD/STZ-induced diabetic conditions and showed it to be a valuable product.
... Among these methods, electrospinning has been widely used in many fields since the 1990s as a technology for simple and effective production of nanofibers [21,22]. There are many materials suitable for electrospinning, which can Bibliometric analysis has been widely used to summarize research trends for detecting the state for a particular research field [27][28][29]. In this paper, bibliometric analysis and systematic literature review analysis were both employed to investigate the application of electrospun nanofibers in dentistry. ...
... Nowadays, due to the unique properties of electrospun nanofibers, and the rapid development of modern electrospinning technology, electrospun nanofibers have been used in various industries. Bibliometric analysis has been widely used to summarize research trends for detecting the state for a particular research field [27][28][29]. In this paper, bibliometric analysis was employed to investigate the application of electrospun nanofibers in dentistry. ...
Electrospun nanofibers have been widely used in dentistry due to their excellent properties, such as high surface area and high porosity, this bibliometric study aimed to review the application fields, research status, and development trends of electrospun nanofibers in different fields of dentistry in recent years. All of the data were obtained from the Web of Science from 2004 to 2021. Origin, Microsoft Excel, VOSviewer, and Carrot2 were used to process, analyze, and evaluate the publication year, countries/region, affiliations, authors, citations, keywords, and journal data. After being refined by the year of publication, document types and research fields, a total of 378 publications were included in this study, and an increasing number of publications was evident. Through linear regression calculations, it is predicted that the number of published articles in 2022 will be 66. The most published journal about electrospun dental materials is Materials Science & Engineering C-Materials for Biological Applications, among the six core journals identified, the percent of journals with Journal Citation Reports (JCR) Q1 was 60%. A total of 17.60% of the publications originated from China, and the most productive institution was the University of Sheffield. Among all the 1949 authors, the most productive author was Marco C. Bottino. Most electrospun dental nanofibers are used in periodontal regeneration, and Polycaprolactone (PCL) is the most frequently used material in all studies. With the global upsurge in research on electrospun dental materials, bone regeneration, tissue regeneration, and cell differentiation and proliferation will still be the research hotspots of electrospun dental materials in recent years. Extensive collaboration and citations among authors, institutions and countries will also reach a new level.
... It is obvious that natural products are an attractive reservoir of antidiabetic compounds [4]. In addition, numerous studies demonstrate an antidiabetic potential of natural products [5]. The antidiabetic effects of many phytochemicals including polyphenols, terpenes, alkaloids, saponins, and quinones have been well-documented [6,7]. ...
... Fruit and vegetables are essential components of the Mediterranean diet and contain many bioactive phytochemicals. Taking into consideration a current study where researchers fished new antidiabetic compounds from various natural products, the search for new antidiabetic agents in Mediterranean edible plants stands as a challenge [5]. ...
Diabetes mellitus is a metabolic disease and one of the leading causes of deaths worldwide. Numerous studies support that the Mediterranean diet has preventive and treatment effects on diabetes. These effects have been attributed to the special bioactive composition of Mediterranean foods. The objective of this work was to decipher the antidiabetic activity of Mediterranean edible plant materials using the DIA-DB inverse virtual screening web server. A literature review on the antidiabetic potential of Mediterranean plants was performed and twenty plants were selected for further examination. Subsequently, the most abundant flavonoids, phenolic acids, and terpenes in plant materials were studied to predict their antidiabetic activity. Results showed that flavonoids are the most active phytochemicals as they modulate the function of 17 protein-targets and present high structural similarity with antidiabetic drugs. Their antidiabetic effects are linked with three mechanisms of action, namely (i) regulation of insulin secretion/sensitivity, (ii) regulation of glucose metabolism, and (iii) regulation of lipid metabolism. Overall, the findings can be utilized to understand the antidiabetic activity of edible Mediterranean plants pinpointing the most active phytoconstituents.
... As mentioned, T2D is a chronic disease that combines different metabolic disorders that coexist in a positive feedback loop guided by inflammation. Therefore, reducing and fighting inflammation, as well as oxidative stress, is one of the main therapeutic objectives [6]. ...
... At present, in addition to these pharmacological resources, an attempt is being made to treat this pathology with natural products [7]. Natural products started being used to control blood glucose levels ever since they took center stage in experimental investigations; some of these plants are Bauhinia forficata, Cecropia obtusifolia (Bertol), Equisetum myriochaetum and Cucurbita ficifolia bouche, among others [6][7][8]. Treatment using them has a notable local connotation, since natural products generally vary depending on the country and its culture. An example of this can be seen in Latin America, where Bauhinia forficata is more often used, while in Sri Lanka Senna auriculata (L.) is used more routinely [9]. ...
The present study was carried out to relate the role of natural products in the metabolism of an increasingly prevalent disease, type 2 diabetes mellitus. At present, in addition to the pharmacological resources, an attempt is being made to treat diabetes mellitus with natural products. We carried out a systematic review of studies focusing on the role of natural products on diabetes mellitus treatment. The bibliographic search was done through Medline (Pubmed) and Web of Science. From 193 records, the title and summary of each were examined according to the criteria and whether they met the selection criteria. A total of 15 articles were included; after reviewing the literature, it is apparent that the concept of natural products is ambiguous as no clear boundary has been established between what is natural and what is synthetic, therefore we feel that a more explicit definition of the concept of “natural product” is needed. Gut microbiota is a promising therapeutic target in the treatment of diabetes. Therefore, it would be necessary to work on the relationship between the microbiome and the benefits in the treatment of diabetes mellitus. Treatment based solely on these natural products is not currently recommended as more studies are needed.
... Nowadays, many natural compounds control DM patients (Widjajakusuma et al., 2019;Yeung et al., 2020). Andrographis paniculata (Burm.f.) Nees is one of the promising plants as a natural source to lower blood glucose (Augustine et al., 2014). ...
... The bubble size indicated the number of words that appeared in the literature. The bubble color indicated the citations per publication containing the term and the proximity of two bubbles if two terms co-appeared more frequently (Yeung et al., 2020(Yeung et al., , 2018. ...
The prevalence of diabetes mellitus has increased over time. Medicinal plants, including Andrographis paniculata (Burm.f) Nees, are recognized for their use to manage hyperglycemia. Nowadays, plenty of papers are published about A. paniculata as an antidiabetic; however, no bibliometric study about the topic exists. This study examines the existing papers about the preclinical trial of A. paniculata as an antidiabetic agent using bibliometric analysis focusing on countries, institutions, publishers, authors, documents, and keywords. Bibliographic information of relevant research and conference articles were obtained from the Scopus database. In total, 97 articles published between 1994 and 2021 were selected, covering 376 authors and 1270 keywords. Data were analyzed bibliometrically using Vosviewer 1.6.16. A total of 97 published papers occurred from 1994 to 2021 were selected. India, Universitas Gadjah Mada (Indonesia), Journal of Ethnopharmacology, and Agung Endro Nugroho (Universitas Gadjah Mada, Indonesia) were the most productive country, institution, publisher, and author, respectively. The analysis of the most influential papers, co-citation network of the most influential papers, bibliographical coupling network based on authors, and keyword co-occurrence network and overlay demonstrated that the abundance and variety of existing papers about preclinical trials of A. paniculata as an antidiabetic were from phytochemistry, pharmacology, and drug formulation. The findings of our analysis have implications for managerial and theoretical aspects on this topic, such as encouraging research collaborations by analyzing the contributions of countries, institutions, publishers, and authors and revealing research gaps (molecular mechanisms, toxicities and side effects, drug formulations, and clinical trials) to accept a phytomedicine as a therapeutic option.
... Flavanone and polyphenols, natural chemical groups, were investigated as a possible therapy in T2DM or adjuvant in DM treatment. Curcumin, resveratrol, and carotenoid were the most commonly studied substances among these [18]. ...
... Flavone compounds exhibited a potential inhibitory effect on the a-glucosidase enzyme in a QSAR investigation. The results of 20 flavone derivatives (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) were compared to the α-glucosidase inhibitor acarbose in this study. The IC50 values of the flavone derivatives varied from 1.02 to 38.1 M, according to the findings. ...
Diabetes represents a major health problem, involving a severe imbalance of blood sugar levels, which can disturb the nerves, eyes, kidneys, and other organs. Diabes management involves several synthetic drugs focused on improving insulin sensitivity, increasing insulin production, and decreasing blood glucose levels, but with unclear molecular mechanisms and severe side effects. Natural chemicals extracted from several plants such as Gymnema sylvestre, Momordica charantia or Ophiopogon planiscapus Niger have aroused great interest for their anti-diabetes activity, but also their hypolipidemic and anti-obesity activity. Here, we focused on the anti-diabetic activity of a few natural and synthetic compounds, in correlation with their pharmacokinetic/pharmacodynamic profiles, especially with their blood-brain barrier (BBB) permeability. We reviewed studies that used bioinformatics methods such as predicted BBB, molecular docking, molecular dynamics and quantitative structure-activity relationship (QSAR) to elucidate the proper action mechanisms of antidiabetic compounds. Currently, it is evident that BBB damage plays a significant role in diabetes disorders, but the molecular mechanisms are not clear. Here, we presented the efficacy of natural (gymnemic acids, quercetin, resveratrol) and synthetic (TAK-242, propofol, or APX3330) compounds in reducing diabetes symptoms and improving BBB dysfunctions. Bioinformatics tools can be helpful in the quest for chemical compounds with effective anti-diabetic activity that can enhance the druggability of molecular targets and provide a deeper understanding of diabetes mechanisms.
... 26 Polyphenols, flavanone, and other natural chemical groups were examined as an adjuvant in the possible management of chronic diseases such as T2DM. 27 There are Several Sources of Such Active Ingredients. This Review Focuses on the Impact of Cinnamon Consumption on Diabetes Control ...
Apart from advances in pharmaceutical antidiabetic agents, efforts are being made toward hypoglycemic agents derived from natural sources. Cinnamon has been reported to have significant benefits for human health, particularly as an anti-inflammatory, antidiabetic, and anti-hypertriglyceridemic agent. The phytochemicals in cinnamon can be extracted from different parts of plant by distillation and solvent extraction. These chemicals help in decreasing insulin resistance and can act against hyperglycemia and dyslipidemia, inflammation and oxidative stress, obesity, overweight, and abnormal glycation of proteins. Cinnamon has shown to improve all of these conditions in in vitro, animal, and/or human studies. However, the mechanism of action of active ingredients found in cinnamon remains unclear. The current review presents the outstanding ability of cinnamon derivatives to control diabetes by various pathways modulating insulin release and insulin receptor signaling. It was also found that the type and dosage of cinnamon as well as subject characteristics including drug interactions are likely to affect the response to cinnamon. Future research directions based on this review include the synergistic usage of various cinnamon derivatives in managing and/or preventing diabetes and possible other relevant chronic diseases.
... For example, it is well-recognised that chronic hyperglycaemia contributes to oxidative stress and chronic low-grade inflammation, both of which worsen t2D complications. throughout the world, numerous natural substances have also been utilised to help diabetic individuals manage their blood glucose levels [7]. For example Senna auriculata (l.) Roxb. ...
Changes in the homeostasis of blood sugar levels are a hallmark of diabetes mellitus, an incurable metabolic condition, for which the first-line treatment is the subcutaneous injection of insulin. However, this method of administration is linked to low patient compliance because of the possibility of local infection, discomfort and pain. To enable the administration of the peptide through more palatable paths without requiring an injection, like by oral routes, the use of nanoparticles as insulin carriers has been suggested. The use of nanoparticles usually improves the bioavailability and physicochemical stability of the loaded medicine. The utilisation of several forms of nanoparticles (like lipid and polymeric nanoparticles, micelles, dendrimers, liposomes, niosomes, nanoemulsions and drug nanosuspensions) is discussed in this article as a way to improve the administration of various oral hypoglycaemic medications when compared to conventional treatments.
... Bauhinia forficata, Cecropia obtusifolia (Bertol), Equisetum myriochaetum, and Cucurbita ficifolia (Bouche) are a few of them. 22,23 Medicinal plants are frequently utilized as a form of treatment, but their prevalence and variation by region and culture make them challenging to use. Ruminant milk and its products are a source of nutrients and energy and possess positive health effects. ...
In this study, albino Wistar rats that have developed diabetes as a result of the drug streptozotocin (STZ) were treated with camel milk and insulin. For this, 36 rats were divided into six different (n = 6) groups: control, control + camel milk, diabetic control, insulin, camel milk, and combined camel milk + insulin. A 50 mg/kg intraperitoneal injection of STZ was used to induce diabetes. Rats with blood glucose levels exceeding 250 mg/dL after the induction of diabetes were taken into consideration for the study. The diabetic rats were treated with camel milk (50 mL/rat/day), insulin (6 units kg-1 b·wt/day), or their combination daily for 30 days. Throughout the course of the study, the rats' glucose levels and body weight were checked. In the diabetic control rats, a reduction in body weight and hyperglycemic condition was seen. Improvements in glycemic levels and weight gain were seen in the camel milk, insulin, and combined treatment groups compared to the diabetic control group; however, the combined treated group did not show the same degree of improvement as the alone treated group. Hematological changes in the diabetic control group included reductions in lymphocytes, platelets, total leukocyte count (TLC), and red blood cell (RBC) indices (mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), packed cell volume (PCV), and mean cell hemoglobin concentration (MCHC)). Each group that got insulin and camel milk separately and combined showed improvement in these changes. The liver, kidney, and pancreas in the diabetic control group had worsened morphological alterations. These histopathological alternations were significantly improved in the treatment groups. Hence, this study demonstrates the antidiabetic effects of camel milk in comparison to insulin. These findings highlight the potential of camel milk as an alternative therapy for diabetes, although further research is warranted to fully understand its mechanisms of action and long-term effects.
... Several studies have found that chronic low-grade inflammation increases the likelihood of developing type 2 diabetes, and that subclinical inflammation leads to insulin resistance and is connected to metabolic syndrome symptoms such as hyperglycemia. As carbohydrate hydrolyzing enzyme inhibitors, α-glucosidase and α-amylase provide an efficient technique for regulating or preventing hyperglycemia by reducing starch breakdown [22][23][24]. When the α-glucosidase enzyme inhibition of the extracts was evaluated, it was determined that the ethyl acetate fraction could inhibit the enzyme with the same significance as standard acarbose at both concentrations studied (p>0.05). ...
Objective: The present study aimed to evaluate the biological activities of Myrtus communis L., which has traditional medicinal use for different purposes, from a broad perspective. Material and Method: The antioxidant (DPPH, ABTS, total phenol, and flavonoid amounts) anti-inflammatory (LOX enzyme inhibition), antidiabetic (α-glucosidase enzyme inhibition), and cytotoxic properties (MTT assay) of a 70% methanol extract made from leaves and dichloromethane, butanol, ethyl acetate, and the residual water fractions were investigated. Result and Discussion: The DPPH radical scavenging effect of the ethyl acetate fraction, with the highest total phenol and flavonoid content, was found to be 1.4 µg/ml, and the ABTS radical scavenging effect was 2.58 mmol/Trolox. The most potent inhibitor of LOX (IC50: 31.17 µg/ml) and α-glucosidase (96% inhibition at 0.5 mg/ml) enzymes was determined as ethyl acetate extract. Dichloromethane fraction was shown to have the most cytotoxic activity in both Hela and Colo cell lines. This research has given us a better understanding of the traditional use of the M. communis plant, which stands out for its therapeutic properties.
... Different traditional medicines rely on the usage of medicinal plants and their phytoconstituents/formulations for treating diabetes; however, there are no scientific data to support these folkloric claims [10]. Many natural products, such as phenolic compounds, flavonoids, alkaloids, terpenoids, coumarins, and glycosides, are known to possess antidiabetic potential through diverse mechanisms, such as alpha-amylase and alpha-glucosidase inhibition, glucose uptake modulation, stimulating insulin secretion and beta-cell proliferation, and controlling insulin resistance and oxidative stress regulation [11,12]. Many plant extracts are rich in flavonoids/phenolics with powerful antioxidant and antidiabetic properties [13] that could have promising advantages and a potential contribution as a prophylactic and/or in the treatment of diabetes and its implications. ...
Diabetes is a chronic fast-growing metabolic disorder that is characterized by high blood glucose levels. Tagetes minuta L. has been used as a traditional remedy for various illnesses for many years, and, furthermore, its oil is used in the perfume and flavor industries. T. minuta contains various metabolites, such as flavonoids, thiophenes, terpenes, sterols, and phenolics, with varied bioactivities. Flavonoids can inhibit carbohydrate-digesting enzymes, such as alpha-amylase, which is a convenient dietary strategy for controlling hyperglycemia. In the current investigation, the isolated flavonoids quercetagetin-6-O-(6-O-caffeoyl-β-D-glucopyranoside), quercetagetin-7-O-β-D-glucopyranoside, quercetagetin-6-O-β-D-glucopyranoside, minutaside A, patuletin-7-O-β-D-glucopyranoside, quercetagetin-7-methoxy-6-O-β-D-glucopyranoside, tagenols A and B, quercetagetin-3,7-dimethoxy-6-O-β-D-glucopyranoside, patuletin, quercetin-3,6-dimethyl ether, and quercetin-3-methyl ether from T. minuta were assessed for their alpha-amylase inhibition (AAI) efficacy using an in vitro assay, as well as molecular docking, dynamics simulation, and ADMET analyses. Our findings show that quercetagetin-6-O-(6-O-caffeoyl-β-D-glucopyranoside) (1), quercetagetin-7-O-β-D-glucopyranoside (2), quercetagetin-6-O-β-D-glucopyranoside (3), minutaside A (4), patuletin-7-O-β-D-glucopyranoside (5), and quercetagetin-7-methoxy-6-O-β-D-glucopyranoside (6) had a notable AAI capacity (IC50s ranged from 7.8 to 10.1 μM) compared to acarbose (IC50 7.1 μM). Furthermore, these compounds with the highest binding affinity among the tested flavonoids revealed high docking scores for AA (ranging from −12.171 to 13.882 kcal/mol) compared to that of acarbose (−14.668 kcal/mol). In MDS, these compounds were observed to show maximum stability and the greatest binding free energy, suggesting that they may contend with native ligands. In addition, the ADMET analysis showed that these active compounds had a broad span of drug-like, pharmacokinetic, and physicochemical features and did not possess any considerable undesired effects. The current results suggest the potential of these metabolites as AAI candidates. However, further in vivo and mechanistic studies are warranted to specify the efficacy of these metabolites.
... Epidemiologic studies have indicated a positive correlation between the raised plasma level of inflammatory cytokines, such as tumor necrosis factor α (TNF-α) and interleukin-6 (IL-6), with a higher risk of diabetes [39]. At the same time, an insufficient consumption of fruits and vegetables is observed that are sources of vitamins, minerals, and bioactivity compounds such as polyphenols [40]. An imbalance between antioxidants and reactive oxygen species (ROS) can lead to damage or apoptosis of pancreatic β-cells and deteriorate the secretion of insulin [41]. ...
Type 2 diabetes (T2D) accounts for a global health problem. It is a complex disease as a result of the combination of environmental as well as genetic factors. Morbidity is still increasing across the world. One of the possibilities for the prevention and mitigation of the negative consequences of type 2 diabetes is a nutritional diet rich in bioactive compounds such as polyphenols. This review is focused on cyanidin-3-O-glucosidase (C3G), which belongs to the anthocyanins subclass, and its anti-diabetic properties. There are numerous pieces of evidence that C3G exerts positive effects on diabetic parameters, including in vitro and in vivo studies. It is involved in alleviating inflammation, reducing blood glucose, controlling postprandial hyperglycemia, and gene expression related to the development of T2D. C3G is one of the beneficial polyphenolic compounds that may help to overcome the public health problems associated with T2D.
... The bubble map visualization represents a term or phrase (Ramamoorthi et al., 2021). Moreover, the bubble size and distance between bubbles demonstrated the word frequency and co-occurrence frequency, respectively 2020). ...
The number of diabetes mellitus (DM) cases has increased, and Tinospora crispa (L.) Hook. f. & Thomson is recognized for treating DM. Despite publications on T. crispa as an antidiabetic, there were no bibliometric reports on this topic. Thus, this study aimed to conduct bibliometric studies of existing articles on the preclinical trials of T. crispa in DM management. We used Scopus to obtain a bibliographic database of primary research related to the topic. There were 24 selected publications between 1989 and 2019. We analyzed data with VOSviewer 1.6.16. Malaysia, John Radcliffe Hospital (United Kingdom), Journal of Ethnopharmacology, Hamdan Noor, and Stephen J.H. Ashcroft (John Radcliffe Hospital, United Kingdom) were the most impactful country, institution, source, and author, respectively. This plant is promising for treating DM, meanwhile, there were case studies of harmful effects on the gastrointestinal tract and liver. The majority and diverse fields of this topic were phytochemistry and pharmacology. Our findings strengthen research collaboration and identify research gaps required for herbal medicine applications.
... Thus, developing food-derived alternatives to oral hypoglycemic drugs without side effects or toxicity is of practical importance [6]. Increasing evidence suggests that food-derived bioactive compounds have vast potential in the mitigation of T2DM [7]. ...
Type 2 diabetes mellitus is a chronic metabolic disease, characterized by persistent hyperglycemia, the prevalence of which is on the rise worldwide. Fermented soybean products (FSP) are rich in diverse functional ingredients which have been shown to exhibit therapeutic properties in alleviating hyperglycemia. This review summarizes the hypoglycemic actions of FSP from the perspective of different target-related molecular signaling mechanisms in vitro, in vivo and clinical trials. FSP can ameliorate glucose metabolism disorder by functioning as carbohydrate digestive enzyme inhibitors, facilitating glucose transporter 4 translocation, accelerating muscular glucose utilization, inhibiting hepatic gluconeogenesis, ameliorating pancreatic dysfunction, relieving adipose tissue inflammation, and improving gut microbiota disorder. Sufficiently recognizing and exploiting the hypoglycemic activity of traditional fermented soybean foods could provide a new strategy in the development of the food fermentation industry.
... opics-and-announcements/). Representative examples of different INPST-based activities (Table 2) are aligned with the multiple dissemination and outreach activities. INPST-based networking has proven to be an excellent catalyst for new collaborative integrated scientific research (Banach et al., 2018;Horbanczuk et al., 2019;Jozwik et al., 2018;Ruscica et al., 2021;Tancheva et al., 2020;Tewari et al., 2020;Tzvetkov et al., 2019;Yang et al., 2019b;Zhubi-Bakija et al., 2021), including joint work conducting meta-analysis of the published literature (Durazzo et al., 2021a(Durazzo et al., , 2021bYeung et al., 2018Yeung et al., , 2019aYeung et al., , 2020aYeung et al., 2019bYeung et al., , 2020bYeung et al., , 2020cYeung et al., 2019cYeung et al., , 2021cYeung et al., , 2019d, and the preparation of scientific collaborative review publications (Khan et al., 2020;Li et al., 2021;Mondal et al., 2021Mondal et al., , 2019Tewari et al., 2018;Vacca et al., 2019;Wang et al., 2022Wang et al., , 2018Wang et al., , 2019a utilizing broadly-international collaborative work. In the latest example of collaborative work type, a special mention deserves a 2021 article from Nature Reviews Drug Discovery entitled "Natural products in drug discovery: advances and opportunities," in which the International Natural Product Sciences Taskforce was used for the first time as an author group designation . ...
Background
The development of digital technologies and the evolution of open innovation approaches have enabled the creation of diverse virtual organizations and enterprises coordinating their activities primarily online. The open innovation platform titled “International Natural Product Sciences Taskforce” (INPST) was established in 2018, to bring together in collaborative environment individuals and organizations interested in natural product scientific research, and to empower their interactions by using digital communication tools.
Methods
In this work, we present a general overview of INPST activities and showcase the specific use of Twitter as a powerful networking tool that was used to host a one-week “2021 INPST Twitter Networking Event” (spanning from 31st May 2021 to 6th June 2021) based on the application of the Twitter hashtag #INPST.
Results and Conclusion
The use of this hashtag during the networking event period was analyzed with Symplur Signals (https://www.symplur.com/), revealing a total of 6,036 tweets, shared by 686 users, which generated a total of 65,004,773 impressions (views of the respective tweets). This networking event's achieved high visibility and participation rate showcases a convincing example of how this social media platform can be used as a highly effective tool to host virtual Twitter-based international biomedical research events.
... At this stage, a bibliometric analysis is carried out using the VOSViewer application by clustering based on the title, abstract, and relevant keywords. Finally, the clustering results are visualised in the form of a network map with several points that describe the frequency of scientific publications and the colour of the network that shows the relevance of publications from researchers [14]. ...
This study aims to demonstrate step-by-step bibliometrics data analysis through VOSViewer. Through mapping tools in the VOSViewer, this study provides insight into digital forensics over ten years (2012–2022). In order to describe the bibliometrics analysis performance of the selected topic, we created a network visualization using qualitative descriptive methods. This study found 117 journal articles published in digital forensics between 2012 and 2021, and then the data was cleaned to produce 103 articles for analysis. The study concludes that Indonesian digital forensics research is still relatively incipient. This bibliometrics analysis study will support discovering new things on similar topics. In addition, research in the field of study is essential because it contributes to understanding the validity of digital evidence, which can support decision-making in court.
... opics-and-announcements/). Representative examples of different INPST-based activities (Table 2) are aligned with the multiple dissemination and outreach activities. INPST-based networking has proven to be an excellent catalyst for new collaborative integrated scientific research (Banach et al., 2018;Horbanczuk et al., 2019;Jozwik et al., 2018;Ruscica et al., 2021;Tancheva et al., 2020;Tewari et al., 2020;Tzvetkov et al., 2019;Yang et al., 2019b;Zhubi-Bakija et al., 2021), including joint work conducting meta-analysis of the published literature (Durazzo et al., 2021a(Durazzo et al., , 2021bYeung et al., 2018Yeung et al., , 2019aYeung et al., , 2020aYeung et al., 2019bYeung et al., , 2020bYeung et al., , 2020cYeung et al., 2019cYeung et al., , 2021cYeung et al., , 2019d, and the preparation of scientific collaborative review publications (Khan et al., 2020;Li et al., 2021;Mondal et al., 2021Mondal et al., , 2019Tewari et al., 2018;Vacca et al., 2019;Wang et al., 2022Wang et al., , 2018Wang et al., , 2019a utilizing broadly-international collaborative work. In the latest example of collaborative work type, a special mention deserves a 2021 article from Nature Reviews Drug Discovery entitled "Natural products in drug discovery: advances and opportunities," in which the International Natural Product Sciences Taskforce was used for the first time as an author group designation . ...
The development of digital technologies and the evolution of open innovation approaches have enabled the creation of diverse virtual organizations and enterprises coordinating their activities primarily online. The open innovation platform titled “International Natural Product Sciences Taskforce” (INPST) was established in 2018, to bring together in collaborative environment individuals and organizations interested in natural product scientific research, and to empower their interactions by using digital communication tools.
... Phytomedicine xxx (xxxx) 154520 Table 2) are aligned with the multiple dissemination and outreach activities. INPST -based networking has proven to be an excellent catalyst for new collaborative integrated scientific research (Banach et al., 2018;Horbanczuk et al., 2019;Ruscica et al., 2021;Tancheva et al., 2020;Tewari et al., 2020;Tzvetkov et al., 2019;Yang et al., 2019b;Zhubi-Bakija et al., 2021), including joint work conducting meta-analysis of the published literature (Durazzo et al., 2021a(Durazzo et al., , 2021bYeung et al., 2018Yeung et al., , 2019aYeung et al., , 2020aYeung et al., 2019bYeung et al., , 2020bYeung et al., , 2020cYeung et al., 2019cYeung et al., , 2021cYeung et al., , 2019d, and the preparation of scientific collaborative review publications (Khan et al., 2020;Li et al., 2021;Mondal et al., 2021Mondal et al., , 2019Tewari et al., 2018;Vacca et al., 2019;Wang et al., 2020aWang et al., , 2018Wang et al., , 2019aWang et al., 2020c) utilizing broadly-international collaborative work. In the latest example of collaborative work type, a special mention deserves a 2021 article from Nature Review Drug Discovery entitled "Natural products in drug discovery: advances and opportunities," in which the International Natural Product Sciences Taskforce was used for the first time as an author group designation . ...
Background: The development of digital technologies and the evolution of open innovation approaches have enabled the creation of diverse virtual organizations and enterprises coordinating their activities primarily online. The open innovation platform titled "International Natural Product Sciences Taskforce" (INPST) was established in 2018, to bring together in collaborative environment individuals and organizations interested in natural product scientific research, and to empower their interactions by using digital communication tools. Methods: In this work, we present a general overview of INPST activities and showcase the specific use of Twit-ter as a powerful networking tool that was used to host a one-week "2021 INPST Twitter Networking Event" (spanning from 31st May 2021 to 6th June 2021) based on the application of the Twitter hashtag #INPST. Results and Conclusion: The use of this hashtag during the networking event period was analyzed with Symplur Signals (https://www.symplur.com/), revealing a total of 6,036 tweets, shared by 686 users, which generated a total of 65,004,773 impressions (views of the respective tweets). This networking event's achieved high visibility and participation rate showcases a convincing example of how this social media platform can be used as a highly effective tool to host virtual Twitter-based international biomedical research events.
... opics-and-announcements/). Representative examples of different INPST-based activities (Table 2) are aligned with the multiple dissemination and outreach activities. INPST-based networking has proven to be an excellent catalyst for new collaborative integrated scientific research (Banach et al., 2018;Horbanczuk et al., 2019;Jozwik et al., 2018;Ruscica et al., 2021;Tancheva et al., 2020;Tewari et al., 2020;Tzvetkov et al., 2019;Yang et al., 2019b;Zhubi-Bakija et al., 2021), including joint work conducting meta-analysis of the published literature (Durazzo et al., 2021a(Durazzo et al., , 2021bYeung et al., 2018Yeung et al., , 2019aYeung et al., , 2020aYeung et al., 2019bYeung et al., , 2020bYeung et al., , 2020cYeung et al., 2019cYeung et al., , 2021cYeung et al., , 2019d, and the preparation of scientific collaborative review publications (Khan et al., 2020;Li et al., 2021;Mondal et al., 2021Mondal et al., , 2019Tewari et al., 2018;Vacca et al., 2019;Wang et al., 2022Wang et al., , 2018Wang et al., , 2019a utilizing broadly-international collaborative work. In the latest example of collaborative work type, a special mention deserves a 2021 article from Nature Reviews Drug Discovery entitled "Natural products in drug discovery: advances and opportunities," in which the International Natural Product Sciences Taskforce was used for the first time as an author group designation . ...
Background: The development of digital technologies and the evolution of open innovation approaches have enabled the creation of diverse virtual organizations and enterprises coordinating their activities primarily online. The open innovation platform titled “International Natural Product Sciences Taskforce” (INPST) was established in 2018, to bring together in collaborative environment individuals and organizations interested in natural product scientific research, and to empower their interactions by using digital communication tools.
Methods: In this work, we present a general overview of INPST activities and showcase the specific use of Twitter as a powerful networking tool that was used to host a one week “2021 INPST Twitter Networking Event” (spanning from 31st May 2021 to 6th June 2021) based on the application of the Twitter hashtag #INPST.
Results and Conclusion: The use of this hashtag during the networking event period was analyzed with Symplur Signals (https://www.symplur.com/), revealing a total of 6,036 tweets, shared by 686 users, which generated a total of 65,004,773 impressions (views of the respective tweets). This networking event’s achieved high visibility and participation rate showcases a convincing example of how this social media platform can be used as a highly effective tool to host virtual Twitter-based international biomedical research events.
... Envisaging the diverse applications of natural products in many areas of industry and healthcare, new natural product-related scientific findings could be of high importance in addressing some key societal problems, such as the search for new medicines, the establishment of innovative technologies that are friendlier to the environment, and the development of better food and dietary supplements. Along this line, both the continuous exploration of the existing natural biodiversity is of benefit, but also cultivated biodiversity, involving improvements mediated through modern genetic techniques, which allow to specifically increase the content of substances of high nutritional and even pharmaceutical interest (Sabbadini et al., 2021 (Banach et al., 2018;Horbanczuk et al., 2019;Jozwik et al., 2018;Ruscica et al., 2021;Tancheva et al., 2020;Tewari et al., 2020;Tzvetkov et al., 2019;Yang et al., 2019b;Zhubi-Bakija et al., 2021), including joint work conducting meta-analysis of the published literature (Durazzo et al., 2021a;Durazzo et al., 2021b;Yeung et al., 2018;Yeung et al., 2019a;Yeung et al., 2020a;Yeung et al., 2020b;Yeung et al., 2020c;Yeung et al., 2019c;Yeung et al., 2021c;Yeung et al., 2019d), and the preparation of 18 scientific collaborative review publications (Khan et al., 2020;Li et al., 2021;Mondal et al., 2021;Mondal et al., 2019;Tewari et al., 2018;Vacca et al., 2019;Wang et al., 2020a;Wang et al., 2018;Wang et al., 2019a;Wang et al., 2020c) utilizing broadlyinternational collaborative work. In the latest example of collaborative work type, a special mention deserves a 2021 article from Nature Review Drug Discovery entitled "Natural products in drug discovery: advances and opportunities," in which the International Natural Product Sciences Taskforce was used for the first time as an author group designation . ...
Background
The development of digital technologies and the evolution of open innovation approaches have enabled the creation of diverse virtual organizations and enterprises coordinating their activities primarily online. The open innovation platform titled “International Natural Product Sciences Taskforce” (INPST) was established in 2018, to bring together in collaborative environment individuals and organizations interested in natural product scientific research, and to empower their interactions by using digital communication tools.
Methods
In this work, we present a general overview of INPST activities and showcase the specific use of Twitter as a powerful networking tool that was used to host a one-week “2021 INPST Twitter Networking Event” (spanning from 31st May 2021 to 6th June 2021) based on the application of the Twitter hashtag #INPST.
Results and Conclusion
The use of this hashtag during the networking event period was analyzed with Symplur Signals (https://www.symplur.com/), revealing a total of 6,036 tweets, shared by 686 users, which generated a total of 65,004,773 impressions (views of the respective tweets). This networking event's achieved high visibility and participation rate showcases a convincing example of how this social media platform can be used as a highly effective tool to host virtual Twitter-based international biomedical research events.
... Herbal therapy can be used as an adjutant in diabetes patients to complement conventional treatments due to its multiple mechanisms of action (Kooti et al., 2016). Although those medicinal plants have been used as a primary form of healthcare for a long time, they have not been fully used as acceptable drugs in the management of diabetes due to a lack of understanding of their chemical profile, standardized preparation procedure, potential side effects, and ambiguity regarding the most effective form and dosage of administration (Yeung et al., 2020). ...
“Mito”, “Andean Papaya” and “kerko” are the popular names of Vasconcellea candicans (A. Gray) A. DC. In some regions in Peru, this species is a shrub tree, endemic to the Peruvian Andes and Ecuador. This study aimed to evaluate the antioxidant and hypoglycemic effect of the ethanolic extract of Vasconcellea candicans fruit on alloxaninduced hyperglycemia in albino mice. Vasconcellea candicans fruits were collected in Uruiza, Lucanas-Ayacucho, Peru. Phytochemical analysis was carried out to confirm chemical groups, and antioxidant activity in vitro was measured using two methods, 2,2- diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-Azino-bis(3-ethylbenzothiazoline-6-sulfonicacid) diammonium salt radical cation (ABTS). In the pharmacological evaluation, hyperglycemia was induced with alloxan using doses of 170 mg/kg in albino mice, animals with a glucose level of more than 250 mg/dL were included in the treatment. Animals were randomized into five groups (I: Alloxan 170 mg/kg; II, III, and IV: Vasconcellea candicans extract: 100, 300, and 500 mg/kg body weight; and V: glibenclamide 5 mg/kg). The phytochemical analysis confirmed the presence of flavonoids, alkaloids, terpenes, saponins, and phenolic compounds. It was observed that at doses of 100, 300, and 500 mg/kg, blood glucose was reduced by 43.6%, 60.8%, and 70.5 %, respectively, after 16 days of treatment. The ethanolic extract had an IC50 = 19.6±0.5 µg/mL and 5.05±0.01 µg/mL against DPPH and the ABTS radical, respectively. In conclusion, the ethanolic extract of the Vasconcellea candicans fruit was demonstrated to be effective at 500 mg/kg following 14 days of treatment in mice.
... Iran (29.9), and Italy (23.34), which means that China still needs to improve the quality of publications ( Table 1). A recent bibliometric study on diabetes showed that India, the USA, China, South Korea, and Brazil were the most productive countries (18). Among them, the average citation rate of the USA remains at the top, but China's development trend is strong and is expected to overtake the USA. ...
Background
Diabetes mellitus (DM) is a metabolic disease that endangers human health, and its prevalence is exploding and younger. Stem cell-derived extracellular vesicles (SC-EVs) have a repair function similar to SCs and no risk of tumor formation, which have been widely used in the repair of DM and its complications. We aim to map the hot trends of SC-EVs for the treatment of DM and providing directions for future research.
Methods
We screened all relevant publications on SC-EVs for DM from the Web of Science (Wos) during 2017–2021, and research trends in this field were analyzed by VOSviewer and CiteSpace.
Results
A total of 255 articles related to SC-EVs for DM were screened out according to the search strategy. China (122 publications and 2,759 citations) was the most productive country, followed by the USA (50 publications and 1,167 citations) and Italy (16 publications and 366 citations). The top five institutions with the most publications were located in Italy and China, with Turin University being the most productive. The journals Stem Cell Research and Therapy and International Journal of Molecular Sciences published most of the studies on SC-EVs for DM. ASHOK KUMAR published the majority of articles in this field, while QING LI was the most cited. Cluster analysis indicated that the current research trend is more focused on the repair mechanism and clinical translation of exosomes and their related preparations in promoting DM and its complications.
Conclusion
In this study, a comprehensive summary and analysis of the global research trends of SC-EVs used in DM and its complications was performed. In the past 5 years, relevant high-quality publications in this field have increased significantly, and SC-EVs have a good prospect for development in the treatment of DM and its complications.
... The use of natural products in diabetes mellitus (DM) research has been investigated [30,31]. Although a previous study from our research group has reported the promising effects to P. insignis seed butter on lipid and hepatic profiles [17], studies regarding properties of P. insignis seeds in hyperglycemia and glycated hemoglobin are scarce, and moreover, the lack of histopathological investigation and role of antioxidant activity and oxidative stress in DM need to be assessed and clarified. ...
This study aimed to investigate the effects of oral administration of Platonia insignis Mart. (“bacuri”) seed butter (BSB) on oxidative stress and diabetes mellitus-related parameters in streptozotocin-induced (STZ) diabetic rats. Diabetes mellitus was induced in female Wistar rats (180–250 g) by the intraperitoneal administration of STZ (45 mg/kg, b.w). BSB (25, 50, and 100 mg/kg) was administered to animals for four weeks. The effect on weight gain, food intake, blood glucose, glycated hemoglobin, hepatic transaminases, plasma and liver TBARS and MPO activity, erythrocyte SOD activity, non-protein sulfhydryl groups (SH-NP), and histopathology of the liver tissue was investigated. BSB at the dose of 100 mg/kg had a positive effect on the reduction in glycated hemoglobin percentage and increased albumin concentration, as well as decreased ALT and AST levels and increased SH-NP liver levels in treated animals compared to normal control rats. Moreover, BSB had no effects on weight gain, food intake, and fasting glucose. Thus, the BSB presented marked properties in improvement of hepatic antioxidant defenses, which demonstrates BSB as a potential hepatoprotective agent in metabolic disorders.
... The antimicrobial properties of hydrogels aimed at wound healing are instrumental for the success of the treatment. Curcumin is known for its anticancer, antibacterial and antioxidant activities [77][78][79]. It has been proposed as an active ingredient in hydrogels for wound healing given its antibacterial and antioxidant properties [80]. ...
Hydrogels for the modified-release drug delivery systems is a continuously growing area of interest for the pharmaceutical industry. According to the global market, the use of polymers in this area is projected to reach $31.4 million by 2027. This review discusses the recent advances and perspectives of hydrogel in drug delivery systems for oral, parenteral, nasal, topical, and ophthalmic. The search strategy did in January 2021, and it conducted an extensive database to identify studies published from January 2010 to December 2020.We described the main characteristic of the polymers to obtain an ideal hydrogel for a specific route of administration and the formulations that was a highlight in the literature. It concluded that the hydrogels are a set useful to decrease the number of doses, side effects, promote adhesion of patient and enhances the bioavailability of the drugs improving the safety and efficacy of the treatment.
... However, developing countries, such as China, tended to catch up in the field of exercise and health science, especially in the HIIT-HP domain. Moreover, a previous study reported that the United States, China, and Brazil were also among the most productive countries in diabetes-related publications (53). We suppose that a large population base and aging tendency may lead to an increase in health risks, which tends to be an important driving force for these countries to invest resources in health researches. ...
Background: High-intensity interval training (HIIT) is an emerging exercise strategy and is considered to be a recipe for health promotion. This study aimed to systematically identify collaboration networks, track research trends, highlight current hotspots, and predict future frontiers in HIIT and its applications in health promotion since the start of the new century.
Methods: Relevant original publications were obtained from the Science Citation Index Expanded of the Web of Science Core Collection (WoSCC) database between 2001 and 2020. CiteSpace and VOSviewer software were used to perform bibliometric visualization and comparative analysis of involved indexes that included countries, institutions, journals, authors, references, and keywords.
Results: A total of 572 papers were included, and the trend of annual publications showed a remarkable growth. The United States and the University of Exeter were the most productive country and institutions, respectively, with 107 and 18 publications, respectively. European Journal of Applied Physiology took the lead in the number of published articles, and Medicine and Science in Sports and Exercise ranked first in the cocitation counts. Barker AR and Gibala MJ were considered as the most productive and the most highly-cited authors.
Conclusions: “Health risks,” “adolescent,” and “aging” are the three noteworthy topics during the evolution of HIIT-health promotion (HIIT-HP) research. The current research hotspots of HIIT and its practices in the health promotion domain lies in “metabolic diseases,” “cardiovascular diseases,” “neurological diseases,” and “musculoskeletal diseases.” The authors summarize that “prevention and rehabilitation,” “micro and molecular level,” and “cognition and mental health” are becoming frontiers and focus on the health topics related to HIIT in the upcoming years, which are worthy of further exploration.
... Natural products have immense potential in the management of diabetes. [83][84][85] Major digestive enzymes such as α-amylase and α-glucosidase are responsible for the digestion of starch into oligosaccharides, disaccharides, and ultimately into glucose. This results in high glucose levels in blood without being used for energy and results in type II diabetes. ...
Background: The increasing frequency of diabetes patients and the reported side effects of commercially available anti-hyperglycemic drugs have gathered the attention of researchers towards the search for new therapeutic approaches. Inhibition of activities of carbohydrate hydrolyzing enzymes is one of the approaches to reduce postprandial hyperglycemia by delaying digestion and absorption of carbohydrates. Objectives: The objective of the study was to investigate phytochemicals, antioxidants, digestive enzymes inhibitory effect, and molecular docking of potent extract. Materials and Methods: In this study, we carry out the substratebased α-glucosidase and α-amylase inhibitory activity of Asparagus racemosus, Bergenia ciliata, Calotropis gigantea, Mimosa pudica, Phyllanthus emblica, and Solanum nigrum along with the determination of total phenolic and flavonoids contents. Likewise, the antioxidant activity was evaluated by measuring the scavenging of DPPH radical. Additionally, antibacterial activity was also studied by Agar well diffusion method. Molecular docking of bioactive compounds from B. ciliata was performed via AutoDock vina. Results: B. ciliata, M. pudica, and P. emblica exhibit significant inhibitory activity against the α-glucosidase and α-amylase with IC50 (μg/ml) of (2.24 ± 0.01, 46.19 ± 1.06), (35.73 ± 0.65, 99.93 ± 0.9) and (8.12 ± 0.29, no significant activity) respectively indicating a good source for isolating a potential drug candidate for diabetes. These plant extracts also showed significant antioxidant activity with the IC50 ranges from 13.2 to 26.5 μg/mL along with the significant antibacterial activity towards Staphylococcus aureus and Klebsiella pneumonia. Conclusion: Bergenia extract appeared to be a potent α-glucosidase and α-amylase inhibitor. Further research should be carried out to characterize inhibitor compounds.
... VOSviewer is a free JAVA-based software developed in 2009 by van Eck and Waltman [41] of the Centre for Science and Technology Studies (CSTS) at Leiden University in the Netherlands, focusing on the visualization of literature data. The keywords co-occurrence method has been applied in different fields such as medical care [42,43], social participation of the elderly [44], and disaster response [45]. The keywords help to focus and refine the core perspectives and topics of the literature in the research area [46,47], and can reflect research hot spots and trends as well [48]. ...
Circular economy (CE) is a concept actively advocated by the European Union (EU), China, Japan, and the United Kingdom. At present, CE is considered to grant the most traction for companies to achieve sustainable development. However, CE is still rarely adopted by enterprises. As the backbone of the fourth industrial revolution, the digital economy (DE) is considered to have a disruptive effect. Studies have shown that digital technology has great potential in promoting the development of CE. Especially during the COVID-19 epidemic that has severely negatively affected the global economy, environment, and society, CE and DE are receiving high attention from policy makers, practitioners, and scholars around the world. However, the integration of CE and digital technology is a small and rapidly developing research field that is still in its infancy. Although there is a large amount of research in the fields of CE and DE, respectively, there are few studies that look into integrating these two fields. Therefore, the purpose of this paper is to explore the research progress and trends of the integration of CE and DE, and provide an overview for future research. This paper adopts a bibliometric research method, employs the Web of Science database as its literature source, and uses VOSviewer visual software to carry out keyword co-occurrence analysis, which focuses on publication trends, journal sources, keyword visualization, multidisciplinary areas, life cycle stages, and application fields.
... Recently, increasing numbers of natural products have been found to have anti-T2D properties [5]. Some have been widely used to control diabetes, such as curcumin, flavanone, resveratrol, carotenoid, and polyphenols [6]. The α-glucosidase inhibitors (AGIs) are described as the most effective anti-diabetic drugs in the management of T2D [7]. ...
Natural products have been widely used in the treatment of type 2 diabetes (T2D). However, their mechanisms are often obscured due to multi-components and multi-targets. The authors constructed a pathway-based protein-protein association (PPA) network for target proteins of 13 α-glucosidase inhibitors (AGIs) identified from Scutellaria baicalensis Georgi (SBG), designed to explore the underlying mechanisms. This network contained 118 nodes and 1167 connections. An uneven degree distribution and small-world property were observed, characterised by high clustering coefficient and short average path length. The PPA network had an inherent hierarchy as C(k)∼k-0.71 . It also exhibited potential weak disassortative mixing pattern, coupled with a decreased function Knn (k) and negative value of assortativity coefficient. These properties indicated that a few nodes were crucial to the network. PGH2, GNAS, MAPK1, MAPK3, PRKCA, and MAOA were then identified as key targets with the highest degree values and centrality indices. Additionally, a core subnetwork showed that chrysin, 5,8,2'-trihydroxy-7-methoxyflavone, and wogonin were the main active constituents of these AGIs, and that the serotonergic synapse pathway was the critical pathway for SBG against T2D. The application of a pathway-based protein-protein association network provides a novel strategy to explore the mechanisms of natural products on complex diseases.
... It is worth mentioning the recent work of Yeung et al. [13] which investigates the natural products in diabetes based on quantitative literature analysis and giving the main directions of natural product research in diabetes up to now and useful hints on promising avenues for future research. Some highly cited natural products or compound classes including curcumin, flavanone, resveratrol, carotenoid, polyphenols, flavonol, flavone and berberine have been considered. ...
Many plants have been known for centuries to have medicinal importance with potential beneficial effects on health. Phytotherapeutic compounds are well known to play a globally significant role, in particular in the management and treatment of various chronic diseases. Among these, diabetes can cause long term damage to the body other than having a relevant economic burden on society being among the costliest chronic diseases. This motivated the focus of the proposed Special Issue, intended to develop and exploit the potential role of plants in the management and treatment of diabetes. The main topics included are: (i) description and use of medicinal plants for diabetes management; (ii) the elucidation and delineation of their main components, properties (anti-hyperglycaemic, hypoglicaemic, anti-infiammatory, apoptotic agents, etc.), (iii) the mechanism of action (in vitro and in vivo studies); (iv) formulation of nutraceuticals, botanicals, and dietary supplements useful as tools as an alternative or support to anti-diabetic pharmacological therapies; (v) development of new markers.
... It was also shown that virgin argan oil, rich in phenolic compounds, fatty acids, tocopherol, has the potential to protect from injuries caused by reactive oxygen species (ROS), as it inhibits LDL-oxidation, and could be used to prevent cardiovascular disease [12]. Since ROS are important pathologic factors in different inflammatory conditions, it seems that argan oil could have supportive effects, especially on diabetic patients and in obesity [13][14][15]. ...
Vegetable oils obtained from different plants are known for their beneficial effects on prophylaxis and supportive treatment of a great deal of inflammatory-mediated conditions. Their wide range of saturated and unsaturated fatty acids, and the presence of other ingredients (e.g., tocopherols, chlorophylls), provide them with anti-inflammatory, antioxidant and anticancer properties, which are worth being exploited. In this study, we have carried out the spectrofluorometric analysis of selected vegetable oils, namely apricot (Prunus armeniaca) kernel oil; blueberry (Vaccinium spp.) seed oil; argan (Argania spinosa) nut oil; kiwi (Actinidia deliciosa) seed oil; grape (Vitis vinifera) seed oil; evening primrose (Oenothera biennis) oil and meadowfoam (Limnanthes alba) seed oil, with the purpose to detect their fluorescent ingredients for further identification and bioactivity comparison. The obtained two-(2D) and three-dimensional (3D) emission spectra offered a complete description of the fluorescent components of the mixture and revealed different features for studied oils.
... Additional factors that play an important role in the setting up of type 2 diabetes mellitus (T2DM) include the chronic hyperglycemia itself but also obesity which is recognised as a risk factor for the insulin resistance development and T2DM. Many natural products of nutraceutical interest [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28] have been proposed worldwide for the management of diabetes, as evidenced in a recent quantitative literature analysis [29]. Hyperglycemia contributes to glycosylation of proteins and lipids, enhances the production of reactive oxygen species, encourages the synthesis and secretion of pro-inflammatory cytokines and also acute phase proteins in various tissues, which promote inflammation processes in the vascular wall [30,31]. ...
A major hallmark of diabetes is a constant high blood glucose level (hyperglycaemia), resulting in endothelial dysfunction. Transient or prolonged hyperglycemia can cause diabetic vasculopathy, a secondary systemic damage. C-Peptide is a product of cleavage of proinsulin by a serine protease that occurs within the pancreatic β-cells, being secreted in similar amounts as insulin. The biological activity of human C-peptide is instrumental in the prevention of diabetic neuropathy, nephropathy and other vascular complications. The main feature of type 1 diabetes mellitus is the lack of insulin and of C-peptide, but the progressive β-cell loss is also observed in later stage of type 2 diabetes mellitus. C-peptide has multifaceted effects in animals and diabetic patients due to the activation of multiple cell signalling pathways, highlighting p38 mitogen-activated protein kinase and extracellular signal–regulated kinase ½, Akt, as well as endothelial nitric oxide production. Recent works highlight the role of C-peptide in the prevention and amelioration of diabetes and also in organ-specific complications. Benefits of C-peptide in microangiopathy and vasculopathy have been shown through conservation of vascular function, and also in the prevention of endothelial cell death, microvascular permeability, neointima formation, and in vascular inflammation. Improvement of microvascular blood flow by replacing a physiological amount of C-peptide, in several tissues of diabetic animals and humans, mainly in nerve tissue, myocardium, skeletal muscle, and kidney has been described. A review of the multiple cell signalling pathways of human proinsulin C-peptide in vasculopathy protection is proposed, where the approaches to move beyond the state of the art in the development of innovative and effective therapeutic options of diabetic neuropathy and nephropathy are discussed.
Galium species are used worldwide for their antioxidant, antibacterial, antifungal, and antiparasitic properties. Although this plant has demonstrated its antitumor properties on various types of cancer, its biological activity on cutaneous melanoma has not been established so far. Therefore, the present study was designed to investigate the phytochemical profile of two extracts of G. verum L. herba (ethanolic and ethyl acetate) as well as the biological profile (antioxidant, antimicrobial, and antitumor effects) on human skin cancer. The extracts showed similar FT-IR phenolic profiles (high chlorogenic acid, isoquercitrin, quercitrin, and rutin), with high antioxidant capacity (EC50 of ethyl acetate phase (0.074 ± 0.01 mg/mL) > ethanol phase (0.136 ± 0.03 mg/mL)). Both extracts showed antimicrobial activity, especially against Gram-positive Streptococcus pyogenes and Staphylococcus aureus bacilli strains, the ethyl acetate phase being more active. Regarding the in vitro antitumor test, the results revealed a dose-dependent cytotoxic effect against A375 melanoma cell lines, more pronounced in the case of the ethyl acetate phase. In addition, the ethyl acetate phase stimulated the proliferation of human keratinocytes (HaCaT), while this effect was not evident in the case of the ethanolic phase at 24 h post-stimulation. Consequently, G. verum l. could be considered a promising phytocompound for the antitumor approach of cutaneous melanoma.
Non-alcoholic fatty liver disease (NAFLD) is defined as a clinical syndrome characterized by excessive fat accumulation in liver, predominantly influenced by dietary choices. This study provides an extensive quantitative literature analysis on dietary influences on NAFLD. Bibliometric data were collected through the search string TOPIC = (“NAFLD*” OR “nonalcoholic fatty liver*” OR “non-alcoholic fatty liver*”) AND TOPIC = (“diet*” OR “nutrition*” OR “food*” OR “feed*”), which yielded 12,445 publications indexed within the Web of Science Core Collection. Utilizing VOSviewer software, term maps were generated to visually illustrate recurring phrases alongside citation data. The literature, which has seen exponential growth since the 2010s, predominantly consists of original articles, with a ratio of 4.7:1 compared to reviews. Notably, the significant contributors to this field were China and the United States. The majority of publications were found journals specialized in Gastroenterology & Hepatology, Nutrition & Dietetics, Biochemistry & Molecular Biology, Endocrinology & Metabolism, and Pharmacology & Pharmacy. Key dietary compounds/compounds classes such as resveratrol, polyphenols, curcumin, berberine, quercetin, flavonoids, omega-3 fatty acids, docosahexaenoic acid (DHA), genistein, and palmitic acid were frequently mentioned and cited. Many of them were demonstrated to have some potential benefits on NAFLD, both in human and animal studies.
Introduction:
Type 2 diabetes mellitus is a globally prevalent chronic disease characterised by hyperglycaemia and oxidative stress. The search for new natural bioactive compounds that contribute to controlling this condition and the application of analytical methodologies that facilitate rapid detection and identification are important challenges for science. Annona cherimola Mill. is an important source of aporphine alkaloids with many bioactivities.
Objective:
The aim of this study is to isolate and identify antidiabetic compounds from alkaloid extracts with α-glucosidase and α-amylase inhibitory activity from A. cherimola Mill. leaves using an effect-directed analysis by thin-layer chromatography (TLC)-bioautography.
Methodology:
Guided fractionation for α-glucosidase and α-amylase inhibitors in leaf extracts was done using TLC-bioassays. The micro-preparative TLC was used to isolate the active compounds, and the identification was performed by mass spectrometry associated with web-based molecular networks. Additionally, in vitro estimation of the inhibitory activity and antioxidant capacity was performed in the isolated compounds.
Results:
Five alkaloids (liriodenine, dicentrinone, N-methylnuciferine, anonaine, and moupinamide) and two non-alkaloid compounds (3-methoxybenzenepropanoic acid and methylferulate) with inhibitory activity were isolated and identified using a combination of simple methodologies. Anonaine, moupinamide, and methylferulate showed promising results with an outstanding inhibitory activity against both enzymes and antioxidant capacity that could contribute to controlling redox imbalance.
Conclusions:
These high-throughput methodologies enabled a rapid isolation and identification of seven compounds with potential antidiabetic activity. To our knowledge, the estimated inhibitory activity of dicentrinone, N-methylnuciferine, and anonaine against α-glucosidase and α-amylase is reported here for the first time.
The technologies for fabrication of nanocrystals have an immense potential to improve solubility of a variety of the poor water-soluble drugs with subsequent enhanced bioavailability. Repaglinide (Rp) is an antihyperglycemic drug having low bioavailability due to its extensive first-pass metabolism. Microfluidics is a cutting-edge technique that provides a new approach for producing nanoparticles (NPs) with controlled properties for a variety of applications. The current study’s goal was to engineer repaglinide smart nanoparticles (Rp-Nc) utilizing microfluidic technology (Dolomite Y shape), and then to perform in-vitro, in-vivo, and toxicity evaluations of them. This method effectively generated nanocrystals with average particle sizes of 71.31 ± 11 nm and a polydispersity index (PDI) of 0.072 ± 12. The fabricated Rp’s crystallinity was verified by Differential scanning calorimetry (DSC) and Powder X-ray diffraction (PXRD). In comparison to the raw and commercially available tablets, the fabricated Rp’s nanoparticles resulted in a higher saturation solubility and dissolving rate (p < 0.05). Rp nanocrystals had a considerably lower (p < 0.05) IC50 value than that of the raw drug and commercial tablets. Moreover, Rp nanocrystals at the 0.5 and 1 mg/kg demonstrated a significant decrease in blood glucose level (mg/dL, p < 0.001, n = 8) compared to its counterparts. Rp nanocrystals at the 0.5 mg/kg demonstrated a significant decrease (p < 0.001, n = 8) in blood glucose compared to its counterparts at a dose of 1 mg/kg. The selected animal model’s histological analyses and the effect of Rp nanocrystals on several internal organs were determined to be equivalent to those of the control animal group. The findings of the present study indicated that nanocrystals of Rp with improved anti-diabetic properties and safety profiles can be successfully produced using controlled microfluidic technology, an innovative drug delivery system (DDS) approach.
Diabetes is a chronic metabolic disorder characterized by raised glucose levels in the blood, resulting in grave damage over time to various body organs, including the nerves, heart, kidneys, eyes, and blood vessels. One of its therapeutic treatment approaches involves the inhibition of enzymes accountable for carbohydrate digestion and absorption. The present work is aimed at evaluating the potential of some reported metabolites from Garcinia mangostana (mangosteen, Guttiferae) as alpha-amylase inhibitors. Forty compounds were assessed for their capacity to inhibit alpha-amylase using in silico studies as well as in vitro assays. Molecular docking was carried out to analyze their binding capacities in the 3D structure of alpha-amylase (PDB ID: 4GQR). Among the tested compounds, 6-O-β-D-glucopyranosyl-2,4,6,3′,4′,6′-hexahydroxybenzophenone (8), aromadendrin-8-C-glucoside (5), epicatechin (6), rhodanthenone (4), and garcixanthone D (40) had a high XP G.score and a Glide G.score of −12.425, −11.855, −11.135, and −11.048 Kcal/mol, respectively. Compound 8 possessed the XP and Glide docking score of −12.425 Kcal/mol compared to the reference compounds myricetin and acarbose which had an XP and Glide docking score of −12.319 and 11.201 Kcal/mol, respectively. It interacted through hydrogen bond formations between its hydroxyl groups and the residues His 101, Asp 197, Glu 233, Asp 300, and His 305, in addition to water bridges and hydrophobic interactions. Molecular mechanics-generalized born surface area (MM-GBSA) was used to calculate the binding free energy and molecular dynamic studies that indicated the stability of the alpha-amylase-compound 8 complex during the 100 ns simulation in comparison with myricetin- and acarbose-alpha-amylase complexes. Additionally, the in vitro alpha-amylase inhibition assay findings validated the in silico study’s findings. This could further validate the potential of G. mangostana as a candidate for diabetes management.
Objective: This study aimed at providing an overview of the current state and the emerging role of trace elements in chronic kidney disease (CKD) using a bibliometric approach.
Methods: Scientific literature on CKD published between Jan 2000 to Nov 2021 was identified and retrieved from Web of Science (WoS) databases. Bibliometric analysis and visualization, including annual outputs, core journals, keywords, co-authorship, citation, and co-cited analysis were carried out using software like R, VOSviewer, Citespace, Scimago, and Pajek. Correlation analysis using quantitative and qualitative indicators, such as publication and citation counts, H-index, and journal citation reports was carried out using R and Microsoft Excel.
Results: A total of 2551 articles published mainly in the USA, China, and Japan were identified. The University of São Paulo was found to be the most prolific institution, Liu Y the most influential author, and Biological Trace Element Research was the most high-yield journal in this field of research. The top 5 trace elements of interest were divided into two groups; beneficial essential elements including zinc and selenium, and environmental toxicants including copper, cadmium, and aluminum. The top 5 researched keywords were found to be “chronic kidney disease”, “oxidative stress”, “zinc”, “copper”, and “hemodialysis”.
Conclusions: This study conducted a comprehensive bibliometric analysis to summarize the trends and structure of trace elements and CKD. Areas like clusters of nutritional status, outcomes of nephropathy, influences of environmental toxicity, and the metabolism of trace elements have been observed to get increasing attention from researchers.
Two new phenolic allopyranosides, named viburluzosides A and B (1, 2), together with eight known phenolic glycosides (3 - 10) were discovered from the stems of Viburnum luzonicum Rolfe under the guidance of LC-MS analyses coupled with bioactivity evaluation. They were purified through various chromatography methods and identified by extensive spectroscopic analyses (1H and 13C NMR, HSQC, HMBC, and HRESIMS) and chemical methods. The in vitro evaluation on α-glucosidase and aldose reductase (AR) inhibitory activities of isolated compounds were conducted. Compounds 1 - 4 and 6 - 9 exhibited α-glucosidase inhibitory activities with IC50 values of 5.35 - 21.34 μM and AR inhibitory activities with IC50 values of 6.21 - 40.06 μM. Moreover, the inhibitory kinetics analyses of compounds 1 and 2 were also performed.
The oxidative stability of jerky made from ostrich, beef and chicken meat with (sea salt or tomato-pepper mixture) or without additives during storage (room temperature, 9 months) and after in vitro gastrointestinal digestion was investigated. Lipid oxidation (thiobarbituric acid reactive substances and hexanal) and protein oxidation (protein carbonyl compounds) were evaluated in both jerky and gastrointestinal digests. Lower lipid oxidation was observed in jerky with flavor additives. The susceptibility to oxidation was the highest in ostrich, lower in beef and the lowest in chicken jerky. Nine months storage time increased both lipid and protein oxidation products levels,
Lycopene intake from tomatoes and other food sources has multiple potential health benefits. This report aimed to evaluate the current research literature on lycopene concerning human and animal health. The electronic Web of Science Core Collection database was searched with (lycopene*) AND (health* OR illness* OR disease* OR medic* OR pharma* OR drug* OR therap*). The resulted 3972 papers were analyzed with the aid of bibliometric software. Besides the United States, the lycopene papers received global contributions, particularly from China, Italy, India, and Spain. Examples of frequently mentioned chemicals/chemical classes were carotenoid, beta carotene, alpha carotene, beta cryptoxanthin, and alpha tocopherol. Examples of frequently mentioned medical conditions were prostate cancer, cardiovascular disease, and obesity. Published scientific articles reveal the diverse potential of lycopene in prompting human and animal health, and the knowledge on the bioactivities of this phytochemical is expected to further grow in the future.
Non-starch polysaccharides (NSPs) have been reported to exert therapeutic potential on managing type 2 diabetes mellitus (T2DM). Various mechanisms have been proposed; however, several studies have not considered the correlations between the anti-T2DM activity of NSPs and their molecular structure. Moreover, the current understanding of the role of NSPs in T2DM treatment is mainly based on in vitro and in vivo data, and more human clinical trials are required to verify the actual efficacy in treating T2DM. The related anti-T2DM mechanisms of NSPs, including regulating insulin action, promoting glucose metabolism and regulating postprandial blood glucose level, anti-inflammatory and regulating gut microbiota (GM), are reviewed. The structure-function relationships are summarized, and the relationships between NSPs structure and anti-T2DM activity from clinical trials are highlighted. The development of anti-T2DM medication or dietary supplements of NSPs could be promoted with an in-depth understanding of the multiple regulatory effects in the treatment/intervention of T2DM.
The widespread use of Brazilian red propolis extract promotes an increased production rate in the Northeast region of Brazil, with an impressive economic turnover for the region. The rational use of the hydroalcoholic extract of red propolis (HERP) raises the question about its value against obesity. In this work, the aim is to evaluate the anti‐obesity effect of HERP in rats submitted to hyperlipid dietary (HLD) supplementation. HERP extraction yield is 17.46% (m/v). The major chemical components of HERP are found to be daidzein (4.16 ± 0.22 mg g ⁻¹ ), formononetin (9.21 ± 0.10 mg g ⁻¹ ), and biochanin A (7.08 ± 0.09 mg g ⁻¹ ). After 8 weeks, the animals under HLD supplementation show significantly greater body weight gain, while after the subsequent 4‐week treatment with HERP, HLD–HERP animal shows lower body weight gain than HLD‐vehicle animals. Oral administration of HERP also attenuates the pathological changes in the liver, kidney, and large intestine caused by HLD supplementation. This study demonstrates that HERP treatment has a hypolipidemic effect in a rodent model of dyslipidemia and that HERP minimizes the impact of a hyperlipidic diet on murine body weight parameters and abdominal fat accumulation.
Practical Applications : Brazilian red propolis is being exploited for a range of biomedical applications. It is demonstrated that its extract has hypolipidemic effect in a rodent model of dyslipidemia and minimizes the impact of a hyperlipidic diet on murine body weight parameters and abdominal fat accumulation.
Diabetes mellitus (DM) is a complicated condition that is accompanied by a plethora of
metabolic symptoms, including disturbed serum glucose and lipid profiles. Several herbs are reputed as traditional medicine to improve DM. The current study was designed to explore the chemical composition and possible ameliorative effects of Ocimum forskolei on blood glucose and lipid profile in high-fat diet/streptozotocin-induced diabetic rats and in 3T3-L1 cell lines as a first report of its bioactivity. Histopathological study of pancreatic and adipose tissues was performed in control and treatment groups, along with quantification of glucose and lipid profiles and the assessment of NF- B, cleaved caspase-3, BAX, and BCL2 markers in rat pancreatic tissue. Glucose uptake, adipogenic
markers, DGAT1, CEBP/ , and PPAR levels were evaluated in the 3T3-L1 cell line. Hesperidin was isolated from total methanol extract (TME). TME and hesperidin significantly controlled the glucose and lipid profile in DM rats. Glibenclamide was used as a positive control. Histopathological assessment showed that TME and hesperidin averted necrosis and infiltration in pancreatic tissues, and led to a substantial improvement in the cellular structure of adipose tissue. TME and hesperidin
distinctly diminished the mRNA and protein expression of NF- B, cleaved caspase-3, and BAX, and increased BCL2 expression (reflecting its protective and antiapoptotic actions). Interestingly, TME and hesperidin reduced glucose uptake and oxidative lipid accumulation in the 3T3-L1 cell line.TME and hesperidin reduced DGAT1, CEBP/ , and PPAR mRNA and protein expression in 3T3-L1 cells. Moreover, docking studies supported the results via deep interaction of hesperidin with the tested biomarkers. Taken together, the current study demonstrates Ocimum forskolei and hesperidin as possible candidates for treating diabetes mellitus.
The trends related to ohmic heating technology in food processing were evaluated using bibliometric analysis based on the scientific literature published in the last decade. Publications from Turkey, Brazil, and Iran represent 32% of all publications. Most studies have targeted the definition of the best combinations of operational parameters for application in different food matrices and their possible effects on the food properties. In addition, a tendency to use ohmic heating as an alternative technology for pasteurization was observed. Future studies should develop mathematical models that evaluate process parameters and food characteristics in the inactivation of microorganisms and enzymes and maintenance of bioactive compounds, the study of the non-thermal effect of electromagnetic waves on the food quality, the evaluation of the processing conditions and food physicochemical properties in the electrode corrosion and migration of metal ions to the treated food, and improvements of homogeneity during processing. This study was the first to perform a bibliometric analysis based on scientific literature concerning ohmic heating in food processing and presented the challenges, future trends, and evolution of scientific research.
Rhizobium rhizogenes induces a disease syndrome in infected plants commonly known as hairy roots (HR) production. These unique organs are considered of transgenic nature since they derived after horizontal gene transfer from the bacterial root-inducing (Ri) plasmid to the plant genome. The HR culture represents a major biotechnological tool facilitating the production of plant-derived compounds exhibiting interesting features for pharmaceutical, cosmetics and food industries. Moreover, HR cultures can be used for studying the biosynthetic pathways of plant-derived molecules or investigating interactions occurring during phytoremediation. Among this wide range of HR applications, it is important to point out the possibility to synthesize some antidiabetic compounds which are of special interest because diabetes is one of the major and frequently occurring debilitating diseases of the human body in the world. The use of available synthetic antidiabetic drugs has several limitations, including drug resistance, side effects, or toxicity. Therefore, the availability of new antidiabetic drugs from a natural source is of big importance. Stevia rebaudiana Bertoni is one of the promising plant species, constituting the source of desired plant molecules. This plant accumulates steviol glycosides (SGs), which are responsible for the sweet flavour of stevia leaves. These secondary metabolites are considered metabolically inert and therefore could be a safe substitute for sugar for diabetic people. In this chapter, we would like to present recent achievements in the range of antidiabetic substances production via genetic transformation of plants using R. rhizogenes strains. In this context, a key role of the so-called rol genes, carried by Ri plasmids, in the biosynthesis of various secondary metabolites is also discussed. Our aim is to bring closer the issue of HR cultures and their big potential in the pharmacognosy of antidiabetic plants.
Numerous investigations on quercetin have revealed that it effectively treats and prevents different diseases, acting as an anti-inflammatory, anti-bacterial, anti-proliferative, anti-atherogenic, anticoagulative, antioxidant, antidiabetic agent, etc. This work aimed to analyze the present research literature on quercetin in the context of human and animal health. The Web of Science Core Collection electronic database was searched with (quercetin*) AND (health* OR illness* OR disease* OR medic* OR pharma* OR drug* OR therap*). The resulted 15685 papers were bibliometrically evaluated with the aid of VOSviewer software. Besides the United States, the quercetin papers received global contributions, particularly from Asian countries such as China, India, and South Korea. Examples of frequently mentioned chemicals/chemical classes were flavonoid, kaempferol, rutin, polyphenol, and catechin. Examples of frequently mentioned medical conditions were cancer, Alzheimer's disease, and atherosclerosis. There are numerous reported beneficial effects of quercetin on human and animal health, which warrants further research for corroboration, understanding mechanism of action, and practical application.
Experience economy and digital economy have special significance and importance under new market conditions. Although the experience economy and the digital economy have played an important role in influencing the consumer experience, and researchers have done extensive research, there are few reviews on consumer experience in the context of the experience economy and the digital economy. Therefore, based on the literature review, this article aims to explore the research progress of consumer experience related fields in the context of experience economy and digital economy. Through the Web of Science database, the bibliometric research method is adopted, and the VOSviewer visualization software is used for keyword co-occurrence analysis. The main contributions of this research include: (1) showing the year of all publications, visualize keywords, analyze the co-occurrence of keywords, discuss high-frequency keywords, research hotspots and trend discussions; (2) overview of the current experience of consumers in physical retailers, online shopping, travel, food, and space environments under the current experience economy and digital economy; (3) revealing the bad experience of the shared service platform to consumers Negative impact; and (4) exploreing the ways in which cities, websites, brands and service industries create consumer experience. It provides trends for researchers, policy makers, organizations, and enterprises who discuss the experience economy, digital economy, and consumer experience in the future.
Apples contain substantial amounts of polyphenols, and diverse phenolics – mainly flavonoids and phenolic acids, have been identified in their flesh and skins. This work aimed to analyze the overall landscape of the research literature published to date on apple phenolic compounds in the context of human and animal health. The Web of Science Core Collection electronic database was queried with (apple* polyphenol*) AND (health* OR illness* OR disease* OR medic* OR pharma*) to identify relevant papers covering these words and their derivatives in the titles, abstracts, and keywords. The resulted 890 papers were bibliometrically analyzed. The VOSviewer software was utilized to produce term maps that illustrate how the frequent phrases fared in terms of publication and citation data. The apple polyphenol papers received global contributions, particularly from China, Italy, the United States, Spain, and Germany. Examples of frequently mentioned chemicals/chemical classes are quercetin, anthocyanin, catechin, epicatechin, and flavonol, while examples of frequently mentioned medical conditions are cardiovascular disease, atherosclerosis, diabetes, Alzheimer’s disease, and obesity. The potential health benefits of apple polyphenols on humans and animals are diverse and warrant further study.
Background
The present study describes the design and production of an oil‐in‐water (o/w) nanoemulsion composed of oil neem as the inner phase to be used as antifungal and antiparasitic control in aquaculture. A 2³ Central Composite Rotatable Design (CCRD) adopting surface response was used as the experimental design, setting the neem oil concentration (4%‐15%), surfactant concentration (0.5%‐10%) and sonication power (20‐90%) as the independent variables, while the droplet size, polydispersity index (PDI) and zeta potential were set as the response (dependent) variables.
Results
Droplet size and PDI showed the best results when using 5 minutes of process using the sonication method. The coefficients of determination were greater than 0.900 for all response. The best formulation was obtained with 9% of neem oil and 5.25 % of polysorbate 20.
Conclusion
Antifungal activity of the optimized nanoemulsion against the Saprolegnia parasitica has been demonstrated, also attributed to the presence of the surfactant. The concentrations of 200 mg/L of nanoemulsion resulted in 100% parasitic mortality.
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Diabetes mellitus is one of the major health problems in the world, the incidence and associated mortality are increasing. Inadequate regulation of the blood sugar imposes serious consequences for health. Conventional antidiabetic drugs are effective, however, also with unavoidable side effects. On the other hand, medicinal plants may act as an alternative source of antidiabetic agents. Examples of medicinal plants with antidiabetic potential are described, with focuses on preclinical and clinical studies. The beneficial potential of each plant matrix is given by the combined and concerted action of their profile of biologically active compounds.
Berberine is an alkaloid with a wide range of reported beneficial health effects. The current work provides an extensive literature analysis on berberine. Bibliometric data were identified by means of the search string TOPIC=(“berberin*” OR “umbellatine*”), which yielded 5,547 publications indexed in the Web of Science Core Collection electronic database. The VOSviewer software generated bubble maps to visualize semantic terms with citation results. The ratio of original articles to reviews was 13.6:1. The literature has been growing more quickly since the 2010s. Major contributing countries were China, the United States, India, Japan, and South Korea. Most of the publications appeared in journals specialized in pharmacology pharmacy, biochemistry molecular biology, chemistry, and plant science. Some of the frequently mentioned chemicals/chemical classes were alkaloid, palmatine, jatrorrhizine, coptisine, isoquinoline, and sanguinarine. The prevalent medical conditions under investigation included Alzheimer’s disease, cancer, diabetes, and obesity.
The incidences of diabetic mellitus and other metabolic diseases such as hypertension and hyperlipidemia are increasing worldwide; however, the current treatment is not able to control the rapidly increasing trend in diabetes mortality and morbidity. Studies related to the effectiveness of extracts and pure compounds obtained from plants have shown promising responses in preclinical and clinical studies related to these metabolic diseases. Plants belonging to the genus Berberis (Family: Berberidaceae) are widely distributed with nearly 550 species worldwide. Extracts and compounds obtained from Berberis species, especially Berberine alkaloid, showed effectiveness in the management of diabetes and other metabolic diseases. Various pharmacological experiments have been performed to evaluate the effects of Berberis extracts, berberine, and its natural and chemically synthesized derivatives against various cell and animal disease models with promising results. Various clinical trials conducted so far also showed preventive effects of Berberis extracts and berberine against metabolic diseases. The present review focuses on i) research updates on traditional uses, ii) phytopharmacology and clinical studies on Berberis species, and iii) active metabolites in the prevention and treatment of diabetes and other metabolic diseases with a detailed mechanism of action. Furthermore, the review critically analyzes current research gaps in the therapeutic use of Berberis species and berberine and provides future recommendations.
Berberine is an alkaloid with a wide range of reported beneficial health effects. The current work provides an extensive literature analysis on berberine. Bibliometric data were identified by means of the search string TOPIC=(“berberin*” OR “umbellatine*”), which yielded 5,547 publications indexed in the Web of Science Core Collection electronic database. The VOSviewer software generated bubble maps to visualize semantic terms with citation results. The ratio of original articles to reviews was 13.6:1. The literature has been growing more quickly since the 2010s. Major contributing countries were China, the United States, India, Japan, and South Korea. Most of the publications appeared in journals specialized in pharmacology pharmacy, biochemistry molecular biology, chemistry, and plant science. Some of the frequently mentioned chemicals/chemical classes were alkaloid, palmatine, jatrorrhizine, coptisine, isoquinoline, and sanguinarine. The prevalent medical conditions under investigation included Alzheimer’s disease, cancer, diabetes, and obesity.
Diabetes mellitus, an incurable metabolic disease, is characterized by changes in the homeostasis of blood sugar levels, being the subcutaneous injection of insulin the first line treatment. This administration route is however associated with limited patient’s compliance, due to the risk of pain, discomfort and local infection. Nanoparticles have been proposed as insulin carriers to make possible the administration of the peptide via friendlier pathways without the need of injection, i.e., via oral or nasal routes. Nanoparticles stand for particles in the nanometer range that can be obtained from different materials (e.g., polysaccharides, synthetic polymers, lipid) and are commonly used with the aim to improve the physicochemical stability of the loaded drug and thereby its bioavailability. This review discusses the use of different types of nanoparticles (e.g., polymeric and lipid nanoparticles, liposomes, dendrimers, niosomes, micelles, nanoemulsions and also drug nanosuspensions) for improved delivery of different oral hypoglycemic agents in comparison to conventional therapies.
Diabetes mellitus (DM) is a metabolic disorder characterized by chronic hyperglycemia together with disturbances in the metabolism of carbohydrates, proteins and fat, which in general results from an insulin availability and need imbalance. In a great number of patients, marketed anti-glycemic agents have shown poor effectiveness in maintaining a long-term glycemic control, thus being associated with severe adverse effects and leading to an emerging interest in natural compounds (e.g., essential oils and other secondary plant metabolites, namely, flavonoid-rich compounds) as a novel approach for prevention, management and/or treatment of either non-insulin-dependent diabetes mellitus (T2DM, type 2 DM) and/or Metabolic Syndrome (MS). In this review, some of these promising glucose-lowering agents will be comprehensively discussed.
The yellow pigment curcumin, extracted from turmeric, is a renowned polyphenol with a broad spectrum of health properties such as antioxidant, anti-inflammatory, anti-cancer, antidiabetic, hepatoprotective, anti-allergic, anti-dermatophyte, and neuroprotective. However, these properties are followed by a poor pharmacokinetic profile which compromises its therapeutic potential. The association of low absorption by the small intestine and the extensive reductive and conjugative metabolism in the liver dramatically weakens the oral bioavailability. Several strategies such as inhibition of curcumin metabolism with adjuvants as well as novel solid and liquid oral delivery systems have been tried to counteract curcumin poor absorption and rapid elimination from the body. Some of these drug deliveries can successfully enhance the solubility, extending the residence in plasma, improving the pharmacokinetic profile and the cellular uptake.
Diabetes is a complex disease characterized by hyperglycemia, together with polyuria, polydipsia, and polyphagia. While Type 1 diabetes mellitus (T1DM) results from genetic, environmental, or immune dysfunction factors leading to pancreatic β-cell destruction depriving the organism from endogenous insulin, Type 2 diabetes mellitus (T2DM) is characterized by peripheral insulin resistance. Depending on the type of diabetes mellitus and drug mechanism to study, the animal model should be carefully selected among the wide variety of the currently available ones. This review discusses the most common animal models currently employed to study T1DM and T2DM. Moreover, an overview on the administration routes that could be used is also discussed.
Resveratrol is a stilbene-type bioactive molecule with a broad spectrum of reported biological effects. In this sense, the current work provides a comprehensive literature analysis on resveratrol, representing a highly-researched commercially available dietary ingredient. Bibliometric data were identified by means of the search string TOPIC=(“resveratrol*”) and analyzed with the VOSviewer software, which yielded 17,561 publications extracted from the Web of Science Core Collection electronic database. The ratio of original articles to reviews was 9.5:1. More than half of the overall manuscripts have been published since 2013. Major contributing countries were USA, China, Italy, South Korea, and Spain. Most of the publications appeared in journals specialized in biochemistry and molecular biology, pharmacology and pharmacy, food science technology, cell biology, or oncology. The phytochemicals or phytochemical classes that were frequently mentioned in the keywords of analyzed publications included, in descending order: resveratrol, trans-resveratrol, polyphenols, flavonoids, quercetin, stilbenes, curcumin, piceatannol, cis-resveratrol, and anthocyanins.
The current study aimed to provide a comprehensive bibliometric overview of the literature on curcumin, complementing the previous reviews and meta-analyses on its potential health benefits. Bibliometric data for the current analysis were extracted from the Web of Science Core Collection database, using the search string TOPIC=(“curcumin*”), and analyzed by the VOSviewer software. The search yielded 18,036 manuscripts. The ratio of original articles to reviews was 10.4:1. More than half of the papers have been published since 2014. The major contributing countries were the United States, China, India, Japan, and South Korea. These publications were mainly published in journals representing the following scientific disciplines: biochemistry, chemistry, oncology, and pharmacology. There was a significant positive correlation between the total publication count and averaged citations per manuscript for affiliations, but not for countries/regions and journals. Chemicals that were frequently mentioned in the keywords of evaluated curcumin publications included curcuminoids, resveratrol, chitosan, flavonoids, quercetin, and polyphenols. The literature mainly focused on curcumin’s effects against cancer, inflammation, and oxidative stress. Cancer types most frequently investigated were breast, colon, colorectal, pancreatic, and prostate cancers.
The main features of the okra, Abelmoschus esculentus (L.), are highlighted. The evaluation of interactions between biologically active compounds and other components of the food matrix can be considered as the first action in the investigation of potential benefits of this annual herb. Moreover, updated examples of current and innovative directions in an integrated and multidisciplinary approach are discussed, with particular attention to chemometrics. Among the main effects attributed to okra, its antidiabetic property is the focus. Finally, the use of okra in different fields will be discussed.
Although biological and pharmacological effects of dietary natural products have been intensively studied, there has been no bibliometric analysis performed on this research field up to now. The current study has aimed to identify and analyze the manuscripts on dietary natural products and their potential to influence health and disease including studies using animal models. Data, including words from titles and abstracts, publication and citation data, have been extracted from Web of Science database and analyzed by the VOSviewer software. Our search has yielded 1,014 manuscripts. The ratio of original articles to reviews was identified to be 1.5:1. Over half of the manuscripts have been published since 2010. The manuscripts have been contributed by 4,301 authors from 1,445 organizations in 76 countries/territories and published in 499 journals. The results from the current study point out that scientific research focusing on the potential of dietary natural products to affect health and disease status (including animal model studies) is expanding, and suggests an increasing significance of this scientific area. With the progressive development and improvement of animal studies, it should be expected that animal models of different human diseases (especially civilization ones) would be an integral part of the research for the evaluation of pharmaceuticals originated from dietary natural products like plants or plant materials. Moreover, natural products can also be fed to animals to improve the quality of animal products, with numerous resulting functional effects.
Antioxidants are abundant in natural dietary sources and consumption of antioxidants has a lot of potential health benefits. However, there has been no literature analysis on this topic to evaluate its scientific impact in terms of citations. This study aimed to identify and analyse the antioxidant publications in the existing scientific literature. In this context, a literature search was performed with the Web of Science database. Full records and cited references of the 299,602 identified manuscripts were imported into VOSviewer for bibliometric analysis. Most of the manuscripts were published since 1991. The publications were mainly related to the categories Biochemistry / molecular biology, Food science technology and Pharmacology / pharmacy. These topics have been prolific since 1990 and before. Polymer science was prolific before, but its publication share declined in the recent two decades. Brazil, China, India, and South Korea have emerged as upcoming major contributors besides USA. Most prolific journals were Food Chemistry, Journal of Agricultural and Food Chemistry, Free Radical Biology and Medicine, and PLOS One. Clinical conditions with high citations included Alzheimer’s disease, cancer, cardiovascular disease, and Parkinson’s disease. Chemical terms and structures with high citations included alpha-tocopherol, anthocyanin, ascorbate, beta-carotene, carotenoid, curcumin, cysteine, flavonoid, flavonol, hydrogen peroxide, kaempferol, N-acetylcysteine, nitric oxide, phenolic acid, uric acid, vitamin C, vitamin E, selenium, and resveratrol. Citation patterns temporal analysis revealed a transition of the scientific interest from research focused on antioxidant vitamins and minerals into stronger attention focus on antioxidant phytochemicals (plant secondary metabolites).
Berberine-containing plants have been traditionally used in different parts of the world for the treatment of inflammatory disorders, skin diseases, wound healing, reducing fevers, affections of eyes, treatment of tumors, digestive and respiratory diseases, and microbial pathologies. The physico-chemical properties of berberine contribute to the high diversity of extraction and detection methods. Considering its particularities this review describes various methods mentioned in the literature so far with reference to the most important factors influencing berberine extraction. Further, the common separation and detection methods like thin layer chromatography, high performance liquid chromatography, and mass spectrometry are discussed in order to give a complex overview of the existing methods. Additionally, many clinical and experimental studies suggest that berberine has several pharmacological properties, such as immunomodulatory, antioxidative, cardioprotective, hepatoprotective, and renoprotective effects. This review summarizes the main information about botanical occurrence, traditional uses, extraction methods, and pharmacological effects of berberine and berberine-containing plants.
Background: The research into bioactive natural products of medicinal plants has a long tradition, but ethnopharmacology as a well-defined field of research has a relatively short history, only dating back 50 years.
Aims: With the fast development of this field and its global importance especially in the fast developing economies of Asia it is timely to assess the most influential articles (as measured by citations) and to identify important drivers and research trends in this field.
Methods: Scopus was searched to identify relevant articles which were assessed by all three authors. The 100 most cited articles were identified and analyzed. Bibliometric software (VOSviewer) was utilized to supplement the analysis and to generate a term map that visualized the citation patterns of the 100 articles containing different terms.
Results: Forty-four of the 100 articles are reviews. On average, each of the 100 articles had 632 citations and since publication was cited 43 times annually. The four core journals were Journal of Ethnopharmacology (n = 17), Food Chemistry (n = 7), Life Sciences (n = 5), and Journal of Agricultural and Food Chemistry (n = 4). Anti-oxidant effects appeared to be a recurring and highly cited topic, whereas the links into drug discovery and neuropharmacology seemed to be less strong. Numerous medicinal plants and functional foods were the foci of research, and the foci shifted when comparing pre-2000 and post-2000 publications (with the later involving a broader spectrum of plants and foods and a wider range of biological effects). Contributions largely came from Asia, and also from the Americas, Africa, and Oceania, besides Europe.
Conclusion: We have identified and analyzed the 100 most-cited articles in ethnopharmacology. Within 50 years the field has gained a profile and while conventionally often linked to “traditional knowledge,” drug discovery and some areas of pharmacology, this analysis highlights its emerging importance in the context of disease prevention (food science), but also the development of research driven by the needs and interests of the fast developing economies most notably of Asia.
Diabetes mellitus is the most common endocrine disorder it is the leading cause of morbidity and mortality in developed countries, and is gradually emerging as an important health problem in developing countries. In the last few years there has been an rapid growth in the field of herbal medicine these medicine are gaining popularity both in developing and developed countries because of their natural and less side effects. Okra, Abelmoschus esculentus L. (Moench) is an important vegetable crop. This plant is popular and has been acclaimed to have various health benefits which include anti-diabetic properties.
Background:
Simultaneously adhering to multiple healthy lifestyle factors has been related to up to 90% reduction in type 2 diabetes (T2DM) incidence in White populations; however, little is known about whether such protective effects persist in other non-White populations.
Methods:
We examined the associations of six lifestyle factors with T2DM in the China Kadoorie Biobank of 461 211 participants aged 30-79 years without diabetes, cardiovascular diseases or cancer at baseline. We defined low-risk lifestyle factors as non-smoking or having stopped for reasons other than illness; alcohol consumption of <30 g/day; upper quarter of the physical activity level; diet rich in vegetables and fruits, low in red meat and with some degree of replacement of rice with wheat; body mass index (BMI) of 18.5-23.9 kg/m 2 ; and waist-to-hip ratio (WHR) <0.90 (men)/<0.85 (women).
Results:
During a median of 7.2 years of follow-up, we identified 8784 incident T2DM. In multivariable-adjusted analyses, two important risk factors for developing T2DM were higher BMI and WHR. Compared with participants without any low-risk factors, the hazard ratio [95% confidence interval (CI)] for those with at least three low-risk factors was 0.20 (0.19, 0.22). Approximately 72.6% (64.2%, 79.3%) of the incident diabetes were attributable to the combination of BMI, WHR, diet and physical activity. The population attributable risk percentage (PAR%) of diabetes appeared to be similar for men and women, and higher among urban, older and obese participants.
Conclusions:
Our findings indicate that adherence to a healthy lifestyle may substantially lower the burden of T2DM in the Chinese population.
Background
Oxidative stress has a key role in the pathogenesis of type II diabetes mellitus (T2DM) and its vascular complications. Antioxidant therapy has been suggested as a potential approach to blunt T2DM development and progression. The aim of this study was to assess the effects of supplementation with curcuminoids, which are natural polyphenolics from turmeric, on oxidative indices in diabetic individuals. Methods
In this randomized double-blind placebo-controlled trial, 118 subjects with T2DM were randomized to curcuminoids (1000 mg/day co-administered with piperine 10 mg/day) or matching placebo for a period of 8 weeks. Serum total antioxidant capacity, superoxide dismutase (SOD) activities and malondialdehyde (MDA) concentrations were measured at baseline and after the supplementation period. ResultsCurcuminoids supplementation caused a significant elevation in serum total antioxidant capacity (TAC) (p < 0.001) and SOD activities (p < 0.001), while serum MDA levels were significantly reduced compared with the placebo group (p < 0.001). These results remained statistically significant after adjustment for potential confounders (baseline differences in body mass index and fasting serum insulin). Conclusion
The present results support an antioxidant effect of curcuminoids supplementation in patients with T2DM, and call for future studies to assess the impact of these antioxidant effects on the occurrence of diabetic complications and cardiovascular endpoints.
Over the years, natural products have shown success as antidiabetics in in vitro, in vivo and clinical trials. Because natural product-derived drugs are more affordable and effective with fewer side-effects compared to conventional therapies, pharmaceutical research is increasingly leaning towards the discovery of new antidiabetic drugs from natural products targeting pathways or components associated with type 2 diabetes mellitus (T2DM) pathophysiology. However, the drug discovery process is very lengthy and costly with significant challenges. Therefore, various techniques are currently being developed for the preclinical research phase of drug discovery with the aim of drug development with less time and efforts from natural products. In this review, we have provided an update on natural products including fruits, vegetables, spices, nuts, beverages and mushrooms with potential antidiabetic activities from in vivo, in vitro and clinical studies. Synergistic interactions between natural products and antidiabetic drugs; and potential antidiabetic active compounds from natural products are also documented to pave the way for combination treatment and new drug discovery, respectively. Additionally, a brief idea of the drug discovery process along with the challenges that arise during drug development from natural products and the methods to conquer those challenges are discussed to create a more convenient future drug discovery process.
Type 2 diabetes mellitus is a metabolic disease characterized by persistent hyperglycemia. High blood sugar can produce long-term complications such as cardiovascular and renal disorders, retinopathy, and poor blood flow. Its development can be prevented or delayed in people with impaired glucose tolerance by implementing lifestyle changes or use of therapeutic agents. Some of these drugs have been obtained from plants or have microbial origin, such as galegine isolated from Galega officinalis, which has a great similarity to the antidiabetic drug metformin. Picnogenol, acarbose miglitol and voglibose are other antidiabetic products of natural origin.
This review compiles the principal articles on medicinal plants used for treating diabetes and its comorbidities, as well as mechanisms of natural products as antidiabetic agents. Inhibition of -glucosidase and -amylase, effects on glucose uptake and glucose transporters, modification of mechanisms mediated by peroxisome proliferator-activated receptor, inhibition of protein tyrosine phosphatase 1B activity, modification of gene expression and activities of hormones involved in glucose homeostasis such as adiponectin, resistin and incretin, and reduction of oxidative stress are some of the mechanisms in which natural products are involved. We also review the most relevant clinical trials performed with medicinal plants and natural products such as aloe, banaba, bitter melon, caper, cinnamon, cocoa, coffee, fenugreek, garlic, guava, gymnema, nettle, sage, soybean, green and black tea, turmeric, walnut and yerba mate. Compounds of high interest as potential anti-diabetics are: fukugetin, palmatine, berberine, honokiol, amorfrutins, trigonelline, gymnemic acids, gurmarin and phlorizin.
The oxidative stress imposed by reactive oxygen species (ROS) plays an important role in many chronic and degenerative diseases. As an important category of phytochemicals, phenolic compounds universally exist in plants, and have been considered to have high antioxidant ability and free radical scavenging capacity, with the mechanism of inhibiting the enzymes responsible for ROS production and reducing highly oxidized ROS. Therefore, phenolic compounds have attracted increasing attention as potential agents for preventing and treating many oxidative stress-related diseases, such as cardiovascular diseases, cancer, ageing, diabetes mellitus and neurodegenerative diseases. This review summarizes current knowledge of natural polyphenols, including resource, bioactivities, bioavailability and potential toxicity.
